Home Nitro Compounds 42397-64-8
42397-64-8,MFCD00010494
Catalog No.:AA003DOL

42397-64-8 | 1,6-Dinitropyrene

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Technical Information
Catalog Number:
AA003DOL
Chemical Name:
1,6-Dinitropyrene
CAS Number:
42397-64-8
Molecular Formula:
C16H8N2O4
Molecular Weight:
292.2457
MDL Number:
MFCD00010494
SMILES:
[O-][N+](=O)c1ccc2c3c1ccc1c3c(cc2)c(cc1)[N+](=O)[O-]
Properties
Computed Properties
 
Complexity:
442  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
XLogP3:
4.7  

Literature

Title: Mechanistic Investigations Into the Developmental Toxicity of Nitrated and Heterocyclic PAHs.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20170501

Title: A new imidazolium-embedded C18 stationary phase with enhanced performance in reversed-phase liquid chromatography.

Journal: Analytica chimica acta 20120813

Title: Environmental nitration processes enhance the mutagenic potency of aromatic compounds.

Journal: Environmental toxicology 20120501

Title: Metabolic activation of diesel exhaust carcinogens in primary and immortalized human TP53 knock-in (Hupki) mouse embryo fibroblasts.

Journal: Environmental and molecular mutagenesis 20120401

Title: Health and cellular impacts of air pollutants: from cytoprotection to cytotoxicity.

Journal: Biochemistry research international 20120101

Title: Impact of a NO₂-regenerated diesel particulate filter on PAH and NPAH emissions from an EURO IV heavy duty engine.

Journal: Journal of environmental monitoring : JEM 20111201

Title: Nitroarenes (selected): 1,6-Dinitropyrene.

Journal: Report on carcinogens : carcinogen profiles 20110101

Title: Mutagenicity of surface soil from residential areas in Kyoto city, Japan, and identification of major mutagens.

Journal: Mutation research 20080108

Title: Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis: possible implications for their mutagenic and carcinogenic effects.

Journal: Toxicology 20070307

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: Nitrocompound activation by cell-free extracts of nitroreductase-proficient Salmonella typhimurium strains.

Journal: Mutagenesis 20061101

Title: In vivo mutagenesis in the lungs of gpt-delta transgenic mice treated intratracheally with 1,6-dinitropyrene.

Journal: Environmental and molecular mutagenesis 20060501

Title: Oxidative DNA damage induced by carcinogenic dinitropyrenes in the presence of P450 reductase.

Journal: Chemical research in toxicology 20041201

Title: Nitroarenes (selected) 1,6-dinitropyrene.

Journal: Report on carcinogens : carcinogen profiles 20040101

Title: Mutagenic activity and quantification of nitroarenes in surface soil in the Kinki region of Japan.

Journal: Mutation research 20030708

Title: Improvement of an automatic HPLC system for nitropolycyclic aromatic hydrocarbons: removal of an interfering peak and increase in the number of analytes.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20030201

Title: Comparative mutagenesis of the C8-guanine adducts of 1-nitropyrene and 1,6- and 1,8-dinitropyrene in a CpG repeat sequence. A slipped frameshift intermediate model for dinucleotide deletion.

Journal: The Journal of biological chemistry 20021122

Title: Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences.

Journal: Archives of toxicology 20020601

Title: Salmonella typhimurium mutagenicity tester strains that overexpress oxygen-insensitive nitroreductases nfsA and nfsB.

Journal: Mutation research 20020425

Title: DNA adducts from nitroreduction of 2,7-dinitrofluorene, a mammary gland carcinogen, catalyzed by rat liver or mammary gland cytosol.

Journal: Chemical research in toxicology 20020401

Title: Dinitropyrenes induce gene mutations in multiple organs of the lambda/lacZ transgenic mouse (Muta Mouse).

Journal: Mutation research 20020325

Title: Nitroarenes (selected). 1,6-Dinitropyrene.

Journal: Report on carcinogens : carcinogen profiles 20020101

Title: Cellular determinants of the mutational specificity of 1-nitroso-6-nitropyrene and 1-nitroso-8-nitropyrene in the lacI gene of Escherichia coli.

Journal: Mutation research 20011212

Title: [Suppression of frameshift mutation as a result of partial inactivation of translation termination factors in Saccharomyces cerevisiae yeast].

Journal: Genetika 20010501

Title: Cytochrome P450 induction by nitrated polycyclic aromatic hydrocarbons, azaarenes, and binary mixtures in fish hepatoma cell line PLHC-1.

Journal: Environmental toxicology and chemistry 20010101

Title: Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1.

Journal: Mutation research 20001220

Title: Carcinogenicity of nitropyrenes in the newborn female rat.

Journal: Carcinogenesis 19951201

Title: Toxicity of monocyclic and polycyclic nitroaromatic compounds in a panel of mammalian test cell lines.

Journal: Toxicology letters 19940601

Title: Comparative reduction of 1-nitro-3-nitrosopyrene and 1-nitro-6-nitrosopyrene: implications for the tumorigenicity of dinitropyrenes.

Journal: Cancer letters 19920731

Title: Decreased clastogenicity of dinitropyrenes in Chinese hamster lung (CHL) subclone cells with low NADPH-cytochrome P-450 reductase activity.

Journal: Mutation research 19910901

Title: Carcinogenicity of dinitropyrenes in the weanling female CD rat.

Journal: Carcinogenesis 19910701

Title: Purified NAD(P)H-quinone oxidoreductase enhances the mutagenicity of dinitropyrenes in vitro.

Journal: Journal of biochemical toxicology 19910101

Title: Inactivation of 1,3-, 1,6-, and 1,8-dinitropyrene by cytochrome P-450 enzymes in human and rat liver microsomes.

Journal: Cancer research 19900401

Title: Metabolism and biological effects of nitropyrene and related compounds.

Journal: Research report (Health Effects Institute) 19880201

Title: Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene, chrysene and benzo[a]pyrene in the newborn mouse assay.

Journal: Carcinogenesis 19860801

Title: Dinitro derivatives of pyrene and fluoranthene in diesel emission particulates and their tumorigenicity in mice and rats.

Journal: Developments in toxicology and environmental science 19860101

Title: Carcinogenic effects of a mixture of nitropyrenes in F344 rats following its repeated oral administrations.

Journal: Developments in toxicology and environmental science 19860101

Title: Induction of 6-thioguanine resistance, chromosome aberrations and SCE by dinitropyrenes in Chinese hamster ovary cells in vitro.

Journal: Mutation research 19851201

Title: Absence of carcinogenicity of 1-nitropyrene, correction of previous results, and new demonstration of carcinogenicity of 1,6-dinitropyrene in rats.

Journal: Cancer letters 19850101

Title: Tumor initiating activities of 1-nitropyrene and its nitrated products in SENCAR mice.

Journal: Cancer letters 19840501

Title: Mutagenicity of mono-, di- and tri-nitropyrenes in Chinese hamster ovary cells.

Journal: Mutation research 19830301

Title: The clastogenic activity of dinitropyrenes in a rat-liver epithelial cell line.

Journal: Mutation research 19821101

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