Name: Name:4-[3-(1-Methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole
Brand: AABLOCKS
SKU: AA01ENJG
Rating: 90 (10 reviews)

Catalog No.: AA01ENJG

374886-51-8 | 4-[3-(1-Methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole

Pack Size： 5mg

Purity： 99%

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$963.00 $674.00

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Technical Information

Catalog Number: AA01ENJG

Chemical Name: 4-[3-(1-Methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole

CAS Number: 374886-51-8

Molecular Formula: C22H18N6O

Molecular Weight: 382.4179

MDL Number: MFCD30182274

SMILES: CC(c1nnc(n1c1cccc2c1non2)c1ccc(nc1)c1ccccc1)C

Properties

Complexity: 541

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 29

Hydrogen Bond Acceptor Count: 6

Hydrogen Bond Donor Count: 0

Isotope Atom Count: 0

Rotatable Bond Count: 4

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3.8

Literature fold

Title: A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease.

Journal: European journal of pharmacology20120615

Title: Harada K, et al. A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4--isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease. Eur J Pharmacol. 2012 Jun 15;685(1-3):59-69.

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