Home Other Building Blocks 3737-09-5
3737-09-5,MFCD00057366
Catalog No.:AA003VD0

3737-09-5 | Disopyramide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
97%
in stock  
$6.00   $4.00
- +
50mg
97%
in stock  
$14.00   $10.00
- +
1g
95%
in stock  
$58.00   $40.00
- +
5g
≥ 98% (Assay)
in stock  
$165.00   $116.00
- +
25g
≥ 98% (Assay)
in stock  
$619.00   $434.00
- +
100g
≥ 98% (Assay)
in stock  
$2,259.00   $1,582.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003VD0
Chemical Name:
Disopyramide
CAS Number:
3737-09-5
Molecular Formula:
C21H29N3O
Molecular Weight:
339.4745
MDL Number:
MFCD00057366
SMILES:
CC(N(C(C)C)CCC(c1ccccn1)(c1ccccc1)C(=O)N)C
Properties
Properties
 
BP:
505.2°C at 760 mmHg  
Form:
Solid  
MP:
94.5-950C  
Refractive Index:
1.6300 (estimate)  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
409  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
1  
XLogP3:
3.2  

Downstream Synthesis Route

[1]CurrentPatentAssignee:SumitomoChemical(w/oDongwooFine-Chem);SUMITOMOCHEMICALCOMPANYLIMITED-EP1655286,2006,A1Locationinpatent:Page/Pagecolumn5

Literature

Title: Why are most phospholipidosis inducers also hERG blockers?

Journal: Archives of toxicology 20171201

Title: Screening of a chemical library reveals novel PXR-activating pharmacologic compounds.

Journal: Toxicology letters 20150105

Title: Management strategy in 249 consecutive patients with obstructive hypertrophic cardiomyopathy referred to a dedicated program.

Journal: The American journal of cardiology 20121015

Title: Validation of visualized transgenic zebrafish as a high throughput model to assay bradycardia related cardio toxicity risk candidates.

Journal: Journal of applied toxicology : JAT 20121001

Title: A novel relay method for determining low-clearance values.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120901

Title: Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Journal: Journal of medicinal chemistry 20120524

Title: Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation.

Journal: The Cochrane database of systematic reviews 20120516

Title: Impact of probe compound in MRP2 vesicular transport assays.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120512

Title: Cardiac amyloidosis mimicking hypertrophic cardiomyopathy with obstruction: treatment with disopyramide.

Journal: Circulation 20120410

Title: Atrial fibrillation with a giant left atrial appendage can be successfully treated with pulmonary vein antrum isolation.

Journal: Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 20120401

Title: Antiarrhythmic drugs for the maintenance of sinus rhythm: risks and benefits.

Journal: International journal of cardiology 20120322

Title: Lansoprazole precipitated QT prolongation and torsade de pointes associated with disopyramide.

Journal: European journal of clinical pharmacology 20120301

Title: Pharmacological prevention and termination of focal atrial fibrillation.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20120301

Title: A novel method of selecting human embryonic stem cell-derived cardiomyocyte clusters for assessment of potential to influence QT interval.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20120301

Title: Molecular determinants of hERG potassium channel inhibition by disopyramide.

Journal: Journal of molecular and cellular cardiology 20120101

Title: Managing atrial fibrillation in the elderly: critical appraisal of dronedarone.

Journal: Clinical interventions in aging 20120101

Title: Mechanisms, risk factors, and management of acquired long QT syndrome: a comprehensive review.

Journal: TheScientificWorldJournal 20120101

Title: Biventricular / left ventricular pacing in hypertrophic obstructive cardiomyopathy: an overview.

Journal: Indian pacing and electrophysiology journal 20120101

Title: A primer of disopyramide treatment of obstructive hypertrophic cardiomyopathy.

Journal: Progress in cardiovascular diseases 20120101

Title: Can pharmacologic gradient reduction decrease mortality in hypertrophic cardiomyopathy?

Journal: Progress in cardiovascular diseases 20120101

Title: Addressing the management of atrial fibrillation - a systematic review of the role of dronedarone.

Journal: International journal of general medicine 20120101

Title: Beers criteria for potentially inappropriate medication use in older adults.

Journal: Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses 20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Efficacy and potency of class I antiarrhythmic drugs for suppression of Ca2+ waves in permeabilized myocytes lacking calsequestrin.

Journal: Journal of molecular and cellular cardiology 20111101

Title: Disopyramide-induced hypoglycemia in a non-diabetic hemodialysis patient: a case report and review of the literature.

Journal: Clinical nephrology 20111101

Title: Hypoglycemia revisited in the acute care setting.

Journal: Yonsei medical journal 20111101

Title: Drugs and pacemakers for vasovagal, carotid sinus and situational syncope.

Journal: The Cochrane database of systematic reviews 20111005

Title: Atrial fibrillation: the cost of illness in Sweden.

Journal: The European journal of health economics : HEPAC : health economics in prevention and care 20111001

Title: The hERG K(+) channel S4 domain L532P mutation: characterization at 37°C.

Journal: Biochimica et biophysica acta 20111001

Title: Negative ionotropic agents for the treatment of left ventricular outflow tract obstruction due to sigmoid septum and concentric left ventricular hypertrophy.

Journal: Heart, lung & circulation 20110901

Title: Is antiarrhythmic treatment in the elderly different? a review of the specific changes.

Journal: Drugs & aging 20110801

Title: Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

Journal: Journal of medicinal chemistry 20110714

Title: Structural insights into differences in drug-binding selectivity between two forms of human alpha1-acid glycoprotein genetic variants, the A and F1*S forms.

Journal: The Journal of biological chemistry 20110422

Title: Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia.

Journal: Circulation. Arrhythmia and electrophysiology 20110401

Title: Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice.

Journal: Pharmaceutical research 20110301

Title: Atrial fibrillation and the use of oral bisphosphonates.

Journal: Therapeutics and clinical risk management 20110101

Title: Monitoring disopyramide, lidocaine, and quinidine by micellar liquid chromatography.

Journal: Journal of AOAC International 20110101

Title: Pharmacological management of atrial fibrillation: one, none, one hundred thousand.

Journal: Cardiology research and practice 20110101

Title: Depression in vascular pathologies: the neurologist's point of view.

Journal: Vascular health and risk management 20110101

Title: Frequent Ventricular Premature Contractions under Anaesthesia in Prone Position.

Journal: Journal of anaesthesiology, clinical pharmacology 20110101

Title: Predictors of atrial fibrillation following coronary artery bypass grafting.

Journal: Clinical Medicine Insights. Cardiology 20110101

Title: Drug use in elderly patients: Are we there yet?

