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38363-40-5,MFCD00864578
Catalog No.:AA00CIKY

38363-40-5 | Penbutolol

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10mg
2 weeks  
$1,258.00   $880.00
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  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00CIKY
Chemical Name:
Penbutolol
CAS Number:
38363-40-5
Molecular Formula:
C18H29NO2
Molecular Weight:
291.4284
MDL Number:
MFCD00864578
SMILES:
CC(C)(C)NCC(COC1=CC=CC=C1C2CCCC2)O
Properties
Computed Properties
 
Complexity:
294  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
4.2  

Literature

Title: Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

Journal: Chemical research in toxicology 20170515

Title: Drug design for ever, from hype to hope.

Journal: Journal of computer-aided molecular design 20120101

Title: Performance scores in general practice: a comparison between the clinical versus medication-based approach to identify target populations.

Journal: PloS one 20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling.

Journal: Trends in pharmacological sciences 20110401

Title: Development of novel in silico model to predict corneal permeability for congeneric drugs: a QSPR approach.

Journal: Journal of biomedicine & biotechnology 20110101

Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

Journal: Healthcare informatics research 20101201

Title: [Determination of fifteen beta-agonists in animal urine by high performance liquid chromatography-tandem mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20100801

Title: In vitro transdermal iontophoretic delivery of penbutolol sulfate.

Journal: Drug delivery 20090101

Title: [Simultaneous determination of nine beta-agonist residues in animal derived foods by ultra performance liquid chromatography-tandem mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20081101

Title: Carvedilol in hypertension treatment.

Journal: Vascular health and risk management 20080201

Title: Stereospecific high-performance liquid chromatographic analysis of tramadol and its O-demethylated (M1) and N,O-demethylated (M5) metabolites in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601

Title: Clinical review: aggressive management and extracorporeal support for drug-induced cardiotoxicity.

Journal: Critical care (London, England) 20070101

Title: Thermotropic liquid crystalline drugs.

Journal: The Journal of pharmacy and pharmacology 20050701

Title: Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

Journal: Journal of medicinal chemistry 20050505

Title: Screening for library-assisted identification and fully validated quantification of 22 beta-blockers in blood plasma by liquid chromatography-mass spectrometry with atmospheric pressure chemical ionization.

Journal: Journal of chromatography. A 20041126

Title: [Pharmacology of beta blockers and their significance for therapy of hypertension].

Journal: Herz 20020801

Title: Synthesis and evaluation of radiolabeled antagonists for imaging of beta-adrenoceptors in the brain with PET.

Journal: Neurochemistry international 20020201

Title: 5-HT receptor subtypes involved in the spinal antinociceptive effect of acetaminophen in rats.

Journal: European journal of pharmacology 20011130

Title: High-performance liquid chromatography with chemiluminescence detection of penbutolol and its hydroxylated metabolite in rat plasma.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010615

Title: Decrease in penbutolol protein binding as a consequence of treatment with some alkylating agents.

Journal: Cancer chemotherapy and pharmacology 19940101

Title: (-)-Penbutolol as a blocker of central 5-HT1A receptor-mediated responses.

Journal: European journal of pharmacology 19921103

Title: [Validity of the use of penbutolol in essential arterial hypertension].

Journal: Minerva medica 19900601

Title: Penbutolol and carteolol: two new beta-adrenergic blockers with partial agonism.

Journal: Journal of clinical pharmacology 19900501

Title: Decrease in penbutolol central response as a cause of changes in its serum protein binding.

Journal: The Journal of pharmacy and pharmacology 19900301

Title: Effect of oral penbutolol on renal haemodynamics of hypertensive patients with renal insufficiency.

Journal: The New Zealand medical journal 19850828

Title: A comparative study of atenolol and penbutolol in hypertensive patients.

Journal: European heart journal 19830701

Title: Single daily dose penbutolol in the treatment of hypertension: a double blind crossover comparison with propranolol.

Journal: European journal of clinical pharmacology 19800601

Title: Clinical electrophysiological properties of penbutolol: a non-selective beta-blocking agent.

Journal: European journal of cardiology 19800101

Title: The effect of clonidine and penbutolol, respectively on catecholamines in blood and urine, plasma renin activity and urinary aldosterone in hypertensive patients.

Journal: Archives internationales de pharmacodynamie et de therapie 19750201

Title: Hjorth S, et al. In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol. J Pharmacol Exp Ther. 1993 May;265(2):707-12.

Title: M E Castro, et al. Affinity of (±)-Pindolol, (-)-Penbutolol, and (-)-Tertatolol for Pre- and Postsynaptic Serotonin 5-HT1A Receptors in Human and Rat Brain. Journal of Neurochemistry, Volume 75, Issue 2, p. 755-762.

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