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40616-75-9,MFCD00043241
Catalog No.:AA0076B3

40616-75-9 | DSP-4 hydrochloride

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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0076B3
Chemical Name:
DSP-4 hydrochloride
CAS Number:
40616-75-9
Molecular Formula:
C11H16BrCl2N
Molecular Weight:
313.0614
MDL Number:
MFCD00043241
SMILES:
ClCCN(Cc1ccccc1Br)CC.Cl
Properties
Computed Properties
 
Complexity:
154  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  

Downstream Synthesis Route
Literature

Title: The effects of the neurotoxin DSP4 on spatial learning and memory in Wistar rats.

Journal: Attention deficit and hyperactivity disorders 20120601

Title: Effects of noradrenaline and serotonin depletions on the neuronal activity of globus pallidus and substantia nigra pars reticulata in experimental parkinsonism.

Journal: Neuroscience 20120127

Title: Effect of DSP-4 induced central noradrenergic depletion on tactile learning in rat.

Journal: Neurological research 20120101

Title: Role of coerulean noradrenergic neurones in general anaesthesia in rats.

Journal: British journal of anaesthesia 20111201

Title: Effects of DSP4 and methylphenidate on spatial memory performance in rats.

Journal: Attention deficit and hyperactivity disorders 20111201

Title: Cytochrome P450 is regulated by noradrenergic and serotonergic systems.

Journal: Pharmacological research 20111001

Title: Changes in postnatal norepinephrine alter alpha-2 adrenergic receptor development.

Journal: Neuroscience 20110929

Title: Antinociceptive effects of neurotropin in a rat model of central neuropathic pain: DSP-4 induced noradrenergic lesion.

Journal: Neuroscience letters 20110926

Title: Effects of the noradrenergic neurotoxin DSP-4 on the expression of α1-adrenoceptor subtypes after antidepressant treatment.

Journal: Pharmacological reports : PR 20110101

Title: Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits.

Journal: Neurochemistry international 20101101

Title: Locus coeruleus stimulation and noradrenergic modulation of hippocampo-prefrontal cortex long-term potentiation.

Journal: The international journal of neuropsychopharmacology 20101001

Title: Central noradrenergic lesion induced by DSP-4 impairs the acquisition of avoidance reactions and prevents molecular changes in the amygdala.

Journal: Neurobiology of learning and memory 20101001

Title: A central neuropathic pain model by DSP-4 induced lesion of noradrenergic neurons: preliminary report.

Journal: Neuroscience letters 20100906

Title: Increasing CNS noradrenaline reduces EAE severity.

Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20100601

Title: Effects of single and simultaneous lesions of serotonergic and noradrenergic pathways on open-space and bright-space anxiety-like behavior in two animal models.

Journal: Behavioural brain research 20100501

Title: A comprehensive analysis of the effect of DSP4 on the locus coeruleus noradrenergic system in the rat.

Journal: Neuroscience 20100310

Title: Chemical destruction of brain noradrenergic neurons affects splenic cytokine production.

Journal: Journal of neuroimmunology 20100226

Title: Effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: implications for MDMA neurotoxicity.

Journal: Journal of neurochemistry 20100201

Title: Antidepressant-like effects of medial prefrontal cortex deep brain stimulation in rats.

Journal: Biological psychiatry 20100115

Title: Gender effect on the accumulation of hyperphosphorylated tau in the brain of locus-ceruleus-injured APP-transgenic mouse.

Journal: Neuroscience letters 20100114

Title: Neonatal DSP-4 treatment impairs 5-HT(1B) receptor reactivity in adult rats. Behavioral and biochemical studies.

Journal: Pharmacological reports : PR 20100101

Title: Central noradrenergic depletion by DSP-4 prevents stress-induced memory impairments in the object recognition task.

Journal: Neuroscience 20091201

Title: Interference of the noradrenergic neurotoxin DSP4 with neuronal and nonneuronal monoamine transporters.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20091201

Title: Effect of the additional noradrenergic neurodegeneration to 6-OHDA-lesioned rats in levodopa-induced dyskinesias and in cognitive disturbances.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20091001

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Monoaminergic changes in locus coeruleus and dorsal raphe nucleus following noradrenaline depletion.

