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41179-33-3,MFCD08703098
Catalog No.:AA00C094

41179-33-3 | 4-(2'-Fluoro-[1,1'-biphenyl]-4-yl)-N-(4-hydroxyphenyl)butanamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$166.00   $116.00
- +
10mg
≥98%
in stock  
$263.00   $184.00
- +
50mg
≥98%
in stock  
$1,085.00   $759.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00C094
Chemical Name:
4-(2'-Fluoro-[1,1'-biphenyl]-4-yl)-N-(4-hydroxyphenyl)butanamide
CAS Number:
41179-33-3
Molecular Formula:
C22H20FNO2
Molecular Weight:
349.3981
MDL Number:
MFCD08703098
SMILES:
O=C(Nc1ccc(cc1)O)CCCc1ccc(cc1)c1ccccc1F
Properties
Computed Properties
 
Complexity:
428  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.7  

Downstream Synthesis Route

[1]Davis,Terence;Bagley,MarkC.;Dix,MatthewC.;Murziani,PaolaG.S.;Rokicki,MichalJ.;Widdowson,CarolineS.;Zayed,JameelM.;Bachler,MarcusA.;Kipling,David[BioorganicandMedicinalChemistryLetters,2007,vol.17,#24,p.6832-6835]

Literature

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38alpha(MAPK) inhibitors in Werner syndrome cells.

Journal: Bioorganic & medicinal chemistry letters 20071215

Title: Gurgis F, et al. Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. Cell Death Discov. 2015 Sep 7;1:15028.

Title: Davidson W, er al. Discovery and characterization of a substrate selective p38alpha inhibitor. Biochemistry. 2004 Sep 21;43(37):11658-71.

Title: Phoa AF, et al. Pharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signalling. Biochem Pharmacol. 2015 Dec 15;98(4):587-601.

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SDS
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Historical Records
159109-11-2

159109-11-2
Tags:41179-33-3 Molecular Formula|41179-33-3 MDL|41179-33-3 SMILES|41179-33-3 4-(2'-Fluoro-[1,1'-biphenyl]-4-yl)-N-(4-hydroxyphenyl)butanamide
Catalog No.: AA00C094
41179-33-3,MFCD08703098
41179-33-3 | 4-(2'-Fluoro-[1,1'-biphenyl]-4-yl)-N-(4-hydroxyphenyl)butanamide
Pack Size： 1mg
Purity： ≥98%
in stock
$46.00 $32.00
Pack Size： 5mg
Purity： ≥98%
in stock
$166.00 $116.00
Pack Size： 10mg
Purity： ≥98%
in stock
$263.00 $184.00
Pack Size： 50mg
Purity： ≥98%
in stock
$1,085.00 $759.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00C094
Chemical Name: 4-(2'-Fluoro-[1,1'-biphenyl]-4-yl)-N-(4-hydroxyphenyl)butanamide
CAS Number: 41179-33-3
Molecular Formula: C22H20FNO2
Molecular Weight: 349.3981
MDL Number: MFCD08703098
SMILES: O=C(Nc1ccc(cc1)O)CCCc1ccc(cc1)c1ccccc1F
Properties
Complexity: 428  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 26  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.7  
Downstream Synthesis Route
40096-53-5    123-30-8    41179-33-3 

[1]Davis,Terence;Bagley,MarkC.;Dix,MatthewC.;Murziani,PaolaG.S.;Rokicki,MichalJ.;Widdowson,CarolineS.;Zayed,JameelM.;Bachler,MarcusA.;Kipling,David[BioorganicandMedicinalChemistryLetters,2007,vol.17,#24,p.6832-6835]

Literature fold

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology20111101

Title: Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38alpha(MAPK) inhibitors in Werner syndrome cells.

Journal: Bioorganic & medicinal chemistry letters20071215

Title: Gurgis F, et al. Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. Cell Death Discov. 2015 Sep 7;1:15028.

Title: Davidson W, er al. Discovery and characterization of a substrate selective p38alpha inhibitor. Biochemistry. 2004 Sep 21;43(37):11658-71.

Title: Phoa AF, et al. Pharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signalling. Biochem Pharmacol. 2015 Dec 15;98(4):587-601.

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