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400827-46-5,MFCD19443689
Catalog No.:AA00CL2U

400827-46-5 | Ceftaroline fosamil acetate

Pack Size
Purity
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Price(USD)
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1mg
≥98%
in stock  
$89.00   $62.00
- +
5mg
≥98%
in stock  
$386.00   $270.00
- +
10mg
98%
in stock  
$516.00   $362.00
- +
50mg
98%
in stock  
$1,559.00   $1,092.00
- +
250mg
98%
in stock  
$6,816.00   $4,772.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00CL2U
Chemical Name:
Ceftaroline fosamil acetate
CAS Number:
400827-46-5
Molecular Formula:
C24H25N8O10PS4
Molecular Weight:
744.7367
MDL Number:
MFCD19443689
SMILES:
[O-]C(=O)C.CCO/N=C(/c1nsc(n1)NP(=O)(O)O)\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)Sc1scc(n1)c1cc[n+](cc1)C
Properties
Computed Properties
 
Complexity:
1240  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
47  
Hydrogen Bond Acceptor Count:
19  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
11  

Literature

Title: Pharmacodynamics of ceftaroline against Staphylococcus aureus studied in an in vitro pharmacokinetic model of infection.

Journal: Antimicrobial agents and chemotherapy 20130601

Title: Summary of ceftaroline fosamil clinical trial studies and clinical safety.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120901

Title: Early response of ceftaroline fosamic in the treatment of soft-tissue infections.

Journal: Expert review of clinical pharmacology 20120901

Title: Ceftaroline fosamil in the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections.

Journal: Drugs 20120730

Title: Ceftaroline fosamil: a cephalosporin with activity against methicillin-resistant Staphylococcus aureus.

Journal: Clinical therapeutics 20120401

Title: New drugs 2012 part I.

Journal: Nursing 20120301

Title: Panton-Valentine leukocidin is not the primary determinant of outcome for Staphylococcus aureus skin infections: evaluation from the CANVAS studies.

Journal: PloS one 20120101

Title: Compatibility of ceftaroline fosamil for injection with selected drugs during simulated Y-site administration.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20111115

Title: Ceftaroline (Teflaro): a new cephalosporin.

Journal: The Nurse practitioner 20111101

Title: Ceftaroline fosamil: a novel broad-spectrum cephalosporin with activity against methicillin-resistant Staphylococcus aureus.

Journal: The Annals of pharmacotherapy 20111101

Title: Ceftaroline fosamil for treatment of community-acquired pneumonia: findings from FOCUS 1 and 2 and potential role in therapy.

Journal: Expert review of anti-infective therapy 20110801

Title: Comparison of ceftaroline fosamil, daptomycin and tigecycline in an experimental rabbit endocarditis model caused by methicillin-susceptible, methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus.

Journal: The Journal of antimicrobial chemotherapy 20110401

Title: Ceftaroline fosamil: a new broad-spectrum cephalosporin.

Journal: The Journal of antimicrobial chemotherapy 20110401

Title: FOCUS 1: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia.

Journal: The Journal of antimicrobial chemotherapy 20110401

Title: FOCUS 2: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia.

Journal: The Journal of antimicrobial chemotherapy 20110401

Title: Review of ceftaroline fosamil microbiology: integrated FOCUS studies.

Journal: The Journal of antimicrobial chemotherapy 20110401

Title: Integrated safety summary of FOCUS 1 and FOCUS 2 trials: Phase III randomized, double-blind studies evaluating ceftaroline fosamil for the treatment of patients with community-acquired pneumonia.

Journal: The Journal of antimicrobial chemotherapy 20110401

Title: What are the properties that make an antibiotic acceptable for therapy of community-acquired pneumonia?

Journal: The Journal of antimicrobial chemotherapy 20110401

Title: Changing needs of community-acquired bacterial pneumonia: experience with ceftaroline fosamil. Preface.

Journal: The Journal of antimicrobial chemotherapy 20110401

Title: Ceftaroline fosamil (Teflaro) - a new IV cephalosporin.

Journal: The Medical letter on drugs and therapeutics 20110124

Title: Ceftaroline fosamil: drug profile and clinical data.

Journal: Future microbiology 20110101

Title: New drugs: Ceftaroline fosamil, pegloticase, and eribulin mesylate.

Journal: Journal of the American Pharmacists Association : JAPhA 20110101

Title: [Ceftaroline fosamil, a broad spectrum cephalosporin antibiotic for the treatment of community-acquired pneumonia and complicated skin and skin structure infections].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20110101

Title: Integrated analysis of FOCUS 1 and FOCUS 2: randomized, doubled-blinded, multicenter phase 3 trials of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in patients with community-acquired pneumonia.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20101215

Title: The problem of complicated skin and skin structure infections: the need for new agents.

Journal: The Journal of antimicrobial chemotherapy 20101101

Title: Pharmacodynamics of ceftaroline fosamil for complicated skin and skin structure infection: rationale for improved anti-methicillin-resistant Staphylococcus aureus activity.

Journal: The Journal of antimicrobial chemotherapy 20101101

Title: CANVAS 1: the first Phase III, randomized, double-blind study evaluating ceftaroline fosamil for the treatment of patients with complicated skin and skin structure infections.

Journal: The Journal of antimicrobial chemotherapy 20101101

Title: CANVAS 2: the second Phase III, randomized, double-blind study evaluating ceftaroline fosamil for the treatment of patients with complicated skin and skin structure infections.

Journal: The Journal of antimicrobial chemotherapy 20101101

Title: Integrated safety summary of CANVAS 1 and 2 trials: Phase III, randomized, double-blind studies evaluating ceftaroline fosamil for the treatment of patients with complicated skin and skin structure infections.

Journal: The Journal of antimicrobial chemotherapy 20101101

Title: Ceftaroline fosamil: a novel broad-spectrum cephalosporin with expanded anti-Gram-positive activity.

Journal: The Journal of antimicrobial chemotherapy 20101101

Title: Evaluation of the in vivo efficacy of intramuscularly administered ceftaroline fosamil, a novel cephalosporin, against a methicillin-resistant Staphylococcus aureus strain in a rabbit endocarditis model.

Journal: The Journal of antimicrobial chemotherapy 20101001

Title: Ceftaroline fosamil: a novel broad-spectrum cephalosporin.

Journal: Drugs of today (Barcelona, Spain : 1998) 20101001

Title: Ceftaroline: a new cephalosporin with activity against resistant gram-positive pathogens.

Journal: Pharmacotherapy 20100401

Title: Stability and stabilization studies of TAK-599 (Ceftaroline Fosamil), a novel N-phosphono type prodrug of anti-methicillin resistant Staphylococcus aureus cephalosporin T-91825.

Journal: Chemical & pharmaceutical bulletin 20081001

Title: Ceftaroline fosamil, a cephalosporin derivative for the potential treatment of MRSA infection.

Journal: Current opinion in investigational drugs (London, England : 2000) 20080201

Title: Ishikawa T, et, al. TAK-599, a novel N-phosphono type prodrug of anti-MRSA cephalosporin T-91825: synthesis, physicochemical and pharmacological properties. Bioorg Med Chem. 2003 May 29;11(11):2427-37.

Title: Jacqueline C, et, al. In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model. Antimicrob Agents Chemother. 2007 Sep;51(9):3397-400.

Title: Parish D, et, al. Ceftaroline fosamil, a cephalosporin derivative for the potential treatment of MRSA infection. Curr Opin Investig Drugs. 2008 Feb;9(2):201-9.

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