Home Amines 383907-43-5
383907-43-5,MFCD08276924
Catalog No.:AA00C08R

383907-43-5 | 6-Chloro-7-((2-morpholinoethyl)amino)quinoline-5,8-dione

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$36.00   $25.00
- +
5mg
≥98%
in stock  
$116.00   $81.00
- +
10mg
≥98%
in stock  
$215.00   $150.00
- +
25mg
≥98%
in stock  
$448.00   $313.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C08R
Chemical Name:
6-Chloro-7-((2-morpholinoethyl)amino)quinoline-5,8-dione
CAS Number:
383907-43-5
Molecular Formula:
C15H16ClN3O3
Molecular Weight:
321.7588
MDL Number:
MFCD08276924
SMILES:
ClC1=C(NCCN2CCOCC2)C(=O)c2c(C1=O)cccn2
NSC Number:
663284
Properties
Properties
 
BP:
478.8±45.0 °C(Predicted)  
Form:
Solid  
Solubility:
DMSO: 16 mg/mL  
Stability:
Light Sensitive  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
488  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
1.4  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Using small molecules to target protein phosphatases.

Journal: Bioorganic & medicinal chemistry 20110401

Title: Pharmacology and antitumor activity of a quinolinedione Cdc25 phosphatase inhibitor DA3003-1 (NSC 663284).

Journal: Anticancer research 20070101

Title: The when and wheres of CDC25 phosphatases.

Journal: Current opinion in cell biology 20060401

Title: Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C.

Journal: Bioorganic & medicinal chemistry letters 20060101

Title: Down-regulation of survivin in nitric oxide-induced cell growth inhibition and apoptosis of the human lung carcinoma cells.

Journal: The Journal of biological chemistry 20040507

Title: NAD(P)H:quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors.

Journal: The Journal of pharmacology and experimental therapeutics 20040401

Title: Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor 6-chloro-7-[corrected](2-morpholin-4-ylethylamino)-quinoline-5,8-dione.

Journal: The Journal of biological chemistry 20021206

Title: Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.

Journal: Journal of medicinal chemistry 20011122

Title: Lazo JS, et al. Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J Med Chem. 2001 Nov 22;44(24):4042-9.

Title: Coussens NP, et al. High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2. J Biol Chem. 2018 Aug 31;293(35):13750-13765.

Title: Guo J, et al. Pharmacology and antitumor activity of a quinolinedione Cdc25 phosphatase inhibitor DA3003-1 (NSC 663284). Anticancer Res. 2007 Sep-Oct;27(5A):3067-73.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 383907-43-5
Tags:383907-43-5 Molecular Formula|383907-43-5 MDL|383907-43-5 SMILES|383907-43-5 6-Chloro-7-((2-morpholinoethyl)amino)quinoline-5,8-dione