[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2004/43939,2004,A1Locationinpatent:Page47
[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2004/43939,2004,A1Locationinpatent:Page41;46-47
[1]CurrentPatentAssignee:MASSGENERALBRIGHAMINC-WO2014/145749,2014,A1Locationinpatent:Page/Pagecolumn25
Title: B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals.
Journal: Toxicology 20170701
Title: Cadmium-induced malignant transformation of rat liver cells: Potential key role and regulatory mechanism of altered apolipoprotein E expression in enhanced invasiveness.
Journal: Toxicology 20170501
Title: Liver X receptor activation promotes differentiation of regulatory T cells.
Journal: PloS one 20170101
Title: Influence of liver-X-receptor on tissue cholesterol, coenzyme Q and dolichol content.
Journal: Molecular membrane biology 20121101
Title: Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors.
Journal: Molecular pharmacology 20121001
Title: Liver X receptors agonists impede hepatitis C virus infection in an Idol-dependent manner.
Journal: Antiviral research 20120901
Title: Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20120901
Title: Insertion-deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin.
Journal: Prostaglandins, leukotrienes, and essential fatty acids 20120701
Title: ABCA1 upregulating apolipoproein M expression mediates via the RXR/LXR pathway in HepG2 cells.
Journal: Biochemical and biophysical research communications 20120427
Title: Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells.
Journal: Brain pathology (Zurich, Switzerland) 20120301
Title: Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule.
Journal: American journal of physiology. Renal physiology 20120301
Title: Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism.
Journal: PloS one 20120101
Title: Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's β-amyloidosis mouse model.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111102
Title: Activation of liver X receptor (LXR) inhibits receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation in an LXRβ-dependent mechanism.
Journal: The Journal of biological chemistry 20110923
Title: Suppression of chronic damage in renal allografts by Liver X receptor (LXR) activation relevant contribution of macrophage LXRα.
Journal: The American journal of pathology 20110701
Title: LXR as a novel antithrombotic target.
Journal: Blood 20110526
Title: Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20110415
Title: Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels.
Journal: British journal of pharmacology 20110401
Title: Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity.
Journal: Journal of lipid research 20101201
Title: ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice.
Journal: The Journal of biological chemistry 20101029
Title: Activation of the liver X receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100908
Title: Recent progress in liver X receptor-selective modulators.
Journal: Current opinion in drug discovery & development 20100701
Title: The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.
Journal: The Journal of biological chemistry 20100625
Title: X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.
Journal: Journal of molecular biology 20100528
Title: Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model.
Journal: Journal of lipid research 20100401
Title: The activation of liver X receptors inhibits toll-like receptor-9-induced foam cell formation.
Journal: Journal of cellular physiology 20100401
Title: Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20100401
Title: Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling.
Journal: The Journal of biological chemistry 20100219
Title: Liver X receptor agonist GW3965 dose-dependently regulates lps-mediated liver injury and modulates posttranscriptional TNF-alpha production and p38 mitogen-activated protein kinase activation in liver macrophages.
Journal: Shock (Augusta, Ga.) 20091101
Title: LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms.
Journal: Atherosclerosis 20091101
Title: Activation of liver X receptor regulates substrate oxidation in white adipocytes.
Journal: Endocrinology 20090901
Title: The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro.
Journal: Diabetologia 20090701
Title: Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism.
Journal: Cell metabolism 20081201
Title: Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20081115
Title: Treatment with LXR agonists after focal cerebral ischemia prevents brain damage.
Journal: FEBS letters 20081015
Title: Intestine-specific regulation of PPARalpha gene transcription by liver X receptors.
Journal: Endocrinology 20081001
Title: Activation of liver X receptors promotes neuroprotection and reduces brain inflammation in experimental stroke.
Journal: Circulation 20080930
Title: Liver X receptor agonists increase airway reactivity in a model of asthma via increasing airway smooth muscle growth.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20080915
Title: Androgen deprivation by activating the liver X receptor.
Journal: Endocrinology 20080801
Title: PPARalpha gene expression is up-regulated by LXR and PXR activators in the small intestine.
Journal: Biochemical and biophysical research communications 20080711
Title: Ligand specificity and evolution of liver X receptors.
Journal: The Journal of steroid biochemistry and molecular biology 20080501
Title: Combination of virtual screening and high throughput gene profiling for identification of novel liver X receptor modulators.
Journal: Journal of medicinal chemistry 20080410
Title: Niemann-Pick C1-like 1 is required for an LXR agonist to raise plasma HDL cholesterol in mice.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20080301
Title: The effect of statins on ABCA1 and ABCG1 expression in human macrophages is influenced by cellular cholesterol levels and extent of differentiation.
Journal: Atherosclerosis 20080101
Title: Liver X receptors (LXR) as therapeutic targets in dyslipidemia.
Journal: Cardiovascular therapeutics 20080101
Title: Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride (GW3965).
Journal: Molecular pharmacology 20071001
Title: GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats.
Journal: British journal of pharmacology 20070601
Title: Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists.
Journal: Molecular human reproduction 20070601
Title: [Advances in the study of anti-atherosclerosis drugs].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070301
Title: Chlamydia pneumoniae--induced macrophage foam cell formation is mediated by Toll-like receptor 2.
Journal: Infection and immunity 20070201
Title: The nuclear receptor LXR is a glucose sensor.
Journal: Nature 20070111
Title: Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels.
Journal: Circulation research 20060929
Title: Assessing the effects of LXR agonists on cellular cholesterol handling: a stable isotope tracer study.
Journal: Journal of lipid research 20060601
Title: A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors.
Journal: The Journal of biological chemistry 20060224
Title: Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor.
Journal: Neuroreport 20060206
Title: Activation of the liver X receptor protects against hepatic injury in endotoxemia by suppressing Kupffer cell activation.
Journal: Shock (Augusta, Ga.) 20060201
Title: Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo.
Journal: Circulation 20060103
Title: Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice.
Journal: American journal of physiology. Endocrinology and metabolism 20051101
Title: Synthetic LXR agonists increase LDL in CETP species.
Journal: Journal of lipid research 20051001
Title: Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries.
Journal: Circulation research 20041210
Title: Raising HDL cholesterol without inducing hepatic steatosis and hypertriglyceridemia by a selective LXR modulator.
Journal: Journal of lipid research 20040801
Title: Miniaturization of cell-based beta-lactamase-dependent FRET assays to ultra-high throughput formats to identify agonists of human liver X receptors.
Journal: Assay and drug development technologies 20031201
Title: FXRE can function as an LXRE in the promoter of human ileal bile acid-binding protein (I-BABP) gene.
Journal: FEBS letters 20031023
Title: Mitro, Nico., et al. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochemistry International (2012), 60(6), 616-621.
Title: Guo, Deliang., et al. An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discovery (2011), 1(5), 442-456.
Title: Spyridon, Michael., et al. LXR as a novel antithrombotic target. Blood (2011), 117(21), 5751-5761.
Title: Collins JL, et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem. 2002 May 9;45(10):1963-6.
