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39809-25-1,MFCD00866931
Catalog No.:AA00IKFL

39809-25-1 | Penciclovir

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50mg
98%
in stock  
$6.00   $4.00
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100mg
98%
in stock  
$8.00   $6.00
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1g
99%(HPLC)
in stock  
$34.00   $24.00
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5g
98%
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00IKFL
Chemical Name:
Penciclovir
CAS Number:
39809-25-1
Molecular Formula:
C10H15N5O3
Molecular Weight:
253.2578
MDL Number:
MFCD00866931
SMILES:
OCC(CCn1cnc2c1[nH]c(N)nc2=O)CO
NSC Number:
759624
Properties
Properties
 
BP:
653.4°C at 760 mmHg  
Form:
Solid  
MP:
275-277°C  
Solubility:
0.02 M potassium phosphate: soluble2mg/mL  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
344  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
5  
XLogP3:
-1.9  

Literature

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Journal: Antiviral research 20131101

Title: Pharmacokinetics of famciclovir and penciclovir in tears following oral administration of famciclovir to cats: a pilot study.

Journal: Veterinary ophthalmology 20120901

Title: Pharmacokinetics of penciclovir in healthy cats following oral administration of famciclovir or intravenous infusion of penciclovir.

Journal: American journal of veterinary research 20120701

Title: Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120301

Title: Positron emission tomography reporter genes and reporter probes: gene and cell therapy applications.

Journal: Theranostics 20120101

Title: Use of the University of Minnesota Biocatalysis/Biodegradation Database for study of microbial degradation.

Journal: Microbial informatics and experimentation 20120101

Title: Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism.

Journal: PloS one 20120101

Title: A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data.

Journal: PloS one 20120101

Title: Unrepairable DNA double-strand breaks initiate cytotoxicity with HSV-TK/ganciclovir.

Journal: Cancer gene therapy 20111001

Title: Antiviral drugs for viruses other than human immunodeficiency virus.

Journal: Mayo Clinic proceedings 20111001

Title: Lentiviral vectors for induction of self-differentiation and conditional ablation of dendritic cells.

Journal: Gene therapy 20110801

Title: Alphaherpesviruses and the cytoskeleton in neuronal infections.

Journal: Viruses 20110701

Title: Safety and pharmacokinetics of a single 1500-mg dose of famciclovir in adolescents with recurrent herpes labialis.

Journal: The Pediatric infectious disease journal 20110601

Title: Determination of penciclovir in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a clinical pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20110401

Title: Biotransformation of the antiviral drugs acyclovir and penciclovir in activated sludge treatment.

Journal: Environmental science & technology 20110401

Title: Evaluation of orally administered famciclovir in cats experimentally infected with feline herpesvirus type-1.

Journal: American journal of veterinary research 20110101

Title: Oil components modulate the skin delivery of 5-aminolevulinic acid and its ester prodrug from oil-in-water and water-in-oil nanoemulsions.

Journal: International journal of nanomedicine 20110101

Title: Unsuccessful therapy with adefovir and entecavir-tenofovir in a patient with chronic hepatitis B infection with previous resistance to lamivudine: a fourteen-year evolution of hepatitis B virus mutations.

Journal: BMC infectious diseases 20110101

Title: Inhibitory effect of caffeic acid on human organic anion transporters hOAT1 and hOAT3: a novel candidate for food-drug interaction.

Journal: Drug metabolism and pharmacokinetics 20110101

Title: Preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery.

Journal: International journal of nanomedicine 20110101

Title: Antivirals reduce the formation of key Alzheimer's disease molecules in cell cultures acutely infected with herpes simplex virus type 1.

Journal: PloS one 20110101

Title: Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2.

Journal: Antiviral therapy 20110101

Title: Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin A.

Journal: BMC bioinformatics 20110101

Title: A new topical treatment protocol for oral hairy leukoplakia.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20101101

Title: Nongenital herpes simplex virus.

Journal: American family physician 20101101

Title: Skin irritation and the inhibition effect on HSV-1 in vivo of penciclovir-loaded microemulsion.

