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42971-09-5,MFCD00211233
Catalog No.:AA00I87C

42971-09-5 | Vinpocetine

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250mg
98%
in stock  
$11.00   $8.00
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1g
98%
in stock  
$17.00   $12.00
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5g
98%
in stock  
$42.00   $29.00
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10g
98%
in stock  
$51.00   $36.00
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25g
98%
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$124.00   $87.00
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100g
98%
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$494.00   $346.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I87C
Chemical Name:
Vinpocetine
CAS Number:
42971-09-5
Molecular Formula:
C22H26N2O2
Molecular Weight:
350.4540
MDL Number:
MFCD00211233
SMILES:
CCOC(=O)C1=C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3
NSC Number:
760093
Properties
Computed Properties
 
Complexity:
617  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
4.1  

Literature

Title: Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines and NF-κB.

Journal: Chemico-biological interactions 20150725

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Vinpocetine suppresses pathological vascular remodeling by inhibiting vascular smooth muscle cell proliferation and migration.

Journal: The Journal of pharmacology and experimental therapeutics 20121101

Title: Vinpocetine inhibits breast cancer cells growth in vitro and in vivo.

Journal: Apoptosis : an international journal on programmed cell death 20121001

Title: Various phosphodiesterase activities in different regions of the heart alter the cardiac effects of nitric oxide.

Journal: Journal of cardiovascular pharmacology 20120901

Title: Early alcohol exposure disrupts visual cortex plasticity in mice.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20120801

Title: Nano-advantage in enhanced drug delivery with biodegradable nanoparticles: contribution of reduced clearance.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120701

Title: [Comment on the paper by A. Valikovics et al. 'The effect of vinpocetin on cognitive function' published in the issue 3-4 of this year].

Journal: Ideggyogyaszati szemle 20120530

Title: Chemical evolution of autotaxin inhibitors.

Journal: Chemical reviews 20120509

Title: The facilitating effect of prucalopride on cholinergic neurotransmission in pig gastric circular muscle is regulated by phosphodiesterase 4.

Journal: Neuropharmacology 20120401

Title: [The observation on curative effect of 90 cases of sudden hearing loss].

Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 20120401

Title: Chiral separation of vinpocetine using cyclodextrin-modified micellar electrokinetic chromatography.

Journal: Chirality 20120301

Title: Visualising neuroinflammation in post-stroke patients: a comparative PET study with the TSPO molecular imaging biomarkers [11C]PK11195 and [11C]vinpocetine.

Journal: Current radiopharmaceuticals 20120101

Title: Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery.

Journal: Journal of drug delivery 20120101

Title: Clinical utility of adjunctive retigabine in partial onset seizures in adults.

Journal: Therapeutics and clinical risk management 20120101

Title: Psychiatric symptoms of patients with primary mitochondrial DNA disorders.

Journal: Behavioral and brain functions : BBF 20120101

Title: Expression of calmodulin and myosin light chain kinase during larval settlement of the Barnacle Balanus amphitrite.

Journal: PloS one 20120101

Title: Role Ca(2+) in mechanisms of the red blood cells microrheological changes.

Journal: Advances in experimental medicine and biology 20120101

Title: Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Vinpocetine inhibits oligodendroglial precursor cell differentiation.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Title: Acute administration of vinpocetine, a phosphodiesterase type 1 inhibitor, ameliorates hyperactivity in a mice model of fetal alcohol spectrum disorder.

Journal: Drug and alcohol dependence 20111201

Title: cGMP Signaling, Phosphodiesterases and Major Depressive Disorder.

Journal: Current neuropharmacology 20111201

Title: Effect of pentoxifylline and vinpocetine on the healing of ischemic colon anastomosis: an experimental study.

Journal: Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 20111101

Title: Vinpocetine inhibits glutamate release induced by the convulsive agent 4-aminopyridine more potently than several antiepileptic drugs.

Journal: Epilepsy research 20111001

Title: Influence of admixed citric acid and physiological variables on the vinpocetine release from sodium alginate compressed matrix tablets.

