38221-21-5,MFCD00012741
Catalog No.:AA00BZ9M

38221-21-5 | 6,7-DIHYDROXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE

Pack Size
Purity
Availability
Price(USD)
Quantity
  
50mg
4 weeks  
$393.00   $275.00
- +
100mg
4 weeks  
$599.00   $419.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00BZ9M
Chemical Name:
6,7-DIHYDROXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE
CAS Number:
38221-21-5
Molecular Formula:
C10H14BrNO2
Molecular Weight:
260.1277
MDL Number:
MFCD00012741
SMILES:
C[C@@H]1NCCc2c1cc(O)c(c2)O.Br
Properties
Computed Properties
 
Complexity:
186  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Oxidative DNA damage and mammary cell proliferation by alcohol-derived salsolinol.

Journal: Chemical research in toxicology 20131021

Title: Salsolinol induced apoptotic changes in neural stem cells: amelioration by neurotrophin support.

Journal: Neurotoxicology 20130301

Title: What is in that drink: the biological actions of ethanol, acetaldehyde, and salsolinol.

Journal: Current topics in behavioral neurosciences 20130101

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Low level of glutathione can intensify the toxic effect of salsolinol in SH-SY5Y neuroblastoma cell line.

Journal: Neurotoxicology 20120601

Title: Effects of photoperiod on salsolinol-induced prolactin secretion in goats.

Journal: Animal science journal = Nihon chikusan Gakkaiho 20120501

Title: Salsolinol and isosalsolinol: condensation products of acetaldehyde and dopamine. Separation of their enantiomers in the presence of a large excess of dopamine.

Journal: Journal of pharmaceutical and biomedical analysis 20120407

Title: Salsolinol stimulates dopamine neurons in slices of posterior ventral tegmental area indirectly by activating μ-opioid receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20120401

Title: Hypotensive and cardio-chronotropic constituents of Tinospora crispa and mechanisms of action on the cardiovascular system in anesthetized rats.

Journal: Journal of ethnopharmacology 20120306

Title: Salsolinol, a tetrahydroisoquinoline-derived neurotoxin, induces oxidative modification of neurofilament-L protection by histidyl dipeptides.

Journal: BMB reports 20120201

Title: Revisiting the controversial role of salsolinol in the neurobiological effects of ethanol: old and new vistas.

Journal: Neuroscience and biobehavioral reviews 20120101

Title: Bromocriptine inhibits salsolinol-induced prolactin release in male goats.

Journal: Animal science journal = Nihon chikusan Gakkaiho 20120101

Title: Salsolinol facilitates glutamatergic transmission to dopamine neurons in the posterior ventral tegmental area of rats.

Journal: PloS one 20120101

Title: Research on an in vitro cell system for testing the neurotoxicity of kynurenine pathway metabolites.

Journal: Die Pharmazie 20111101

Title: Induction of conditioned place preference and dopamine release by salsolinol in posterior VTA of rats: involvement of μ-opioid receptors.

Journal: Neurochemistry international 20111001

Title: Chip electrophoresis of active banana ingredients with label-free detection utilizing deep UV native fluorescence and mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20110201

Title: Isolation of salsolinol, a tetrahydroisoquinoline alkaloid, from the marine sponge Xestospongia cf. vansoesti as a proteasome inhibitor.

Journal: Chemical & pharmaceutical bulletin 20110101

Title: The influence of salsolinol on dopaminergic system activity within the mediobasal hypothalamus of anestrous sheep: a model for studies on the salsolinol-dopamine relationship.

Journal: Acta neurobiologiae experimentalis 20110101

Title: The effects of salsolinol on the mucosal mast cells in the rat gut.

Journal: Folia medica Cracoviensia 20110101

Title: Opioid-salsolinol relationship in the control of prolactin release during lactation.

Journal: Neuroscience 20101110

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Characteristics of prolactin-releasing response to salsolinol in vivo in cattle.

