Title: Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20160301
Title: Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders.
Journal: Journal of medicinal chemistry 20151210
Title: FTY720 Phosphate Activates Sphingosine-1-Phosphate Receptor 2 and Selectively Couples to Gα12/13/Rho/ROCK to Induce Myofibroblast Contraction.
Journal: Molecular pharmacology 20150601
Title: ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.
Journal: PloS one 20140101
Title: Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels.
Journal: British journal of pharmacology 20130301
Title: The sphingosine-1-phosphate receptor agonist FTY720 and its phosphorylated form affect the function of CD4+CD25+ T cells in vitro.
Journal: International journal of molecular medicine 20120701
Title: LC-MS/MS determination of FTY720 and FTY720-phosphate in murine intracellular compartments and human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120301
Title: Fast simultaneous quantitative analysis of FTY720 and its metabolite FTY720-P in human blood by on-line solid phase extraction coupled with liquid chromatography-tandem mass spectrometry.
Journal: Journal of pharmaceutical and biomedical analysis 20120125
Title: Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution.
Journal: The Journal of biological chemistry 20110826
Title: Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice.
Journal: The Journal of clinical investigation 20110601
Title: Plasma gelsolin modulates cellular response to sphingosine 1-phosphate.
Journal: American journal of physiology. Cell physiology 20101201
Title: (S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity.
Journal: Cellular signalling 20101001
Title: Removal of sphingosine 1-phosphate receptor-3 (S1P(3)) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P(1) agonists with reduced effect on heart rate.
Journal: Journal of medicinal chemistry 20100422
Title: Phosphorylation of the immunomodulator FTY720 inhibits programmed cell death of fibroblasts via the S1P3 receptor subtype and Bcl-2 activation.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Title: Utilization of the Tango beta-arrestin recruitment technology for cell-based EDG receptor assay development and interrogation.
Journal: Journal of biomolecular screening 20091001
Title: Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P(3)).
Journal: British journal of pharmacology 20090401
Title: Accumulation of fingolimod (FTY720) in lymphoid tissues contributes to prolonged efficacy.
Journal: The Journal of pharmacology and experimental therapeutics 20090301
Title: Sphingosine 1-phosphate receptor agonism impairs skin dendritic cell migration and homing to secondary lymphoid tissue: association with prolonged allograft survival.
Journal: Transplant immunology 20081101
Title: Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.
Journal: Cancer letters 20080808
Title: Selective activation of G alpha i mediated signalling of S1P3 by FTY720-phosphate.
Journal: Cellular signalling 20080601
Title: A novel sphingosine 1-phosphate receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), regulates chronic colitis in interleukin-10 gene-deficient mice.
Journal: The Journal of pharmacology and experimental therapeutics 20080101
Title: Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells.
Journal: Glia 20071201
Title: Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats.
Journal: Regulatory peptides 20070201
Title: Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists.
Journal: Bioorganic & medicinal chemistry 20070115
Title: A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model.
Journal: Chemistry & biology 20061101
Title: Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer.
Journal: Journal of medicinal chemistry 20050811
Title: Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists.
Journal: Bioorganic & medicinal chemistry letters 20050801
Title: A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.
Journal: Journal of medicinal chemistry 20041230
Title: Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.
Journal: Bioorganic & medicinal chemistry letters 20040621
Title: Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.
Journal: The Journal of pharmacology and experimental therapeutics 20040501
Title: Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate.
Journal: The Journal of biological chemistry 20040402
Title: The immune modulator FTY720 targets sphingosine 1-phosphate receptors.
Journal: The Journal of biological chemistry 20020614
Title: Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.
Journal: Science (New York, N.Y.) 20020412
