40796-97-2,MFCD00865533
Catalog No.:AA00BZJG

40796-97-2 | 3-TROPANYL-3,5-DICHLOROBENZOATE

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Purity
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1mg
97%
in stock  
$20.00   $14.00
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5mg
97%
in stock  
$48.00   $34.00
- +
10mg
97%
in stock  
$72.00   $50.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00BZJG
Chemical Name:
3-TROPANYL-3,5-DICHLOROBENZOATE
CAS Number:
40796-97-2
Molecular Formula:
C15H17Cl2NO2
Molecular Weight:
314.2070
MDL Number:
MFCD00865533
SMILES:
CN1[C@@H]2CC[C@@H]1CC(C2)OC(=O)c1cc(Cl)cc(c1)Cl
Properties
Computed Properties
 
Complexity:
355  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.2  

Downstream Synthesis Route

[1]Maksay,Gabor;Nemes,Péter;Biró,Tímea[JournalofMedicinalChemistry,2004,vol.47,#25,p.6384-6391]

[2]CurrentPatentAssignee:SANOFI-US4563465,1986,A

Literature

Title: Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.

Journal: European journal of medicinal chemistry 20130501

Title: Noradrenergic activity regulated dexamethasone-induced increase of 5-HT₃ receptor-mediated glutamate release in the rat's prelimbic cortex.

Journal: Biochimica et biophysica acta 20121201

Title: Inhibition of NMDA-type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii).

Journal: Journal of neurochemistry 20120901

Title: A novel α-conotoxin MII-sensitive nicotinic acetylcholine receptor modulates [(3) H]-GABA release in the superficial layers of the mouse superior colliculus.

Journal: Journal of neurochemistry 20120701

Title: Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.

Journal: Journal of medicinal chemistry 20110811

Title: Multiple subtypes of serotonin receptors in the feeding circuit of a pond snail.

Journal: Zoological science 20110701

Title: Modulation of ligand-gated ion channels as a novel pharmacological principle.

Journal: Pharmacopsychiatry 20110501

Title: Colonic submucosal 5-HT(3) receptor-mediated somatostatin-dependent secretoinhibitory pathway is suppressed in water-immersion restraint stressed rats.

Journal: European journal of pharmacology 20110410

Title: Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT₃ receptor antagonists.

Journal: Cancer chemotherapy and pharmacology 20110301

Title: The chemical basis of pharmacology.

Journal: Biochemistry 20101207

Title: 5-HT3 receptor-dependent modulation of respiratory burst frequency, regularity, and episodicity in isolated adult turtle brainstems.

Journal: Respiratory physiology & neurobiology 20100630

Title: GABA(A) receptors mediate the attenuating effects of a 5-HT(3) receptor antagonist on methamphetamine-induced behavioral sensitization in mice.

Journal: Synapse (New York, N.Y.) 20100401

Title: Effects of serotonin on acid secretion in isolated rat stomach: the role of 5-HT3 receptors.

Journal: The Chinese journal of physiology 20091130

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Effects of triterpenoids from Poria cocos Wolf on the serotonin type 3A receptor-mediated ion current in Xenopus oocytes.

Journal: European journal of pharmacology 20090801

Title: Quinazolindione derivatives as potent 5-HT3A receptor antagonists.

Journal: Bioorganic & medicinal chemistry 20090701

Title: Mechanisms of analgesic action of pulsed radiofrequency on adjuvant-induced pain in the rat: roles of descending adrenergic and serotonergic systems.

Journal: European journal of pain (London, England) 20090301

Title: cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.

Journal: Journal of medicinal chemistry 20081127

Title: Long-term depression in the superior cervical ganglion of the rat.

Journal: Brain research 20081009

Title: Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.

Journal: Journal of medicinal chemistry 20080724

Title: A dual role of 5-hydroxytryptamine receptor 3 in serotonin induced ion transport in rat distal colon.

Journal: European journal of pharmacology 20080414

Title: Dopamine neurotransmission is involved in the attenuating effects of 5-HT3 receptor antagonist MDL 72222 on acute methamphetamine-induced locomotor hyperactivity in mice.

Journal: Synapse (New York, N.Y.) 20080101

Title: Involvement of 5-HT receptors in the development and expression of methamphetamine-induced behavioral sensitization: 5-HT receptor channel and binding study.

Journal: Journal of neurochemistry 20061101

Title: Effects of repeated daily treatments with a 5-HT3 receptor antagonist on dopamine neurotransmission and functional activity of 5-HT3 receptors within the nucleus accumbens of Wistar rats.

Journal: Pharmacology, biochemistry, and behavior 20060601

Title: Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20060501

Title: Rewarding properties of 1-benzylpiperazine, a new drug of abuse, in rats.

