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37000-20-7,MFCD00867031
Catalog No.:AA00BZOJ

37000-20-7 | N-(2-Hydroxy-5-(1-hydroxy-2-(2-methyl-1-phenylpropan-2-ylamino)ethyl)phenyl)methanesulfonamide

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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BZOJ
Chemical Name:
N-(2-Hydroxy-5-(1-hydroxy-2-(2-methyl-1-phenylpropan-2-ylamino)ethyl)phenyl)methanesulfonamide
CAS Number:
37000-20-7
Molecular Formula:
C19H27ClN2O4S
Molecular Weight:
414.9467
MDL Number:
MFCD00867031
SMILES:
OC(c1ccc(c(c1)NS(=O)(=O)C)O)CNC(Cc1ccccc1)(C)C.Cl
Properties
Computed Properties
 
Complexity:
526  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
1  
XLogP3:
1.8  

Literature

Title: Rapid turnover of glycogen in memory formation.

Journal: Neurochemical research 20121101

Title: Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte.

Journal: Journal of molecular and cellular cardiology 20120201

Title: The pharmacological effects of the thermostabilising (m23) mutations and intra and extracellular (β36) deletions essential for crystallisation of the turkey β-adrenoceptor.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20110701

Title: Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling.

Journal: Trends in pharmacological sciences 20110401

Title: Inhalation by design: novel ultra-long-acting β(2)-adrenoreceptor agonists for inhaled once-daily treatment of asthma and chronic obstructive pulmonary disease that utilize a sulfonamide agonist headgroup.

Journal: Journal of medicinal chemistry 20100923

Title: Tissue functions mediated by beta(3)-adrenoceptors-findings and challenges.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20100801

Title: The selectivity of beta-adrenoceptor agonists at human beta1-, beta2- and beta3-adrenoceptors.

Journal: British journal of pharmacology 20100701

Title: A full pharmacological analysis of the three turkey β-adrenoceptors and comparison with the human β-adrenoceptors.

Journal: PloS one 20100101

Title: Laminin enhances beta(2)-adrenergic receptor stimulation of L-type Ca(2+) current via cytosolic phospholipase A(2) signalling in cat atrial myocytes.

Journal: The Journal of physiology 20091015

Title: The beta3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor.

Journal: Molecular pharmacology 20081101

Title: Energy metabolism and memory processing: role of glucose transport and glycogen in responses to adrenoceptor activation in the chicken.

Journal: Brain research bulletin 20080615

Title: Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load.

Journal: Circulation research 20080606

Title: Greater glycogen utilization during 1- than 2-adrenergic receptor stimulation in the isolated perfused rat heart.

Journal: American journal of physiology. Endocrinology and metabolism 20071201

Title: Beta2- and beta3-adrenoceptors activate glucose uptake in chick astrocytes by distinct mechanisms: a mechanism for memory enhancement?

Journal: Journal of neurochemistry 20071101

Title: beta2-Adrenergic receptor agonists stimulate L-type calcium current independent of PKA in newborn rabbit ventricular myocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20071101

Title: (-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through beta2 -adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070301

Title: Endurance exercise training attenuates cardiac beta2-adrenoceptor responsiveness and prevents ventricular fibrillation in animals susceptible to sudden death.

Journal: American journal of physiology. Heart and circulatory physiology 20060601

Title: Agonist effects of zinterol at the mouse and human beta(3)-adrenoceptor.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20060501

Title: Multiple signalling pathways involved in beta2-adrenoceptor-mediated glucose uptake in rat skeletal muscle cells.

Journal: British journal of pharmacology 20060201

Title: Temporal dynamics of inotropic, chronotropic, and metabolic responses during beta1- and beta2-AR stimulation in the isolated, perfused rat heart.

Journal: American journal of physiology. Endocrinology and metabolism 20050901

Title: The cytosolic phospholipase A2 pathway, a safeguard of beta2-adrenergic cardiac effects in rat.

Journal: The Journal of biological chemistry 20050513

Title: Beneficial effects of chronic pharmacological manipulation of beta-adrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy.

Journal: Circulation 20040831

Title: Characterization of agonist stimulation of cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies.

Journal: Molecular pharmacology 20040101

Title: beta2-Adrenergic signaling in human heart: shift from the cyclic AMP to the arachidonic acid pathway.

Journal: Molecular pharmacology 20031101

Title: Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts.

Journal: Circulation 20030930

Title: New insights into beta2-adrenoceptor signaling in the adult rat heart.

Journal: Cardiovascular research 20030301

Title: High spinal anesthesia for cardiac surgery: effects on beta-adrenergic receptor function, stress response, and hemodynamics.

Journal: Anesthesiology 20030201

Title: Opposite action of beta1- and beta2-adrenergic receptors on Ca(V)1 L-channel current in rat adrenal chromaffin cells.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030101

Title: Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways.

Journal: Cell 20020920

Title: Characterization of the beta-adrenoceptor subtype involved in mediation of glucose transport in L6 cells.

Journal: British journal of pharmacology 20020901

Title: Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during beta2-adrenergic stimulation.

Journal: Circulation research 20020712

Title: beta(1)-Receptors increase cAMP and induce abnormal Ca(i) cycling in the German shepherd sudden death model.

Journal: American journal of physiology. Heart and circulatory physiology 20020401

Title: Effects of glucose and 2-deoxyglucose on memory formation in the chick: interaction with beta(3)-adrenoceptor agonists.

Journal: Neuroscience 20020101

Title: Beta(2)-adrenergic receptor agonists increase intracellular free Ca(2+) concentration cycling in ventricular cardiomyocytes through p38 and p42/44 MAPK-mediated cytosolic phospholipase A(2) activation.

Journal: The Journal of biological chemistry 20011026

Title: Enhanced cardiac L-type calcium current response to beta2-adrenergic stimulation in heart failure.

Journal: The Journal of pharmacology and experimental therapeutics 20010701

Title: Release of norepinephrine from human ovary: coupling to steroidogenic response.

Journal: Endocrine 20010701

Title: Murine ventricular L-type Ca(2+) current is enhanced by zinterol via beta(1)-adrenoceptors, and is reduced in TG4 mice overexpressing the human beta(2)-adrenoceptor.

Journal: British journal of pharmacology 20010501

Title: beta-Adrenergic receptor stimulation of L-type Ca2+ channels in rabbit portal vein myocytes involves both alphas and betagamma G protein subunits.

Journal: The Journal of physiology 20010215

Title: Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium.

Journal: Molecular pharmacology 19890301

Title: Gwee MC, et al. Pharmacological actions of a new -adrenoceptor agonist, MJ-9184-1, in anaesthetized cats. Br J Pharmacol. 1972 Nov;46(3):375-85.

Title: Skeberdis VA, et al. Beta-2 adrenergic activation of L-type Ca2+ current in cardiac myocytes. J Pharmacol Exp Ther. 1997 Nov;283(2):452-61.

Title: Desantiago J, et al. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res. 2008 Jun 6;102(11):1389-97.

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Tags:37000-20-7 Molecular Formula|37000-20-7 MDL|37000-20-7 SMILES|37000-20-7 N-(2-Hydroxy-5-(1-hydroxy-2-(2-methyl-1-phenylpropan-2-ylamino)ethyl)phenyl)methanesulfonamide