115-77-5
[1]CurrentPatentAssignee:AERIEPHARMACEUTICALSINC-US2007/254920,2007,A1Locationinpatent:Page/Pagecolumn33
[1]CurrentPatentAssignee:DUKEUNIVERSITY-US2006/135609,2006,A1Locationinpatent:Page/Pagecolumn6-7
[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-US3989838,1976,A
[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-US4166061,1979,A
Title: Cell-based assay using glutathione-depleted HepaRG and HepG2 human liver cells for predicting drug-induced liver injury.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20180401
Title: Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.
Journal: Archives of toxicology 20180101
Title: Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.
Journal: Chemical research in toxicology 20170515
Title: High content analysis assay for prediction of human hepatotoxicity in HepaRG and HepG2 cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20160601
Title: Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions.
Journal: Journal of applied toxicology : JAT 20130201
Title: Identification of CYP isozymes involved in benzbromarone metabolism in human liver microsomes.
Journal: Biopharmaceutics & drug disposition 20121101
Title: Identification of protein targets of reactive metabolites of tienilic acid in human hepatocytes.
Journal: Chemical research in toxicology 20120521
Title: Differential oxidation of two thiophene-containing regioisomers to reactive metabolites by cytochrome P450 2C9.
Journal: Chemical research in toxicology 20120416
Title: Development of an in vitro system with human liver microsomes for phenotyping of CYP2C9 genetic polymorphisms with a mechanism-based inactivator.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120401
Title: Idiosyncratic reactions and metabolism of sulfur-containing drugs.
Journal: Expert opinion on drug metabolism & toxicology 20120401
Title: Antihypertensive drugs and risk of incident gout among patients with hypertension: population based case-control study.
Journal: BMJ (Clinical research ed.) 20120101
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110701
Title: CYP2C9-mediated metabolic activation of losartan detected by a highly sensitive cell-based screening assay.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110501
Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201
Title: Novel metabolic bioactivation mechanism for a series of anti-inflammatory agents (2,5-diaminothiophene derivatives) mediated by cytochrome p450 enzymes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100901
Title: Characterization of glutathione conjugates of duloxetine by mass spectrometry and evaluation of in silico approaches to rationalize the site of conjugation for thiophene containing drugs.
Journal: Chemical research in toxicology 20100816
Title: Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase.
Journal: European journal of medicinal chemistry 20100201
Title: Chem2Bio2RDF: a semantic framework for linking and data mining chemogenomic and systems chemical biology data.
Journal: BMC bioinformatics 20100101
Title: Evaluation of the potential for drug-induced liver injury based on in vitro covalent binding to human liver proteins.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20091201
Title: New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I.
Journal: Current drug metabolism 20091201
Title: Aqua-(2,2'-bipyridine-κN,N')bis-(thio-phene-2-carboxyl-ato-κO)copper(II).
Journal: Acta crystallographica. Section E, Structure reports online 20090801
Title: Cocktail-substrate assay system for mechanism-based inhibition of CYP2C9, CYP2D6, and CYP3A using human liver microsomes at an early stage of drug development.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20090601
Title: Mechanism-based inactivation of cytochrome P450 2C9 by tienilic acid and (+/-)-suprofen: a comparison of kinetics and probe substrate selection.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090101
Title: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development.
Journal: Current medicinal chemistry 20090101
Title: Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles.
Journal: PloS one 20090101
Title: Involvement of cytochrome P450-mediated metabolism in tienilic acid hepatotoxicity in rats.
Journal: Toxicology letters 20081215
Title: The crucial protective role of glutathione against tienilic acid hepatotoxicity in rats.
Journal: Toxicology and applied pharmacology 20081015
Title: Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose.
Journal: Chemical research in toxicology 20080901
Title: Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080501
Title: A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20080401
Title: A novel approach to cyclin-dependent kinase 5/p25 inhibitors: A potential treatment for Alzheimer's disease.
Journal: Bioorganic & medicinal chemistry 20071001
Title: Changes in gene expression induced by tienilic Acid and sulfamethoxazole: testing the danger hypothesis.
Journal: Journal of immunotoxicology 20071001
Title: Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.
Journal: Critical reviews in toxicology 20070601
Title: Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans.
Journal: Chemical research in toxicology 20070301
Title: Ethanol oxidation into acetaldehyde by 16 recombinant human cytochrome P450 isoforms: role of CYP2C isoforms in human liver microsomes.
Journal: Toxicology letters 20061215
Title: Evaluation of time-dependent cytochrome P450 inhibition using cultured human hepatocytes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060801
Title: Tienilic acid enhances hyperbilirubinemia in Eisai hyperbilirubinuria rats through hepatic multidrug resistance-associated protein 3 and heme oxygenase-1 induction.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060601
Title: Kinetics of tienilic acid bioactivation and functional generation of drug-protein adducts in intact rat hepatocytes.
Journal: Biochemical pharmacology 20051205
Title: Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flow.
Journal: Biological & pharmaceutical bulletin 20051201
Title: Automated assessment of time-dependent inhibition of human cytochrome P450 enzymes using liquid chromatography-tandem mass spectrometry analysis.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20051101
Title: Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Journal: Current drug metabolism 20051001
Title: Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050801
Title: Screening procedure for detection of diuretics and uricosurics and/or their metabolites in human urine using gas chromatography-mass spectrometry after extractive methylation.
Journal: Therapeutic drug monitoring 20050801
Title: Cytochrome P450 and liver diseases.
Journal: Current drug metabolism 20040601
Title: Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes.
Journal: Archives of biochemistry and biophysics 20030101
Title: Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid.
Journal: Archives of biochemistry and biophysics 20030101
Title: Immune-mediated drug-induced liver disease.
Journal: Clinics in liver disease 20020801
Title: Ticlopidine as a selective mechanism-based inhibitor of human cytochrome P450 2C19.
Journal: Biochemistry 20011009
Title: Use of isotopes and LC-MS-ESI-TOF for mechanistic studies of tienilic acid metabolic activation.
Journal: Advances in experimental medicine and biology 20010101
Title: Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis.
Journal: Chemical research in toxicology 19960101
Title: Drug-induced hepatitis associated with anticytoplasmic organelle autoantibodies.
Journal: Hepatology (Baltimore, Md.) 19850101
Title: Vocal cord hematomas complicating anticoagulant therapy.
Journal: Annals of emergency medicine 19840701
Title: A new anti-liver-kidney microsome antibody (anti-LKM2) in tienilic acid-induced hepatitis.
Journal: Clinical and experimental immunology 19840301
Title: Acute effects of alkylating agents on canine renal function and ultrastructure: high-dose ethacrynic acid vs. dihydroethacrynic acid and ticrynafen.
Journal: The Journal of pharmacology and experimental therapeutics 19840301
Title: Hepatotoxicity associated with ticrynafen--a uricosuric diuretic.
Journal: The American journal of gastroenterology 19820601
Title: Effects of prostaglandins inhibition on changes in active and inactive renin induced by antihypertensive drugs.
Journal: Clinical and experimental hypertension. Part A, Theory and practice 19820101
Title: Adverse reactions associated with ticrynafen use.
Journal: JAMA 19800201
Title: Tienilic acid in the treatment of mild to moderate hypertension.
Journal: Clinical and experimental pharmacology & physiology 19800101
Title: Comparison of natriuretic, uricosuric, and antihypertensive properties of tienilic acid, bendrofluazide, and spironolactone.
Journal: British medical journal 19790127
