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Catalog No.:AA003IR3

3687-18-1 | 3-Amino-1-propanesulfonic acid

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
Chemical Name:
3-Amino-1-propanesulfonic acid
CAS Number:
Molecular Formula:
Molecular Weight:
MDL Number:
NSC Number:
293 °C (dec.)(lit.)  
Refractive Index:
1.5130 (estimate)  
Room Temperature;  

Computed Properties
Covalently-Bonded Unit Count:
Heavy Atom Count:
Hydrogen Bond Acceptor Count:
Hydrogen Bond Donor Count:
Rotatable Bond Count:


Title: High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach.

Journal: The Journal of biological chemistry 20121102

Title: Variable-temperature 17O NMR studies allow quantitative evaluation of molecular dynamics in organic solids.

Journal: Journal of the American Chemical Society 20120905

Title: Acamprosate for treatment of alcohol dependence: mechanisms, efficacy, and clinical utility.

Journal: Therapeutics and clinical risk management 20120101

Title: Metal chaperones: a holistic approach to the treatment of Alzheimer's disease.

Journal: Frontiers in psychiatry 20120101

Title: Alzheimer's disease and the amyloid cascade hypothesis: a critical review.

Journal: International journal of Alzheimer's disease 20120101

Title: Alzheimer's disease: a clinical practice-oriented review.

Journal: Frontiers in neurology 20120101

Title: Probing and trapping a sensitive conformation: amyloid-β fibrils, oligomers, and dimers.

Journal: Journal of Alzheimer's disease : JAD 20120101

Title: Calcium acamprosate: a triclinic polymorph.

Journal: Acta crystallographica. Section E, Structure reports online 20111201

Title: Alzheimer's disease: pathological mechanisms and recent insights.

Journal: Current neuropharmacology 20111201

Title: Current and emerging drug treatment options for Alzheimer's disease: a systematic review.

Journal: Drugs 20111022

Title: Reversed-phase liquid chromatographic determination of tramiprosate in rat plasma using evaporative light scattering detector.

Journal: Biomedical chromatography : BMC 20110801

Title: Precolumn derivatization followed by liquid chromatographic separation and determination of tramiprosate in rat plasma by fluorescence detector: application to pharmacokinetics.

Journal: Journal of pharmaceutical and biomedical analysis 20110515

Title: Gas-phase binding energies for non-covalent Aβ-40 peptide/small molecule complexes from CID mass spectrometry and RRKM theory.

Journal: Physical chemistry chemical physics : PCCP 20110321

Title: Predicting harms and benefits in translational trials: ethics, evidence, and uncertainty.

Journal: PLoS medicine 20110301

Title: Inhibition of glycosaminoglycan-mediated amyloid formation by islet amyloid polypeptide and proIAPP processing intermediates.

Journal: Journal of molecular biology 20110225

Title: Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study).

Journal: Archives of medical science : AMS 20110201

Title: Investigational drugs for the treatment of AD: what can we learn from negative trials?

Journal: Alzheimer's research & therapy 20110101

Title: Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment.

Journal: International journal of Alzheimer's disease 20110101

Title: Neurosteroid Binding Sites on the GABA(A) Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence.

Journal: Advances in pharmacological sciences 20110101

Title: Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease.

Journal: Frontiers in endocrinology 20110101

Title: Determination of the natural abundance δ15N of taurine by gas chromatography-isotope ratio measurement mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20101215

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: The persisting burden of intracerebral haemorrhage: can effective treatments be found?

Journal: PLoS medicine 20101001

Title: Investigation of the noncovalent interactions between anti-amyloid agents and amyloid beta peptides by ESI-MS.

Journal: Journal of the American Society for Mass Spectrometry 20100901

Title: [Progress in the development of anti-amyloid drugs for treatment of Alzheimer's disease.].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20100701

Title: Update on the pharmacological treatment of Alzheimer's disease.

Journal: Current neuropharmacology 20100301

Title: Glycine receptors in the nucleus accumbens involved in the ethanol intake-reducing effect of acamprosate.

Journal: Alcoholism, clinical and experimental research 20100101

Title: Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy.