Journal: Journal of pharmacology & pharmacotherapeutics 20110101

Title: Anaesthetic management of Wolff-Parkinson-White syndrome for hysterectomy.

Journal: Indian journal of anaesthesia 20110101

Title: Combined effect of disopyramide and erythromycin on ventricular repolarization in dogs with complete atrioventricular block.

Journal: International heart journal 20110101

Title: Pharmacokinetics and pharmacodynamics of insulin analogs in special populations with type 2 diabetes mellitus.

Journal: International journal of general medicine 20110101

Title: Hypertrophic Cardiomyopathy in a Young Adult with RV Aneurysm: Report of a Rare Finding and Review of the Literature.

Journal: Heart views : the official journal of the Gulf Heart Association 20110101

Title: Successful drug development despite adverse preclinical findings part 1: processes to address issues and most important findings.

Journal: Journal of toxicologic pathology 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Comparison of acute reduction in left ventricular outflow tract pressure gradient in obstructive hypertrophic cardiomyopathy by disopyramide versus pilsicainide versus cibenzoline.

Journal: The American journal of cardiology 20101101

Title: Hypertrophic cardiomyopathy in childhood and adolescence - strategies to prevent sudden death.

Journal: Fundamental & clinical pharmacology 20101001

Title: Prospective comparative study of intravenous cibenzoline and disopyramide therapy in the treatment of paroxysmal atrial fibrillation after cardiovascular surgery.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20100901

Title: An anesthetic experience with cesarean section in a patient with vasovagal syncope -A case report-.

Journal: Korean journal of anesthesiology 20100801

Title: High efficacy of disopyramide in the management of ventricular fibrillation storms in a patient with Brugada syndrome.

Journal: Pacing and clinical electrophysiology : PACE 20100601

Title: Synergistic effect of dual chamber pacing and disopyramide in obstructive hypertrophic cardiomyopathy.

Journal: International journal of cardiology 20100528

Title: Recurrent Torsade de Pointes during mild hypothermia therapy for a survivor of sudden cardiac arrest due to drug-induced long-QT syndrome.

Journal: Journal of cardiovascular electrophysiology 20100401

Title: Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.

Journal: Clinical and experimental nephrology 20100401

Title: Pilsicainide.

Journal: Drugs 20100305

Title: Prediction of phospholipidosis-inducing potential of drugs by in vitro biochemical and physicochemical assays followed by multivariate analysis.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100301

Title: Possible acute and chronic synergistic effect of dual chamber pacing and disopyramide in obstructive hypertrophic cardiomyopathy: a case report.

Journal: European journal of heart failure 20100101

Title: Evaluation of selective competitive binding of basic drugs to alpha1-acid glycoprotein variants.

Journal: Biological & pharmaceutical bulletin 20100101

Title: Congenital short QT syndrome.

Journal: Indian pacing and electrophysiology journal 20100101

Title: Construction of an expression system for human alpha(1)-acid glycoprotein in E. coli: The roles of oligosaccharide moieties in structural and functional properties.

Journal: Drug metabolism and pharmacokinetics 20100101

Title: Principal component analysis of HPLC retention data and molecular modeling structural parameters of cardiovascular system drugs in view of their pharmacological activity.

Journal: International journal of molecular sciences 20100101

Title: Dronedarone for the treatment of atrial fibrillation and atrial flutter: approval and efficacy.

Journal: Vascular health and risk management 20100101

Title: Evidence at a glance: error matrix approach for overviewing available evidence.

Journal: BMC medical research methodology 20100101

Title: Sudden cause of cardiac death-be aware of me: a case report and short review on brugada syndrome.

Journal: Case reports in medicine 20100101

Title: Evaluation of bachmann bundle pacing versus right atrial pacing in prevention of atrial fibrillation after coronary artery bypass surgery.

Journal: Indian pacing and electrophysiology journal 20100101

Title: Medical management of hypertrophic cardiomyopathy.

Journal: Reviews in cardiovascular medicine 20100101

Title: Stereoselective Inhibition of the hERG1 Potassium Channel.

Journal: Frontiers in pharmacology 20100101

Title: Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome.

Journal: Journal of molecular and cellular cardiology 20091101

Title: Empirical correlation of triggered activity and spatial and temporal re-entrant substrates with arrhythmogenicity in a murine model for Jervell and Lange-Nielsen syndrome.

Journal: Pflugers Archiv : European journal of physiology 20090901

Title: Toward a new 'EPOCH': optimising treatment outcomes with phosphodiesterase type 5 inhibitors for erectile dysfunction.

Journal: International journal of clinical practice 20090801

Title: Quantitative assessment of cibenzoline administration for vagally mediated paroxysmal atrial fibrillation using frequency-domain heart rate variability analysis.

Journal: Journal of cardiology 20090801

Title: Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance.

Journal: Current cardiology reviews 20090801

Title: Cardiopulmonary exercise testing diagnosis of myocardial suppression.

Journal: Anaesthesia 20090701

Title: [Drug treatment for hypertrophic cardiomyopathy].

Journal: Presse medicale (Paris, France : 1983) 20090601

Title: Effects of antiarrhythmic drugs on the hyperpolarization-activated cyclic nucleotide-gated channel current.

Journal: Journal of pharmacological sciences 20090601

Title: New trends in treatment of hypertrophic cardiomyopathy.

Journal: Archives of cardiovascular diseases 20090501

Title: Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome.

Journal: Human mutation 20090401

Title: Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes).

Journal: The Journal of toxicological sciences 20090401

Title: Provokable left ventricular outflow tract obstruction in a patient without hypertrophy.

Journal: Nature reviews. Cardiology 20090401

Title: Drug-induced hypoglycaemia.

Journal: Prescrire international 20090401

Title: Right ventricular outflow tract obstruction after bilateral lung transplantation.

Journal: The Thoracic and cardiovascular surgeon 20090201

Title: Mechanism of disopyramide-induced hypoglycaemia in a patient with Type 2 diabetes.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20090101

Title: Extracorporeal life support in severe drug intoxication: a retrospective cohort study of seventeen cases.

Journal: Critical care (London, England) 20090101

Title: Myocardial ischemia with left ventricular outflow obstruction.

Journal: Journal of cardiothoracic surgery 20090101

Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.

Journal: PloS one 20090101

Title: Short QT syndrome: a review.

Journal: Cardiology in review 20090101

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs.

Journal: British journal of pharmacology 20081101

Title: Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.

Journal: Journal of medicinal chemistry 20081009

Title: 1H NMR and UPLC-MS(E) statistical heterospectroscopy: characterization of drug metabolites (xenometabolome) in epidemiological studies.

Journal: Analytical chemistry 20080915

Title: Kv1.5 open channel block by the antiarrhythmic drug disopyramide: molecular determinants of block.

