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4033-27-6,MFCD00149226
Catalog No.:AA003PG8

4033-27-6 | DIHYDROFOLIC ACID

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5mg
≥90%
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$82.00   $57.00
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10mg
≥90%
in stock  
$136.00   $95.00
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25mg
≥90%
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$298.00   $208.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003PG8
Chemical Name:
DIHYDROFOLIC ACID
CAS Number:
4033-27-6
Molecular Formula:
C19H21N7O6
Molecular Weight:
443.4133
MDL Number:
MFCD00149226
SMILES:
OC(=O)CCC(C(=O)O)NC(=O)c1ccc(cc1)NCC1=Nc2c(NC1)nc([nH]c2=O)N
Properties
Properties
 
Form:
Solid  
MP:
>160℃ (dec.)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
889  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
7  
Rotatable Bond Count:
9  
XLogP3:
-0.9  

Literature

Title: Multiple point action mechanism of valproic acid-teratogenicity alleviated by folic acid, vitamin C, and N-acetylcysteine in chicken embryo model.

Journal: Toxicology 20120127

Title: Distribution of quinolones, sulfonamides, tetracyclines in aquatic environment and antibiotic resistance in indochina.

Journal: Frontiers in microbiology 20120101

Title: Systematic review of disease-modifying antirheumatic drugs for juvenile idiopathic arthritis.

Journal: BMC pediatrics 20120101

Title: Accounting for differences in the bioactivity and bioavailability of vitamers.

Journal: Food & nutrition research 20120101

Title: Exploiting ligand-protein conjugates to monitor ligand-receptor interactions.

Journal: PloS one 20120101

Title: A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis.

Journal: PloS one 20120101

Title: Evolutionarily conserved linkage between enzyme fold, flexibility, and catalysis.

Journal: PLoS biology 20111101

Title: Effect of genetic polymorphisms in the folate pathway on methotrexate therapy in rheumatic diseases.

Journal: Pharmacogenomics 20111001

Title: Comparative hydrogen-deuterium exchange for a mesophilic vs thermophilic dihydrofolate reductase at 25 °C: identification of a single active site region with enhanced flexibility in the mesophilic protein.

Journal: Biochemistry 20110927

Title: Multiple sclerosis: pathogenesis and treatment.

Journal: Current neuropharmacology 20110901

Title: Tea drinking as a risk factor for neural tube defects in northern China.

Journal: Epidemiology (Cambridge, Mass.) 20110701

Title: NMR structures of apo L. casei dihydrofolate reductase and its complexes with trimethoprim and NADPH: contributions to positive cooperative binding from ligand-induced refolding, conformational changes, and interligand hydrophobic interactions.

Journal: Biochemistry 20110510

Title: Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase.

Journal: PloS one 20110101

Title: Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate.

Journal: Arthritis research & therapy 20110101

Title: On the curvature in logarithmic plots of rate coefficients for chemical reactions.

Journal: Chemistry Central journal 20110101

Title: Critical appraisal of pralatrexate in the management of difficult-to-treat peripheral T cell lymphoma.

Journal: Therapeutics and clinical risk management 20110101

Title: Systematic drug repositioning based on clinical side-effects.

Journal: PloS one 20110101

Title: Oral lichen planus: An update on pathogenesis and treatment.

Journal: Journal of oral and maxillofacial pathology : JOMFP 20110101

Title: Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition.

Journal: Molecular and biochemical parasitology 20100701

Title: Complete genomic sequence of bacteriophage felix o1.

Journal: Viruses 20100301

Title: Cobalamin deficiency, hyperhomocysteinemia, and dementia.

Journal: Neuropsychiatric disease and treatment 20100101

Title: [Photobiochemistry of folates: a photochemical reduction of folic acid].

Journal: Prikladnaia biokhimiia i mikrobiologiia 20100101

Title: Dynamic subcellular localization of isoforms of the folate pathway enzyme serine hydroxymethyltransferase (SHMT) through the erythrocytic cycle of Plasmodium falciparum.

Journal: Malaria journal 20100101

Title: Management of Pneumocystis Jirovecii pneumonia in HIV infected patients: current options, challenges and future directions.

Journal: HIV/AIDS (Auckland, N.Z.) 20100101

Title: Antimicrobial evaluation of novel substituted pyrimidinopyrazoles and pyrimidinotriazoles.

Journal: Journal of advanced pharmaceutical technology & research 20100101

Title: Mechanistic insights into folic acid-dependent vascular protection: dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: a novel HPLC-based fluorescent assay for DHFR activity.

Journal: Journal of molecular and cellular cardiology 20091201

Title: Binding of natural and synthetic polyphenols to human dihydrofolate reductase.

Journal: International journal of molecular sciences 20091201

Title: A mapping of drug space from the viewpoint of small molecule metabolism.