Journal: Journal of Alzheimer's disease : JAD 20100101

Title: Reciprocal regulation between taurine and glutamate response via Ca2+-dependent pathways in retinal third-order neurons.

Journal: Journal of biomedical science 20100101

Title: Regulation of in vitro Aβ1-40 aggregation mediated by small molecules.

Journal: Journal of Alzheimer's disease : JAD 20100101

Title: Domain-specific cognitive effects of tramiprosate in patients with mild to moderate Alzheimer's disease: ADAS-cog subscale results from the Alphase Study.

Journal: The journal of nutrition, health & aging 20091101

Title: Homotaurine: a failed drug for Alzheimer's disease and now a nutraceutical for memory protection.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20091101

Title: Homotaurine metabolized to 3-sulfopropanoate in Cupriavidus necator H16: enzymes and genes in a patchwork pathway.

Journal: Journal of bacteriology 20091001

Title: Effect of tramiprosate in patients with mild-to-moderate Alzheimer's disease: exploratory analyses of the MRI sub-group of the Alphase study.

Journal: The journal of nutrition, health & aging 20090601

Title: Drug development for Alzheimer's disease: where are we now and where are we headed?

Journal: The American journal of geriatric pharmacotherapy 20090601

Title: Lessons learned in the use of volumetric MRI in therapeutic trials in Alzheimer's disease: the ALZHEMED (Tramiprosate) experience.

Journal: The journal of nutrition, health & aging 20090401

Title: Multivalent & multifunctional ligands to beta-amyloid.

Journal: Current pharmaceutical design 20090101

Title: Recent developments in Alzheimer's disease therapeutics.

Journal: BMC medicine 20090101

Title: The effects of taurine, taurine homologs and hypotaurine on cell and membrane antioxidative system alterations caused by type 2 diabetes in rat erythrocytes.

Journal: Advances in experimental medicine and biology 20090101

Title: The effects of taurine, hypotaurine, and taurine homologs on erythrocyte morphology, membrane fluidity and cytoskeletal spectrin alterations due to diabetes, alcoholism and diabetes-alcoholism in the rat.

Journal: Advances in experimental medicine and biology 20090101

Title: Alzheimer's disease therapeutic research: the path forward.

Journal: Alzheimer's research & therapy 20090101

Title: Present and prospective clinical therapeutic regimens for Alzheimer's disease.

Journal: Neuropsychiatric disease and treatment 20080801

Title: [New approaches for the development of anti-Alzheimer's disease drugs based on the cholinergic hypothesis and amyloid hypothesis].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20080501

Title: Assimilation of homotaurine-nitrogen by Burkholderia sp. and excretion of sulfopropanoate.

Journal: FEMS microbiology letters 20080201

Title: Preventing beta-amyloid fibrillization and deposition: beta-sheet breakers and pathological chaperone inhibitors.

Journal: BMC neuroscience 20080101

Title: Taurine, an inducer for tau polymerization and a weak inhibitor for amyloid-beta-peptide aggregation.

Journal: Neuroscience letters 20071218

Title: Pharmacogenetic aspects of addictive behaviors.

Journal: Dialogues in clinical neuroscience 20071201

Title: Anti-inflammatory and immune therapy for Alzheimer's disease: current status and future directions.

Journal: Current neuropharmacology 20071201

Title: Current therapeutic options for Alzheimer's disease.

Journal: Current genomics 20071201

Title: Progress update: Pharmacological treatment of Alzheimer's disease.

Journal: Neuropsychiatric disease and treatment 20071001

Title: The amyloid beta ion channel hypothesis of Alzheimer's disease.

Journal: Neuropsychiatric disease and treatment 20071001

Title: Therapies for Alzheimer's disease.

Journal: Nature reviews. Drug discovery 20070501

Title: Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis.

Journal: Neurobiology of aging 20070401

Title: Influences of different developmental periods of taurine supplements on synaptic plasticity in hippocampal CA1 area of rats following prenatal and perinatal lead exposure.

Journal: BMC developmental biology 20070101

Title: Changing the course of Alzheimer's disease: anti-amyloid disease-modifying treatments on the horizon.