Journal: Journal of pharmacological sciences 20080901

Title: Hemodynamics changes after tilting and the efficacy of preventive drugs.

Journal: Pacing and clinical electrophysiology : PACE 20080901

Title: Nifekalant and disopyramide in a patient with short QT syndrome: evaluation of pharmacological effects and electrophysiological properties.

Journal: Pacing and clinical electrophysiology : PACE 20080901

Title: The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy.

Journal: Cardiovascular research 20080801

Title: Disopyramide for transient high-degree atrioventricular block in a young patient with a history of syncope.

Journal: Journal of cardiology 20080801

Title: Effects of serum concentrations of disopyramide and its metabolite mono-N-dealkyldisopyramide on the anticholinergic side effects associated with disopyramide.

Journal: Biological & pharmaceutical bulletin 20080701

Title: [How to treat arrhythmias in thoracic surgery].

Journal: Kyobu geka. The Japanese journal of thoracic surgery 20080701

Title: Oral disopyramide for the acute treatment of severe outflow obstruction in hypertrophic cardiomyopathy in the ICU setting.

Journal: Chest 20080501

Title: Utility of isoproterenol to provoke outflow tract gradients in patients with hypertrophic cardiomyopathy.

Journal: The American journal of cardiology 20080215

Title: Removal efficiency of 66 pharmaceuticals during wastewater treatment process in Japan.

Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20080101

Title: Effect of drugs on defibrillation capacity.

Journal: Drugs 20080101

Title: Pediatric electrophysiology in India: a sub-speciality come of age.

Journal: Indian pacing and electrophysiology journal 20080101

Title: Laugh syncope as a rare sub-type of the situational syncopes: a case report.

Journal: Journal of medical case reports 20080101

Title: Severe respiratory failure and torsades de pointes induced by disopyramide in a patient with myasthenia gravis.

Journal: Internal medicine (Tokyo, Japan) 20080101

Title: Role of cytochrome P450 in drug interactions.

Journal: Nutrition & metabolism 20080101

Title: The prince and the pauper. A tale of anticancer targeted agents.

Journal: Molecular cancer 20080101

Title: Dual chamber pacing in a patient of hypertrophic cardiomyopathy with failure to wean from mechanical ventilator.

Journal: Indian pacing and electrophysiology journal 20080101

Title: Drug use in children: cohort study in three European countries.

Journal: BMJ (Clinical research ed.) 20080101

Title: Syncope: Evaluation and management.

Journal: The Libyan journal of medicine 20080101

Title: In vivo effects of mutant HERG K+ channel inhibition by disopyramide in patients with a short QT-1 syndrome: a pilot study.

Journal: Journal of cardiovascular electrophysiology 20071101

Title: Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation.

Journal: The Cochrane database of systematic reviews 20071017

Title: Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin.

Journal: Biochemical pharmacology 20070801

Title: Selective binding of tamsulosin to genetic variants of human alpha1-acid glycoprotein.

Journal: Biological & pharmaceutical bulletin 20070801

Title: Phase II testing of sunitinib: the National Cancer Institute of Canada Clinical Trials Group IND Program Trials IND.182-185.

Journal: Current oncology (Toronto, Ont.) 20070801

Title: Syncope in athletes: a guide to getting them back on their feet.

Journal: The Journal of family practice 20070701

Title: Serum cardiac markers in patients with acute myocardial infarction: oxidative stress, C-reactive protein and N-terminal probrain natriuretic Peptide.

Journal: Journal of clinical biochemistry and nutrition 20070701

Title: Case of paroxysmal atrial fibrillation improved after the administration of proton pump inhibitor for associated reflux esophagitis.

Journal: Fukuoka igaku zasshi = Hukuoka acta medica 20070601

Title: Extractive-spectrophotometric determination of disopyramide and irbesartan in their pharmaceutical formulation.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070401

Title: Determinants of potential drug-drug interaction associated dispensing in community pharmacies in the Netherlands.

Journal: Pharmacy world & science : PWS 20070401

Title: NIP-141, a multiple ion channel blocker, terminates aconitine-induced atrial fibrillation and prevents the rapid pacing-induced atrial effective refractory period shortening in dogs.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20070401

Title: Alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a review of the literature.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20070401

Title: Neuropsychiatric consequences of cardiovascular medications.

Journal: Dialogues in clinical neuroscience 20070301

Title: Involvement of alpha1-acid glycoprotein in inter-individual variation of disposition kinetics of ropivacaine following epidural infusion in off-pump coronary artery bypass grafting.

Journal: The Journal of pharmacy and pharmacology 20070101

Title: Clinical review: aggressive management and extracorporeal support for drug-induced cardiotoxicity.

Journal: Critical care (London, England) 20070101

Title: Antiarrhythmics: elimination and dosage considerations in hepatic impairment.

Journal: Clinical pharmacokinetics 20070101

Title: Pathophysiology of hypertrophic cardiomyopathy determines its medical treatment.

Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20061201

Title: Echocardiography in the treatment of hypertrophic cardiomyopathy.

Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20061201

Title: CE coupling with end-column electrochemiluminescence detection for chiral separation of disopyramide.

Journal: Electrophoresis 20061101

Title: Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome.

Journal: Journal of molecular and cellular cardiology 20060901

Title: Disopyramide: although potentially life-threatening in the setting of long QT, could it be life-saving in short QT syndrome?

Journal: Journal of molecular and cellular cardiology 20060901

Title: Frequency of high-risk use of QT-prolonging medications.

Journal: Pharmacoepidemiology and drug safety 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Increased AAI mode pacing threshold after termination of atrial fibrillation by acute administration of disopyramide phosphate.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20060501

Title: Na'Fuzzy space': does it exist, and is it important in ischemic injury?

Journal: Journal of cardiovascular electrophysiology 20060501

Title: Malignant vasovagal syncope.

Journal: Dental update 20060501

Title: Phase I and pharmacokinetic study of amrubicin, a synthetic 9-aminoanthracycline, in patients with refractory or relapsed lung cancer.

Journal: Cancer chemotherapy and pharmacology 20060201

Title: Effects of cardioactive medications on retrograde conduction: continuing relevance for current devices.

Journal: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20060101

Title: Potassium channel gene mutations rarely cause atrial fibrillation.

Journal: BMC medical genetics 20060101

Title: Stability-indicating methods for the determination of disopyramide phosphate.

Journal: Journal of AOAC International 20060101

Title: Cardiac effects of ST-6, a novel cyclohexane dicarboximide derivative.

Journal: Cardiovascular drug reviews 20060101

Title: [Atrial flutter and fibrillation].

