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4079-26-9,MFCD05664738
Catalog No.:AA00C09X

4079-26-9 | PD 146176

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1mg
98%
in stock  
$23.00   $16.00
- +
5mg
98%
in stock  
$54.00   $38.00
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10mg
98%
in stock  
$81.00   $57.00
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25mg
98%
in stock  
$134.00   $94.00
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50mg
98%
in stock  
$228.00   $160.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C09X
Chemical Name:
PD 146176
CAS Number:
4079-26-9
Molecular Formula:
C15H11NS
Molecular Weight:
237.3195
MDL Number:
MFCD05664738
SMILES:
c1ccc2c(c1)SCc1c2[nH]c2c1cccc2
NSC Number:
168807
Properties
Properties
 
Form:
Solid  
MP:
>150°C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
293  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
XLogP3:
3.8  

Downstream Synthesis Route

[1]Kidwai,M.M.;Ahluwalia,V.K.[IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,1988,vol.27,#1-12,p.962]

[2]Kiang;Mann[JournaloftheChemicalSociety,1951,p.1909,1913]

[3]Buu-Hoi;Martani;Croisy;Jacquignon;Perin[JournaloftheChemicalSociety.PerkintransactionsI,1966,vol.20,p.1787-1789]

[1]Tetrahedron,2016,vol.72,p.5612-5619

[2]Patent:KR101627841,2016,B1.Locationinpatent:Paragraph0045;0047-0049

[3]JournalofgeneralchemistryoftheUSSR,1963,vol.33,p.3593-3597    ZhurnalObshcheiKhimii,1963,vol.33,p.3662-3667

[4]BioorganicandMedicinalChemistryLetters,2006,vol.16,p.3233-3237

[1]Kucherova,N.F.etal.[JournalofgeneralchemistryoftheUSSR,1963,vol.33,p.3593-3597][ZhurnalObshcheiKhimii,1963,vol.33,p.3662-3667]

Literature

Title: Involvement of 15-lipoxygenase in the inflammatory arthritis.

Journal: Journal of cellular biochemistry 20120701

Title: cPLA(2)α gene activation by IL-1β is dependent on an upstream kinase pathway, enzymatic activation and downstream 15-lipoxygenase activity: a positive feedback loop.

Journal: Cellular signalling 20111201

Title: Arachidonic acid epoxygenase and 12(S)-lipoxygenase: evidence of their concerted involvement in ductus arteriosus constriction to oxygen.

Journal: Canadian journal of physiology and pharmacology 20110501

Title: A cell-based assay for screening lipoxygenase inhibitors.

Journal: Prostaglandins & other lipid mediators 20091201

Title: 15-lipoxygenase metabolites play an important role in the development of a T-helper type 1 allergic inflammation induced by double-stranded RNA.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20090601

Title: Role of lipoxygenases and the lipoxin A(4)/annexin 1 receptor in ischemia-reperfusion-induced gastric mucosal damage in rats.

Journal: Pharmacology 20090101

Title: Role of lipoxygenases and lipoxin A(4)/annexin-1 receptor in gastric protection induced by 20% ethanol or sodium salicylate in rats.

Journal: Pharmacology 20090101

Title: Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.

Journal: Cell metabolism 20080901

Title: Selenium inhibits 15-hydroperoxyoctadecadienoic acid-induced intracellular adhesion molecule expression in aortic endothelial cells.

Journal: Free radical biology & medicine 20080101

Title: A role for 12/15 lipoxygenase in the amyloid beta precursor protein metabolism.

Journal: Journal of neurochemistry 20071001

Title: Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti.

Journal: Journal of natural products 20070501

Title: Lipoxin biosynthesis in inflammatory bowel disease.

Journal: Prostaglandins & other lipid mediators 20060301

Title: Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.

Journal: Bioorganic & medicinal chemistry letters 20050301

Title: Regulation of bone mass in mice by the lipoxygenase gene Alox15.

Journal: Science (New York, N.Y.) 20040109

Title: Sendobry SM, et al. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br J Pharmacol. 1997;120(7):1199-1206.

Title: Bocan TM, et al. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit [published correction appears in Atherosclerosis 1998 Jul;139(1):201 Atherosclerosis. 1998;136(2):203-216.

Title: Di Meco A, et al. 12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice. Biol Psychiatry. 2017;81(2):92-100.

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