Journal: International immunopharmacology 20101001

Title: Synthesis and early development of hexadecyloxypropylcidofovir: an oral antipoxvirus nucleoside phosphonate.

Journal: Viruses 20101001

Title: A new pyrimidine-specific reporter gene: a mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100901

Title: [Recurrent herpes simplex labialis infections. Possible prevention with a new therapeutic regimen].

Journal: Lakartidningen 20100801

Title: Famciclovir: a focus on efficacy and safety.

Journal: Expert opinion on drug safety 20100701

Title: New trends in nucleoside biotechnology.

Journal: Acta naturae 20100701

Title: Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus.

Journal: Antiviral research 20100601

Title: 5-Fluoro-1-[(4S,5R)-5-(2-hydroxy-ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]pyrimidine-2,4(1H,3H)-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20100601

Title: Computational identification of uncharacterized cruzain binding sites.

Journal: PLoS neglected tropical diseases 20100501

Title: Pharmacokinetics of penciclovir after oral administration of its prodrug famciclovir to horses.

Journal: The Journal of veterinary medical science 20100301

Title: Antiviral drugs in wastewater and surface waters: a new pharmaceutical class of environmental relevance?

Journal: Environmental science & technology 20100301

Title: Prevention of ulcerative lesions by episodic treatment of recurrent herpes labialis: A literature review.

Journal: Acta dermato-venereologica 20100301

Title: Alteration of the carbohydrate for deoxyguanosine analogs markedly changes DNA replication fidelity, cell cycle progression and cytotoxicity.

Journal: Mutation research 20100203

Title: Antiviral selection in the management of acute retinal necrosis.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20100101

Title: Therapeutic efficacy of human hepatocyte transplantation in a SCID/uPA mouse model with inducible liver disease.

Journal: PloS one 20100101

Title: Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome.

Journal: PloS one 20100101

Title: Topical ganciclovir in the treatment of acute herpetic keratitis.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20100101

Title: HSV Recombinant Vectors for Gene Therapy.

Journal: The open virology journal 20100101

Title: Testing of herpes simplex virus for resistance to antiviral drugs.

Journal: Virulence 20100101

Title: The effects of maribavir on the autophosphorylation of ganciclovir resistant mutants of the cytomegalovirus UL97 protein.

Journal: Herpesviridae 20100101

Title: Herpes zoster oticus: A rare clinical entity.

Journal: Contemporary clinical dentistry 20100101

Title: Testing the susceptibility of human herpesviruses to antivirals.

Journal: Future microbiology 20091101

Title: 9-[4-Hydr-oxy-3-(hydroxy-meth-yl)but-yl]guanine monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20091101

Title: Population pharmacokinetics and optimal design of paediatric studies for famciclovir.

Journal: British journal of clinical pharmacology 20091001

Title: A perspective on antiviral resistance.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20090901

Title: Microemulsion-based hydrogel formulation of penciclovir for topical delivery.

Journal: International journal of pharmaceutics 20090813

Title: Simultaneous determination of acyclovir, ganciclovir, and (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine in human plasma using high-performance liquid chromatography.

Journal: Biomedical chromatography : BMC 20090801

Title: Vitreous penetration of orally administered famciclovir.

Journal: American journal of ophthalmology 20090701

Title: Development and evaluation of penciclovir-loaded solid lipid nanoparticles for topical delivery.

Journal: International journal of pharmaceutics 20090508

Title: Oxidation and glycolytic cleavage of etheno and propano DNA base adducts.

Journal: Biochemistry 20090203

Title: PET imaging of heat-inducible suicide gene expression in mice bearing head and neck squamous cell carcinoma xenografts.

Journal: Cancer gene therapy 20090201

Title: Single-day famciclovir for the treatment of genital herpes: follow-up results of time to next recurrence and assessment of antiviral resistance.

Journal: Current medical research and opinion 20090201

Title: PET imaging of thymidine kinase gene expression in the liver of non-human primates following systemic delivery of an adenoviral vector.

Journal: Gene therapy 20090101

Title: Antimicrobial strategies: inhibition of viral polymerases by 3'-hydroxyl nucleosides.