Journal: Praxis 20051109

Title: Heart rate variability is a useful parameter for evaluation of anticholinergic effect associated with inducibility of atrial fibrillation.

Journal: Pacing and clinical electrophysiology : PACE 20051101

Title: Influence of hypothyroidism induced by thiamazole on the toxic interaction between propranolol and disopyramide in chick embryos.

Journal: Biological & pharmaceutical bulletin 20051001

Title: Cough reflex by ventricular premature contractions.

Journal: International heart journal 20050901

Title: Population pharmacokinetic investigation of disopyramide by mixed effect modelling using routine clinical pharmacokinetic data in Japanese patients.

Journal: Journal of clinical pharmacy and therapeutics 20050801

Title: The novel formulation design of self-emulsifying drug delivery systems (SEDDS) type O/W microemulsion I: enhancing effects on oral bioavailability of poorly water soluble compounds in rats and beagle dogs.

Journal: Drug metabolism and pharmacokinetics 20050801

Title: Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.

Journal: Journal of pharmaceutical sciences 20050701

Title: Repolarization dynamics in patients with idiopathic ventricular fibrillation: pharmacological therapy with bepridil and disopyramide.

Journal: Journal of cardiovascular pharmacology 20050601

Title: Atrial pacing failure following termination of atrial fibrillation by acute administration of disopyramide phosphate.

Journal: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20050601

Title: Class I antiarrhythmics inhibit Na+ absorption and Cl- secretion in rabbit descending colon epithelium.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050601

Title: Expert Canadian consensus suggestions on the rational, clinical use of ziprasidone in the treatment of schizophrenia and related psychotic disorders.

Journal: Neuropsychiatric disease and treatment 20050601

Title: Multicenter study of the efficacy and safety of disopyramide in obstructive hypertrophic cardiomyopathy.

Journal: Journal of the American College of Cardiology 20050419

Title: [Chiral separation of disopyramide enantiomers by capillary electrophoresis].

Journal: Se pu = Chinese journal of chromatography 20050301

Title: Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4.

Journal: Therapeutics and clinical risk management 20050301

Title: A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20050201

Title: Appropriate dosing of antiarrhythmic drugs in Japan requires therapeutic drug monitoring.

Journal: Journal of clinical pharmacy and therapeutics 20050201

Title: Pilsicainide in breast milk from a mother: comparison with disopyramide and propafenone.

Journal: British journal of clinical pharmacology 20050101

Title: Toxic interactions between fluconazole and disopyramide in chick embryos.

Journal: Biological & pharmaceutical bulletin 20050101

Title: [Atrial fibrillation: choice of the method of pharmacological cardioversion].

Journal: Kardiologiia 20050101

Title: Serial antiarrhythmic therapy: role of amiodarone in prevention of atrial fibrillation recurrence--a lesson from the HOT CAFE Polish Study.

Journal: Cardiology 20050101

Title: Deglutition-induced atrial fibrillation.

Journal: Texas Heart Institute journal 20050101

Title: Rate-control or rhythm-control: where do we stand?

Journal: Indian pacing and electrophysiology journal 20050101

Title: Role of biatrial pacing in prevention of atrial fibrillation after coronary artery bypass surgery.

Journal: Indian pacing and electrophysiology journal 20050101

Title: Electrical storms in Brugada syndrome: review of pharmacologic and ablative therapeutic options.

Journal: Indian pacing and electrophysiology journal 20050101

Title: Simultaneous supraventricular tachycardias in both fetuses of a twin gestation.

Journal: Archives of gynecology and obstetrics 20041201

Title: Failure of disopyramide to improve right ventricular outflow tract obstruction after living-donor lobar lung transplantation.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20041101

Title: Acute ventricular rate control in atrial fibrillation and atrial flutter.

Journal: International journal of cardiology 20041001

Title: Pharmacological treatment of reflex syncope.

Journal: Clinical autonomic research : official journal of the Clinical Autonomic Research Society 20041001

Title: Human organic cation transporter 3 mediates the transport of antiarrhythmic drugs.

Journal: European journal of pharmacology 20040919

Title: Myocardial bundles with slow conduction properties are present on the left interventricular septal surface of normal human hearts.

Journal: Journal of cardiovascular electrophysiology 20040901

Title: A patient responding to combined therapy with pirmenol and midodrine for refractory neurally mediated syncope complicated by prostatic hypertrophy.

Journal: Cardiovascular drugs and therapy 20040901

Title: Accuracy of calculated pH-dependent aqueous drug solubility.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040801

Title: Rate control vs rhythm control in patients with nonvalvular persistent atrial fibrillation: the results of the Polish How to Treat Chronic Atrial Fibrillation (HOT CAFE) Study.

Journal: Chest 20040801

Title: Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channels.

Journal: Journal of pharmacological sciences 20040701

Title: Is this form of syncope to blame?

Journal: RN 20040601

Title: Effects of antiarrhythmic agents on left ventricular function during exercise in patients with chronic left ventricular dysfunction.

Journal: Annals of nuclear medicine 20040501

Title: Recurrent syncopic episodes as a consequence of combined Brugada syndrome and paroxysmal atrial fibrillation. Which is the therapy of choice?

Journal: International journal of cardiology 20040401

Title: Atrial fibrillation: rate control often better than rhythm control.

Journal: Prescrire international 20040401

Title: Sex-dependent modulation of treatment response.

Journal: Dialogues in clinical neuroscience 20040301

Title: Antiarrhythmic drug therapy of atrial fibrillation.

Journal: Cardiology clinics 20040201

Title: Two cases of ventricular tachycardia with congenital left ventricular malformation in an adult.

Journal: Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20040201

Title: Effects of class I antiarrhythmic drugs on the digitalis-induced triggered activity arrhythmia model: a rationale for the short-term use of class I drugs against triggered arrhythmias.

Journal: Heart and vessels 20040101

Title: Theoretical possibilities for the development of novel antiarrhythmic drugs.

Journal: Current medicinal chemistry 20040101

Title: Repolarization abnormality in idiopathic ventricular fibrillation: assessment using 24-hour QT-RR and QaT-RR relationships.

Journal: Journal of cardiovascular electrophysiology 20040101

Title: Interactions between grapefruit juice and cardiovascular drugs.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20040101

Title: Role of pharmacotherapy in Brugada syndrome.

Journal: Indian pacing and electrophysiology journal 20040101

Title: Management of newly detected atrial fibrillation: a clinical practice guideline from the American Academy of Family Physicians and the American College of Physicians.

Journal: Annals of internal medicine 20031216

Title: Management of atrial fibrillation: review of the evidence for the role of pharmacologic therapy, electrical cardioversion, and echocardiography.