Journal: Primary care companion to the Journal of clinical psychiatry 20070101

Title: Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau.

Journal: Molecular neurodegeneration 20070101

Title: Acamprosate: a new tool in the battle against alcohol dependence.

Journal: Neuropsychiatric disease and treatment 20061201

Title: A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease.

Journal: Neurology 20061128

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20061001

Title: Substrate specificity of the amino acid transporter PAT1.

Journal: Amino acids 20060901

Title: Influence of a proton gradient on the transport kinetics of the H+/amino acid cotransporter PAT1 in Caco-2 cells.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Tramiprosate.

Journal: Drugs of today (Barcelona, Spain : 1998) 20060501

Title: Diazepam inhibits the induction and maintenance of LTP of C-fiber evoked field potentials in spinal dorsal horn of rats.

Journal: Neuropharmacology 20060201

Title: Molecule of the month. Tramiprosate.

Journal: Drug news & perspectives 20060101

Title: A phase 2 study of tramiprosate for cerebral amyloid angiopathy.

Journal: Alzheimer disease and associated disorders 20060101

Title: The regulation of alpha-MSH release by GABA is mediated by a chloride-dependent [Ca2+]c increase in frog melanotrope cells.

Journal: Peptides 20051001

Title: Inhibitors arrest myofibrillogenesis in skeletal muscle cells at early stages of assembly.

Journal: Cell motility and the cytoskeleton 20040901

Title: Taurine-induced long-lasting potentiation in the rat hippocampus shows a partial dissociation from total hippocampal taurine content and independence from activation of known taurine transporters.

Journal: Journal of neurochemistry 20040601

Title: Transport of pharmacologically active proline derivatives by the human proton-coupled amino acid transporter hPAT1.

Journal: The Journal of pharmacology and experimental therapeutics 20040401

Title: Interactions of taurine and structurally related analogues with the GABAergic system and taurine binding sites of rabbit brain.

Journal: British journal of pharmacology 20030301

Title: Effects of sulfur containing amino acids on iron and nitric oxide stimulated catecholamine oxidation.

Journal: Amino acids 20020601

Title: Effects of acute acamprosate and homotaurine on ethanol intake and ethanol-stimulated mesolimbic dopamine release.

Journal: European journal of pharmacology 20020215

Title: Interactions between taurine and ethanol in the central nervous system.

Journal: Amino acids 20020101

Title: Role of K+ -channels in homotaurine-induced analgesia.

Journal: Fundamental & clinical pharmacology 20010601

Title: Synthesis and characterization of N,N-dichlorinated amino acids: taurine, homotaurine, GABA and L-leucine.

Journal: Neurochemical research 20010601

Title: Neurotoxic effect of acamprosate, n-acetyl-homotaurine, in cultured neurons.

Journal: Journal of biomedical science 20010101

Title: Taurine is a weak scavenger of peroxynitrite and does not attenuate sodium nitroprusside toxicity to cells in culture.

Journal: Amino acids 20010101

Title: Treatment of alcohol-dependent outpatients with acamprosate: a clinical review.

Journal: The Journal of clinical psychiatry 20010101

Title: GABAA receptor-mediated positive inotropism in guinea-pig isolated left atria: evidence for the involvement of capsaicin-sensitive nerves.

Journal: British journal of pharmacology 19890501

Title: Baclofen induces catatonia in rats.

Journal: Neuropharmacology 19870901

Title: The effect of peripherally administered GABA on noradrenaline-induced reflex vagal bradycardia in urethane anaesthetized rats.

Journal: General pharmacology 19850101

Title: Wu S et al. Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS. Neuropharmacology. 2014 Aug;83:107-17.

Title: Francine Gervais, et al. Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis. Neurobiol Aging. 2007 Apr;28(4):537-47.

Title: R G Fariello, et al. Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid. Neurology. 1982 Mar;32(3):241-5.

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Tags:3687-18-1 Molecular Formula|3687-18-1 MDL|3687-18-1 SMILES|3687-18-1 3-Amino-1-propanesulfonic acid