Home Other Building Blocks 40846-94-4
40846-94-4,MFCD09028032
Catalog No.:AA00741D

40846-94-4 | DL-Alpha-lipoic acid-nhs

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50mg
>96.0%(HPLC)
in stock  
$156.00   $109.00
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1g
98%
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$238.00   $167.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00741D
Chemical Name:
DL-Alpha-lipoic acid-nhs
CAS Number:
40846-94-4
Molecular Formula:
C12H17NO4S2
Molecular Weight:
303.3977
MDL Number:
MFCD09028032
SMILES:
O=C(ON1C(=O)CCC1=O)CCCCC1SSCC1
Properties
Computed Properties
 
Complexity:
359  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
1  
XLogP3:
1.1  

Downstream Synthesis Route
41764-74-3    40846-94-4   
N'-(5-(1,2-dithiolan-3-yl)pentanoyl)-3,4-dimethoxybenzohydrazide 

[1]BioorganicandMedicinalChemistryLetters,2007,vol.17,p.4223-4227

[1]CurrentPatentAssignee:L'OREALSA-WO2008/58999,2008,A1Locationinpatent:Page/Pagecolumn46-47

[1]Jung,Jongjin;Solanki,Aniruddh;Memoli,KevinA.;Kamei,Ken-Ichiro;Kim,Hiyun;Drahl,MichaelA.;Williams,LawrenceJ.;Tseng,Hsian-Rong;Lee,Kibum[AngewandteChemie-InternationalEdition,2010,vol.49,#1,p.103-107]

[1]DeLaReberdiere,Arnaud;Lachaud,Fabien;Chuburu,Francoise;Cadiou,Cyril;Lemercier,Gilles[TetrahedronLetters,2012,vol.53,#45,p.6115-6118,4]

583-89-1    40846-94-4   
ethyl2-(6,8-dimercaptooctanamido)-3-mercaptopropanoate 

[1]Bolognesi,MariaLaura;Bergamini,Christian;Fato,Romana;Oiry,Joël;Vasseur,Jean-Jacques;Smietana,Michael[ChemicalBiologyandDrugDesign,2014,vol.83,#6,p.688-696]

Literature

Title: An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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Tags:40846-94-4 Molecular Formula|40846-94-4 MDL|40846-94-4 SMILES|40846-94-4 DL-Alpha-lipoic acid-nhs