Journal: Basic & clinical pharmacology & toxicology 20060401

Title: Blockade of 5-HT(3) receptor with MDL7222 and Y25130 reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells.

Journal: Life sciences 20051205

Title: Antinociceptive effect of shakuyakukanzoto, a Kampo medicine, in diabetic mice.

Journal: Journal of pharmacological sciences 20051201

Title: 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.

Journal: Journal of medicinal chemistry 20051103

Title: High affinity ligands for the alpha7 nicotinic receptor that show no cross-reactivity with the 5-HT3 receptor.

Journal: Bioorganic & medicinal chemistry letters 20051101

Title: Blockade of 5-HT(3) receptor with MDL 72222 and Y 25130 reduces beta-amyloid protein (25--35)-induced neurotoxicity in cultured rat cortical neurons.

Journal: European journal of pharmacology 20050927

Title: Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on temporal differentiation: evidence for the involvement of 5-HT2A but not 5-HT3 receptors in interval timing behaviour.

Journal: Psychopharmacology 20050901

Title: The serotonin type 3A receptor facilitates luteinizing hormone release and LHbeta promoter activity in immortalized pituitary gonadotropes.

Journal: Endocrine 20050601

Title: Mechanisms of analgesic action of neurotropin on chronic pain in adjuvant-induced arthritic rat: roles of descending noradrenergic and serotonergic systems.

Journal: Journal of pharmacological sciences 20050301

Title: Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on the discrimination of durations: evidence for the involvement of 5-HT2A but not 5-HT3 receptors.

Journal: Behavioural pharmacology 20050201

Title: Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew).

Journal: European journal of pharmacology 20050131

Title: Synthesis of tropeines and allosteric modulation of ionotropic glycine receptors.

Journal: Journal of medicinal chemistry 20041202

Title: 5HT2 and 5HT3 receptors' contribution to modeling of post-serotonin respiratory pattern in cats.

Journal: Life sciences 20040924

Title: Reduced 5-HT3 receptor binding and lower baseline plus maze anxiety in the alcohol-preferring inbred fawn-hooded rat.

Journal: Pharmacology, biochemistry, and behavior 20040201

Title: Roles for CCK1 and 5-HT3 receptors in the effects of CCK on presympathetic vasomotor neuronal discharge in the rat.

Journal: British journal of pharmacology 20030501

Title: 5-HT2 and 3 receptor antagonists suppress the response of rat type I slowly adapting mechanoreceptor: an in vitro study.

Journal: Brain research 20030418

Title: Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes.

Journal: Molecules and cells 20030227

Title: Pretreatment with serotonin 5-HT(3) receptor antagonists produces no observable blockade of long-term motor sensitization to cocaine in rats.

Journal: Psychopharmacology 20030201

Title: Conditional involvement of striatal serotonin3 receptors in the control of in vivo dopamine outflow in the rat striatum.

Journal: The European journal of neuroscience 20030201

Title: Dual cooperative allosteric modulation of binding to ionotropic glycine receptors.

Journal: Neuropharmacology 20021201

Title: Pharmacology of serotonin receptors modulating electrically-induced [3h]-norepinephrine release from isolated mammalian iris-ciliary bodies.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020801

Title: 5-HT3 receptor antagonist MDL 72222 attenuates cocaine- and mazindol-, but not methylphenidate-induced neurochemical and behavioral effects in the rat.

Journal: Psychopharmacology 20020201

Title: Effects of 5-HT2 and 5-HT3 receptors on the modulation of nociceptive transmission in rat spinal cord according to the formalin test.

Journal: European journal of pharmacology 20010713

Title: Serotonin and NO complementarily regulate generation of oscillatory activity in the olfactory CNS of a terrestrial mollusk.

Journal: Journal of neurophysiology 20010601

Title: First tricyclic oximino derivatives as 5-HT3 ligands.

Journal: Bioorganic & medicinal chemistry letters 20010226

Title: Modulatory role of 5-HT3 receptors in mediation of apomorphine-induced aggressive behaviour in male rats.

Journal: Behavioural brain research 19991201

Title: The analgesic tropane analogue (+/-)-SM 21 has a high affinity for sigma2 receptors.

Journal: Life sciences 19990101

Title: Serotoninergic modulation of excitability in area CA1 of the in vitro rat hippocampus.

Journal: Neuroscience letters 19951027

Title: 5HT3 receptor antagonists do not block nicotine induced hyperactivity in rats.

Journal: Psychopharmacology 19950501

Title: The effect of ketanserin on cardiovascular reflexes in conscious normotensive and spontaneously hypertensive rats.