Journal: Domestic animal endocrinology 20100701

Title: Determination of salsolinol, norsalsolinol, and twenty-one biogenic amines using micellar electrokinetic capillary chromatography-electrochemical detection.

Journal: Electrophoresis 20100601

Title: Locomotor stimulant effects of acute and repeated intrategmental injections of salsolinol in rats: role of mu-opioid receptors.

Journal: Psychopharmacology 20100301

Title: A critical evaluation of influence of ethanol and diet on salsolinol enantiomers in humans and rats.

Journal: Alcoholism, clinical and experimental research 20100201

Title: Effects of a structural analogue of salsolinol, 1-MeDIQ, on pituitary prolactin release and dopaminergic activity in the mediobasal hypothalamus in nursing sheep.

Journal: Brain research 20100111

Title: Effects of salsolinol and its antagonistic analogue, 1-MeDIQ, on growth hormone release in nursing sheep.

Journal: Acta neurobiologiae experimentalis 20100101

Title: Different mechanisms of NMDA-mediated protection against neuronal apoptosis: a stimuli-dependent effect.

Journal: Neurochemical research 20091101

Title: Local salsolinol modulates dopamine extracellular levels from rat nucleus accumbens: shell/core differences.

Journal: Neurochemistry international 20090901

Title: Ferritin enhances salsolinol-mediated DNA strand breakage: protection by carnosine and related compounds.

Journal: Toxicology letters 20090710

Title: Fast liquid chromatography separation and multiple-reaction monitoring mass spectrometric detection of neurotransmitters.

Journal: Journal of separation science 20090701

Title: Characteristics of prolactin-releasing response to salsolinol (SAL) and thyrotropin-releasing hormone (TRH) in ruminants.

Journal: Domestic animal endocrinology 20090201

Title: Quantification of salsolinol enantiomers by stable isotope dilution liquid chromatography with tandem mass spectrometric detection.

Journal: Rapid communications in mass spectrometry : RCM 20081201

Title: The formation of catechol isoquinolines in PC12 cells exposed to manganese.

Journal: Neuroscience letters 20081024

Title: Identification of salsolinol in the mediobasal hypothalamus of lactating ewes and its relation to suckling-induced prolactin and GH release.

Journal: The Journal of endocrinology 20080701

Title: Salsolinol, an endogenous neurotoxin, enhances platelet aggregation and thrombus formation.

Journal: Thrombosis and haemostasis 20080701

Title: Iron contributes to the formation of catechol isoquinolines and oxidative toxicity induced by overdose dopamine in dopaminergic SH-SY5Y cells.

Journal: Neuroscience bulletin 20080601

Title: Interaction between salsolinol (SAL) and thyrotropin-releasing hormone (TRH) or dopamine (DA) on the secretion of prolactin in ruminants.

Journal: Domestic animal endocrinology 20080401

Title: Effect of (R)-salsolinol and N-methyl-(R)-salsolinol on the balance impairment between dopamine and acetylcholine in rat brain: involvement in pathogenesis of Parkinson disease.

Journal: Clinical chemistry 20080401

Title: Quantitative chiral analysis of salsolinol in different brain regions of rats genetically predisposed to alcoholism.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080301

Title: Salsolinol is present in the bovine posterior pituitary gland and stimulates the release of prolactin both in vivo and in vitro in ruminants.

Journal: Domestic animal endocrinology 20080201

Title: The reinforcing properties of salsolinol in the ventral tegmental area: evidence for regional heterogeneity and the involvement of serotonin and dopamine.

Journal: Alcoholism, clinical and experimental research 20080201

Title: The attenuating effect of memantine on staurosporine-, salsolinol- and doxorubicin-induced apoptosis in human neuroblastoma SH-SY5Y cells.

Journal: Neurochemistry international 20080101

Title: Simultaneous determination of salsolinol enantiomers and dopamine in human plasma and cerebrospinal fluid by chemical derivatization coupled to chiral liquid chromatography/electrospray ionization-tandem mass spectrometry.

Journal: Analytical chemistry 20071201

Title: The role of catecholamines in the prolactin release induced by salsolinol.

