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398473-34-2,MFCD05974930
Catalog No.:AA00C9EL

398473-34-2 | JNJ 5207852 dihydrochloride

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Purity
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1mg
99+%
in stock  
$17.00   $12.00
- +
5mg
99+%
in stock  
$42.00   $29.00
- +
10mg
99+%
in stock  
$62.00   $43.00
- +
25mg
99+%
in stock  
$104.00   $73.00
- +
50mg
99+%
in stock  
$175.00   $123.00
- +
100mg
95%
in stock  
$331.00   $232.00
- +
250mg
95%
in stock  
$506.00   $354.00
- +
1g
95%
in stock  
$1,231.00   $862.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C9EL
Chemical Name:
JNJ 5207852 dihydrochloride
CAS Number:
398473-34-2
Molecular Formula:
C20H32N2O
Molecular Weight:
316.4809
MDL Number:
MFCD05974930
SMILES:
C1CCN(CC1)CCCOc1ccc(cc1)CN1CCCCC1
Properties
Computed Properties
 
Complexity:
303  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
3.8  

Literature

Title: Radiofluorinated histamine H₃ receptor antagonist as a potential probe for in vivo PET imaging: radiosynthesis and pharmacological evaluation.

Journal: Bioorganic & medicinal chemistry 20120501

Title: Novel and highly potent histamine H3 receptor ligands. Part 2: exploring the cyclohexylamine-based series.

Journal: Bioorganic & medicinal chemistry letters 20110915

Title: Histamine H3 receptor as a drug discovery target.

Journal: Journal of medicinal chemistry 20110113

Title: Indole- and benzothiophene-based histamine H3 antagonists.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20100501

Title: Acidic elements in histamine H(3) receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20100301

Title: Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists.

Journal: European journal of medicinal chemistry 20091101

Title: 5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.

Journal: Journal of medicinal chemistry 20090709

Title: Fluorinated non-imidazole histamine H3 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20090415

Title: 2-Aryloxymethylmorpholine histamine H(3) antagonists.

Journal: Bioorganic & medicinal chemistry letters 20081101

Title: Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H3 receptor antagonists. Part I.

Journal: Bioorganic & medicinal chemistry letters 20080401

Title: Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling.

Journal: Bioorganic & medicinal chemistry 20080315

Title: Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20070901

Title: A new class of histamine H3 receptor antagonists derived from ligand based design.

Journal: Bioorganic & medicinal chemistry letters 20070701

Title: Histamine H3 receptor antagonists: from target identification to drug leads.

Journal: Biochemical pharmacology 20070415

Title: 4-[6-(2-Aminoethyl)naphthalen-2-yl]benzonitriles are potent histamine H3 receptor antagonists with high CNS penetration.

Journal: Bioorganic & medicinal chemistry letters 20070301

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice.

Journal: Neuropharmacology 20060301

Title: Aplysamine-1 and related analogs as histamine H3 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20060215

Title: 4-phenoxypiperidines: potent, conformationally restricted, non-imidazole histamine H3 antagonists.

Journal: Journal of medicinal chemistry 20050324

Title: 2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists.

Journal: Journal of medicinal chemistry 20050113

Title: Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist.

Journal: British journal of pharmacology 20041101

Title: A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines.

Journal: Journal of medicinal chemistry 20030828

Title: Barbier AJ, et al. Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004 Nov;143(5):649-61.

Title: Abuhamdah RM, et al. Effects of methimepip and JNJ-5207852 in Wistar rats exposed to an open-field with and without object and in Balb/c mice exposed to a radial-arm maze. Front Syst Neurosci. 2012 Jul 16;6:54.

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Tags:398473-34-2 Molecular Formula|398473-34-2 MDL|398473-34-2 SMILES|398473-34-2 JNJ 5207852 dihydrochloride