Journal: Drugs 20090101

Title: Evaluation of the in vitro skin permeation of antiviral drugs from penciclovir 1% cream and acyclovir 5% cream used to treat herpes simplex virus infection.

Journal: BMC dermatology 20090101

Title: Tenofovir and its potential in the treatment of hepatitis B virus.

Journal: Therapeutics and clinical risk management 20090101

Title: Characterization of a spontaneous drug-resistant mutant of monkey B virus (Macacine herpesvirus 1).

Journal: Archives of virology 20090101

Title: HPLC method for the determination of penciclovir in human plasma and application to a bioequivalence study.

Journal: Journal of chromatographic science 20081001

Title: Development of a quantitative real-time TaqMan PCR assay for testing the susceptibility of feline herpesvirus-1 to antiviral compounds.

Journal: Journal of virological methods 20080901

Title: Formulation design of microemulsion for dermal delivery of penciclovir.

Journal: International journal of pharmaceutics 20080806

Title: Penciclovir is a potent inhibitor of feline herpesvirus-1 with susceptibility determined at the level of virus-encoded thymidine kinase.

Journal: Antiviral research 20080601

Title: Simultaneous determination of aciclovir, ganciclovir, and penciclovir in human plasma by high-performance liquid chromatography with fluorescence detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080515

Title: Regression of herpes viral infection symptoms using melatonin and SB-73: comparison with Acyclovir.

Journal: Journal of pineal research 20080501

Title: Single-day treatment for orolabial and genital herpes: a brief review of pathogenesis and pharmacology.

Journal: Therapeutics and clinical risk management 20080401

Title: Substrate specificity and molecular modelling of the feline herpesvirus-1 thymidine kinase.

Journal: Archives of virology 20080101

Title: Herpes simplex virus helicase-primase inhibitors: recent findings from the study of drug resistance mutations.

Journal: Antiviral chemistry & chemotherapy 20080101

Title: Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile (2nd edition): DNA viruses.

Journal: Antiviral chemistry & chemotherapy 20080101

Title: Isolation of liver aldehyde oxidase containing fractions from different animals and determination of kinetic parameters for benzaldehyde.

Journal: Indian journal of pharmaceutical sciences 20080101

Title: Pharmacokinetics and safety of penciclovir following oral administration of famciclovir to cats.

Journal: American journal of veterinary research 20071101

Title: Clinical inquiries. What are the best treatments for herpes labialis?

Journal: The Journal of family practice 20070701

Title: Development and validation of a high-performance liquid chromatography-tandem mass spectrometry for the determination of penciclovir in human plasma: application to a bioequivalence study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601

Title: Management of recurrent oral herpes simplex infections.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20070301

Title: 5'AMP-activated protein kinase alpha deficiency enhances stress-induced apoptosis in BHK and PC12 cells.

Journal: Journal of cellular and molecular medicine 20070301

Title: Factors that affect in vitro measurement of the susceptibility of herpes simplex virus to nucleoside analogues.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20070201

Title: Single-day therapy: an expert opinion on a recent development for the episodic treatment of recurrent genital herpes.

Journal: Archives of gynecology and obstetrics 20070101

Title: Platinum(II) and palladium(II) complexes of pyridine-2-carbaldehyde thiosemicarbazone as alternative antiherpes simplex virus agents.

Journal: Bioinorganic chemistry and applications 20070101

Title: Famciclovir for the treatment of recurrent genital herpes: a clinical and pharmacological perspective.

Journal: Expert opinion on pharmacotherapy 20061101

Title: Herpes labialis.

Journal: BMJ clinical evidence 20061001

Title: Comparative efficacy of famciclovir and valacyclovir for suppression of recurrent genital herpes and viral shedding.

Journal: Sexually transmitted diseases 20060901

Title: Intracellular uptake of thymidine and antiherpetic drugs for thymidine kinase-deficient mutants of herpes simplex virus type 1.

Journal: Antiviral research 20060701

Title: Valacyclovir for the treatment of genital herpes.

