Home Fluorides 376594-67-1
376594-67-1,MFCD20526510
Catalog No.:AA00C6DH

376594-67-1 | (R)-3,5-Difluoro-n-(4-(1-(1-methylethylsulfonamido)propan-2-yl)phenyl)benzamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98% by HPLC
in stock  
$289.00   $202.00
- +
10mg
98% by HPLC
in stock  
$444.00   $311.00
- +
25mg
98% by HPLC
in stock  
$868.00   $608.00
- +
50mg
98% by HPLC
in stock  
$1,434.00   $1,004.00
- +
100mg
98% by HPLC
in stock  
$2,435.00   $1,705.00
- +
500mg
98% by HPLC
in stock  
$7,722.00   $5,405.00
- +
1000mg
98% by HPLC
in stock  
$12,318.00   $8,623.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C6DH
Chemical Name:
(R)-3,5-Difluoro-n-(4-(1-(1-methylethylsulfonamido)propan-2-yl)phenyl)benzamide
CAS Number:
376594-67-1
Molecular Formula:
C19H22F2N2O3S
Molecular Weight:
396.4514
MDL Number:
MFCD20526510
SMILES:
Fc1cc(F)cc(c1)C(=O)Nc1ccc(cc1)[C@H](CNS(=O)(=O)C(C)C)C
Properties
Computed Properties
 
Complexity:
576  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
3.5  

Literature

Title: Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator.

Journal: Journal of medicinal chemistry 20100812

Title: Simon E Ward1, Benjamin D Bax, Mark Harries. Challenges for and current status of research into positive modulators of AMPA receptors. British Journal of Pharmacology. 2010,160(2):181-190.

Title: O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20.

Title: Jhee SS, Chappell AS, Zarotsky V, et al. Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects. J Clin Pharmacol. 2006 Apr;46(4):424-32.

Title: Douglas A. Schober, Martin B. Gill, Hong Yu, et al. Transmembrane AMPA Receptor Regulatory Proteins and Cornichon-2 Allosterically Regulate AMPA Receptor Antagonists and Potentiators. The Journal of Biological Chemistry, 286, 13134-13142.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 376594-67-1
Tags:376594-67-1 Molecular Formula|376594-67-1 MDL|376594-67-1 SMILES|376594-67-1 (R)-3,5-Difluoro-n-(4-(1-(1-methylethylsulfonamido)propan-2-yl)phenyl)benzamide