Journal: Neurochemistry international 20071001

Title: Salsolinol, a tetrahydroisoquinoline catechol neurotoxin, induces human Cu,Zn-superoxidie dismutase modificaiton.

Journal: Journal of biochemistry and molecular biology 20070930

Title: Antiapoptotic effects of nicotine in its protection against salsolinol-induced cytotoxicity.

Journal: Neurotoxicity research 20070701

Title: Salsolinol and the peripheral sympathetic activity: the effects of hypophysectomy, adrenalectomy and adrenal medullectomy.

Journal: Ideggyogyaszati szemle 20070330

Title: Effect of direct infusion of acetaldehyde on dopamine and dopamine-derived salsolinol in the striatum of free-moving rats using a reverse microdialysis technique.

Journal: Archives of toxicology 20070201

Title: The peripheral noradrenergic terminal as possible site of action of salsolinol as prolactoliberin.

Journal: Neurochemistry international 20070101

Title: TRPC1 protects human SH-SY5Y cells against salsolinol-induced cytotoxicity by inhibiting apoptosis.

Journal: Brain research 20060712

Title: Determination of salsolinol and related catecholamines through on-line preconcentration and liquid chromatography/atmospheric pressure photoionization mass spectrometry.

Journal: Analytical chemistry 20060515

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Salsolinol, a derivate of dopamine, is a possible modulator of catecholaminergic transmission: a review of recent developments.

Journal: Physiological research 20060101

Title: Chronic polysystemic candidiasis as a possible contributor to onset of idiopathic Parkinson's disease.

Journal: Bratislavske lekarske listy 20060101

Title: Neuroprotective effects of nicotine against salsolinol-induced cytotoxicity: implications for Parkinson's disease.

Journal: Neurotoxicity research 20051101

Title: Systematic regional study of dopamine, norsalsolinol, and (R/S)-salsolinol levels in human brain areas of alcoholics.

Journal: Alcoholism, clinical and experimental research 20050101

Title: Salsolinol, an antagonist of prolactoliberine, induces an increase in plasma catecholamine levels in the rat.

Journal: Autonomic neuroscience : basic & clinical 20040930

Title: Immobilization stress-induced increase in plasma catecholamine levels is inhibited by a prolactoliberin (salsolinol) administration.

Journal: Annals of the New York Academy of Sciences 20040601

Title: Pivotal role of an endogenous tetrahydroisoquinoline, salsolinol, in stress- and suckling-induced release of prolactin.

Journal: Annals of the New York Academy of Sciences 20040601

Title: Bioconversion studies in cultured cells of Corydalis species.

Journal: Die Pharmazie 20040601

Title: Salsolinol, a dopamine-derived tetrahydroisoquinoline, induces cell death by causing oxidative stress in dopaminergic SH-SY5Y cells, and the said effect is attenuated by metallothionein.

Journal: Brain research 20040416

Title: Increased systemic levels of norsalsolinol derivatives are induced by levodopa treatment and do not represent biological markers of Parkinson's disease.

Journal: Journal of neurology, neurosurgery, and psychiatry 20040401

Title: Liquid chromatography with amperometric detection at a nano crystalline Ce-doped lead dioxide film modified electrode for determination of (R)-Salsolinol, (R)-N-methylsalsolinol and monoamine neurotransmitters in Parkinsonian patients' cerebrospinal fluid.

Journal: The Analyst 20040301

Title: Stress- as well as suckling-induced prolactin release is blocked by a structural analogue of the putative hypophysiotrophic prolactin-releasing factor, salsolinol.

Journal: Journal of neuroendocrinology 20040301

Title: Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: occurrence, metabolism and function in human brains.

Journal: Neurotoxicology 20040101

Title: Inhibition of DT-diaphorase potentiates the in vivo neurotoxic effect of intranigral injection of salsolinol in rats.

