Home Other Building Blocks 426834-69-7
426834-69-7,MFCD18432708
Catalog No.:AA00CMIY

426834-69-7 | NS 5806

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$53.00   $37.00
- +
5mg
≥98%
in stock  
$203.00   $142.00
- +
10mg
98% by HPLC
in stock  
$335.00   $234.00
- +
25mg
98% by HPLC
in stock  
$637.00   $446.00
- +
50mg
98% by HPLC
in stock  
$1,040.00   $728.00
- +
100mg
98% by HPLC
in stock  
$1,752.00   $1,227.00
- +
500mg
98% by HPLC
in stock  
$5,515.00   $3,861.00
- +
1000mg
98% by HPLC
in stock  
$8,787.00   $6,151.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00CMIY
Chemical Name:
NS 5806
CAS Number:
426834-69-7
Molecular Formula:
C16H8Br2F6N6O
Molecular Weight:
574.0727
MDL Number:
MFCD18432708
SMILES:
O=C(Nc1c(Br)cc(cc1c1[nH]nnn1)Br)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Properties
Computed Properties
 
Complexity:
619  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
4.8  

Literature

Title: Comparison of the effects of a transient outward potassium channel activator on currents recorded from atrial and ventricular cardiomyocytes.

Journal: Journal of cardiovascular electrophysiology 20110901

Title: Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2.

Journal: British journal of pharmacology 20100801

Title: Differential effects of the transient outward K(+) current activator NS5806 in the canine left ventricle.

Journal: Journal of molecular and cellular cardiology 20100101

Title: A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome.

Journal: Cardiovascular research 20090301

Title: Lundby A, et al. Effect of the I(to) activator NS5806 on cloned KV4 channels depends on the accessory protein KChIP2. Br J Pharmacol. 2010 Aug;160(8):2028-44. doi: 10.1111/j.1476-5381.2010.00859.x.

Title: Cheng H, et al. Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Itomodulator NS5806. Physiol Rep. 2017 Mar;5(5). pii: e13172.

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