[1]Patent:US2009/137681,2009,A1.Locationinpatent:Page/Pagecolumn30;32-33
[1]SyntheticCommunications,2014,vol.44,p.665-673
[1]JournaloftheAmericanChemicalSociety,2018,vol.140,p.2919-2925
Title: Genipin protects the liver from ischemia/reperfusion injury by modulating mitochondrial quality control.
Journal: Toxicology and applied pharmacology 20170801
Title: Acute Treatment of Resveratrol Alleviates Doxorubicin-Induced Myotoxicity in Aged Skeletal Muscle Through SIRT1-Dependent Mechanisms.
Journal: The journals of gerontology. Series A, Biological sciences and medical sciences 20160601
Title: The Effects of Class-Specific Histone Deacetylase Inhibitors on the Development of Limbs During Organogenesis.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20151101
Title: Structural modification of resveratrol leads to increased anti-tumor activity, but causes profound changes in the mode of action.
Journal: Toxicology and applied pharmacology 20150815
Title: Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis.
Journal: The Journal of physiology 20150415
Title: Melatonin Improves mitochondrial function by promoting MT1/SIRT1/PGC-1 alpha-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20141101
Title: Non-specific SIRT inhibition as a mechanism for the cytotoxicity of ginkgolic acids and urushiols.
Journal: Toxicology letters 20140902
Title: Resveratrol-enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice.
Journal: Journal of cellular and molecular medicine 20140801
Title: Attenuation of β-amyloid-induced tauopathy via activation of CK2α/SIRT1: targeting for cilostazol.
Journal: Journal of neuroscience research 20140201
Title: Resveratrol restores sirtuin 1 (SIRT1) activity and pyruvate dehydrogenase kinase 1 (PDK1) expression after hemorrhagic injury in a rat model.
Journal: Molecular medicine (Cambridge, Mass.) 20140101
Title: Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway.
Journal: Neuroscience letters 20131011
Title: Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration-dependent modulation of multiple nuclear receptor-mediated pathways in androgen-responsive prostate cancer cell LNCaP.
Journal: Molecular carcinogenesis 20130901
Title: Growth inhibition and apoptosis-inducing effects of cudraflavone B in human oral cancer cells via MAPK, NF-κB, and SIRT1 signaling pathway.
Journal: Planta medica 20130901
Title: S-allyl cysteine attenuates free fatty acid-induced lipogenesis in human HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway.
Journal: The Journal of nutritional biochemistry 20130801
Title: SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1.
Journal: Apoptosis : an international journal on programmed cell death 20130601
Title: Visfatin is expressed in human granulosa cells: regulation by metformin through AMPK/SIRT1 pathways and its role in steroidogenesis.
Journal: Molecular human reproduction 20130501
Title: SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging.
Journal: Biochemical pharmacology 20130501
Title: Sirt1 inhibits the transcription factor CREB to regulate pituitary growth hormone synthesis.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20130401
Title: SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes.
Journal: Osteoarthritis and cartilage 20130301
Title: Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms.
Journal: The Journal of nutritional biochemistry 20121101
Title: SIRT1 regulates TNF-α-induced expression of CD40 in 3T3-L1 adipocytes via NF-κB pathway.
Journal: Cytokine 20121101
Title: Red wine extract protects against oxidative-stress-induced endothelial senescence.
Journal: Clinical science (London, England : 1979) 20121001
Title: Evaluation of sirtuin role in neuroprotection of retinal ganglion cells in hypoxia.
Journal: Investigative ophthalmology & visual science 20120628
Title: Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells.
Journal: Clinical and experimental immunology 20120401
Title: Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner.
Journal: Rheumatology international 20120101
Title: Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle.
Journal: Vascular pharmacology 20120101
Title: Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2α.
Journal: Molecular vision 20120101
Title: The role of sirtuin 1 in osteoblastic differentiation in human periodontal ligament cells.
Journal: Journal of periodontal research 20111201
Title: Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction.
Journal: Circulation research 20110902
Title: Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells.
Journal: Cardiovascular research 20110201
Title: Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants.
Journal: International journal of obesity (2005) 20101001
Title: Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice.
Journal: The Journal of pharmacology and experimental therapeutics 20101001
Title: Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation.
Journal: Current neurovascular research 20100501
Title: Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype.
Journal: Cardiovascular research 20100201
Title: SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes.
Journal: Journal of cellular and molecular medicine 20090901
Title: Hemeoxygenase-1 upregulation is critical for sirtinol-mediated attenuation of lung injury after trauma-hemorrhage in a rodent model.
Journal: Anesthesia and analgesia 20090601
Title: Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons.
Journal: Neuromolecular medicine 20090101
Title: A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.
Journal: Nature 20081113
Title: Roles of PI3-K/Akt pathways in nanoparticle realgar powders-induced apoptosis in U937 cells.
Journal: Acta pharmacologica Sinica 20080301
Title: SIRT1 activation confers neuroprotection in experimental optic neuritis.
Journal: Investigative ophthalmology & visual science 20070801
Title: Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging.
Journal: American journal of physiology. Lung cellular and molecular physiology 20070201
Title: Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.
Journal: Journal of medicinal chemistry 20051201
Title: Wang J, et al. Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Int J Oncol. 2012 Sep;41(3):1101-1109.
Title: Fong Y, et al. The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. ScientificWorldJournal. 2014;2014:937051.
Title: Mai A, et al. Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem. 2005 Dec 1;48(24):7789-95.
Title: Tsai YF, et al. Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice. Sci Rep. 2015 Feb 10;5:8347.
