Home Other Building Blocks 375345-95-2
375345-95-2,MFCD18251566
Catalog No.:AA0079FO

375345-95-2 | Ly451395

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$93.00   $65.00
- +
5mg
95%
1 week  
$130.00   $91.00
- +
10mg
95%
1 week  
$156.00   $109.00
- +
25mg
95%
1 week  
$210.00   $147.00
- +
50mg
95%
1 week  
$278.00   $195.00
- +
250mg
98+%
1 week  
$1,132.00   $792.00
- +
1g
98+%
1 week  
$3,063.00   $2,144.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0079FO
Chemical Name:
Ly451395
CAS Number:
375345-95-2
Molecular Formula:
C21H30N2O4S2
Molecular Weight:
438.6039
MDL Number:
MFCD18251566
SMILES:
C[C@H](c1ccc(cc1)c1ccc(cc1)CCNS(=O)(=O)C)CNS(=O)(=O)C(C)C
Properties
Computed Properties
 
Complexity:
679  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
10  
XLogP3:
3.4  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ELILILLY&CO-US2003/225163,2003,A1Locationinpatent:Page12-13

[1]Patent:US2003/225163,2003,A1

Literature

Title: Cognitive enhancing effects of an AMPA receptor positive modulator on place learning in mice.

Journal: Behavioural brain research 20120101

Title: Delta oscillation and short-term plasticity in the rat medial prefrontal cortex: modelling NMDA hypofunction of schizophrenia.

Journal: The international journal of neuropsychopharmacology 20110201

Title: Positive allosteric modulators of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor.

Journal: Journal of medicinal chemistry 20101028

Title: AMPA receptor potentiation can prevent ethanol-induced intoxication.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080601

Title: AMPA potentiator treatment of cognitive deficits in Alzheimer disease.

Journal: Neurology 20070327

Title: Application of biocatalysis to drug metabolism: preparation of mammalian metabolites of a biaryl-bis-sulfonamide AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor potentiator using Actinoplanes missouriensis.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060601

Title: Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects.

Journal: Journal of clinical pharmacology 20060401

Title: Zmijewski M, et al. Application of biocatalysis to drug metabolism: preparation of mammalian metabolites of a biaryl-bis-sulfonamide AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor potentiator using Actinoplanes missouriensis. Drug Metab Dispos. 2006 Jun;34(6):925-31.

Title: Jones N, et al. AMPA receptor potentiation can prevent ethanol-induced intoxication. Neuropsychopharmacology. 2008 Jun;33(7):1713-23.

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SDS
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