Journal: Annals of internal medicine 20031216

Title: Differential binding of disopyramide and warfarin enantiomers to human alpha(1)-acid glycoprotein variants.

Journal: British journal of clinical pharmacology 20031201

Title: Ropivacaine combined with various anti-arrhythmic drugs results in mild alterations in myocardial contractility in pigs.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20031201

Title: Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.

Journal: British journal of cancer 20031117

Title: [An approach to complete the manual for determination of serum pirmenol levels].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20031101

Title: Randomized clinical trials of neurally mediated syncope.

Journal: Journal of cardiovascular electrophysiology 20030901

Title: [Drug binding analysis of human alpha 1-acid glycoprotein using capillary electrophoresis].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20030901

Title: [Relationship between duration of arrhythmia and subsequent preventive effect of disopyramide after cardioversion in patients with symptomatic paroxysmal and persistent atrial fibrillation].

Journal: Journal of cardiology 20030901

Title: Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.

Journal: Bioorganic & medicinal chemistry letters 20030818

Title: Capillary electrophoretic study on pH dependence of enantioselective disopyramide binding to genetic variants of human alpha1-acid glycoprotein.

Journal: The Analyst 20030801

Title: Interaction of quinidine, disopyramide and metoprolol with melanin in vitro in relation to drug-induced ocular toxicity.

Journal: Die Pharmazie 20030701

Title: Inhibitory effect of erythromycin on potassium currents in rat ventricular myocytes in comparison with disopyramide.

Journal: The Journal of pharmacy and pharmacology 20030701

Title: Characterisation of recombinant HERG K+ channel blockade by the Class Ia antiarrhythmic drug procainamide.

Journal: Biochemical and biophysical research communications 20030627

Title: Safety and feasibility of a clinical pathway for the outpatient initiation of antiarrhythmic medications in patients with atrial fibrillation or atrial flutter.

Journal: The American journal of cardiology 20030615

Title: [Drug therapy of atrial fibrillation].

Journal: Orvosi hetilap 20030615

Title: Effects of orthostatic self-training on head-up tilt testing for the prevention of tilt-induced neurocardiogenic syncope: comparison of pharmacological therapy.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20030401

Title: [Comparison of the efficacies of disopyramide, cibenzoline and aprindine for the termination of paroxysmal and persistent atrial fibrillation in elderly and non-elderly patients].

Journal: Journal of cardiology 20030401

Title: Comparison of the effect of class IA antiarrhythmic drugs on transmembrane potassium currents in rabbit ventricular myocytes.

Journal: Journal of cardiovascular pharmacology and therapeutics 20030301

Title: Ventricular tachycardia with congenital left ventricular aneurysm in an adult.

Journal: Interactive cardiovascular and thoracic surgery 20030301

Title: Abnormal response to sodium channel blockers in patients with Brugada syndrome: augmented localised wall motion abnormalities in the right ventricular outflow tract region detected by electron beam computed tomography.

Journal: Heart (British Cardiac Society) 20030201

Title: The effect of commonly used drugs on angiogenesis.

Journal: Anticancer research 20030101

Title: Multivariate analysis of risk factors for QT prolongation following subarachnoid hemorrhage.

Journal: Critical care (London, England) 20030101

Title: [Anti-arrhythmic therapy: diagnostic possibilities of signal-averaged electrocardiography and heart rate variability].

Journal: Kardiologiia 20030101

Title: QT prolongation and fatal arrhythmias: a review of clinical implications and effects of drugs.

Journal: American journal of therapeutics 20030101

Title: Hypertrophic obstructive cardiomyopathy: mechanism of obstruction and response to therapy.

Journal: Reviews in cardiovascular medicine 20030101

Title: Role of atrial fibrillation threshold evaluation on guiding treatment.

Journal: Indian pacing and electrophysiology journal 20030101

Title: Age- and gender-related differences in carbohydrate concentrations of alpha1-acid glycoprotein variants and the effects of glycoforms on their drug-binding capacities.

Journal: European journal of clinical pharmacology 20021201

Title: MDR1-mediated interaction of digoxin with antiarrhythmic or antianginal drugs.

Journal: Biological & pharmaceutical bulletin 20021201

Title: [Role amiodarone in sinus rhythm maintenance after successful cardioversion in patients with chronic non-valvular atrial fibrillation].

Journal: Polskie Archiwum Medycyny Wewnetrznej 20021201

Title: [Molecular diversity of organic cation transporter (OCT) mediating renal excretion of drugs].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20021101

Title: What is the minimal pacing rate that prevents torsades de pointes? Insights from patients with permanent pacemakers.

Journal: Pacing and clinical electrophysiology : PACE 20021101

Title: Atrial fibrillation threshold predicted long-term efficacy of pharmacological treatment of patients without structural heart disease.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20021001

Title: Maintaining stability of sinus rhythm in atrial fibrillation: antiarrhythmic drugs versus ablation.

Journal: Current cardiology reports 20020901

Title: Effects of disopyramide and mexiletine on the terminal repolarization process of the in situ heart assessed using the halothane-anesthetized in vivo canine model.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20020901

Title: Quantification of pilsicainide in serum by capillary electrophoresis.

Journal: Journal of pharmaceutical and biomedical analysis 20020720

Title: Effective disopyramide treatment in a boy with mid-ventricular hypertrophic obstructive cardiomyopathy.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20020701

Title: [Antiarrhythmic drugs in atrial fibrillation].

Journal: La Revue du praticien 20020615

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Attenuation of aortic banding-induced cardiac hypertrophy by propranolol is independent of beta-adrenoceptor blockade.

Journal: Journal of hypertension 20020401

Title: Cisapride reverses the anticholinergic effect of disopyramide on the isolated guinea-pig urinary bladder.

Journal: Journal of veterinary pharmacology and therapeutics 20020401

Title: Hypertrophic cardiomyopathy: a systematic review.

Journal: JAMA 20020313

Title: Disopyramide-induced neuropathy.

Journal: Neurology 20020226

Title: An intraoperative diagnosis of dynamic left ventricular outflow tract obstruction using transesophageal echocardiography leads to the treatment with intravenous disopyramide.

Journal: Anesthesia and analgesia 20020201

Title: [Syncope - a systematic overview of classification, pathogenesis, diagnosis and management].

Journal: Fortschritte der Neurologie-Psychiatrie 20020201

Title: Effects of HNS-32, a novel antiarrhythmic agent, on guinea-pig myocardium.

Journal: Pharmacology 20020101

Title: Risk of mortality in a cohort of patients newly diagnosed with chronic atrial fibrillation.

Journal: BMC cardiovascular disorders 20020101

Title: Strategy for the management of vasovagal syncope.

