Home Nitro Compounds 42397-65-9
42397-65-9,MFCD00010495
Catalog No.:AA003DPE

42397-65-9 | 1,8-Dinitropyrene

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Technical Information
Catalog Number:
AA003DPE
Chemical Name:
1,8-Dinitropyrene
CAS Number:
42397-65-9
Molecular Formula:
C16H8N2O4
Molecular Weight:
292.2457
MDL Number:
MFCD00010495
SMILES:
[O-][N+](=O)c1ccc2c3c1ccc1c3c(cc2)ccc1[N+](=O)[O-]
Properties
Properties
 
Storage:
2-8℃;  

Computed Properties
 
Complexity:
442  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
XLogP3:
4.7  

Literature

Title: Mechanistic Investigations Into the Developmental Toxicity of Nitrated and Heterocyclic PAHs.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20170501

Title: Classification of polycyclic aromatic hydrocarbons based on mutagenicity in lung tissue through DNA microarray.

Journal: Environmental toxicology 20131101

Title: A new imidazolium-embedded C18 stationary phase with enhanced performance in reversed-phase liquid chromatography.

Journal: Analytica chimica acta 20120813

Title: Environmental nitration processes enhance the mutagenic potency of aromatic compounds.

Journal: Environmental toxicology 20120501

Title: Metabolic activation of diesel exhaust carcinogens in primary and immortalized human TP53 knock-in (Hupki) mouse embryo fibroblasts.

Journal: Environmental and molecular mutagenesis 20120401

Title: Genetic requirement for mutagenesis of the G[8,5-Me]T cross-link in Escherichia coli: DNA polymerases IV and V compete for error-prone bypass.

Journal: Biochemistry 20110329

Title: Nitroarenes (selected): 1,8-Dinitropyrene.

Journal: Report on carcinogens : carcinogen profiles 20110101

Title: Mutagenicity of surface soil from residential areas in Kyoto city, Japan, and identification of major mutagens.

Journal: Mutation research 20080108

Title: Mutagenicity of the 1-nitropyrene-DNA adduct N-(deoxyguanosin-8-yl)-1-aminopyrene in mammalian cells.

Journal: Chemical research in toxicology 20071101

Title: Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis: possible implications for their mutagenic and carcinogenic effects.

Journal: Toxicology 20070307

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: Nitrocompound activation by cell-free extracts of nitroreductase-proficient Salmonella typhimurium strains.

Journal: Mutagenesis 20061101

Title: Detection of a novel mutagen, 3,6-dinitrobenzo[e]pyrene, as a major contaminant in surface soil in Osaka and Aichi Prefectures, Japan.

Journal: Chemical research in toxicology 20050201

Title: Oxidative DNA damage induced by carcinogenic dinitropyrenes in the presence of P450 reductase.

Journal: Chemical research in toxicology 20041201

Title: Nitroarenes (selected) 1,8-dinitropyrene.

Journal: Report on carcinogens : carcinogen profiles 20040101

Title: Mutagenic activity and quantification of nitroarenes in surface soil in the Kinki region of Japan.

Journal: Mutation research 20030708

Title: Comparative mutagenesis of the C8-guanine adducts of 1-nitropyrene and 1,6- and 1,8-dinitropyrene in a CpG repeat sequence. A slipped frameshift intermediate model for dinucleotide deletion.

Journal: The Journal of biological chemistry 20021122

Title: Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences.

Journal: Archives of toxicology 20020601

Title: Dinitropyrenes induce gene mutations in multiple organs of the lambda/lacZ transgenic mouse (Muta Mouse).

Journal: Mutation research 20020325

Title: Induction of sister chromatid exchanges and chromosome aberrations in cultured mammalian cells treated with aminophenylnorharman formed by norharman with aniline.

Journal: Mutation research 20020325

Title: Nitroarenes (selected). 1,8-Dinitropyrene.

Journal: Report on carcinogens : carcinogen profiles 20020101

Title: Catechins are not major components responsible for anti-genotoxic effects of tea extracts against nitroarenes.

Journal: Mutation research 20010920

Title: [Suppression of frameshift mutation as a result of partial inactivation of translation termination factors in Saccharomyces cerevisiae yeast].

Journal: Genetika 20010501

Title: Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1.

Journal: Mutation research 20001220

Title: Carcinogenicity of nitropyrenes in the newborn female rat.

Journal: Carcinogenesis 19951201

Title: Decreased clastogenicity of dinitropyrenes in Chinese hamster lung (CHL) subclone cells with low NADPH-cytochrome P-450 reductase activity.

Journal: Mutation research 19910901

Title: Carcinogenicity of dinitropyrenes in the weanling female CD rat.

Journal: Carcinogenesis 19910701

Title: Purified NAD(P)H-quinone oxidoreductase enhances the mutagenicity of dinitropyrenes in vitro.

Journal: Journal of biochemical toxicology 19910101

Title: 1,8-Dinitropyrene: comparative mutagenicity in Chinese hamster V79 and CHO cells.

Journal: Mutagenesis 19900501

Title: Inactivation of 1,3-, 1,6-, and 1,8-dinitropyrene by cytochrome P-450 enzymes in human and rat liver microsomes.

Journal: Cancer research 19900401

Title: Metabolism and biological effects of nitropyrene and related compounds.

Journal: Research report (Health Effects Institute) 19880201

Title: Tumorigenicity test of 1,3- and 1,8-dinitropyrene in BALB/c mice.

Journal: Journal of the National Cancer Institute 19870701

Title: Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene, chrysene and benzo[a]pyrene in the newborn mouse assay.

Journal: Carcinogenesis 19860801

Title: Structure of the c-Ki-ras gene in a rat fibrosarcoma induced by 1,8-dinitropyrene.

Journal: Molecular and cellular biology 19860401

Title: Dinitro derivatives of pyrene and fluoranthene in diesel emission particulates and their tumorigenicity in mice and rats.

Journal: Developments in toxicology and environmental science 19860101

Title: Carcinogenic effects of a mixture of nitropyrenes in F344 rats following its repeated oral administrations.

Journal: Developments in toxicology and environmental science 19860101

Title: Induction of 6-thioguanine resistance, chromosome aberrations and SCE by dinitropyrenes in Chinese hamster ovary cells in vitro.

Journal: Mutation research 19851201

Title: Activation of K-ras and oncogenes other than ras family in rat fibrosarcomas induced by 1,8-dinitropyrene.

Journal: Cancer letters 19851101

Title: DNA adduct formation and mutation induction by nitropyrenes in Salmonella and Chinese hamster ovary cells: relationships with nitroreduction and acetylation.

Journal: Environmental health perspectives 19851001

Title: Absence of carcinogenicity of 1-nitropyrene, correction of previous results, and new demonstration of carcinogenicity of 1,6-dinitropyrene in rats.

Journal: Cancer letters 19850101

Title: Induction of sarcomas in rats by subcutaneous injection of dinitropyrenes.

Journal: Carcinogenesis 19840501

Title: Tumor initiating activities of 1-nitropyrene and its nitrated products in SENCAR mice.

Journal: Cancer letters 19840501

Title: Mutagenicity of mono-, di- and tri-nitropyrenes in Chinese hamster ovary cells.

Journal: Mutation research 19830301

Title: Nitration of carcinogenic and non-carcinogenic polycyclic aromatic hydrocarbons results in products able to induce transformation of Syrian hamster cells.

Journal: Carcinogenesis 19830101

Title: The clastogenic activity of dinitropyrenes in a rat-liver epithelial cell line.

Journal: Mutation research 19821101

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