Journal: Neurotoxicity research 20040101

Title: [Change of dopamine, serotonin and opioid neuromediator systems in the brain of rats adapted to prolonged effect of ethanol].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20040101

Title: Neuroprotective or neurotoxic activity of 1-methyl-1,2,3,4-tetrahydroisoquinoline and related compounds.

Journal: Bioorganic & medicinal chemistry letters 20030901

Title: In vivo study of salsolinol produced by a high concentration of acetaldehyde in the striatum and nucleus accumbens of free-moving rats.

Journal: Alcoholism, clinical and experimental research 20030801

Title: Simultaneous gas chromatographic-mass spectrometric determination of dopamine, norsalsolinol and salsolinol enantiomers in brain samples of a large human collective.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20030701

Title: Tyrosinase protects human melanocytes from ROS-generating compounds.

Journal: Biochemical and biophysical research communications 20030530

Title: Insulin-like growth factor-1 protects human dopaminergic SH-SY5Y cells from salsolinol-induced toxicity.

Journal: Neuroscience letters 20030410

Title: Salsolinol produces reinforcing effects in the nucleus accumbens shell of alcohol-preferring (P) rats.

Journal: Alcoholism, clinical and experimental research 20030301

Title: Effect of different doses of cyanamide on striatal salsolinol formation after ethanol treatment.

Journal: Legal medicine (Tokyo, Japan) 20030301

Title: Binding site of salsolinol: its properties in different regions of the brain and the pituitary gland of the rat.

Journal: Neurochemistry international 20030101

Title: ['Starburst' conjugates of proteins with carbocene polymers, carrying low molecular weight biologically-active compounds, and their immunogenicity].

Journal: Bioorganicheskaia khimiia 20030101

Title: In vivo formation of salsolinol induced by high acetaldehyde concentration in rat striatum employing microdialysis.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20030101

Title: Axonal degeneration and progressive neurologic disability in multiple sclerosis.

Journal: Neurotoxicity research 20030101

Title: Salsolinol causing parkinsonism activates endoplasmic reticulum-stress signaling pathways in human dopaminergic SK-N-SH cells.

Journal: Neuro-Signals 20030101

Title: Assay of salsolinol in peripheral blood mononuclear cells of alcoholics and healthy subjects by gas chromatography-mass spectrometry.

Journal: Addiction biology 20021001

Title: Formation of novel toxic compounds from oxidative interaction between salsolinol and cysteine.

Journal: Journal of pharmaceutical and biomedical analysis 20020905

Title: Iron enhancement of oxidative DNA damage and neuronal cell death induced by salsolinol.

Journal: Journal of toxicology and environmental health. Part A 20020301

Title: Resistance of the insect cell line IPLB-LdFB to salsolinol-induced apoptosis.

Journal: Archives of insect biochemistry and physiology 20020101

Title: Physiological role of salsolinol: its hypophysiotrophic function in the regulation of pituitary prolactin secretion.

Journal: Neurotoxicology and teratology 20020101

Title: Salsolinol is a putative endogenous neuro-intermediate lobe prolactin-releasing factor.

Journal: Journal of neuroendocrinology 20011201

Title: Differential cell death induced by salsolinol with and without copper: possible role of reactive oxygen species.

Journal: Molecular pharmacology 20010901

Title: Oxidative DNA damage and cytotoxicity induced by copper-stimulated redox cycling of salsolinol, a neurotoxic tetrahydroisoquinoline alkaloid.

Journal: Free radical biology & medicine 20010615

Title: Possible role of salsolinol quinone methide in the decrease of RCSN-3 cell survival.

Journal: Biochemical and biophysical research communications 20010525

Title: Salsolinol, a naturally occurring tetrahydroisoquinoline alkaloid, induces DNA damage and chromosomal aberrations in cultured Chinese hamster lung fibroblast cells.