Journal: Expert review of anti-infective therapy 20060601

Title: Oral and perioral herpes simplex virus type 1 (HSV-1) infection: review of its management.

Journal: Oral diseases 20060501

Title: Evidence that amphotericin B mediates reactivation of latent Epstein-Barr virus in Hodgkin's lymphoma allowing cytotoxicity by acyclovir.

Journal: Yonsei medical journal 20060430

Title: New antiviral agents.

Journal: Indian journal of pediatrics 20060401

Title: Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapy.

Journal: British journal of pharmacology 20060101

Title: Inhibitory efficacy of cyclosal-nucleoside monophosphates of aciclovir and brivudin on DNA synthesis of orthopoxvi ruses.

Journal: Antiviral chemistry & chemotherapy 20060101

Title: In vitro comparison of antiviral drugs against feline herpesvirus 1.

Journal: BMC veterinary research 20060101

Title: Improved industrial syntheses of penciclovir and famciclovir using N2-acetyl-7-benzylguanine and a cyclic side chain precursor.

Journal: Nucleosides, nucleotides & nucleic acids 20060101

Title: Second-generation triple reporter for bioluminescence, micro-positron emission tomography, and fluorescence imaging.

Journal: Molecular imaging 20060101

Title: Famciclovir: a review of its use in herpes zoster and genital and orolabial herpes.

Journal: Drugs 20060101

Title: Development and validation of a new reversed-phase ion pairing liquid chromatographic method with fluorescence detection for penciclovir analysis in plasma and aqueous humor.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051105

Title: Clinic-initiated, twice-daily oral famciclovir for treatment of recurrent genital herpes: a randomized, double-blind, controlled trial.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20051015

Title: In vitro activity of cycloSal-nucleoside monophosphates and polyhydroxycarboxylates against orthopoxviruses.

Journal: Antiviral research 20050901

Title: [Genital herpes].

Journal: Revue medicale de Bruxelles 20050901

Title: Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus.

Journal: The Journal of general virology 20050801

Title: Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster.

Journal: The FEBS journal 20050801

Title: Structural-functional relationships between terminal deoxynucleotidyltransferase and 5'-triphosphates of nucleoside analogs.

Journal: Biochemistry. Biokhimiia 20050801

Title: Recurrent antiviral-resistant genital herpes in an immunocompetent patient.

Journal: The Journal of infectious diseases 20050701

Title: Platinum(II) complexes with antitumoral/antiviral aromatic heterocycles: effect of glutathione upon in vitro cell growth inhibition.

Journal: Journal of medicinal chemistry 20050505

Title: Drugs for non-HIV viral infections.

Journal: Treatment guidelines from the Medical Letter 20050401

Title: Antiadenovirus activities of several classes of nucleoside and nucleotide analogues.

Journal: Antimicrobial agents and chemotherapy 20050301

Title: Susceptibilities of several clinical varicella-zoster virus (VZV) isolates and drug-resistant VZV strains to bicyclic furano pyrimidine nucleosides.

Journal: Antimicrobial agents and chemotherapy 20050301

Title: Agents and strategies in development for improved management of herpes simplex virus infection and disease.

Journal: Expert opinion on investigational drugs 20050201

Title: Comparison of [14C]FMAU, [3H]FEAU, [14C]FIAU, and [3H]PCV for monitoring reporter gene expression of wild type and mutant herpes simplex virus type 1 thymidine kinase in cell culture.

Journal: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20050101

Title: Topical treatment of herpes labialis.

Journal: Cutis 20041101

Title: Recent clinical experience with famciclovir--a 'third generation' nucleoside prodrug.

Journal: Antiviral chemistry & chemotherapy 20040901

Title: Antiviral properties and cytotoxic activity of platinum(II) complexes with 1,10-phenanthrolines and acyclovir or penciclovir.

Journal: Journal of inorganic biochemistry 20040801

Title: Therapeutic options for herpes labialis, II: Topical agents.

Journal: Cutis 20040701

Title: Antiviral drugs in current clinical use.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20040601

Title: Characterisation of penciclovir resistant acyclovir sensitive herpes simplex virus type 2 isolated from an AIDS patient.

