Catalog No.:AA00CL7R

412950-08-4 | 2-[[(2,3-Difluorophenyl)methyl]thio]-N-[1-(2-methoxyethyl)-4-piperidinyl]-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1(4H)-quinolineacetamide

Name: Name:2-[[(2,3-Difluorophenyl)methyl]thio]-N-[1-(2-methoxyethyl)-4-piperidinyl]-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1(4H)-quinolineacetamide
Brand: AABLOCKS
SKU: AA00CL7R
Availability: InStock
Rating: 90 (10 reviews)

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25mg

95%

in stock

$1,303.00 $912.00

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50mg

95%

in stock

$2,254.00 $1,578.00

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Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA00CL7R

Chemical Name:

2-[[(2,3-Difluorophenyl)methyl]thio]-N-[1-(2-methoxyethyl)-4-piperidinyl]-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1(4H)-quinolineacetamide

CAS Number:

412950-08-4

Molecular Formula:

C40H38F5N3O3S

Molecular Weight:

735.8050

MDL Number:

MFCD13195581

SMILES:

COCCN1CCC(CC1)N(C(=O)Cn1c(SCc2cccc(c2F)F)cc(=O)c2c1cccc2)Cc1ccc(cc1)c1ccc(cc1)C(F)(F)F

Properties

Storage:

-20 ℃;

Computed Properties

Complexity:

1200

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Rotatable Bond Count:

XLogP3:

8.1

Literature

Title: Darapladib, a lipoprotein-associated phospholipase A2 inhibitor, in diabetic macular edema: a 3-month placebo-controlled study.

Journal: Ophthalmology 20150501

Title: Lipoprotein-associated phospholipase A2 and risk of dementia in the Cardiovascular Health Study.

Journal: Atherosclerosis 20140801

Title: Plasma lipoprotein-associated phospholipase A2 activity in Alzheimer's disease, amnestic mild cognitive impairment, and cognitively healthy elderly subjects: a cross-sectional study.

Journal: Alzheimer's research & therapy 20120101

Title: Lipoprotein-associated phospholipase A(2) and atherosclerosis.

Journal: Current opinion in lipidology 20091001

Title: Anti-inflammatory properties of a platelet-activating factor acetylhydrolase.

Journal: Nature 19950406

Title: Shaddinger BC, et al. Platelet aggregation unchanged by lipoprotein-associated phospholipase A₂ inhibition: results from an in vitro study and two randomized phase I trials. PLoS One. 2014 Jan 27;9(1):e83094.

Title: Athanasios Papakyriakou, et al. Computational Investigation of Darapladib and Rilapladib Binding to Platelet Activating Factor Receptor. A Possible Mechanism of Their Involvement in Atherosclerosis. International Journal of Chemistry; Vol. 6, No. 1; 2014.

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