Home Fluorides 3821-81-6
3821-81-6,MFCD00041324
Catalog No.:AA003PPZ

3821-81-6 | Dl-2-fluoro-3-alanine

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25mg
97%
1 week  
$119.00   $84.00
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250mg
95%
1 week  
$392.00   $274.00
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1g
95%
1 week  
$872.00   $610.00
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5g
95%
1 week  
$2,471.00   $1,730.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003PPZ
Chemical Name:
Dl-2-fluoro-3-alanine
CAS Number:
3821-81-6
Molecular Formula:
C3H6FNO2
Molecular Weight:
107.0836
MDL Number:
MFCD00041324
SMILES:
NCC(C(=O)O)F
Properties
Properties
 
Form:
Solid  
MP:
>220°C (dec.)  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
75.3  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
7  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-3  

Literature

Title: γ-Aminobutyric acid transporter 2 mediates the hepatic uptake of guanidinoacetate, the creatine biosynthetic precursor, in rats.

Journal: PloS one 20120101

Title: The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, α-fluoro-β-ureidopropionate, α-fluoro-β-alanine using LC-MS.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110415

Title: Biological monitoring of occupational exposure to 5-fluorouracil: urinary α-fluoro-β-alanine assay by high performance liquid chromatography tandem mass spectrometry in health care personnel.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101001

Title: Ecotoxicity and genotoxicity assessment of cytotoxic antineoplastic drugs and their metabolites.

Journal: Chemosphere 20100901

Title: Validation of an isocratic HPLC method to detect 2-fluoro-beta-alanine for the analysis of dihydropyrimidine dehydrogenase activity.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100701

Title: Development of a sensitive and selective LC-MS/MS method for the determination of alpha-fluoro-beta-alanine, 5-fluorouracil and capecitabine in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090415

Title: Pharmacokinetic study of S-1.

Journal: International journal of clinical pharmacology and therapeutics 20090101

Title: Alternative pharmacokinetics of S-1 components, 5-fluorouracil, dihydrofluorouracil and alpha-fluoro-beta-alanine after oral administration of S-1 following total gastrectomy.

Journal: Cancer science 20071001

Title: Systemic absorption of 5-fluorouracil during vitrectomy.

Journal: American journal of ophthalmology 20060701

Title: [Plasma concentrations of 5-fluorouracil and F-beta-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20060601

Title: Assay of urinary alpha-fluoro-beta-alanine by gas chromatography-mass spectrometry for the biological monitoring of occupational exposure to 5-fluorouracil in oncology nurses and pharmacy technicians.

Journal: Biomedical chromatography : BMC 20060301

Title: 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine.

Journal: International journal of clinical oncology 20051201

Title: Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.

Journal: Anti-cancer drugs 20041101

Title: Neurotoxic effects of alpha-fluoro-beta-alanine (FBAL) and fluoroacetic acid (FA) on dogs.

Journal: The Journal of toxicological sciences 20040501

Title: Pharmacokinetics of capecitabine (Xeloda) in Japanese and Caucasian patients with breast cancer.

Journal: Cancer chemotherapy and pharmacology 20030901

Title: Optimization of localized 19F magnetic resonance spectroscopy for the detection of fluorinated drugs in the human liver.

Journal: Magnetic resonance in medicine 20030801

Title: Population pharmacokinetics and concentration-effect relationships of capecitabine metabolites in colorectal cancer patients.

Journal: British journal of clinical pharmacology 20030301

Title: 5-fluorocytosine-related bone-marrow depression and conversion to fluorouracil: a pilot study.

Journal: Fundamental & clinical pharmacology 20020201

Title: Dihydropyrimidine dehydrogenase activity of cancerous and non-cancerous tissues in liver and large intestine.

Journal: Oncology reports 20010101

Title: Possible regulation of 5-fluorouracil-induced neuro- and oral toxicities by two biochemical modulators consisting of S-1, a new oral formulation of 5-fluorouracil.

Journal: Anticancer research 20010101

Title: 5-Ethynyluracil (776C85): protection from 5-fluorouracil-induced neurotoxicity in dogs.

Journal: Biochemical pharmacology 19940719

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Tags:3821-81-6 Molecular Formula|3821-81-6 MDL|3821-81-6 SMILES|3821-81-6 Dl-2-fluoro-3-alanine