Journal: Journal of medical virology 20040501

Title: Synthesis and biological evaluation of novel tert-azido or tert-amino substituted penciclovir analogs.

Journal: Organic & biomolecular chemistry 20040421

Title: Once, twice, or three times daily famciclovir compared with aciclovir for the oral treatment of herpes zoster in immunocompetent adults: a randomized, multicenter, double-blind clinical trial.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20040401

Title: In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1.

Journal: American journal of veterinary research 20040401

Title: Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase.

Journal: Biochemical and biophysical research communications 20040319

Title: Penciclovir solubility in Eudragit films: a comparison of X-ray, thermal, microscopic and release rate techniques.

Journal: Journal of pharmaceutical and biomedical analysis 20040310

Title: In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir?

Journal: Antiviral research 20040301

Title: Can clinical trials requiring frequent participant contact be conducted over the Internet? Results from an online randomized controlled trial evaluating a topical ointment for herpes labialis.

Journal: Journal of medical Internet research 20040101

Title: Penciclovir cream--improved topical treatment for herpes simplex infections.

Journal: Skin pharmacology and physiology 20040101

Title: Efficacy of antiviral agents in feline herpetic keratitis: results of an in vitro study.

Journal: Current eye research 20040101

Title: Comparison of [18F]FHBG and [14C]FIAU for imaging of HSV1-tk reporter gene expression: adenoviral infection vs stable transfection.

Journal: European journal of nuclear medicine and molecular imaging 20031101

Title: Recurrent herpes simplex labialis: selected therapeutic options.

Journal: Journal (Canadian Dental Association) 20030901

Title: Profiling penciclovir susceptibility and prevalence of resistance of herpes simplex virus isolates across eleven clinical trials.

Journal: Archives of virology 20030901

Title: Review of antiviral therapy for herpes labialis, genital herpes and herpes zoster.

Journal: Expert review of anti-infective therapy 20030801

Title: Generation of stable cell lines expressing Lamivudine-resistant hepatitis B virus for antiviral-compound screening.

Journal: Antimicrobial agents and chemotherapy 20030601

Title: Optimization of cellular nucleotide extraction and sample preparation for nucleotide pool analyses using capillary electrophoresis.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030505

Title: Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing.

Journal: Drugs of today (Barcelona, Spain : 1998) 20030501

Title: Susceptibility of herpes simplex virus isolates to nucleoside analogues and the proportion of nucleoside-resistant variants after repeated topical application of penciclovir to recurrent herpes labialis.

Journal: The Journal of infectious diseases 20030415

Title: Molecular imaging of protein-protein interactions: controlled expression of p53 and large T-antigen fusion proteins in vivo.

Journal: Cancer research 20030415

Title: MicroPET imaging of prostate cancer in LNCAP-SR39TK-GFP mouse xenografts.

Journal: The Prostate 20030401

Title: The role of stratum corneum and dermal microvascular perfusion in penetration and tissue levels of water-soluble drugs investigated by microdialysis.

Journal: The British journal of dermatology 20030301

Title: Novel agents and strategies to treat herpes simplex virus infections.

Journal: Expert opinion on investigational drugs 20030201

Title: Herpes simplex virus resistance to antiviral drugs.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20030101

Title: In vitro activity of potential anti-poxvirus agents.

Journal: Antiviral research 20030101

Title: Current and potential therapies for the treatment of herpes-virus infections.

Journal: Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 20030101

Title: Inhibition of sickling in vitro by three purine-based antiviral agents: an approach to the treatment of sickle cell disease.

Journal: Blood cells, molecules & diseases 20030101

Title: Valacyclovir in the treatment of herpes simplex, herpes zoster, and other viral infections.

Journal: Journal of cutaneous medicine and surgery 20030101

Title: Changing paradigms in dermatology: antivirals in dermatology.

Journal: Clinics in dermatology 20030101

Title: Contemporary antiviral drug regimens for the prevention and treatment of orolabial and anogenital herpes simplex virus infection in the normal host: Four approved indications and 13 off-label uses.