Journal: Drugs & aging 20020101

Title: Impact of stereoselectivity on the pharmacokinetics and pharmacodynamics of antiarrhythmic drugs.

Journal: Clinical pharmacokinetics 20020101

Title: Development and use of a computer program to detect potentially inappropriate prescribing in older adults residing in Canadian long-term care facilities.

Journal: BMC geriatrics 20020101

Title: Use of beta-blockers in atrial fibrillation.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20020101

Title: Stereoselective pharmacokinetics and pharmacodynamics of disopyramide and its metabolite in rabbits.

Journal: The Journal of pharmacy and pharmacology 20011201

Title: Hypoglycaemia induced by disopyramide in a patient with Type 2 diabetes mellitus.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20011201

Title: Drug block of I(kr): model systems and relevance to human arrhythmias.

Journal: Journal of cardiovascular pharmacology 20011101

Title: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules.

Journal: Pharmaceutical research 20011101

Title: Enantioselective binding of disopyramide to alpha1-acid glycoprotein and its variants.

Journal: European journal of clinical pharmacology 20011001

Title: Disopyramide: interactions with marcolide antibiotics.

Journal: Prescrire international 20011001

Title: Disopyramide-induced pneumonitis, diagnosed by lymphocyte stimulation test using bronchoalveolar lavage fluid.

Journal: Internal medicine (Tokyo, Japan) 20010801

Title: ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.

Journal: Journal of medicinal chemistry 20010719

Title: The effects of flecainide on ATP-sensitive K(+) channels in pig urethral myocytes.

Journal: British journal of pharmacology 20010701

Title: Medical therapy of neurocardiogenic syncope.

Journal: Cardiology clinics 20010501

Title: Electrophysiologic effects of an antiarrhythmic agent, bidisomide, on sodium current in isolated rat ventricular myocytes: comparison with mexiletine and disopyramide.

Journal: Japanese journal of pharmacology 20010501

Title: Influence of the light schedule on the toxic interaction between propranolol and disopyramide in chick embryos.

Journal: Biological & pharmaceutical bulletin 20010401

Title: Simultaneous determination of disopyramide and mono-N-dealkyldisopyramide enantiomers in human plasma by capillary electrophoresis.

Journal: Electrophoresis 20010401

Title: Importance of QT interval determination and renal function assessment during antiarrhythmic drug therapy.

Journal: Journal of cardiovascular pharmacology and therapeutics 20010401

Title: Role of biantennary glycans and genetic variants of human alpha1-acid glycoprotein in enantioselective binding of basic drugs as studied by high performance frontal analysis/capillary electrophoresis.

Journal: Pharmaceutical research 20010301

Title: Inhibition of HERG potassium channel current by the class 1a antiarrhythmic agent disopyramide.

Journal: Biochemical and biophysical research communications 20010209

Title: Cardiovascular action of a cardioselective Ca(2+)channel blocker AH-1058 in conscious dogs assessed by telemetry.

Journal: European journal of pharmacology 20010209

Title: Species difference in stereoselective involvement of CYP3A in the mono-N-dealkylation of disopyramide.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20010201

Title: Efficacy of sequential antiarrhythmic treatment in sinus rhythm maintenance after successful electrocardioversion in patients with chronic non-valvular atrial fibrillation.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20010101

Title: Disopyramide and its metabolite enhance insulin release from clonal pancreatic beta-cells by blocking K(ATP) channels.

Journal: Cardiovascular drugs and therapy 20010101

Title: Comparative safety of the different macrolides.

Journal: International journal of antimicrobial agents 20010101

Title: [Acute intoxication with disopyramide: case report with literature review].

Journal: Therapie 20010101

Title: Population pharmacokinetics, protein binding and antiarrhythmic effects of disopyramide enantiomers in arrhythmic patients.

Journal: International journal of clinical pharmacology research 20010101

Title: Is arrhythmogenic right ventricular cardiomyopathy a paediatric problem too?

Journal: Images in paediatric cardiology 20010101

Title: Potentially fatal interaction between azithromycin and disopyramide.

Journal: Pacing and clinical electrophysiology : PACE 20000901

Title: Identification of CYP3A4 as the enzyme involved in the mono-N-dealkylation of disopyramide enantiomers in humans.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20000801

Title: Effects of AH-1058, a new antiarrhythmic drug, on experimental arrhythmias and cardiac membrane currents.

Journal: Journal of cardiovascular pharmacology 19990401

Title: Torsades de pointes ventricular tachycardia induced by clarithromycin and disopyramide in the presence of hypokalemia.

Journal: Pacing and clinical electrophysiology : PACE 19990401

Title: Torsades de pointes due to drug interaction between disopyramide and clarithromycin.

Journal: Heart disease (Hagerstown, Md.) 19990101

Title: [A patient with disopyramide intoxication rescued by percutaneous cardiopulmonary support].

Journal: Journal of cardiology 19980801

Title: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).

Journal: The Journal of pharmacology and experimental therapeutics 19980701

Title: Early afterdepolarizationlike activity in patients with class IA induced long QT syndrome and torsades de pointes.

Journal: Pacing and clinical electrophysiology : PACE 19970301

Title: [Iatrogenic collapse; can this be prevented?].

Journal: Nederlands tijdschrift voor geneeskunde 19970208

Title: Binding of disopyramide, methadone, dipyridamole, chlorpromazine, lignocaine and progesterone to the two main genetic variants of human alpha 1-acid glycoprotein: evidence for drug-binding differences between the variants and for the presence of two separate drug-binding sites on alpha 1-acid glycoprotein.

Journal: Pharmacogenetics 19961001

Title: Propafenone versus disopyramide for maintenance of sinus rhythm after electrical cardioversion of chronic atrial fibrillation: a randomized, double-blind study. PRODIS Study Group.

Journal: Cardiovascular drugs and therapy 19960501

Title: [Familial hypertrophic cardiomyopathy generating a marked left ventricular pressure gradient in an 82-year-old woman].

Journal: Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 19960401

Title: Antiarrhythmic effects of optical isomers of disopyramide on canine ventricular arrhythmias.

Journal: Journal of cardiovascular pharmacology 19960301

Title: Antiarrhythmic and bradycardic drugs inhibit currents of cloned K+ channels, KV1.2 and KV1.4.

Journal: European journal of pharmacology 19950804

Title: Complex frequency-dependent interaction of class-I antiarrhythmic drugs as they affect intraventricular conduction.

Journal: European heart journal 19950601

Title: [A case report. Sotalol-disopyramide caused asystole].

Journal: Lakartidningen 19940601

Title: Transient sexual dysfunction observed during antiarrhythmic therapy by long-acting disopyramide in a male Wolff-Parkinson-White patient.

