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41194-00-7,MFCD04113635
Catalog No.:AA00C0AV

41194-00-7 | 5-Hydroxy-1-methylpyrrolidin-2-one

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250mg
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$204.00   $143.00
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1g
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$474.00   $332.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C0AV
Chemical Name:
5-Hydroxy-1-methylpyrrolidin-2-one
CAS Number:
41194-00-7
Molecular Formula:
C5H9NO2
Molecular Weight:
115.1305
MDL Number:
MFCD04113635
SMILES:
OC1CCC(=O)N1C
Properties
Computed Properties
 
Complexity:
113  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
8  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-0.7  

Downstream Synthesis Route

[1]Peixoto,Sabrina;Nguyen,TuanMinh;Crich,David;Delpech,Bernard;Marazano,Christian[OrganicLetters,2010,vol.12,#21,p.4760-4763]

[2]Harada,Shingo;Kato,Ryosuke;Nemoto,Tetsuhiro[AdvancedSynthesisandCatalysis,2016,vol.358,#19,p.3123-3129]

Literature

Title: Embryotoxic potential of N-methyl-pyrrolidone (NMP) and three of its metabolites using the rat whole embryo culture system.

Journal: Toxicology and applied pharmacology 20090601

Title: Human experimental exposure study on the uptake and urinary elimination of N-methyl-2-pyrrolidone (NMP) during simulated workplace conditions.

Journal: Archives of toxicology 20070501

Title: Human volunteer study on the influence of exposure duration and dilution of dermally applied N-methyl-2-pyrrolidone (NMP) on the urinary elimination of NMP metabolites.

Journal: International archives of occupational and environmental health 20070201

Title: Comparative developmental toxicities of the three major metabolites of N-methyl-2-pyrrolidone after oral administration in rats.

Journal: Journal of applied toxicology : JAT 20070101

Title: Human experimental exposure to N-methyl-2-pyrrolidone (NMP): toxicokinetics of NMP, 5-hydroxy- N-methyl-2-pyrrolidone, N-methylsuccinimide and 2-hydroxy- N-methylsuccinimide (2-HMSI), and biological monitoring using 2-HMSI as a biomarker.

Journal: International archives of occupational and environmental health 20030501

Title: Contribution of CYP2E1 to N-methyl-2-pyrrolidone metabolism.

Journal: Archives of toxicology 20030501

Title: Toxicokinetics and metabolism of N-[14C]methylpyrrolidone in male Sprague-Dawley rats. A saturable NMP elimination process.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20021201

Title: Quantitative determination of 5-hydroxy-N-methylpyrrolidone in urine for biological monitoring of N-methylpyrrolidone exposure.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021005

Title: Dermal exposure to aqueous solutions of N-methyl pyrrolidone.

Journal: Toxicology letters 20020805

Title: Determination of 5-hydroxy-N-methyl-2-pyrrolidone and 2-hydroxy-N-methylsuccinimide in human plasma and urine using liquid chromatography-electrospray tandem mass spectrometry.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010915

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