Journal: The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses 20030101

Title: Antiviral agents: Non-antiretroviral [correction of Nonantiviral] drugs.

Journal: Journal of the American Academy of Dermatology 20021001

Title: CL1-SR39: A noninvasive molecular imaging model of prostate cancer suicide gene therapy using positron emission tomography.

Journal: The Journal of urology 20020901

Title: Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues aciclovir, ganciclovir and penciclovir.

Journal: Mutation research 20020829

Title: Studies on the thermal decomposition process and kinetics of purine drugs.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020801

Title: Topical application of penciclovir cream for the treatment of herpes simplex facialis/labialis: a randomized, double-blind, multicentre, aciclovir-controlled trial.

Journal: The Journal of dermatological treatment 20020601

Title: The A167Y mutation converts the herpes simplex virus type 1 thymidine kinase into a guanosine analogue kinase.

Journal: Biochemistry 20020521

Title: Temporal pattern of herpes simplex virus type 1 infection and cell death in the mouse brain stem: influence of guanosine nucleoside analogues.

Journal: Journal of virological methods 20020401

Title: [Genital herpes: epidemiology, transmission, clinic, asymptomatic viral excretion, impact on other sexually transmitted diseases, prevention, and treatment].

Journal: Annales de dermatologie et de venereologie 20020401

Title: [Local treatments using antiviral and non-antiviral drugs for herpes facialis and genitalis (excluding pregnant females and neonates at risk)].

Journal: Annales de dermatologie et de venereologie 20020401

Title: Effective treatment of herpes simplex labialis with penciclovir cream: combined results of two trials.

Journal: Journal of the American Dental Association (1939) 20020301

Title: Drugs for non-HIV viral infections.

Journal: The Medical letter on drugs and therapeutics 20020204

Title: New treatments for genital herpes.

Journal: Current opinion in infectious diseases 20020201

Title: Comparison of methods for identifying resistant herpes simplex virus and measuring antiviral susceptibility.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20020101

Title: Viral diseases of the skin: diagnosis and antiviral treatment.

Journal: Paediatric drugs 20020101

Title: Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations.

Journal: BMC infectious diseases 20020101

Title: Herpes simplex virus infection.

Journal: Seminars in pediatric infectious diseases 20020101

Title: [4'-Thio-5-ethyl-2'-deoxyuridine 5'-phosphonates: synthesis and antiviral activity].

Journal: Bioorganicheskaia khimiia 20020101

Title: Separation methods for acyclovir and related antiviral compounds.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20011125

Title: Novel 5-vinyl pyrimidine nucleosides with potent anti-hepatitis B virus activity.

Journal: Bioorganic & medicinal chemistry letters 20011119

Title: Preclinical evaluation of the penciclovir analog 9-(4-[(18)F]fluoro-3-hydroxymethylbutyl)guanine for in vivo measurement of suicide gene expression with PET.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20011101

Title: Pediatric uses of valacyclovir, penciclovir and famciclovir.

Journal: The Pediatric infectious disease journal 20011101

Title: Famiciclovir therapy (famvir) for herpes simplex and herpes zoster infections.

Journal: Skin therapy letter 20011101

Title: Lack of effect of treatment with penciclovir or acyclovir on the establishment of latent HSV-1 in primary sensory neurons in culture.

Journal: Antiviral research 20011001

Title: A simplified one-pot synthesis of 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine([18F]FHPG) and 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) for gene therapy.

Journal: Nuclear medicine and biology 20011001

Title: Comparison of new topical treatments for herpes labialis: efficacy of penciclovir cream, acyclovir cream, and n-docosanol cream against experimental cutaneous herpes simplex virus type 1 infection.

Journal: Archives of dermatology 20010901

Title: A review of antiviral therapy for herpes labialis.

Journal: Archives of dermatology 20010901

Title: Antiviral drugs: current state of the art.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20010801

Title: Pharmacokinetic studies of 2-amino-9-(3-acetoxymethyl-4-isopropoxycarbonyl-oxybut-1-yl)purine, an oral prodrug for the antiviral agent penciclovir.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010701

Title: Cross-resistance testing of antihepadnaviral compounds using novel recombinant baculoviruses which encode drug-resistant strains of hepatitis B virus.