Journal: Drug development and industrial pharmacy 20110801

Title: Enhanced oral bioavailability of vinpocetine through mechanochemical salt formation: physico-chemical characterization and in vivo studies.

Journal: Pharmaceutical research 20110801

Title: Age and disease related changes in the translocator protein (TSPO) system in the human brain: positron emission tomography measurements with [11C]vinpocetine.

Journal: NeuroImage 20110601

Title: Oxidative stress in a model of toxic demyelination in rat brain: the effect of piracetam and vinpocetine.

Journal: Neurochemical research 20110601

Title: Regulatory mechanism of duodenal bicarbonate secretion: Roles of endogenous prostaglandins and nitric oxide.

Journal: Pharmacology & therapeutics 20110401

Title: Preventive effect of piracetam and vinpocetine on hypoxia-reoxygenation induced injury in primary hippocampal culture.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110401

Title: [Interdisciplinary approach to vestibular system impairment].

Journal: Ideggyogyaszati szemle 20110330

Title: Multidisciplinary approach on characterizing a mechanochemically activated composite of vinpocetine and crospovidone.

Journal: Journal of pharmaceutical sciences 20110301

Title: Conserved expression and functions of PDE4 in rodent and human heart.

Journal: Basic research in cardiology 20110301

Title: Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1.

Journal: Hypertension (Dallas, Tex. : 1979) 20110301

Title: S-Petasin, the Main Sesquiterpene of Petasites formosanus, Inhibits Phosphodiesterase Activity and Suppresses Ovalbumin-Induced Airway Hyperresponsiveness.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Novel sugar esters proniosomes for transdermal delivery of vinpocetine: preclinical and clinical studies.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110101

Title: Therapeutic utility of phosphodiesterase type I inhibitors in neurological conditions.

Journal: Frontiers in neuroscience 20110101

Title: Hyperbaric oxygen therapy in idiopathic sudden sensorineural hearing loss (ISSNHL) in association with combined treatment.

Journal: Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc 20110101

Title: Identification of cytosolic phosphodiesterases in the erythrocyte: a possible role for PDE5.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20110101

Title: [The use of vinpotropile in brain ischemia].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

Title: Preparation and in vitro/in vivo evaluation of vinpocetine elementary osmotic pump system.

Journal: Advances in pharmacological sciences 20110101

Title: Reversing brain damage in former NFL players: implications for traumatic brain injury and substance abuse rehabilitation.

Journal: Journal of psychoactive drugs 20110101

Title: [Endothelium-protective effects of vinpocetine, pentoxifylline and enalapril in patients with chronic brain ischemia].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20110101

Title: Role of vinpocetine in cerebrovascular diseases.

Journal: Pharmacological reports : PR 20110101

Title: Red blood cell aggregation changes are depended on its initial value: Effect of long-term drug treatment and short-term cell incubation with drug.

Journal: Clinical hemorheology and microcirculation 20110101

Title: Effect of five common anticonvulsant drugs on naloxone-precipitated morphine withdrawal in mice.

Journal: Research in pharmaceutical sciences 20110101

Title: In situ formation of nanocrystals from a self-microemulsifying drug delivery system to enhance oral bioavailability of fenofibrate.

Journal: International journal of nanomedicine 20110101

Title: Pentoxifylline sensitizes human cervical tumor cells to cisplatin-induced apoptosis by suppressing NF-kappa B and decreased cell senescence.

Journal: BMC cancer 20110101

Title: Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.

Journal: Journal of biomedical science 20110101

Title: Omeprazole does not change the oral bioavailability or pharmacokinetics of vinpocetine in rats.

Journal: Pharmacological reports : PR 20110101

Title: Macro- and microrheological parameters of blood in patients with cerebral and peripheral atherosclerosis: the molecular change mechanisms after pentoxifylline treatment.

Journal: Clinical hemorheology and microcirculation 20110101

Title: Fabrication, appraisal, and transdermal permeation of sildenafil citrate-loaded nanostructured lipid carriers versus solid lipid nanoparticles.