Journal: PLoS computational biology 20090801

Title: Voltammetric determination of sulfamethoxazole at a multiwalled carbon nanotube modified glassy carbon sensor and its application studies.

Journal: Drug testing and analysis 20090701

Title: (E)-N'-(3,3-Diphenyl-allyl-idene)-p-toluene-sulfonohydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20090501

Title: (E)-N'-(4-Chloro-benzyl-idene)-p-toluene-sulfonohydrazide 0.15-hydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20090501

Title: (E)-N'-(4-Bromo-benzyl-idene)-p-toluene-sulfonohydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20090401

Title: QM/MM study of thymidylate synthase: enzymatic motions and the temperature dependence of the rate limiting step.

Journal: The journal of physical chemistry. A 20090312

Title: Regulation of translation in haloarchaea: 5'- and 3'-UTRs are essential and have to functionally interact in vivo.

Journal: PloS one 20090101

Title: (E)-N'-(5-Bromo-2-hydroxy-benzyl-idene)-p-toluene-sulfonohydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20081201

Title: (E)-N'-(5-Chloro-2-hydroxy-benzyl-idene)-p-toluene-sulfonohydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20081201

Title: (E)-N'-Benzyl-idene-p-toluene-sulfono-hydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20080901

Title: Metabolism of halophilic archaea.

Journal: Extremophiles : life under extreme conditions 20080301

Title: Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo.

Journal: PLoS neglected tropical diseases 20080301

Title: catena-Poly[bis-(sulfamethoxazolium) [[trichloridocadmate(II)]-μ-chlorido] monohydrate].

Journal: Acta crystallographica. Section E, Structure reports online 20080101

Title: Experimental characterization of Cis-acting elements important for translation and transcription in halophilic archaea.

Journal: PLoS genetics 20071201

Title: Ligand binding and circular permutation modify residue interaction network in DHFR.

Journal: PLoS computational biology 20070601

Title: A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users.

Journal: The American journal of clinical nutrition 20070401

Title: A quantum mechanics/molecular mechanics study of the catalytic mechanism of the thymidylate synthase.

Journal: Biochemistry 20070327

Title: Adenosine in inflammatory joint diseases.

Journal: Purinergic signalling 20070301

Title: Role of airway lactoperoxidase in scavenging of hydrogen peroxide damage in asthma.

Journal: Annals of thoracic medicine 20070101

Title: Protein motions during catalysis by dihydrofolate reductases.

Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20060829

Title: Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner.

Journal: Endocrine-related cancer 20060601

Title: Sulfonamides in the environment as veterinary drugs.

Journal: Reviews of environmental contamination and toxicology 20060101

Title: Methotrexate enhances the anti-inflammatory effect of CF101 via up-regulation of the A3 adenosine receptor expression.

Journal: Arthritis research & therapy 20060101

Title: Kinetics of the inhibition of bovine liver dihydrofolate reductase by tea catechins: origin of slow-binding inhibition and pH studies.

Journal: Biochemistry 20050524

Title: The antifolate activity of tea catechins.

Journal: Cancer research 20050315

Title: Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1.

Journal: The protein journal 20050201

Title: Folate requirements of the 2-keto-L-gulonic acid-producing strain Ketogulonigenium vulgare LMP P-20356 in L-sorbose/CSL medium.

Journal: Applied microbiology and biotechnology 20040801

Title: Microscale synthesis of isotopically labeled R-[6-xH]N5,N10-methylene-5,6,7,8-tetrahydrofolate as a cofactor for thymidylate synthase.

Journal: Analytical biochemistry 20040501

Title: Sodium-dependent methotrexate carrier-1 is expressed in rat kidney: cloning and functional characterization.

Journal: American journal of physiology. Renal physiology 20040301

Title: Inhibition of the rat breast cytosolic bioactivation of ethanol to acetaldehyde by some plant polyphenols and folic acid.

Journal: Nutrition and cancer 20040101

Title: Reaction-path energetics and kinetics of the hydride transfer reaction catalyzed by dihydrofolate reductase.

Journal: Biochemistry 20031125

Title: Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima.

Journal: The Biochemical journal 20030901

Title: Role of water in the catalytic cycle of E. coli dihydrofolate reductase.

Journal: Protein science : a publication of the Protein Society 20020601

Title: Molecular action of methotrexate in inflammatory diseases.

Journal: Arthritis research 20020101

Title: Preliminary application of liquid chromatography-electrospray-ionization mass spectrometry to the detection of 5-methyltetrahydrofolic acid monoglutamate in human plasma.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20011225

Title: Developing a dynamic pharmacophore model for HIV-1 integrase.

Journal: Journal of medicinal chemistry 20000601

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