Home Other Building Blocks 39524-08-8
39524-08-8,MFCD25371916
Catalog No.:AA00C7AH

39524-08-8 | Asperosaponin VI

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
≥98%
in stock  
$98.00   $68.00
- +
50mg
≥98%
in stock  
$432.00   $302.00
- +
100mg
98% by HPLC
in stock  
$708.00   $495.00
- +
500mg
98% by HPLC
in stock  
$2,141.00   $1,499.00
- +
1000mg
98% by HPLC
in stock  
$3,388.00   $2,371.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C7AH
Chemical Name:
Asperosaponin VI
CAS Number:
39524-08-8
Molecular Formula:
C47H76O18
Molecular Weight:
929.0955
MDL Number:
MFCD25371916
SMILES:
OC[C@H]1O[C@@H](OC[C@H]2O[C@@H](OC(=O)[C@]34CC[C@@]5(C(=CC[C@H]6[C@@]5(C)CC[C@@H]5[C@]6(C)CC[C@@H]([C@@]5(C)CO)O[C@@H]5OC[C@@H]([C@@H]([C@H]5O)O)O)[C@@H]4CC(CC3)(C)C)C)[C@@H]([C@H]([C@@H]2O)O)O)[C@@H]([C@H]([C@@H]1O)O)O
Properties
Computed Properties
 
Complexity:
1770  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
23  
Heavy Atom Count:
65  
Hydrogen Bond Acceptor Count:
18  
Hydrogen Bond Donor Count:
11  
Rotatable Bond Count:
10  
XLogP3:
0.8  

Upstream Synthesis Route

[1]ChemicalandPharmaceuticalBulletin,1985,vol.33,#8,p.3473-3478

[1]ChemicalandPharmaceuticalBulletin,1985,vol.33,#8,p.3473-3478

[1]Phytochemistry,1993,vol.34,#5,p.1389-1394

Downstream Synthesis Route

[1]ChemicalandPharmaceuticalBulletin,1985,vol.33,p.3473-3478

[1]LiebigsAnnalenderChemie,1992,p.453-460

[1]Phytochemistry,1993,vol.34,p.1389-1394

[2]LiebigsAnnalenderChemie,1986,vol.1986,p.638-646

[1]ChemicalandPharmaceuticalBulletin,1985,vol.33,p.3473-3478

[1]Phytochemistry,1993,vol.34,p.1389-1394

Literature

Title: Long-term oral Asperosaponin VI attenuates cardiac dysfunction, myocardial fibrosis in a rat model of chronic myocardial infarction.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501

Title: Akebia saponin D attenuates ibotenic acid-induced cognitive deficits and pro-apoptotic response in rats: involvement of MAPK signal pathway.

Journal: Pharmacology, biochemistry, and behavior 20120501

Title: Determination of asperosaponin VI in dog plasma by high-performance liquid chromatography-tandem mass spectrometry and its application to a pilot pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20120101

Title: Simultaneous determination of asperosaponin VI and its active metabolite hederagenin in rat plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111115

Title: [Studies on optimizing preparation technics of wumeitougu oral liquid by response surface methodology].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110201

Title: Asperosaponin VI protects cardiac myocytes from hypoxia-induced apoptosis via activation of the PI3K/Akt and CREB pathways.

Journal: European journal of pharmacology 20101215

Title: In vitro & in vivo assessment of a herbal formula used topically for bone fracture treatment.

Journal: Journal of ethnopharmacology 20100915

Title: Determination of asperosaponin VI in rat plasma by HPLC-ESI-MS and its application to preliminary pharmacokinetic studies.

Journal: Biomedical chromatography : BMC 20100501

Title: Protective roles of Asperosaponin VI, a triterpene saponin isolated from Dipsacus asper Wall on acute myocardial infarction in rats.

Journal: European journal of pharmacology 20100210

Title: Akebia saponin D, a saponin component from Dipsacus asper Wall, protects PC 12 cells against amyloid-beta induced cytotoxicity.

Journal: Cell biology international 20091001

Title: Niu Y, et al. Asperosaponin VI, a saponin component from Dipsacus asper wall, induces osteoblast differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway. Phytother Res. 2011 Nov;25(11):1700-6.

Title: Li C, et al. Asperosaponin VI protects cardiac myocytes from hypoxia-induced apoptosis via activation of the PI3K/Akt and CREB pathways. Eur J Pharmacol. 2010 Dec 15;649(1-3):100-7.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:39524-08-8 Molecular Formula|39524-08-8 MDL|39524-08-8 SMILES|39524-08-8 Asperosaponin VI