Journal: Antimicrobial agents and chemotherapy 20010601

Title: Contact dermatitis from topical antiviral drugs.

Journal: Contact dermatitis 20010501

Title: Herpes simplex virus: clinical presentation and treatment.

Journal: Dentistry today 20010501

Title: Ganciclovir and penciclovir, but not acyclovir, induce apoptosis in herpes simplex virus thymidine kinase-transformed baby hamster kidney cells.

Journal: Antiviral chemistry & chemotherapy 20010501

Title: Recent developments in herpesvirus therapy.

Journal: Herpes : the journal of the IHMF 20010301

Title: Genetic risks of antiviral nucleoside analogues--a survey.

Journal: Antiviral research 20010201

Title: Reporter genes and imagene.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20010101

Title: 8-[18F]Fluoropenciclovir: an improved reporter probe for imaging HSV1-tk reporter gene expression in vivo using PET.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20010101

Title: Recent advances in imaging endogenous or transferred gene expression utilizing radionuclide technologies in living subjects: applications to breast cancer.

Journal: Breast cancer research : BCR 20010101

Title: Topical treatment of recurrent herpes labialis.

Journal: Oral diseases 20010101

Title: Recurrent herpes labialis: efficacy of topical therapy with penciclovir compared with acyclovir (aciclovir).

Journal: Oral diseases 20010101

Title: Current and potential therapies for the treatment of herpesvirus infections.

Journal: Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 20010101

Title: In vitro and in vivo activity of 1-O-hexadecylpropanediol-3-phospho-ganciclovir and 1-O-hexadecylpropanediol-3-phospho-penciclovir in cytomegalovirus and herpes simplex virus infections.

Journal: Antiviral chemistry & chemotherapy 20010101

Title: Current and potential therapies for the treatment of herpesvirus infections.

Journal: Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 20010101

Title: Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents.

Journal: Nucleosides, nucleotides & nucleic acids 20010101

Title: Penciclovir for the treatment of herpes simplex labialis: a review.

Journal: ASDC journal of dentistry for children 20010101

Title: Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8.

Journal: Reviews in medical virology 20010101

Title: Absence of rapid selection for acyclovir or penciclovir resistance following suboptimal oral prodrug therapy of HSV-infected mice.

Journal: BMC infectious diseases 20010101

Title: Synthesis, Characterization and Antiviral Properties of Pd(II) Complexes With Penciclovir.

Journal: Metal-based drugs 20010101

Title: Ribavirin and mycophenolic acid potentiate the activity of guanine- and diaminopurine-based nucleoside analogues against hepatitis B virus.

Journal: Antiviral research 20001101

Title: Lamivudine, adefovir and tenofovir exhibit long-lasting anti-hepatitis B virus activity in cell culture.

Journal: Journal of viral hepatitis 20000101

Title: Guanosine analogues as anti-herpesvirus agents.

Journal: Nucleosides, nucleotides & nucleic acids 20000101

Title: Hydroxyurea potentiates the antiherpesvirus activities of purine and pyrimidine nucleoside and nucleoside phosphonate analogs.

Journal: Antimicrobial agents and chemotherapy 19991201

Title: Phenotypic and genetic characterization of thymidine kinase from clinical strains of varicella-zoster virus resistant to acyclovir.

Journal: Antimicrobial agents and chemotherapy 19991001

Title: Selective activity of various antiviral compounds against HHV-7 infection.

Journal: Antiviral research 19990801

Title: Perspectives for the treatment of hepatitis B virus infections.

Journal: International journal of antimicrobial agents 19990701

Title: Sensitivity of L-(-)2,3-dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues.

Journal: Biochemical pharmacology 19990615

Title: Evaluation of anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]- guanine (A-5021) in mice.

Journal: Antiviral research 19990601

Title: Comparison of antiviral compounds against human herpesvirus 6 and 7.

Journal: Antiviral research 19981201

Title: Chemistry and anti-herpes simplex virus type 1 evaluation of cycloSal-nucleotides of acyclic nucleoside analogues.