Journal: Mutation research 20010301

Title: Opposite effect of simple tetrahydroisoquinolines on amphetamine- and morphine-stimulated locomotor activity in mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20010101

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Tags:38221-21-5 Molecular Formula|38221-21-5 MDL|38221-21-5 SMILES|38221-21-5 6,7-DIHYDROXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE
Catalog No.: AA00BZ9M
38221-21-5,MFCD00012741
38221-21-5 | 6,7-DIHYDROXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE
Pack Size: 50mg
Purity:
4 weeks
$393.00 $275.00
Pack Size: 100mg
Purity:
4 weeks
$599.00 $419.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00BZ9M
Chemical Name: 6,7-DIHYDROXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE
CAS Number: 38221-21-5
Molecular Formula: C10H14BrNO2
Molecular Weight: 260.1277
MDL Number: MFCD00012741
SMILES: C[C@@H]1NCCc2c1cc(O)c(c2)O.Br
Properties
Complexity: 186  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 1  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 14  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 4  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Oxidative DNA damage and mammary cell proliferation by alcohol-derived salsolinol.

Journal: Chemical research in toxicology20131021

Title: Salsolinol induced apoptotic changes in neural stem cells: amelioration by neurotrophin support.

Journal: Neurotoxicology20130301

Title: What is in that drink: the biological actions of ethanol, acetaldehyde, and salsolinol.

Journal: Current topics in behavioral neurosciences20130101

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry20121115

Title: Low level of glutathione can intensify the toxic effect of salsolinol in SH-SY5Y neuroblastoma cell line.

Journal: Neurotoxicology20120601

Title: Effects of photoperiod on salsolinol-induced prolactin secretion in goats.

Journal: Animal science journal = Nihon chikusan Gakkaiho20120501

Title: Salsolinol and isosalsolinol: condensation products of acetaldehyde and dopamine. Separation of their enantiomers in the presence of a large excess of dopamine.

Journal: Journal of pharmaceutical and biomedical analysis20120407

Title: Salsolinol stimulates dopamine neurons in slices of posterior ventral tegmental area indirectly by activating μ-opioid receptors.

Journal: The Journal of pharmacology and experimental therapeutics20120401

Title: Hypotensive and cardio-chronotropic constituents of Tinospora crispa and mechanisms of action on the cardiovascular system in anesthetized rats.

Journal: Journal of ethnopharmacology20120306

Title: Salsolinol, a tetrahydroisoquinoline-derived neurotoxin, induces oxidative modification of neurofilament-L protection by histidyl dipeptides.

Journal: BMB reports20120201

Title: Revisiting the controversial role of salsolinol in the neurobiological effects of ethanol: old and new vistas.

Journal: Neuroscience and biobehavioral reviews20120101

Title: Bromocriptine inhibits salsolinol-induced prolactin release in male goats.

Journal: Animal science journal = Nihon chikusan Gakkaiho20120101

Title: Salsolinol facilitates glutamatergic transmission to dopamine neurons in the posterior ventral tegmental area of rats.

Journal: PloS one20120101

Title: Research on an in vitro cell system for testing the neurotoxicity of kynurenine pathway metabolites.

Journal: Die Pharmazie20111101

Title: Induction of conditioned place preference and dopamine release by salsolinol in posterior VTA of rats: involvement of μ-opioid receptors.

Journal: Neurochemistry international20111001

Title: Chip electrophoresis of active banana ingredients with label-free detection utilizing deep UV native fluorescence and mass spectrometry.

Journal: Analytical and bioanalytical chemistry20110201

Title: Isolation of salsolinol, a tetrahydroisoquinoline alkaloid, from the marine sponge Xestospongia cf. vansoesti as a proteasome inhibitor.

Journal: Chemical & pharmaceutical bulletin20110101

Title: The influence of salsolinol on dopaminergic system activity within the mediobasal hypothalamus of anestrous sheep: a model for studies on the salsolinol-dopamine relationship.

Journal: Acta neurobiologiae experimentalis20110101

Title: The effects of salsolinol on the mucosal mast cells in the rat gut.

Journal: Folia medica Cracoviensia20110101

Title: Opioid-salsolinol relationship in the control of prolactin release during lactation.