Journal: Neurochemical research 20090801

Title: Noradrenergic modulation of the motor response induced by long-term levodopa administration in Parkinsonian rats.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20090701

Title: Enhancement of the function of rat serotonin and norepinephrine neurons by sustained vagus nerve stimulation.

Journal: Journal of psychiatry & neuroscience : JPN 20090701

Title: Developmental emergence of power-law wake behavior depends upon the functional integrity of the locus coeruleus.

Journal: Sleep 20090701

Title: Flow cytometric analysis of BrdU incorporation as a high-throughput method for measuring adult neurogenesis in the mouse.

Journal: Journal of pharmacological and toxicological methods 20090101

Title: Evolution of neurotoxins: from research modalities to clinical realities.

Journal: Current protocols in neuroscience 20090101

Title: Neonatal co-lesion by DSP-4 and 5,7-DHT produces adulthood behavioral sensitization to dopamine D(2) receptor agonists.

Journal: Pharmacological reports : PR 20090101

Title: Differential effects of neonatal norepinephrine lesions on immediate early gene expression in developing and adult rat brain.

Journal: Neuroscience 20081210

Title: Reactivity of 5-HT1A receptor in adult rats after neonatal noradrenergic neurons' lesion--implications for antidepressant-like action.

Journal: Brain research 20081106

Title: Noradrenergic deficits alter processing of communication signals in female songbirds.

Journal: Brain, behavior and evolution 20081101

Title: Noradrenergic neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4), treatment eliminates estrogenic effects on song responsiveness in female zebra finches (Taeniopygia guttata).

Journal: Behavioral neuroscience 20081001

Title: Differential blockade of CRF-evoked behaviors by depletion of norepinephrine and serotonin in rats.

Journal: Psychopharmacology 20080901

Title: Neurotoxic effects of DSP-4 on the central noradrenergic system in male zebra finches.

Journal: Behavioural brain research 20080409

Title: Absence and rescue of morphine withdrawal in GIRK/Kir3 knock-out mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080409

Title: Genetic or pharmacological blockade of noradrenaline synthesis enhances the neurochemical, behavioral, and neurotoxic effects of methamphetamine.

Journal: Journal of neurochemistry 20080401

Title: Ontogenetic noradrenergic lesion alters histaminergic activity in adult rats.

Journal: Neurotoxicity research 20080401

Title: Serotonergic and noradrenergic lesions suppress the enhancing effect of maternal exercise during pregnancy on learning and memory in rat pups.

Journal: Neuroscience 20080219

Title: Effects of the noradrenergic neurotoxin DSP4 on spatial memory in the rat.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20080101

Title: Neonatal DSP-4 treatment modifies GABAergic neurotransmission in the prefrontal cortex of adult rats.

Journal: Neurotoxicity research 20080101

Title: Neonatal N-(-2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) treatment modifies the vulnerability to phenobarbital- and ethanol-evoked sedative-hypnotic effects in adult rats.

Journal: Pharmacological reports : PR 20080101

Title: Modulation of the motor response to dopaminergic drugs in a parkinsonian model of combined dopaminergic and noradrenergic degeneration.

Journal: European journal of pharmacology 20071208

Title: Noradrenergic control of odor recognition in a nonassociative olfactory learning task in the mouse.

Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20071201

Title: Norepinephrine depletion facilitates recovery of function after focal ischemia in the rat.

Journal: The European journal of neuroscience 20071001

Title: Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease.

Journal: Neurobiology of aging 20070801

Title: Evidence that norepinephrine influences responses to male courtship song and activity within song control regions and the ventromedial nucleus of the hypothalamus in female European starlings.

Journal: Brain research 20070529

Title: MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity.

Journal: Neurobiology of disease 20070501

Title: Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070401

Title: Postnatal iron overload destroys NA-DA functional interactions.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20070201

Title: The role of noradrenergic tone in the dorsal raphe nucleus of the mouse in the acute behavioral effects of antidepressant drugs.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070201

Title: Monoaminergic system lesions increase post-sigh respiratory pattern disturbance during sleep in rats.