Journal: Antiviral chemistry & chemotherapy 19980901

Title: Robustaflavone, a potential non-nucleoside anti-hepatitis B agent.

Journal: Antiviral research 19980801

Title: Antiherpesvirus activities of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine (A-5021) in cell culture.

Journal: Antimicrobial agents and chemotherapy 19980701

Title: The novel immunosuppressive agent mycophenolate mofetil markedly potentiates the antiherpesvirus activities of acyclovir, ganciclovir, and penciclovir in vitro and in vivo.

Journal: Antimicrobial agents and chemotherapy 19980201

Title: Antiviral drug susceptibility of human herpesvirus 8.

Journal: Antimicrobial agents and chemotherapy 19971201

Title: Phosphorylation of aciclovir, ganciclovir, penciclovir and S2242 by the cytomegalovirus UL97 protein: a quantitative analysis using recombinant vaccinia viruses.

Journal: Antiviral research 19970901

Title: Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus.

Journal: Antimicrobial agents and chemotherapy 19970701

Title: Antiviral efficacies of famciclovir, valaciclovir, and brivudin in disseminated herpes simplex virus type 1 infection in mice.

Journal: Intervirology 19970101

Title: Penciclovir is a selective inhibitor of hepatitis B virus replication in cultured human hepatoblastoma cells.

Journal: Antimicrobial agents and chemotherapy 19960501

Title: Activity of penciclovir in antiviral assays against herpes simplex virus.

Journal: The Journal of antimicrobial chemotherapy 19960201

Title: Comparison of a DNA probe assay with the plaque reduction assay for measuring the sensitivity of herpes simplex virus and varicella-zoster virus to penciclovir and acyclovir.

Journal: Journal of virological methods 19960101

Title: In vitro evaluation of combination therapies against hepatitis B virus replication.

Journal: Antiviral research 19960101

Title: Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6.

Journal: Antiviral research 19951201

Title: Famciclovir. A review of its pharmacological properties and therapeutic efficacy in herpesvirus infections.

Journal: Drugs 19950801

Title: Activity of penciclovir against Epstein-Barr virus.

Journal: Antimicrobial agents and chemotherapy 19950701

Title: Susceptibilities of several drug-resistant herpes simplex virus type 1 strains to alternative antiviral compounds.

Journal: Antimicrobial agents and chemotherapy 19950701

Title: Comparative activity of selected antiviral compounds against clinical isolates of varicella-zoster virus.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 19950401

Title: In vitro antiviral activity of penciclovir, a novel purine nucleoside, against duck hepatitis B virus.

Journal: Antimicrobial agents and chemotherapy 19940401

Title: In vitro activities of penciclovir and acyclovir against herpes simplex virus types 1 and 2.

Journal: Antimicrobial agents and chemotherapy 19920901

Title: Selection of an oral prodrug (BRL 42810; famciclovir) for the antiherpesvirus agent BRL 39123 [9-(4-hydroxy-3-hydroxymethylbut-l-yl)guanine; penciclovir].

Journal: Antimicrobial agents and chemotherapy 19891001

Title: Mode of action of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (BRL 39123) against herpes simplex virus in MRC-5 cells.

Journal: Antimicrobial agents and chemotherapy 19890201

Title: Synthesis and antiherpetic activity of (+/-)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds.

Journal: Journal of medicinal chemistry 19881201

Title: Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxymethylbut-1-yl) guanine (BRL 39123) in animals.

Journal: Antimicrobial agents and chemotherapy 19880301

Title: Synthesis and antiviral activity of 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]purines.

Journal: Journal of medicinal chemistry 19870901

Title: Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxy-methylbut-1-yl)guanine (BRL 39123) in cell culture.

Journal: Antimicrobial agents and chemotherapy 19870801

Title: Influence of twenty potentially antiviral substances on in vitro multiplication of hepatitis A virus.

Journal: Antiviral research 19860301

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Tags:39809-25-1 Molecular Formula|39809-25-1 MDL|39809-25-1 SMILES|39809-25-1 Penciclovir