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4143-64-0,MFCD00017600
Catalog No.:AA003IEZ

4143-64-0 | 2-(3,4-Dihydroxyphenyl)-4H-chromen-4-one

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50mg
≥95%
in stock  
$58.00   $40.00
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100mg
≥95%
in stock  
$103.00   $72.00
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200mg
>97.0%(T)
in stock  
$157.00   $110.00
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1g
>97.0%(T)
in stock  
$467.00   $327.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003IEZ
Chemical Name:
2-(3,4-Dihydroxyphenyl)-4H-chromen-4-one
CAS Number:
4143-64-0
Molecular Formula:
C15H10O4
Molecular Weight:
254.2375
MDL Number:
MFCD00017600
SMILES:
Oc1ccc(cc1O)c1cc(=O)c2c(o1)cccc2
Properties
Properties
 
Form:
Solid  
MP:
251-253°C  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
390  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
2.8  

Downstream Synthesis Route

[1]Hiza,Aiki;Tsukaguchi,Yuta;Ogawa,Takahiro;Inai,Makoto;Asakawa,Tomohiro;Hamashima,Yoshitaka;Kan,Toshiyuki[Heterocycles,2014,vol.8,#2,p.1371-1396]

[1]Heterocycles,2014,vol.8,p.1371-1396

Literature

Title: Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression.

Journal: Chemico-biological interactions 20151205

Title: The O-methylation of chrysin markedly improves its intestinal anti-inflammatory properties: Structure-activity relationships of flavones.

Journal: Biochemical pharmacology 20131215

Title: Inhibition of platelet-mediated arterial thrombosis and platelet granule exocytosis by 3',4'-dihydroxyflavonol and quercetin.

Journal: Platelets 20130101

Title: Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening.

Journal: Journal of medicinal chemistry 20121011

Title: 3,3',4',5,5'-Pentahydroxyflavone is a potent inhibitor of amyloid β fibril formation.

Journal: Neuroscience letters 20120328

Title: Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.

Journal: Bioorganic & medicinal chemistry 20110501

Title: Characterization of an O-methyltransferase from Streptomyces avermitilis MA-4680.

Journal: Journal of microbiology and biotechnology 20100901

Title: 7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.

Journal: Journal of medicinal chemistry 20091112

Title: Flavonoid-induced morphological modifications of endothelial cells through microtubule stabilization.

Journal: Nutrition and cancer 20090101

Title: Iron-binding properties of plant phenolics and cranberry's bio-effects.

Journal: Dalton transactions (Cambridge, England : 2003) 20071121

Title: 3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.

Journal: Bioorganic & medicinal chemistry letters 20070301

Title: Evaluation of novel chromogenic substrates for the detection of bacterial beta-glucosidase.

Journal: Journal of applied microbiology 20070201

Title: The anti-apoptotic and anti-oxidant effect of eriodictyol on UV-induced apoptosis in keratinocytes.

Journal: Biological & pharmaceutical bulletin 20070101

Title: Spectroscopic and theoretical studies of the Zn(II) chelation with hydroxyflavones.

Journal: The journal of physical chemistry. A 20061116

Title: Influence of biotransformation of luteolin, luteolin 7-O-glucoside, 3',4'-dihydroxyflavone and apigenin by cultured rat hepatocytes on antioxidative capacity and inhibition of EGF receptor tyrosine kinase activity.

Journal: Planta medica 20060601

Title: Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids.

Journal: The Journal of biological chemistry 20050909

Title: Time dependent density functional theory study of electronic absorption properties of lead(II) complexes with a series of hydroxyflavones.

Journal: The journal of physical chemistry. A 20050804

Title: Stability of ferric complexes with 3-hydroxyflavone (flavonol), 5,7-dihydroxyflavone (chrysin), and 3',4'-dihydroxyflavone.

Journal: Journal of agricultural and food chemistry 20050420

Title: Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2.

Journal: Biochemical pharmacology 20050215

Title: Catecholic flavonoids acting as telomerase inhibitors.

Journal: Journal of medicinal chemistry 20041216

Title: 3',4'-Dihydroxyflavonol reduces infarct size and injury associated with myocardial ischaemia and reperfusion in sheep.

Journal: British journal of pharmacology 20040601

Title: The regioselectivity of glutathione adduct formation with flavonoid quinone/quinone methides is pH-dependent.

Journal: Chemical research in toxicology 20020301

Title: Complexes of Al(III) with 3'4'-dihydroxy-flavone: characterization, theoretical and spectroscopic study.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20010301

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Tags:4143-64-0 Molecular Formula|4143-64-0 MDL|4143-64-0 SMILES|4143-64-0 2-(3,4-Dihydroxyphenyl)-4H-chromen-4-one