Journal: International journal of nanomedicine 20110101

Title: [Potentials of the neuroprotective treatment of polymodal action in acute and early rehabilitation period of stroke].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

Title: Separation of vinca alkaloid enantiomers by capillary electrophoresis applying cyclodextrin derivatives and characterization of cyclodextrin complexes by nuclear magnetic resonance spectroscopy.

Journal: Journal of pharmaceutical and biomedical analysis 20101215

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Preparation and characterization of vinpocetine loaded nanostructured lipid carriers (NLC) for improved oral bioavailability.

Journal: International journal of pharmaceutics 20100715

Title: Determination of vinpocetine and its primary metabolite, apovincaminic acid, in rat plasma by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100715

Title: Antinociceptive effect of vinpocetine--a comprehensive survey.

Journal: Ideggyogyaszati szemle 20100530

Title: Phosphodiesterase type 1 inhibition improves learning in rats exposed to alcohol during the third trimester equivalent of human gestation.

Journal: Neuroscience letters 20100412

Title: Recent advances in adjunctive therapy for epilepsy: focus on sodium channel blockers as third-generation antiepileptic drugs.

Journal: Drugs of today (Barcelona, Spain : 1998) 20100401

Title: Prostaglandin EP receptor subtypes involved in regulating HCO(3)(-) secretion from gastroduodenal mucosa.

Journal: Current pharmaceutical design 20100101

Title: Effects of rolipram on U46619-induced contraction and cyclic nucleotide content in the porcine coronary artery.

Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20100101

Title: [Possibilities of preventive treatment of Alzheimer's disease: results of the 3-year open prospective comparative study on efficacy and safety of the course therapy with cerebrolysin and cavinton in elderly patients with the syndrome of mild cognitive impairment].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

Title: Sensitization of cervix cancer cells to Adriamycin by Pentoxifylline induces an increase in apoptosis and decrease senescence.

Journal: Molecular cancer 20100101

Title: [Approaches to the therapy of neurological presentations in diabetes mellitus].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

Title: [Electrophoresis of vasoactive drugs in the treatment and rehabilitation of patients with cerebral ischemic diseases].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

Title: Crosstalk between adenylyl cyclase signaling pathway and Ca2+ regulatory mechanism under red blood cell microrheological changes.

Journal: Clinical hemorheology and microcirculation 20100101

Title: [Chronic disorders of cerebral blood circulation: possibilities of the use of cavinton].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

Title: Solid State Characterization of Domperidone: Hydroxypropyl-β-Cyclodextrin Inclusion Complex.

Journal: Indian journal of pharmaceutical sciences 20100101

Title: Recent advances in management of bladder overactivity.

Journal: F1000 medicine reports 20100101

Title: Preparation and in vitro/in vivo characterization of porous sublingual tablets containing ternary kneaded solid system of vinpocetine with î-cyclodextrin and hydroxy Acid.

Journal: Scientia pharmaceutica 20100101

Title: [Efficacy of vinpotropile in the therapy of initial signs of cerebrovascular pathology].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

Title: [Vinpotropil in the treatment of dyscirculatory encephalopathy with cognitive impairment without dementia].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

Title: [Efficacy of cavinton in the treatment of patients with chronic blood flow insufficiency. Russian multicenter clinical-epidemiological program 'CALIPSO'].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

Title: [Polymorphic effects of cavinton: experimental and clinical evidence].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

Title: [The use of cavinton and cerebrolusin in the preventive therapy of Alzheimer's disease].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

Title: Optimized preparation of vinpocetine proliposomes by a novel method and in vivo evaluation of its pharmacokinetics in New Zealand rabbits.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20091116

Title: A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel.

Journal: Analytical biochemistry 20091101

Title: Calcium-dependent phosphodiesterase 1C inhibits renin release from isolated juxtaglomerular cells.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20091101

Title: Effects of various selective phosphodiesterase inhibitors on relaxation and cyclic nucleotide contents in porcine iris sphincter.

