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372523-75-6,MFCD12828766
Catalog No.:AA007A2Y

372523-75-6 | TCS OX2 29

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
95%
in stock  
$199.00   $139.00
- +
10mg
95%
in stock  
$268.00   $188.00
- +
25mg
95%
in stock  
$463.00   $324.00
- +
50mg
95%
in stock  
$657.00   $460.00
- +
100mg
95%
in stock  
$1,118.00   $783.00
- +
250mg
95%
in stock  
$2,445.00   $1,712.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007A2Y
Chemical Name:
TCS OX2 29
CAS Number:
372523-75-6
Molecular Formula:
C23H32ClN3O3
Molecular Weight:
433.9715
MDL Number:
MFCD12828766
SMILES:
COc1cc2CN(CCc2cc1OC)C(=O)[C@H](C(C)(C)C)NCc1ccncc1.Cl
Properties
Computed Properties
 
Complexity:
530  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  

Literature

Title: Hypocretin/orexin signaling in the hypothalamic paraventricular nucleus is essential for the expression of nicotine withdrawal.

Journal: Biological psychiatry 20120201

Title: Orexins depolarize rostral ventrolateral medulla neurons and increase arterial pressure and heart rate in rats mainly via orexin 2 receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20100801

Title: Hirose M et al. N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidicantagonist. Bioorg Med Chem Lett, 2003 Dec 15, 13(24):4497-9.

Title: Tabaeizadeh M, et al. The differential effects of OX1R and OX2R selective antagonists on morphine conditioned place preference in naïve versus morphine-dependent mice. Behav Brain Res. 2013 Jan 15;237:41-8.

Title: R Mould et al. Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. Br J Pharmacol. 2014 Jan; 171(2): 351-363.

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