Journal: Cardiovascular drugs and therapy 19940401

Title: Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs.

Journal: JAMA 19931201

Title: Prolonged cardiopulmonary resuscitation during acute disopyramide poisoning.

Journal: Veterinary and human toxicology 19930601

Title: Precordial QT interval dispersion as a marker of torsade de pointes. Disparate effects of class Ia antiarrhythmic drugs and amiodarone.

Journal: Circulation 19921101

Title: [Torsades de pointes ventricular tachycardia induced by disopyramide at therapeutic serum concentration].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 19920820

Title: Acquired long QT syndrome due to antiarrhythmic drugs and bradyarrhythmias.

Journal: Annals of the New York Academy of Sciences 19920127

Title: [Recurrent ventricular tachyarrhythmias primarily diagnosed as epilepsy].

Journal: Ugeskrift for laeger 19910513

Title: Cytochrome P-450 isozyme pattern is related to individual susceptibility to diethylnitrosamine-induced liver cancer in rats.

Journal: Japanese journal of cancer research : Gann 19910201

Title: Combined application of class I antiarrhythmic drugs causes 'additive', 'reductive', or 'synergistic' sodium channel block in cardiac muscles.

Journal: Cardiovascular research 19901101

Title: Relative efficacy and safety of intravenous drugs for termination of sustained ventricular tachycardia.

Journal: Lancet (London, England) 19900915

Title: [Dissociated (dissimilar) atrial rhythms after administration of ritmilen].

Journal: Kardiologiia 19900501

Title: Differentiation and mechanisms of prevention and termination of verapamil-sensitive sustained ventricular tachycardia.

Journal: The American journal of cardiology 19891205

Title: Cardioprotective effects of various class I antiarrhythmic drugs in canine hearts.

Journal: Journal of the American College of Cardiology 19890701

Title: Broad sensitivity of rodent arrhythmia models to class I, II, III, and IV antiarrhythmic agents.

Journal: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 19890601

Title: Fatal torsade de pointes following jaundice in a patient treated with disopyramide.

Journal: Postgraduate medical journal 19890501

Title: Potentially fatal interaction between erythromycin and disopyramide.

Journal: The American journal of medicine 19890401

Title: Impairment of the antagonism of vecuronium-induced paralysis and intra-operative disopyramide administration.

Journal: Anaesthesia 19890101

Title: General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system.

Journal: Arzneimittel-Forschung 19881001

Title: Clinical characteristics of patients with ventricular fibrillation during antiarrhythmic drug therapy.

Journal: The New England journal of medicine 19880804

Title: Ventricular Wenckebach after intravenous therapy with class I antiarrhythmic agents.

Journal: International journal of cardiology 19880701

Title: Actions of a newly synthesized compound (711389-S) on various types of experimentally induced arrhythmias in mammalian species in situ.

Journal: Japanese journal of pharmacology 19880401

Title: Proarrhythmic effects of antiarrhythmic drugs during programmed ventricular stimulation in patients without ventricular tachycardia.

Journal: Journal of the American College of Cardiology 19870201

Title: Effects of disopyramide on detrusor muscle contraction: in vitro experiment and report of 3 cases with disopyramide-induced urinary retention.

Journal: Urologia internationalis 19870101

Title: Comparative haemodynamic effects of intravenous lignocaine, disopyramide and flecainide in uncomplicated acute myocardial infarction.

Journal: British journal of clinical pharmacology 19861201

Title: Effects of four antiarrhythmic drugs on the induction and termination of paroxysmal supraventricular tachycardia.

Journal: Japanese circulation journal 19861001

Title: Amiodarone-induced torsades de pointes.

Journal: European heart journal 19860301

Title: [Erythema nodosum due to disopyramide].

Journal: Harefuah 19850515

Title: Disopyramide induced second and third degree atrioventricular block in patients with bifascicular block. An acute stress test to predict atrioventricular block progression.

Journal: British heart journal 19850301

Title: Atrial tachyarrhythmias after cardiac surgery: results of disopyramide therapy.

Journal: Australian and New Zealand journal of medicine 19850201

Title: Drug-induced torsade de pointes.

Journal: Clinical pharmacy 19850101

Title: Ocular side effects of disopyramide.

Journal: The British journal of ophthalmology 19841201

Title: Disopyramide-induced urinary retention.

Journal: Archives of internal medicine 19841001

Title: [A case of atypical ventricular tachycardia induced by disopyramide].

Journal: Kokyu to junkan. Respiration & circulation 19840401

Title: [Torsade de pointes induced by disopyramide. Presentation of a case with fatal outcome].

Journal: Revista espanola de cardiologia 19840101

Title: Antiarrhythmic drugs: a possible cause of out-of-hospital cardiac arrest.

Journal: The New England journal of medicine 19831124

Title: Hypoglycemic coma due to disopyramide toxicity.

Journal: Southern medical journal 19831101

Title: Hypoglycemia in patients receiving disopyramide phosphate.

Journal: Drug intelligence & clinical pharmacy 19830901

Title: Disopyramide-induced urinary retention. Report of nine cases and review of the literature.

Journal: Archives of internal medicine 19830901

Title: Local anesthetic activity and disopyramide toxicity.

Journal: Archives internationales de pharmacodynamie et de therapie 19830601

Title: Selective blockade of retrograde fast pathway by intravenous disopyramide in paroxysmal supraventricular tachycardia mediated by dual atrioventricular nodal pathways.

Journal: British heart journal 19830601

Title: Infective endocarditis in hypertrophic cardiomyopathy secondary to amiodarone treatment.

Journal: Chest 19830501

Title: Disopyramide-induced QT prolongation and ventricular tachyarrhythmias.

Journal: American heart journal 19830501

Title: Disopyramide-associated liver dysfunction.

Journal: Mayo Clinic proceedings 19830401

Title: [Effects of lorcainide, a new antiarrhythmic agent, on experimental cardiac arrhythmias].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19830201

Title: Effective plasma concentrations of antiarrhythmic drugs against sustained halothane-adrenaline arrhythmia in dogs.

Journal: Journal of cardiovascular pharmacology 19830101

Title: Quantitative analysis of the antiarrhythmic effect of drugs on canine ventricular arrhythmias by the determination of minimum effective plasma concentrations.

Journal: Japanese circulation journal 19830101

Title: The response to procainamide during electrophysiologic study for sustained ventricular tachyarrhythmias predicts the response to other medications.

Journal: Circulation 19830101

Title: [Effect of intravenous disopyramide in supraventricular paroxysmal tachycardia refractory to vagal maneuvers].

