Home Other Building Blocks 4105-38-8
4105-38-8,MFCD00023795
Catalog No.:AA003FCS

4105-38-8 | 2',3',5'-Triacetyluridine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5g
97%
in stock  
$7.00   $5.00
- +
25g
97%
in stock  
$29.00   $21.00
- +
100g
97%
in stock  
$99.00   $69.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003FCS
Chemical Name:
2',3',5'-Triacetyluridine
CAS Number:
4105-38-8
Molecular Formula:
C15H18N2O9
Molecular Weight:
370.3114
MDL Number:
MFCD00023795
SMILES:
CC(=O)O[C@@H]1[C@H](OC(=O)C)[C@H](O[C@H]1n1ccc(=O)[nH]c1=O)COC(=O)C
Properties
Properties
 
Form:
Solid  
MP:
127.0 to 131.0 °C  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
660  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
-0.5  

Literature

Title: A rational approach to the regioselective deacetylation of 2',3',5'-tri-O-acetyluridine by Novozym 435 catalysed alcoholysis.

Journal: Biochimica et biophysica acta 20120401

Title: Use of uridine triacetate for the management of fluorouracil overdose.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20111001

Title: Enhanced uridine bioavailability following administration of a triacetyluridine-rich nutritional supplement.

Journal: PloS one 20110101

Title: Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients.

Journal: Experimental and clinical psychopharmacology 20080601

Title: Phthalocyanine-based molecularly imprinted polymers as nucleoside receptors.

Journal: Metal-based drugs 20080101

Title: Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington's disease.

Journal: Neurobiology of disease 20061201

Title: Phase II trial of PN401, 5-FU, and leucovorin in unresectable or metastatic adenocarcinoma of the stomach: a Southwest Oncology Group study.

Journal: Investigational new drugs 20061101

Title: 5-Fluorouracil dose escalation enabled with PN401 (triacetyluridine): toxicity reduction and increased antitumor activity in mice.

Journal: Cancer chemotherapy and pharmacology 20060701

Title: Continued survival of more than ten years, without resection of metastatic disease, in patients with metastatic colorectal cancer treated with biomodulated fluorouracil: report of two cases.

Journal: Diseases of the colon and rectum 20060301

Title: Severe cytochrome c oxidase inhibition in vivo does not induce a pyrimidine deficiency; neuroprotective action of oral uridine prodrug PN401 requires supraphysiological levels of uridine.

Journal: Brain research 20051220

Title: Neuroprotective effects of oral administration of triacetyluridine against MPTP neurotoxicity.

Journal: Neuromolecular medicine 20040101

Title: Oral uridine pro-drug PN401 decreases neurodegeneration, behavioral impairment, weight loss and mortality in the 3-nitropropionic acid mitochondrial toxin model of Huntington's disease.

Journal: Brain research 20031219

Title: Synthesis and hypnotic activities of 4-thio analogues of N3-substituted uridines.

Journal: Chemical & pharmaceutical bulletin 20010901

Title: Ma WW, et al. Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity. Cancer. 2017 Jan 1;123(2):345-356.

Title: Cada DJ, et al. Uridine Triacetate. Hosp Pharm. 2016 Jun;51(6):484-8.

Title: Rolando A G Garcia, et al. Prompt treatment with uridine triacetate improves survival and reduces toxicity due to fluorouracil and capecitabine overdose or dihydropyrimidine dehydrogenase deficiency. Toxicol Appl Pharmacol. 2018 Aug 15;353:67-73.

Title: Siennah R Miller, et al. Predicting Drug Interactions with Human Equilibrative Nucleoside Transporters 1 and 2 Using Functional Knockout Cell Lines and Bayesian Modeling. Mol Pharmacol. 2021 Feb;99(2):147-162.

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