Journal: Physiology & behavior 20070130

Title: Desensitization of 5-HT(1A) autoreceptors induced by neonatal DSP-4 treatment.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070115

Title: Mechanisms underlying the long-term behavioral effects of traumatic experience in rats: the role of serotonin/noradrenaline balance and NMDA receptors.

Journal: Brain research bulletin 20070109

Title: Abnormal latent inhibition and impulsivity in coloboma mice, a model of ADHD.

Journal: Neurobiology of disease 20070101

Title: Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.

Journal: Journal of neuroinflammation 20070101

Title: Degeneration of noradrenergic fibres from the locus coeruleus causes tight-junction disorganisation in the rat brain.

Journal: The European journal of neuroscience 20061201

Title: Influence of noradrenaline denervation on MPTP-induced deficits in mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20060901

Title: Methamphetamine administration reduces hippocampal vesicular monoamine transporter-2 uptake.

Journal: The Journal of pharmacology and experimental therapeutics 20060801

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: DSP-4 prevents dopamine receptor priming by quinpirole.

Journal: Pharmacology, biochemistry, and behavior 20060501

Title: Age-dependent interactive changes in serotonergic and noradrenergic cortical axon terminals in F344 rats.

Journal: Neuroscience research 20060301

Title: Specificity and efficacy of noradrenaline, serotonin depletion in discrete brain areas of Swiss mice by neurotoxins.

Journal: Journal of neuroscience methods 20060115

Title: Enhanced nicotinic acetylcholine receptor-mediated [3H]norepinephrine release from neonatal rat hypothalamus.

Journal: Neuropharmacology 20060101

Title: Effect of noradrenergic system on the anxiolytic-like effect of DOI (5-HT2A/2C agonists) in the four-plate test.

Journal: Psychopharmacology 20060101

Title: Beta-amyloid-dependent expression of NOS2 in neurons: prevention by an alpha2-adrenergic antagonist.

Journal: Antioxidants & redox signaling 20060101

Title: Locus coeruleus and neuronal plasticity in a model of focal limbic epilepsy.

Journal: Epilepsia 20060101

Title: Short and long term analysis of heart rate variations in spontaneously hypertensive rats: effects of DSP-4 administration.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20051001

Title: Alpha-2 adrenoceptor activation inhibits phencyclidine-induced deficits of spatial working memory in rats.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050801

Title: Anxiolytic-like effect of milnacipran in the four-plate test in mice: mechanism of action.

Journal: Pharmacology, biochemistry, and behavior 20050701

Title: The effect of auditory distractors on song discrimination in male canaries (Serinus canaria).

Journal: Behavioural processes 20050630

Title: Locus ceruleus control of slow-wave homeostasis.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050504

Title: The role of adrenergic and cholinergic transmission in volatile anesthetic-induced pain enhancement.

Journal: Anesthesia and analgesia 20050401

Title: A role for norepinephrine in the regulation of context-dependent ZENK expression in male zebra finches (Taeniopygia guttata).

Journal: The European journal of neuroscience 20050401

Title: Identification of complement 5a-like receptor (C5L2) from astrocytes: characterization of anti-inflammatory properties.

Journal: Journal of neurochemistry 20050301

Title: The effect of central cholinergic and noradrenergic denervation on hippocampal sympathetic ingrowth and apoptosis-like reactivity in the rat.

Journal: Brain research 20050201

Title: Effects of low dose N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine administration on exploratory and amphetamine-induced behavior and dopamine D2 receptor function in rats with high or low exploratory activity.

Journal: Neuroscience 20050101

Title: Dopaminergic-adrenergic interactions in the wake promoting mechanism of modafinil.

Journal: Neuroscience 20050101

Title: In vitro inactivation of rat brain acetylcholinesterase by DSP-4 and its derivatives OS-21 and OS-23 and protective activity of tacrine (9-amino-1,2,3,4-tetrahydroacridine).

