Catalog No.:AA003MOV

399-76-8 | 5-Fluoroindole-2-carboxylic acid

Name: Name:5-Fluoroindole-2-carboxylic acid
Brand: AABLOCKS
SKU: AA003MOV
Availability: InStock
Rating: 90 (10 reviews)

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97%

in stock

$21.00 $15.00

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97%

in stock

$27.00 $19.00

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25g

97%

in stock

$133.00 $93.00

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Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature
Request for Quotation
Download SDS

Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA003MOV

Chemical Name:

5-Fluoroindole-2-carboxylic acid

CAS Number:

399-76-8

Molecular Formula:

C9H6FNO2

Molecular Weight:

179.1478

MDL Number:

MFCD00005612

SMILES:

Fc1ccc2c(c1)cc([nH]2)C(=O)O

Properties

BP:

422.2°C at 760 mmHg

Form:

Solid

MP:

259 °C (dec.);(lit.);

Storage:

Inert atmosphere;2-8℃;

Computed Properties

Complexity:

222

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

2.4

Upstream Synthesis Route

348-36-7

399-76-8

[1]Patent:CN104402795,2017,B,.Locationinpatent:Paragraph0040;0043

[2]AdvancedSynthesisandCatalysis,2016,vol.358,#24,p.3938-3942

[3]EuropeanJournalofMedicinalChemistry,2011,vol.46,#7,p.3149-3157

[4]Hoppe-Seyler'sZeitschriftfuerPhysiologischeChemie,1954,vol.297,p.229,233

[5]JournaloftheChemicalSociety,1955,p.1283,1284

782-10-5

399-76-8

[1]JournaloftheChemicalSociety,1959,p.1913

[2]JournaloftheAmericanChemicalSociety,1959,vol.81,p.94,95,97

351-64-4

399-76-8

[1]JournaloftheChemicalSociety,1955,p.1283,1284

[2]Hoppe-Seyler'sZeitschriftfuerPhysiologischeChemie,1954,vol.297,p.229,233

[3]Patent:CN104402795,2017,B,

823-85-8

399-76-8

[1]EuropeanJournalofMedicinalChemistry,2011,vol.46,#7,p.3149-3157

371-40-4

399-76-8

[1]EuropeanJournalofMedicinalChemistry,2011,vol.46,#7,p.3149-3157

Downstream Synthesis Route

399-76-8

399-52-0

[1]JournalofOrganicChemistry,1993,vol.58,p.5558-5559

[2]OrganicLetters,2011,vol.13,p.280-283

[3]EuropeanJournalofMedicinalChemistry,2011,vol.46,p.3149-3157

[4]JournaloftheChemicalSociety,1955,p.1283,1284

399-76-8

71086-99-2

500536-56-1

[1]JournalofMedicinalChemistry,2003,vol.46,p.634-637

34803-66-2

399-76-8

220941-96-8

[1]JournalofMedicinalChemistry,2004,vol.47,p.3853-3864

[2]Patent:US2006/172995,2006,A1.Locationinpatent:Page/Pagecolumn53-54

[3]Patent:US2004/2488,2004,A1

[4]Patent:WO2003/101994,2003,A1.Locationinpatent:Page85-86

399-76-8

79112-09-7

[1]BioorganicandMedicinalChemistryLetters,2013,vol.23,p.147-152

[2]BioorganicandMedicinalChemistryLetters,2004,vol.14,p.3345-3349

[3]BioorganicandMedicinalChemistryLetters,2005,vol.15,p.5439-5441

[4]Patent:US2003/166615,2003,A1

[5]Patent:US5489593,1996,A

[6]Patent:US2008/4241,2008,A1.Locationinpatent:Page/Pagecolumn77

[7]BioorganicandMedicinalChemistry,2011,vol.19,p.1550-1561

[8]Phosphorus,SulfurandSiliconandtheRelatedElements,2011,vol.186,p.1790-1800

[9]JournalofEnzymeInhibitionandMedicinalChemistry,2014,vol.29,p.846-867

[10]Patent:CN106674221,2017,A.Locationinpatent:Paragraph0055;0056;0057

[11]BioorganicandMedicinalChemistryLetters,2018,vol.28,p.1127-1131

[12]JournaloftheAmericanChemicalSociety,2019,vol.141,p.981-989

[13]JournalofOrganicChemistry,2019,vol.84,p.5886-5892

[14]AnalyticalChemistry,2020,vol.92,p.2953-2960

Literature

Title: Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening.

Journal: Bioorganic & medicinal chemistry letters 20120615

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening.

Journal: Journal of medicinal chemistry 20040506

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

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