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383150-41-2,MFCD09878275
Catalog No.:AA00C0TS

383150-41-2 | JTE-013

Pack Size
Purity
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Price(USD)
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1mg
98%
in stock  
$36.00   $25.00
- +
5mg
≥98%
in stock  
$140.00   $98.00
- +
10mg
≥98%
in stock  
$193.00   $135.00
- +
25mg
98%
in stock  
$224.00   $157.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C0TS
Chemical Name:
JTE-013
CAS Number:
383150-41-2
Molecular Formula:
C17H19Cl2N7O
Molecular Weight:
408.2851
MDL Number:
MFCD09878275
SMILES:
O=C(Nc1cc(Cl)nc(c1)Cl)NNc1cc(C(C)C)c2c(n1)n(C)nc2C
Properties
Computed Properties
 
Complexity:
516  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
4.4  

Downstream Synthesis Route

[1]CurrentPatentAssignee:BRACCOSPA-WO2011/159864,2011,A1Locationinpatent:Page/Pagecolumn44

383150-41-2    5292-43-3   
C23H29Cl2N7O3 

[1]CurrentPatentAssignee:SWENSON,Rolf,Eric-WO2014/158302,2014,A1Locationinpatent:Page/Pagecolumn27

[2]CurrentPatentAssignee:ARROYOBIOSCIENCES-JP2015/524789,2015,ALocationinpatent:Paragraph0065-0066;0067

Literature

Title: Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate Receptor 2 in a Human Cholangiocarcinoma Cell Line.

Journal: The Journal of biological chemistry 20151225

Title: Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents.

Journal: Hepatology (Baltimore, Md.) 20121001

Title: Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor.

Journal: Journal of neurophysiology 20120901

Title: S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition.

Journal: Experimental cell research 20120501

Title: Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes.

Journal: Hepatology (Baltimore, Md.) 20120101

Title: Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20110601

Title: S1P₂ receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology.

Journal: American journal of physiology. Cell physiology 20110501

Title: Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20110101

Title: Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells.

Journal: The Journal of biological chemistry 20101112

Title: Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules.

Journal: American journal of physiology. Heart and circulatory physiology 20101101

Title: Downregulation of sphingosine-1-phosphate receptors in bronchial smooth muscle of mouse experimental asthma.

Journal: Pharmacological research 20101001

Title: Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic beta-cells.

Journal: Biochemical and biophysical research communications 20100205

Title: An autocrine sphingosine-1-phosphate signaling loop enhances NF-kappaB-activation and survival.

Journal: BMC cell biology 20100101

Title: Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20091001

Title: Antagonism of sphingosine 1-phosphate receptor-2 enhances migration of neural progenitor cells toward an area of brain.

Journal: Stroke 20081201

Title: G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase.

Journal: Cardiovascular research 20080901

Title: Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor.

Journal: Biochemical and biophysical research communications 20080711

Title: Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin.

Journal: Thrombosis and haemostasis 20080701

Title: New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets.

Journal: Biochemical pharmacology 20080515

Title: Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools.

Journal: British journal of pharmacology 20080101

Title: Sphingosine 1-phosphate accelerates wound healing in diabetic mice.

Journal: Journal of dermatological science 20071001

Title: Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20070601

Title: Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation.

Journal: Biochemical and biophysical research communications 20040730

Title: Sphingosine 1-phosphate inhibits migration of RBL-2H3 cells via S1P2: cross-talk between platelets and mast cells.

Journal: Journal of biochemistry 20040601

Title: Platelet-derived sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2.

Journal: Journal of thrombosis and haemostasis : JTH 20040101

Title: Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity.

Journal: The Journal of biological chemistry 20030829

Title: Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2.

Journal: Cardiovascular research 20030401

Title: Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5.

Journal: Gastroenterology 20030201

Title: Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist.

Journal: Biochemical and biophysical research communications 20021206

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