Journal: Acta medica (Hradec Kralove) 20050101

Title: Role of locus coeruleus alpha1-adrenoceptors in motor activity in rats.

Journal: Synapse (New York, N.Y.) 20041201

Title: Electrophysiological evidence for the tonic activation of 5-HT(1A) autoreceptors in the rat dorsal raphe nucleus.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20041001

Title: Effects of norepinephrine depletion in rats during cerebral post-ischemic reperfusion.

Journal: Neurotoxicology 20040901

Title: Behavioral and neurochemical effects of noradrenergic depletions with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine in 6-hydroxydopamine-induced rat model of Parkinson's disease.

Journal: Behavioural brain research 20040505

Title: Involvement of locus coeruleus noradrenergic neurons in supraspinal antinociception by alpha,beta-methylene-ATP in rats.

Journal: Journal of pharmacological sciences 20040201

Title: Functional recovery of locus coeruleus noradrenergic neurons after DSP-4 lesion: effects on dopamine levels and neuroleptic induced-parkinsonian symptoms in rats.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20040101

Title: The effects of ageing and of DSP-4 administration on the micturition characteristics of male Wistar rats.

Journal: Brain research 20031024

Title: [Effect of substance K on the contractility of cardiomyocytes].

Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20030801

Title: Effect of denervation of the locus coeruleus projections by DSP-4 treatment on [3H]-raclopride binding to dopamine D(2) receptors and D(2) receptor-G protein interaction in the rat striatum.

Journal: Brain research 20030627

Title: Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in rats.

Journal: The European journal of neuroscience 20030601

Title: A damage to locus coeruleus neurons converts sporadic seizures into self-sustaining limbic status epilepticus.

Journal: The European journal of neuroscience 20030601

Title: Possible antinociceptive mechanisms of opioid receptor antagonists in the mouse formalin test.

Journal: Pharmacology, biochemistry, and behavior 20030501

Title: Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression.

Journal: Journal of neurochemistry 20030401

Title: Norepinephrine regulates locomotor hyperactivity in the mouse mutant coloboma.

Journal: Pharmacology, biochemistry, and behavior 20030401

Title: Effects of partial locus coeruleus denervation and chronic mild stress on behaviour and monoamine neurochemistry in the rat.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20030101

Title: Influence of postweaning social isolation in the rat on brain development, conditioned behavior, and neurotransmission.

Journal: Neuroscience and behavioral physiology 20030101

Title: The influence of specific noradrenergic and serotonergic lesions on the expression of hippocampal brain-derived neurotrophic factor transcripts following voluntary physical activity.

Journal: Neuroscience 20030101

Title: The toxicity of tumor necrosis factor-alpha upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for Alzheimer's disease.

Journal: Neuroscience 20030101

Title: Synaptic loss following depletion of noradrenaline and/or serotonin in the rat visual cortex: a quantitative electron microscopic study.

Journal: Neuroscience 20030101

Title: Depletion of norepinephrine decreases the proliferation, but does not influence the survival and differentiation, of granule cell progenitors in the adult rat hippocampus.

Journal: The European journal of neuroscience 20021101

Title: Denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 [N (2-chloroethyl)-N-ethyl-2-bromobenzylamine] reduces dopamine release potential in the nucleus accumbens shell in conscious rats.

Journal: Neuroscience letters 20021031

Title: Determination of the norepinephrine level by high-performance liquid chromatography to assess the protective effect of MAO-B inhibitors against DSP-4 toxicity.

Journal: Journal of chromatographic science 20021001

Title: Interaction of stress and noradrenergic drugs in the control of picrotoxin-induced seizures.

Journal: Epilepsy research 20020901

Title: Noradrenergic control of auditory information processing in female canaries.

Journal: Behavioural brain research 20020718

Title: Striatal postsynaptic ultrastructural alterations following methylenedioxymethamphetamine administration.

Journal: Annals of the New York Academy of Sciences 20020601

Title: Desensitization of alpha(2)-adrenoceptors which regulate noradrenaline synthesis and release after chronic treatment with clorgyline in the rat brain.

