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410074-74-7,MFCD26405807
Catalog No.:AA00C6FU

410074-74-7 | DOV 21947 hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
99%
1 week  
$511.00   $358.00
- +
10mg
99%
1 week  
$828.00   $580.00
- +
25mg
99
1 week  
$1,016.00   $712.00
- +
50mg
99%
1 week  
$1,781.00   $1,247.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C6FU
Chemical Name:
DOV 21947 hydrochloride
CAS Number:
410074-74-7
Molecular Formula:
C11H12Cl3N
Molecular Weight:
264.5787
MDL Number:
MFCD26405807
SMILES:
Clc1ccc(cc1Cl)[C@@]12CNC[C@H]2C1.Cl
Properties
Computed Properties
 
Complexity:
245  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  

Literature

Title: The triple reuptake inhibitor DOV 216,303 induces long-lasting enhancement of brain reward activity as measured by intracranial self-stimulation in rats.

Journal: European journal of pharmacology 20121015

Title: Differential BDNF responses of triple versus dual reuptake inhibition in neuronal and astrocytoma cells as well as in rat hippocampus and prefrontal cortex.

Journal: Journal of molecular neuroscience : MN 20120901

Title: Effects of the triple reuptake inhibitor amitifadine on extracellular levels of monoamines in rat brain regions and on locomotor activity.

Journal: Synapse (New York, N.Y.) 20120501

Title: Efficacy and tolerability of the novel triple reuptake inhibitor amitifadine in the treatment of patients with major depressive disorder: a randomized, double-blind, placebo-controlled trial.

Journal: Journal of psychiatric research 20120101

Title: The triple reuptake inhibitor DOV216,303 exhibits limited antidepressant-like properties in the differential reinforcement of low-rate 72-second responding assay, likely due to dopamine reuptake inhibition.

Journal: Journal of psychopharmacology (Oxford, England) 20111001

Title: 1-Heteroaryl-6-(3,4-dichlorophenyl)-3-azabicyclo[4.1.0]heptane: further insights into a class of triple re-uptake inhibitors.

Journal: Bioorganic & medicinal chemistry 20110601

Title: The secrets of a successful clinical trial: compliance, compliance, and compliance.

Journal: Molecular interventions 20110401

Title: Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons.

Journal: The international journal of neuropsychopharmacology 20110301

Title: The potential and limitations of DOV 216,303 as a triple reuptake inhibitor for the treatment of major depression: a microdialysis study in olfactory bulbectomized rats.

Journal: Pharmacology, biochemistry, and behavior 20110101

Title: The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties.

Journal: The Journal of pharmacology and experimental therapeutics 20101201

Title: The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats.

Journal: European journal of pharmacology 20100510

Title: The triple monoaminergic reuptake inhibitor DOV 216,303 has antidepressant effects in the rat olfactory bulbectomy model and lacks sexual side effects.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20081201

Title: The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity.

Journal: The Journal of pharmacology and experimental therapeutics 20080301

Title: Triple reuptake inhibitors ('broad spectrum' antidepressants).

Journal: CNS & neurological disorders drug targets 20070401

Title: Stereocontrolled synthesis of trisubstituted cyclopropanes: expedient, atom-economical, asymmetric syntheses of (+)-Bicifadine and DOV21947.

Journal: Organic letters 20060817

Title: Preclinical and clinical pharmacology of DOV 216,303, a 'triple' reuptake inhibitor.

Journal: CNS drug reviews 20060101

Title: DOV 216,303, a 'triple' reuptake inhibitor: safety, tolerability, and pharmacokinetic profile.

Journal: Journal of clinical pharmacology 20041201

Title: 'Broad spectrum' antidepressants: is more better for the treatment of depression?

Journal: Life sciences 20031107

Title: Antidepressant-like actions of DOV 21,947: a 'triple' reuptake inhibitor.

Journal: European journal of pharmacology 20030214

Title: Skolnick P1, et al. Antidepressant-like actions of DOV 21,947: a "triple" reuptake inhibitor. Eur J Pharmacol. 2003 Feb 14;461(2-3):99-104.

Title: Levin ED, et al. Amitifadine, a triple monoamine re-uptake inhibitor, reduces nicotine self-administration in female rats. Eur J Pharmacol. 2015 Jun 20;764:30-37.

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Tags:410074-74-7 Molecular Formula|410074-74-7 MDL|410074-74-7 SMILES|410074-74-7 DOV 21947 hydrochloride