Journal: European journal of pharmacology 19900904

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SDS
Tags:40796-97-2 Molecular Formula|40796-97-2 MDL|40796-97-2 SMILES|40796-97-2 3-TROPANYL-3,5-DICHLOROBENZOATE
Catalog No.: AA00BZJG
40796-97-2,MFCD00865533
40796-97-2 | 3-TROPANYL-3,5-DICHLOROBENZOATE
Pack Size: 1mg
Purity: 97%
in stock
$20.00 $14.00
Pack Size: 5mg
Purity: 97%
in stock
$48.00 $34.00
Pack Size: 10mg
Purity: 97%
in stock
$72.00 $50.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00BZJG
Chemical Name: 3-TROPANYL-3,5-DICHLOROBENZOATE
CAS Number: 40796-97-2
Molecular Formula: C15H17Cl2NO2
Molecular Weight: 314.2070
MDL Number: MFCD00865533
SMILES: CN1[C@@H]2CC[C@@H]1CC(C2)OC(=O)c1cc(Cl)cc(c1)Cl
Properties
Complexity: 355  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 2  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 20  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.2  
Downstream Synthesis Route
2905-62-6    120-29-6    40796-97-2 

[1]Maksay,Gabor;Nemes,Péter;Biró,Tímea[JournalofMedicinalChemistry,2004,vol.47,#25,p.6384-6391]

[2]CurrentPatentAssignee:SANOFI-US4563465,1986,A

Literature fold

Title: Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.

Journal: European journal of medicinal chemistry20130501

Title: Noradrenergic activity regulated dexamethasone-induced increase of 5-HT₃ receptor-mediated glutamate release in the rat's prelimbic cortex.

Journal: Biochimica et biophysica acta20121201

Title: Inhibition of NMDA-type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii).

Journal: Journal of neurochemistry20120901

Title: A novel α-conotoxin MII-sensitive nicotinic acetylcholine receptor modulates [(3) H]-GABA release in the superficial layers of the mouse superior colliculus.

Journal: Journal of neurochemistry20120701

Title: Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.

Journal: Journal of medicinal chemistry20110811

Title: Multiple subtypes of serotonin receptors in the feeding circuit of a pond snail.

Journal: Zoological science20110701

Title: Modulation of ligand-gated ion channels as a novel pharmacological principle.

Journal: Pharmacopsychiatry20110501

Title: Colonic submucosal 5-HT(3) receptor-mediated somatostatin-dependent secretoinhibitory pathway is suppressed in water-immersion restraint stressed rats.

Journal: European journal of pharmacology20110410

Title: Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT₃ receptor antagonists.

Journal: Cancer chemotherapy and pharmacology20110301

Title: The chemical basis of pharmacology.

Journal: Biochemistry20101207

Title: 5-HT3 receptor-dependent modulation of respiratory burst frequency, regularity, and episodicity in isolated adult turtle brainstems.

Journal: Respiratory physiology & neurobiology20100630

Title: GABA(A) receptors mediate the attenuating effects of a 5-HT(3) receptor antagonist on methamphetamine-induced behavioral sensitization in mice.

Journal: Synapse (New York, N.Y.)20100401

Title: Effects of serotonin on acid secretion in isolated rat stomach: the role of 5-HT3 receptors.

Journal: The Chinese journal of physiology20091130

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology20091001

Title: Effects of triterpenoids from Poria cocos Wolf on the serotonin type 3A receptor-mediated ion current in Xenopus oocytes.

Journal: European journal of pharmacology20090801

Title: Quinazolindione derivatives as potent 5-HT3A receptor antagonists.

Journal: Bioorganic & medicinal chemistry20090701

Title: Mechanisms of analgesic action of pulsed radiofrequency on adjuvant-induced pain in the rat: roles of descending adrenergic and serotonergic systems.

Journal: European journal of pain (London, England)20090301

Title: cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.

Journal: Journal of medicinal chemistry20081127

Title: Long-term depression in the superior cervical ganglion of the rat.

Journal: Brain research20081009

Title: Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.

Journal: Journal of medicinal chemistry20080724

Title: A dual role of 5-hydroxytryptamine receptor 3 in serotonin induced ion transport in rat distal colon.

Journal: European journal of pharmacology20080414

Title: Dopamine neurotransmission is involved in the attenuating effects of 5-HT3 receptor antagonist MDL 72222 on acute methamphetamine-induced locomotor hyperactivity in mice.

Journal: Synapse (New York, N.Y.)20080101

Title: Involvement of 5-HT receptors in the development and expression of methamphetamine-induced behavioral sensitization: 5-HT receptor channel and binding study.

Journal: Journal of neurochemistry20061101

Title: Effects of repeated daily treatments with a 5-HT3 receptor antagonist on dopamine neurotransmission and functional activity of 5-HT3 receptors within the nucleus accumbens of Wistar rats.

