Home Other Building Blocks 3878-55-5
3878-55-5,MFCD00002788
Catalog No.:AA0037GL

3878-55-5 | Mono-methyl succinate

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Purity
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5g
97%
in stock  
$11.00   $8.00
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25g
97%
in stock  
$17.00   $12.00
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100g
95%
in stock  
$32.00   $23.00
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500g
95%
in stock  
$78.00   $55.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0037GL
Chemical Name:
Mono-methyl succinate
CAS Number:
3878-55-5
Molecular Formula:
C5H8O4
Molecular Weight:
132.1146
MDL Number:
MFCD00002788
SMILES:
COC(=O)CCC(=O)O
NSC Number:
511
Properties
Properties
 
BP:
259.233 °C at 760 mmHg  
Form:
Solid  
MP:
54-57 °C(lit.);  
Refractive Index:
1.4240 (estimate)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
118  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  

Upstream Synthesis Route

[1]JournalofOrganicChemistry,1969,vol.34,#4,p.1172-1173

[1]Patent:CN105503746,2016,A,.Locationinpatent:Paragraph0054;0055;0056

[1]JournaldeChimiePhysiqueetdePhysico-ChimieBiologique,1995,vol.92,#7-8,p.1344-1364

[1]ChemicalandPharmaceuticalBulletin,1974,vol.22,#8,p.1795-1799

[1]JournalofOrganicChemistry,1982,vol.47,#24,p.4605-4611

Downstream Synthesis Route

[1]CollectionofCzechoslovakChemicalCommunications,1954,vol.19,p.716

[1]HuaxueXuebao/ActaChimicaSinica,1959,vol.25,p.129,134    Chem.Abstr.,1960,p.4365

[1]JournaloftheChemicalSociety,1959,p.3258,3263

[1]JournaloftheChemicalSociety,1954,p.4219,4223

[1]JournaloftheChemicalSociety,1953,p.1538,1540

Literature

Title: Repeated, selection-driven genome reduction of accessory genes in experimental populations.

Journal: PLoS genetics 20120501

Title: Supplementation of pyruvate prevents palmitate-induced impairment of glucose uptake in C2 myotubes.

Journal: Molecular and cellular endocrinology 20111015

Title: Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment.

Journal: The Biochemical journal 20110801

Title: Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20110301

Title: Development of an orthodontic elastic material using EMA-based resin combined with 1-butanol.

Journal: Dental materials journal 20110101

Title: 2-Phenyl-biguanidinium hydrogen succinate methanol monosolvate.

Journal: Acta crystallographica. Section E, Structure reports online 20101201

Title: Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion.

Journal: American journal of physiology. Endocrinology and metabolism 20090601

Title: Total synthesis of the natural succinate derivative of 5-(hydroxymethyl)furfural isolated from the Noni fruit (Morinda citrifolia).

Journal: Natural product research 20090101

Title: Comprehensive proteomics of Methylobacterium extorquens AM1 metabolism under single carbon and nonmethylotrophic conditions.

Journal: Proteomics 20080901

Title: [Studies on chemical constituents of Ranunculus ternatus].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080401

Title: Acetoacetate and beta-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion.

Journal: American journal of physiology. Cell physiology 20080201

Title: Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose.

Journal: The Biochemical journal 20070401

Title: Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.

Journal: British journal of pharmacology 20070401

Title: Synergistic potent insulin release by combinations of weak secretagogues in pancreatic islets and INS-1 cells.

Journal: The Journal of biological chemistry 20070302

Title: Identification of monomenthyl succinate in natural mint extracts by LC-ESI-MS-MS and GC-MS.

Journal: Journal of agricultural and food chemistry 20060628

Title: Fumarate reductase: structural and mechanistic insights from the catalytic reduction of 2-methylfumarate.

Journal: FEBS letters 20060306

Title: Selective loss of glucose-induced amplification of insulin secretion in mouse pancreatic islets pretreated with sulfonylurea in the absence of fuels.

Journal: Diabetologia 20051201

Title: P2Y purinergic potentiation of glucose-induced insulin secretion and pancreatic beta-cell metabolism.

Journal: Diabetes 20041201

Title: Liquid chromatographic determination of oxaliplatin in blood using post-column derivatization in a microwave field followed by photometric detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031005

Title: Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis.

Journal: Cell death and differentiation 20030601

Title: Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis.

Journal: American journal of physiology. Endocrinology and metabolism 20020801

Title: Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats.

Journal: Diabetes 20020301

Title: A neuronal isoform of nitric oxide synthase expressed in pancreatic beta-cells controls insulin secretion.

Journal: Diabetes 20010601

Title: Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes.

Journal: Diabetes 20010201

Title: Differential acute and long term actions of succinic acid monomethyl ester exposure on insulin-secreting BRIN-BD11 cells.

Journal: International journal of experimental diabetes research 20010101

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