Journal: Neuroscience20101110

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Characteristics of prolactin-releasing response to salsolinol in vivo in cattle.

Journal: Domestic animal endocrinology20100701

Title: Determination of salsolinol, norsalsolinol, and twenty-one biogenic amines using micellar electrokinetic capillary chromatography-electrochemical detection.

Journal: Electrophoresis20100601

Title: Locomotor stimulant effects of acute and repeated intrategmental injections of salsolinol in rats: role of mu-opioid receptors.

Journal: Psychopharmacology20100301

Title: A critical evaluation of influence of ethanol and diet on salsolinol enantiomers in humans and rats.

Journal: Alcoholism, clinical and experimental research20100201

Title: Effects of a structural analogue of salsolinol, 1-MeDIQ, on pituitary prolactin release and dopaminergic activity in the mediobasal hypothalamus in nursing sheep.

Journal: Brain research20100111

Title: Effects of salsolinol and its antagonistic analogue, 1-MeDIQ, on growth hormone release in nursing sheep.

Journal: Acta neurobiologiae experimentalis20100101

Title: Different mechanisms of NMDA-mediated protection against neuronal apoptosis: a stimuli-dependent effect.

Journal: Neurochemical research20091101

Title: Local salsolinol modulates dopamine extracellular levels from rat nucleus accumbens: shell/core differences.

Journal: Neurochemistry international20090901

Title: Ferritin enhances salsolinol-mediated DNA strand breakage: protection by carnosine and related compounds.

Journal: Toxicology letters20090710

Title: Fast liquid chromatography separation and multiple-reaction monitoring mass spectrometric detection of neurotransmitters.

Journal: Journal of separation science20090701

Title: Characteristics of prolactin-releasing response to salsolinol (SAL) and thyrotropin-releasing hormone (TRH) in ruminants.

Journal: Domestic animal endocrinology20090201

Title: Quantification of salsolinol enantiomers by stable isotope dilution liquid chromatography with tandem mass spectrometric detection.

Journal: Rapid communications in mass spectrometry : RCM20081201

Title: The formation of catechol isoquinolines in PC12 cells exposed to manganese.

Journal: Neuroscience letters20081024

Title: Identification of salsolinol in the mediobasal hypothalamus of lactating ewes and its relation to suckling-induced prolactin and GH release.

Journal: The Journal of endocrinology20080701

Title: Salsolinol, an endogenous neurotoxin, enhances platelet aggregation and thrombus formation.

Journal: Thrombosis and haemostasis20080701

Title: Iron contributes to the formation of catechol isoquinolines and oxidative toxicity induced by overdose dopamine in dopaminergic SH-SY5Y cells.

Journal: Neuroscience bulletin20080601

Title: Interaction between salsolinol (SAL) and thyrotropin-releasing hormone (TRH) or dopamine (DA) on the secretion of prolactin in ruminants.

Journal: Domestic animal endocrinology20080401

Title: Effect of (R)-salsolinol and N-methyl-(R)-salsolinol on the balance impairment between dopamine and acetylcholine in rat brain: involvement in pathogenesis of Parkinson disease.

Journal: Clinical chemistry20080401

Title: Quantitative chiral analysis of salsolinol in different brain regions of rats genetically predisposed to alcoholism.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20080301

Title: Salsolinol is present in the bovine posterior pituitary gland and stimulates the release of prolactin both in vivo and in vitro in ruminants.

Journal: Domestic animal endocrinology20080201

Title: The reinforcing properties of salsolinol in the ventral tegmental area: evidence for regional heterogeneity and the involvement of serotonin and dopamine.

Journal: Alcoholism, clinical and experimental research20080201

Title: The attenuating effect of memantine on staurosporine-, salsolinol- and doxorubicin-induced apoptosis in human neuroblastoma SH-SY5Y cells.

Journal: Neurochemistry international20080101

Title: Simultaneous determination of salsolinol enantiomers and dopamine in human plasma and cerebrospinal fluid by chemical derivatization coupled to chiral liquid chromatography/electrospray ionization-tandem mass spectrometry.

