Title: Effects of four chemotherapeutic agents, bleomycin, etoposide, cisplatin, and cyclophosphamide, on DNA damage and telomeres in a mouse spermatogonial cell line.
Journal: Biology of reproduction 20140401
Title: Methylated chrysin reduced cell proliferation, but antagonized cytotoxicity of other anticancer drugs in acute lymphoblastic leukemia.
Journal: Anti-cancer drugs 20120401
Title: The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance.
Journal: Chemico-biological interactions 20120105
Title: Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs.
Journal: PloS one 20120101
Title: Teratogen responsive signaling pathways in organogenesis stage mouse limbs.
Journal: Reproductive toxicology (Elmsford, N.Y.) 20090401
Title: Inhibition of human sperm respiration by 4-hydroperoxycyclophosphamide and protection by mesna and WR-1065.
Journal: Fertility and sterility 20090101
Title: The gene expression profiles of medulloblastoma cell lines resistant to preactivated cyclophosphamide.
Journal: Current cancer drug targets 20080501
Title: 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG.
Journal: Cell death and differentiation 20080201
Title: Heterogeneity of aldehyde dehydrogenase expression in lung cancer cell lines is revealed by Aldefluor flow cytometry-based assay.
Journal: Cytometry. Part B, Clinical cytometry 20070701
Title: Cyclophosphamide-induced apoptosis in COV434 human granulosa cells involves oxidative stress and glutathione depletion.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070701
Title: Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines.
Journal: Investigational new drugs 20070201
Title: RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide.
Journal: Cancer chemotherapy and pharmacology 20070101
Title: Teratogen-induced activation of p53 in early postimplantation mouse embryos.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070101
Title: Chemotherapy disrupts activity of translational regulatory proteins in bone marrow stromal cells.
Journal: Experimental hematology 20061101
Title: Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation.
Journal: Journal of medicinal chemistry 20060713
Title: Characterizing the ovotoxicity of cyclophosphamide metabolites on cultured mouse ovaries.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060401
Title: Cyclophosphamide enhances TNF-alpha-induced apoptotic cell death in murine vascular endothelial cell.
Journal: FEBS letters 20060306
Title: Predictive value of in vitro assessment of cytotoxic drug activity in advanced breast cancer.
Journal: Anti-cancer drugs 20050701
Title: Retinoic acid down-regulates aldehyde dehydrogenase and increases cytotoxicity of 4-hydroperoxycyclophosphamide and acetaldehyde.
Journal: The Journal of pharmacology and experimental therapeutics 20050101
Title: Oxidative DNA damage induced by a hydroperoxide derivative of cyclophosphamide.
Journal: Free radical biology & medicine 20040915
Title: Alterations in gene expression induced in day-9 mouse embryos exposed to hyperthermia (HS) or 4-hydroperoxycyclophosphamide (4CP): analysis using cDNA microarrays.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040601
Title: Interleukin-12 enhances the sensitivity of human osteosarcoma cells to 4-hydroperoxycyclophosphamide by a mechanism involving the Fas/Fas-ligand pathway.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040115
Title: Teratogen-induced activation of caspase-6 and caspase-7 in early postimplantation mouse embryos.
Journal: Cell biology and toxicology 20030801
Title: 4-hydroperoxycyclophosphamide--purged peripheral blood stem cells for autologous transplantation in patients with acute myeloid leukemia.
Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20030301
Title: Teratogen-induced activation of the mitochondrial apoptotic pathway in the yolk sac of day 9 mouse embryos.
Journal: Birth defects research. Part A, Clinical and molecular teratology 20030201
Title: Enhanced bystander cytotoxicity of P450 gene-directed enzyme prodrug therapy by expression of the antiapoptotic factor p35.
Journal: Cancer research 20021201
Title: Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs.
Journal: Cancer research 20021201
Title: Novel competitive irreversible inhibitors of aldehyde dehydrogenase (ALDH1): restoration of chemosensitivity of L1210 cells overexpressing ALDH1 and induction of apoptosis in BAF(3) cells overexpressing bcl(2).
Journal: Biochemical pharmacology 20021015
Title: Kinetic analysis of the reactions of 4-hydroperoxycyclophosphamide and acrolein with glutathione, mesna, and WR-1065.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020801
Title: Teratogen-induced activation of caspase-9 and the mitochondrial apoptotic pathway in early postimplantation mouse embryos.
Journal: Toxicology and applied pharmacology 20020601
Title: Autologous bone marrow transplantation with 4-hydroperoxycyclophosphamide purging for acute myeloid leukaemia beyond first remission: a 10-year experience.
Journal: British journal of haematology 20020601
Title: Purging in autologous hematopoietic stem cell transplantation using adenosine triphosphate (ATP) and 4-hydroperoxycyclophosphamide (4-HC).
Journal: Leukemia research 20020501
Title: Cellular mechanisms of cyclophosphamide resistance: model studies in human medulloblastoma cell lines.
Journal: Cancer treatment and research 20020101
Title: Expression of base excision, mismatch, and recombination repair genes in the organogenesis-stage rat conceptus and effects of exposure to a genotoxic teratogen, 4-hydroperoxycyclophosphamide.
Journal: Teratology 20011201
Title: DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20011101
Title: L-buthionine sulfoximine potentiates the antitumor effect of 4-hydroperoxycyclophosphamide when administered locally in a rat glioma model.
Journal: Neurosurgery 20010201
Title: Generation of dual resistance to 4-hydroperoxycyclophosphamide and methotrexate by retroviral transfer of the human aldehyde dehydrogenase class 1 gene and a mutated dihydrofolate reductase gene.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20010101
Title: Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
Journal: Cancer research 20001001
Title: De novo expression of transfected human class 1 aldehyde dehydrogenase (ALDH) causes resistance to oxazaphosphorine anti-cancer alkylating agents in hamster V79 cell lines. Elevated class 1 ALDH activity is closely correlated with reduction in DNA interstrand cross-linking and lethality.
Journal: The Journal of biological chemistry 19960517
Title: Immediate hypersensitivity reaction to cyclophosphamide.
Journal: Arthritis and rheumatism 19940701
Title: Intrathecal 4-hydroperoxycyclophosphamide: neurotoxicity, cerebrospinal fluid pharmacokinetics, and antitumor activity in a rabbit model of VX2 leptomeningeal carcinomatosis.
Journal: Cancer research 19921115
Title: Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention--I. Experimental studies on the urotoxicity of alkylating compounds.
Journal: European journal of cancer 19810601
Title: 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG
