Home Other Building Blocks 410528-02-8
410528-02-8,MFCD10565968
Catalog No.:AA00C6E8

410528-02-8 | Palovarotene

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$116.00   $81.00
- +
10mg
≥98%
in stock  
$218.00   $152.00
- +
25mg
≥98%
in stock  
$480.00   $336.00
- +
1000mg
98% by HPLC
in stock  
$15,433.00   $10,803.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C6E8
Chemical Name:
Palovarotene
CAS Number:
410528-02-8
Molecular Formula:
C27H30N2O2
Molecular Weight:
414.5393
MDL Number:
MFCD10565968
SMILES:
OC(=O)c1ccc(cc1)/C=C/c1cc2c(cc1Cn1cccn1)C(C)(C)CCC2(C)C
Properties
Computed Properties
 
Complexity:
662  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
6.8  

Literature

Title: Randomised controlled trial for emphysema with a selective agonist of the γ-type retinoic acid receptor.

Journal: The European respiratory journal 20120801

Title: The COPD Pipeline XIII.

Journal: COPD 20111201

Title: Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists.

Journal: Nature medicine 20110401

Title: Retinoid treatment of Emphysema in Patients on the Alpha-1 International Registry. The REPAIR study: study design, methodology and quality control of study assessments.

Journal: Therapeutic advances in respiratory disease 20101201

Title: The COPD pipeline VII.

Journal: COPD 20101201

Title: Palovarotene, a novel retinoic acid receptor gamma agonist for the treatment of emphysema.

Journal: Current opinion in investigational drugs (London, England : 2000) 20091101

Title: Treatment of patients who have fibrodysplasia ossificans progressiva with isotretinoin.

Journal: Clinical orthopaedics and related research 19980101

Title: Pavey GJ, et al. Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model. Bone. 2016 Sep;90:159-67.

Title: Chakkalakal SA, et al. Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation. J Bone Miner Res. 2016 Sep;31(9):1666-75.

Title: Lees-Shepard JB, et al. Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity. Elife. 2018 Sep 18;7. pii: e40814.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 410528-02-8
Tags:410528-02-8 Molecular Formula|410528-02-8 MDL|410528-02-8 SMILES|410528-02-8 Palovarotene