Name: Name:Pyr-41
Brand: AABLOCKS
SKU: AA00C6ER
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00C6ER

Chemical Name: Pyr-41

CAS Number: 418805-02-4

Molecular Formula: C17H13N3O7

Molecular Weight: 371.3010

MDL Number: MFCD01469983

SMILES: CCOC(=O)c1ccc(cc1)N1NC(=O)C(=Cc2ccc(o2)[N+](=O)[O-])C1=O

NSC Number: 746131

Properties

Complexity: 664

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 1

Formal Charge: 0

Heavy Atom Count: 27

Hydrogen Bond Acceptor Count: 7

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 5

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 2.3

Literature fold

Title: Ubiquitin-activating enzyme E1 inhibitor PYR-41 retards sperm enlargement after fusion to the egg.

Journal: Reproductive toxicology (Elmsford, N.Y.)20180301

Title: Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.

Journal: Molecular neurobiology20161001

Title: Ziram and sodium N,N-dimethyldithiocarbamate inhibit ubiquitin activation through intracellular metal transport and increased oxidative stress in HEK293 cells.

Journal: Chemical research in toxicology20150420

Title: Ubiquitin-activating enzyme E1 inhibitor PYR41 attenuates angiotensin II-induced activation of dendritic cells via the IκBa/NF-κB and MKP1/ERK/STAT1 pathways.

Journal: Immunology20140601

Title: Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage.

Journal: Cell cycle (Georgetown, Tex.)20120415

Title: Ubiquitin-activating enzyme (UBA1) is required for sperm capacitation, acrosomal exocytosis and sperm-egg coat penetration during porcine fertilization.

Journal: International journal of andrology20120401

Title: Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA.

Journal: PLoS biology20111001

Title: Protein cross-linking as a novel mechanism of action of a ubiquitin-activating enzyme inhibitor with anti-tumor activity.

Journal: Biochemical pharmacology20110815

Title: The cell senescence inducing gene product MORF4 is regulated by degradation via the ubiquitin/proteasome pathway.

Journal: Experimental cell research20100101

Title: Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.

Journal: Cancer research20071001

Title: Yang Y, et al. Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Res. 2007 Oct 1;67(19):9472-81.

Title: Kapuria V, et al. Protein cross-linking as a novel mechanism of action of a ubiquitin-activating enzyme inhibitor with anti-tumor activity. Biochem Pharmacol. 2011 Aug 15;82(4):341-9.

418805-02-4 | Pyr-41