Journal: Archivos del Instituto de Cardiologia de Mexico 19830101

Title: Acceleration of ventricular rate by fibrillation associated with the Wolff-Parkinson-White syndrome.

Journal: British medical journal (Clinical research ed.) 19821009

Title: Torsades de pointes, a common arrhythmia, induced by medication.

Journal: Canadian Medical Association journal 19820901

Title: The antiarrhythmic effect of intravenous disopyramide in an open study.

Journal: Australian and New Zealand journal of medicine 19820801

Title: Disopyramide hepatotoxicity and disseminated intravascular coagulation.

Journal: Southern medical journal 19820401

Title: [Atypical ventricular tachycardia due to disopyramide].

Journal: Harefuah 19820315

Title: Disopyramide.

Journal: Annals of internal medicine 19820301

Title: Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.

Journal: Chest 19820301

Title: [Cardiac shock after disopyramide].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 19811020

Title: [Ventricular fibrillation during disopyramide treatment].

Journal: Lakartidningen 19811007

Title: [Acute left ventricular failure induced by oral disopyramide. A case of a patient with Friedreich's disease].

Journal: La Nouvelle presse medicale 19810801

Title: Torsade de pointes ventricular tachycardia. A complication of disopyramide shared with quinidine.

Journal: Journal of electrocardiology 19810701

Title: Ventricular tachyarrhythmias induced by disopyramide and other similar anti-arrhythmic drugs.

Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 19810606

Title: Disopyramide-induced Torsade de Pointes.

Journal: Archives of internal medicine 19810601

Title: Cardiovascular collapse associated with disopyramide therapy.

Journal: Chest 19810501

Title: Disopyramide-induced heart block.

Journal: Chest 19810401

Title: Cardiac problems caused by disopyramide.

Journal: FDA drug bulletin 19810301

Title: Thioridazine-associated ventricular tachycardia and isoproterenol.

Journal: Annals of internal medicine 19810301

Title: Synthesis and antiarrhythmic activity of new benzofuran derivatives.

Journal: Journal of medicinal chemistry 19810201

Title: Enhancement of the antiarrhythmic action of disopyramide by digoxin.

Journal: Journal of cardiovascular pharmacology 19810101

Title: Ventricular pacing in atypical ventricular tachycardia.

Journal: Journal of electrocardiology 19810101

Title: Disopyramide induced atypical ventricular tachycardia.

Journal: Australian and New Zealand journal of medicine 19801201

Title: Extreme tachycardia complicating the use of disopyramide in atrial flutter.

Journal: British heart journal 19801101

Title: Toxic synergism of disopyramide and hyperkalemia.

Journal: Chest 19801001

Title: A case of intra-hepatic cholestasis after disopyramide therapy.

Journal: European journal of clinical pharmacology 19801001

Title: Ventricular tachycardia with torsade de pointes morphology induced by oral disopyramide.

Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 19800913

Title: Disopyramide-induced ventricular arrhythmia.

Journal: The American journal of cardiology 19800801

Title: [Paradoxic response to disopyramide and quinidine (author's transl)].

Journal: Zeitschrift fur Kardiologie 19800801

Title: Disopyramide and impotence.

Journal: Southern medical journal 19800701

Title: Disopyramide and cholestasis.

Journal: Annals of internal medicine 19800701

Title: Some cardiovascular problems with disopyramide.

Journal: Postgraduate medical journal 19800401

Title: Prolonged QT interval, atrioventricular block, and torsade de pointes after antiarrhythmic therapy.

Journal: British medical journal 19800329

Title: Congestive heart failure caused by oral disopyramide.

Journal: The New England journal of medicine 19800313

Title: Disopyramide-induced ventricular tachycardia.

Journal: Archives of internal medicine 19800301

Title: Unusual hepatocellular and cardiovascular complications of disopyramide.

Journal: Chest 19800101

Title: Disopyramide-induced syncope.

Journal: The American journal of cardiology 19790801

Title: Adverse reaction to disopyramide.

Journal: Postgraduate medical journal 19790801

Title: Disopyramide-induced ventricular fibrillation.

Journal: The American journal of cardiology 19790501

Title: Complications of disopyramide therapy.

Journal: Lancet (London, England) 19790210

Title: Electrophysiologic effects of disopyramide phosphate on sinus node function in patients with sinus node dysfunction.

Journal: Circulation 19790201

Title: Atypical ventricular tachycardia as a manifestation of disopyramide toxicity.

Journal: The American journal of cardiology 19781201

Title: Epileptiform convulsion with intravenous disopyramide.

Journal: Lancet (London, England) 19781014

Title: Quinidine effects due to disopyramide.

Journal: The New England journal of medicine 19780427

Title: Increase of ventricular extrasystoles after disopyramide.

Journal: Lancet (London, England) 19780401

Title: Peripheral neuropathy with disopyramide.

Journal: Lancet (London, England) 19780211

Title: Disopyramide in myocardial infarction.

Journal: Lancet (London, England) 19780211

Title: Ventricular tachycardia after disopyramide.

Journal: Lancet (London, England) 19780114

Title: Ventricular tachycardia-flutter associated with disopyramide therapy: a report of three cases.

Journal: Heart & lung : the journal of critical care 19780101

Title: Disopyramide-induced intrahepatic cholestasis.

Journal: Lancet (London, England) 19771201

Title: Disopyramide-induced intrahepatic cholestasis.

Journal: Lancet (London, England) 19771015

Title: Impotence in patient on disopyramide.

Journal: Lancet (London, England) 19770416

Title: Oral disopyramide in prophylaxis of arrhythmias following myocardial infarction.

Journal: Lancet (London, England) 19760110

Title: Compounds related to 4-disopropylamino-2-phenyl-2(2-pyridyl)butyramide. Their synthesis and antiarrhythmic activity.

Journal: Journal of medicinal chemistry 19741101

Title: Cardiovascular effects of a newer antiarrhythmic agent, disopyramide phosphate.

Journal: American heart journal 19721201

Title: S V Jones, et al. Non-competitive Effects of Disopyramide at the Neuromuscular Junction: Evidence for Endplate Ion Channel Block. Br J Anaesth. 1987 Jun;59(6):776-83.

Title: L A Siddoway, et al. Clinical Pharmacokinetics of Disopyramide. Clin Pharmacokinet. May-Jun 1986;11(3):214-22.

Title: A A Paul, et al. Inhibition of HERG Potassium Channel Current by the Class 1a Antiarrhythmic Agent Disopyramide. Biochem Biophys Res Commun. 2001 Feb 9;280(5):1243-50.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:3737-09-5 Molecular Formula|3737-09-5 MDL|3737-09-5 SMILES|3737-09-5 Disopyramide