Journal: Analytical chemistry20071201

Title: The role of catecholamines in the prolactin release induced by salsolinol.

Journal: Neurochemistry international20071001

Title: Salsolinol, a tetrahydroisoquinoline catechol neurotoxin, induces human Cu,Zn-superoxidie dismutase modificaiton.

Journal: Journal of biochemistry and molecular biology20070930

Title: Antiapoptotic effects of nicotine in its protection against salsolinol-induced cytotoxicity.

Journal: Neurotoxicity research20070701

Title: Salsolinol and the peripheral sympathetic activity: the effects of hypophysectomy, adrenalectomy and adrenal medullectomy.

Journal: Ideggyogyaszati szemle20070330

Title: Effect of direct infusion of acetaldehyde on dopamine and dopamine-derived salsolinol in the striatum of free-moving rats using a reverse microdialysis technique.

Journal: Archives of toxicology20070201

Title: The peripheral noradrenergic terminal as possible site of action of salsolinol as prolactoliberin.

Journal: Neurochemistry international20070101

Title: TRPC1 protects human SH-SY5Y cells against salsolinol-induced cytotoxicity by inhibiting apoptosis.

Journal: Brain research20060712

Title: Determination of salsolinol and related catecholamines through on-line preconcentration and liquid chromatography/atmospheric pressure photoionization mass spectrometry.

Journal: Analytical chemistry20060515

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Salsolinol, a derivate of dopamine, is a possible modulator of catecholaminergic transmission: a review of recent developments.

Journal: Physiological research20060101

Title: Chronic polysystemic candidiasis as a possible contributor to onset of idiopathic Parkinson's disease.

Journal: Bratislavske lekarske listy20060101

Title: Neuroprotective effects of nicotine against salsolinol-induced cytotoxicity: implications for Parkinson's disease.

Journal: Neurotoxicity research20051101

Title: Systematic regional study of dopamine, norsalsolinol, and (R/S)-salsolinol levels in human brain areas of alcoholics.

Journal: Alcoholism, clinical and experimental research20050101

Title: Salsolinol, an antagonist of prolactoliberine, induces an increase in plasma catecholamine levels in the rat.

Journal: Autonomic neuroscience : basic & clinical20040930

Title: Immobilization stress-induced increase in plasma catecholamine levels is inhibited by a prolactoliberin (salsolinol) administration.

Journal: Annals of the New York Academy of Sciences20040601

Title: Pivotal role of an endogenous tetrahydroisoquinoline, salsolinol, in stress- and suckling-induced release of prolactin.

Journal: Annals of the New York Academy of Sciences20040601

Title: Bioconversion studies in cultured cells of Corydalis species.

Journal: Die Pharmazie20040601

Title: Salsolinol, a dopamine-derived tetrahydroisoquinoline, induces cell death by causing oxidative stress in dopaminergic SH-SY5Y cells, and the said effect is attenuated by metallothionein.

Journal: Brain research20040416

Title: Increased systemic levels of norsalsolinol derivatives are induced by levodopa treatment and do not represent biological markers of Parkinson's disease.

Journal: Journal of neurology, neurosurgery, and psychiatry20040401

Title: Liquid chromatography with amperometric detection at a nano crystalline Ce-doped lead dioxide film modified electrode for determination of (R)-Salsolinol, (R)-N-methylsalsolinol and monoamine neurotransmitters in Parkinsonian patients' cerebrospinal fluid.

Journal: The Analyst20040301

Title: Stress- as well as suckling-induced prolactin release is blocked by a structural analogue of the putative hypophysiotrophic prolactin-releasing factor, salsolinol.

Journal: Journal of neuroendocrinology20040301

Title: Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: occurrence, metabolism and function in human brains.

Journal: Neurotoxicology20040101

Title: Inhibition of DT-diaphorase potentiates the in vivo neurotoxic effect of intranigral injection of salsolinol in rats.