Journal: Pharmacology 20020501

Title: Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020401

Title: Partial denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 potentiates the long-term effect of parachloroamphetamine on 5-hydroxytryptamine metabolism in the rat.

Journal: Neuroscience letters 20020329

Title: Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test.

Journal: European journal of pharmacology 20020202

Title: Locus coeruleus noradrenergic lesions attenuate intraoral intake.

Journal: Neuroreport 20011008

Title: Effect of noradrenergic denervation of medial prefrontal cortex and dentate gyrus on recovery after sleep deprivation in the rat.

Journal: Neuroscience letters 20010928

Title: Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by dizocilpine.

Journal: Brain research 20010525

Title: Effects of central noradrenaline depletion by the selective neurotoxin DSP-4 on the behaviour of the isolated rat in the elevated plus maze and water maze.

Journal: Psychopharmacology 20010501

Title: The effects of CRA 1000, a non-peptide antagonist of corticotropin-releasing factor receptor type 1, on adaptive behaviour in the rat.

Journal: Neuropeptides 20010401

Title: Cardiovascular and behavioural responses to psychological stress in spontaneously hypertensive rats: effect of treatment with DSP-4.

Journal: Behavioural brain research 20010315

Title: Biochemical effects of the monoamine neurotoxins DSP-4 and MDMA in specific brain regions of MAO-B-deficient mice.

Journal: Synapse (New York, N.Y.) 20010301

Title: Effects of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) on alpha2-adrenoceptors which regulate the synthesis and release of noradrenaline in the rat brain.

Journal: Pharmacology & toxicology 20010301

Title: Modulation of MK-801-induced behaviour by noradrenergic agents in mice.

Journal: Psychopharmacology 20010301

Title: The antidepressant activity of inositol in the forced swim test involves 5-HT(2) receptors.

Journal: Behavioural brain research 20010108

Title: Protective effect of 7-nitroindazole against DSP-4 induced noradrenaline depletion in mouse hippocampus.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20010101

Title: N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine reduces intracellular calcium response to noradrenaline in rat visual cortex.

Journal: Neuroscience 20010101

Title: The effect of low oral doses of (-)-deprenyl and its metabolites on DSP-4 toxicity.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20010101

Title: Modulatory role of 5-HT3 receptors in mediation of apomorphine-induced aggressive behaviour in male rats.

Journal: Behavioural brain research 19991201

Title: Effects of pretreatment with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) on methamphetamine pharmacokinetics and striatal dopamine losses.

Journal: Journal of neurochemistry 19990201

Title: Systemic injection with DSP-4 decreases the clonidine hypotension in bicuculline-treated rats.

Journal: Research communications in molecular pathology and pharmacology 19990101

Title: Antagonization of fentanyl-induced muscular rigidity by denervation of the coerulospinal noradrenergic pathway in the rat.

Journal: Neuroscience letters 19930723

Title: Norepinephrine-mediated suppression of apomorphine-induced aggression and locomotor activity in the rat amygdala.

Journal: Pharmacology, biochemistry, and behavior 19870201

Title: Chemical lesions of the nucleus accumbens septi in rats: effects on muricide and apomorphine-induced aggression.

Journal: Behavioural brain research 19860201

Title: Central noradrenaline depletion antagonizes aspects of d-amphetamine-induced hyperactivity in the rat.

Journal: Psychopharmacology 19860101

Title: Evidence for a selective brain noradrenergic involvement in the locomotor stimulant effects of amphetamine in the rat.

Journal: Neuroscience letters 19831230

Title: Hormigo S, et al. The selective neurotoxin DSP-4 impairs the noradrenergic projections from the locus coeruleus to the inferior colliculus in rats. Front Neural Circuits. 2012 Jun 28;6:41.

Title: Jaim-Etcheverry G, et al. DSP-4: a novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats. Brain Res. 1980 Apr 28;188(2):513-23.

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Tags:40616-75-9 Molecular Formula|40616-75-9 MDL|40616-75-9 SMILES|40616-75-9 DSP-4 hydrochloride