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423169-68-0,MFCD00951253
Catalog No.:AA00C985

423169-68-0 | SC 57461A

Pack Size
Purity
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Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$156.00   $109.00
- +
10mg
≥98%
in stock  
$242.00   $169.00
- +
25mg
98% by HPLC
in stock  
$473.00   $331.00
- +
50mg
98% by HPLC
in stock  
$761.00   $533.00
- +
100mg
98% by HPLC
in stock  
$1,270.00   $889.00
- +
500mg
98% by HPLC
in stock  
$3,958.00   $2,771.00
- +
1000mg
98% by HPLC
in stock  
$6,295.00   $4,407.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C985
Chemical Name:
SC 57461A
CAS Number:
423169-68-0
Molecular Formula:
C20H26ClNO3
Molecular Weight:
363.8783
MDL Number:
MFCD00951253
SMILES:
CN(CCC(=O)O)CCCOc1ccc(cc1)Cc1ccccc1.Cl
Properties
Properties
 
Form:
Solid  
MP:
163-165°C  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
347  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
10  

Literature

Title: QSAR, docking studies and pharmacophore identification of phenylmethyl phenoxy propyl amino propanoic acid derivatives as leukotriene A4 hydrolase inhibitors.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100501

Title: Arachidonic acid activates phospholipase D in human neutrophils; essential role of endogenous leukotriene B4 and inhibition by adenosine A2A receptor engagement.

Journal: Journal of leukocyte biology 20030401

Title: Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase.

Journal: Bioorganic & medicinal chemistry letters 20021202

Title: Synthesis of potent leukotriene A(4) hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid.

Journal: Journal of medicinal chemistry 20020801

Title: Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase I: in vitro studies.

Journal: The Journal of pharmacology and experimental therapeutics 20020201

Title: Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase II: in vivo studies.

Journal: The Journal of pharmacology and experimental therapeutics 20020201

Title: Inhibitors of leukotriene A4 (LTA4) hydrolase as potential anti-inflammatory agents.

Journal: Current pharmaceutical design 20010201

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