Journal: Neurotoxicity research20040101

Title: [Change of dopamine, serotonin and opioid neuromediator systems in the brain of rats adapted to prolonged effect of ethanol].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 )20040101

Title: Neuroprotective or neurotoxic activity of 1-methyl-1,2,3,4-tetrahydroisoquinoline and related compounds.

Journal: Bioorganic & medicinal chemistry letters20030901

Title: In vivo study of salsolinol produced by a high concentration of acetaldehyde in the striatum and nucleus accumbens of free-moving rats.

Journal: Alcoholism, clinical and experimental research20030801

Title: Simultaneous gas chromatographic-mass spectrometric determination of dopamine, norsalsolinol and salsolinol enantiomers in brain samples of a large human collective.

Journal: Cellular and molecular biology (Noisy-le-Grand, France)20030701

Title: Tyrosinase protects human melanocytes from ROS-generating compounds.

Journal: Biochemical and biophysical research communications20030530

Title: Insulin-like growth factor-1 protects human dopaminergic SH-SY5Y cells from salsolinol-induced toxicity.

Journal: Neuroscience letters20030410

Title: Salsolinol produces reinforcing effects in the nucleus accumbens shell of alcohol-preferring (P) rats.

Journal: Alcoholism, clinical and experimental research20030301

Title: Effect of different doses of cyanamide on striatal salsolinol formation after ethanol treatment.

Journal: Legal medicine (Tokyo, Japan)20030301

Title: Binding site of salsolinol: its properties in different regions of the brain and the pituitary gland of the rat.

Journal: Neurochemistry international20030101

Title: ['Starburst' conjugates of proteins with carbocene polymers, carrying low molecular weight biologically-active compounds, and their immunogenicity].

Journal: Bioorganicheskaia khimiia20030101

Title: In vivo formation of salsolinol induced by high acetaldehyde concentration in rat striatum employing microdialysis.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire)20030101

Title: Axonal degeneration and progressive neurologic disability in multiple sclerosis.

Journal: Neurotoxicity research20030101

Title: Salsolinol causing parkinsonism activates endoplasmic reticulum-stress signaling pathways in human dopaminergic SK-N-SH cells.

Journal: Neuro-Signals20030101

Title: Assay of salsolinol in peripheral blood mononuclear cells of alcoholics and healthy subjects by gas chromatography-mass spectrometry.

Journal: Addiction biology20021001

Title: Formation of novel toxic compounds from oxidative interaction between salsolinol and cysteine.

Journal: Journal of pharmaceutical and biomedical analysis20020905

Title: Iron enhancement of oxidative DNA damage and neuronal cell death induced by salsolinol.

Journal: Journal of toxicology and environmental health. Part A20020301

Title: Resistance of the insect cell line IPLB-LdFB to salsolinol-induced apoptosis.

Journal: Archives of insect biochemistry and physiology20020101

Title: Physiological role of salsolinol: its hypophysiotrophic function in the regulation of pituitary prolactin secretion.

Journal: Neurotoxicology and teratology20020101

Title: Salsolinol is a putative endogenous neuro-intermediate lobe prolactin-releasing factor.

Journal: Journal of neuroendocrinology20011201

Title: Differential cell death induced by salsolinol with and without copper: possible role of reactive oxygen species.

Journal: Molecular pharmacology20010901

Title: Oxidative DNA damage and cytotoxicity induced by copper-stimulated redox cycling of salsolinol, a neurotoxic tetrahydroisoquinoline alkaloid.

Journal: Free radical biology & medicine20010615

Title: Possible role of salsolinol quinone methide in the decrease of RCSN-3 cell survival.

Journal: Biochemical and biophysical research communications20010525

Title: Salsolinol, a naturally occurring tetrahydroisoquinoline alkaloid, induces DNA damage and chromosomal aberrations in cultured Chinese hamster lung fibroblast cells.

Journal: Mutation research20010301

Title: Opposite effect of simple tetrahydroisoquinolines on amphetamine- and morphine-stimulated locomotor activity in mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20010101

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