Journal: Pharmacology, biochemistry, and behavior20060601

Title: Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20060501

Title: Rewarding properties of 1-benzylpiperazine, a new drug of abuse, in rats.

Journal: Basic & clinical pharmacology & toxicology20060401

Title: Blockade of 5-HT(3) receptor with MDL7222 and Y25130 reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells.

Journal: Life sciences20051205

Title: Antinociceptive effect of shakuyakukanzoto, a Kampo medicine, in diabetic mice.

Journal: Journal of pharmacological sciences20051201

Title: 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.

Journal: Journal of medicinal chemistry20051103

Title: High affinity ligands for the alpha7 nicotinic receptor that show no cross-reactivity with the 5-HT3 receptor.

Journal: Bioorganic & medicinal chemistry letters20051101

Title: Blockade of 5-HT(3) receptor with MDL 72222 and Y 25130 reduces beta-amyloid protein (25--35)-induced neurotoxicity in cultured rat cortical neurons.

Journal: European journal of pharmacology20050927

Title: Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on temporal differentiation: evidence for the involvement of 5-HT2A but not 5-HT3 receptors in interval timing behaviour.

Journal: Psychopharmacology20050901

Title: The serotonin type 3A receptor facilitates luteinizing hormone release and LHbeta promoter activity in immortalized pituitary gonadotropes.

Journal: Endocrine20050601

Title: Mechanisms of analgesic action of neurotropin on chronic pain in adjuvant-induced arthritic rat: roles of descending noradrenergic and serotonergic systems.

Journal: Journal of pharmacological sciences20050301

Title: Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on the discrimination of durations: evidence for the involvement of 5-HT2A but not 5-HT3 receptors.

Journal: Behavioural pharmacology20050201

Title: Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew).

Journal: European journal of pharmacology20050131

Title: Synthesis of tropeines and allosteric modulation of ionotropic glycine receptors.

Journal: Journal of medicinal chemistry20041202

Title: 5HT2 and 5HT3 receptors' contribution to modeling of post-serotonin respiratory pattern in cats.

Journal: Life sciences20040924

Title: Reduced 5-HT3 receptor binding and lower baseline plus maze anxiety in the alcohol-preferring inbred fawn-hooded rat.

Journal: Pharmacology, biochemistry, and behavior20040201

Title: Roles for CCK1 and 5-HT3 receptors in the effects of CCK on presympathetic vasomotor neuronal discharge in the rat.

Journal: British journal of pharmacology20030501

Title: 5-HT2 and 3 receptor antagonists suppress the response of rat type I slowly adapting mechanoreceptor: an in vitro study.

Journal: Brain research20030418

Title: Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes.

Journal: Molecules and cells20030227

Title: Pretreatment with serotonin 5-HT(3) receptor antagonists produces no observable blockade of long-term motor sensitization to cocaine in rats.

Journal: Psychopharmacology20030201

Title: Conditional involvement of striatal serotonin3 receptors in the control of in vivo dopamine outflow in the rat striatum.

Journal: The European journal of neuroscience20030201

Title: Dual cooperative allosteric modulation of binding to ionotropic glycine receptors.

Journal: Neuropharmacology20021201

Title: Pharmacology of serotonin receptors modulating electrically-induced [3h]-norepinephrine release from isolated mammalian iris-ciliary bodies.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20020801

Title: 5-HT3 receptor antagonist MDL 72222 attenuates cocaine- and mazindol-, but not methylphenidate-induced neurochemical and behavioral effects in the rat.

Journal: Psychopharmacology20020201

Title: Effects of 5-HT2 and 5-HT3 receptors on the modulation of nociceptive transmission in rat spinal cord according to the formalin test.

Journal: European journal of pharmacology20010713

Title: Serotonin and NO complementarily regulate generation of oscillatory activity in the olfactory CNS of a terrestrial mollusk.

Journal: Journal of neurophysiology20010601

Title: First tricyclic oximino derivatives as 5-HT3 ligands.

Journal: Bioorganic & medicinal chemistry letters20010226

Title: Modulatory role of 5-HT3 receptors in mediation of apomorphine-induced aggressive behaviour in male rats.

Journal: Behavioural brain research19991201

Title: The analgesic tropane analogue (+/-)-SM 21 has a high affinity for sigma2 receptors.

Journal: Life sciences19990101

Title: Serotoninergic modulation of excitability in area CA1 of the in vitro rat hippocampus.

Journal: Neuroscience letters19951027

Title: 5HT3 receptor antagonists do not block nicotine induced hyperactivity in rats.

Journal: Psychopharmacology19950501

Title: The effect of ketanserin on cardiovascular reflexes in conscious normotensive and spontaneously hypertensive rats.

Journal: European journal of pharmacology19900904

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