Journal: The Journal of veterinary medical science 20091101

Title: The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue.

Journal: European journal of pharmacology 20091012

Title: Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine -- a PDE1 inhibitor.

Journal: European journal of pharmacology 20091012

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: [Significance of phosphodiesterase isoenzymes in the control of human detrusor smooth muscle function. An immunohistochemical and functional study].

Journal: Der Urologe. Ausg. A 20090701

Title: Effects of phosphodiesterase inhibitors on contraction induced by endothelin-1 of isolated human prostatic tissue.

Journal: Urology 20090601

Title: Comparison of self-microemulsifying drug delivery system versus solid dispersion technology used in the improvement of dissolution rate and bioavailability of vinpocetine.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090601

Title: Preparation and evaluation of self-microemulsifying drug delivery system containing vinpocetine.

Journal: Drug development and industrial pharmacy 20090501

Title: Characterization of phosphodiesterase 1 in human malignant melanoma cell lines.

Journal: Anticancer research 20090401

Title: Characterization of phenytoin, carbamazepine, vinpocetine and clorgyline simultaneous effects on sodium channels and catecholamine metabolism in rat striatal nerve endings.

Journal: Neurochemical research 20090301

Title: Effect of parenteral or oral vinpocetine on the hemorheological parameters of patients with chronic cerebrovascular diseases.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20090301

Title: Effects of phosphodiesterase inhibitors on the contractile responses of isolated human seminal vesicle tissue to adrenergic stimulation.

Journal: The journal of sexual medicine 20090201

Title: Selective phosphodiesterase inhibitors: a promising target for cognition enhancement.

Journal: Psychopharmacology 20090101

Title: A novel PDE2A reporter cell line: characterization of the cellular activity of PDE inhibitors.

Journal: Molecular pharmaceutics 20090101

Title: Examination of a pre-exercise, high energy supplement on exercise performance.

Journal: Journal of the International Society of Sports Nutrition 20090101

Title: [Efficacy of dynamic magnetic therapy in the complex treatment of cognitive disturbances in patients with chronic cerebrovascular insufficiency].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

Title: Neuroprotective effects of vinpocetine and its major metabolite cis-apovincaminic acid on NMDA-induced neurotoxicity in a rat entorhinal cortex lesion model.

Journal: CNS neuroscience & therapeutics 20090101

Title: Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity.

Journal: Molecular systems biology 20090101

Title: Phosphodiesterase inhibition increases CREB phosphorylation and restores orientation selectivity in a model of fetal alcohol spectrum disorders.

Journal: PloS one 20090101

Title: [Effect of cavinton forte on the cerebral hemodynamic and autoregulation mechanisms of cerebral blood flow in patients with chronic cerebral ischemia].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

Title: [Cavinton in the complex treatment of patients with chronic cerebrovascular insufficiency].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

Title: [A multicenter program on assessment of efficacy and safety of a new therapeutic scheme for patients with chronic cerebrovascular insufficiency].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

Title: [Selective trabeculoplasty in combination with vasoactive agents in the complex treatment of primary open-angle glaucoma].

Journal: Vestnik oftalmologii 20090101

Title: [Membrane and functional effects of vinpocetine and tocopherol in rats with experimental cerebral ischemia].

Journal: Biomeditsinskaia khimiia 20090101

Title: [Cavinton in the treatment of cochleovestibular disorders of vascular genesis].

Journal: Vestnik otorinolaringologii 20090101

Title: [The new scheme of cavinton application to the treatment of chronic neurosensory loss of hearing].

Journal: Vestnik otorinolaringologii 20090101

Title: [The use of cavinton in the therapy of cognitive disorders in patients with discirculatory encephalopathy].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

Title: [Positron-emission tomography in the diagnosis of middle cerebral artery lesions].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

Title: Effects of Vinpocetine on mitochondrial function and neuroprotection in primary cortical neurons.

Journal: Neurochemistry international 20081201

Title: Development and validation of an adsorptive stripping voltammetric method for the quantification of vincamine in its formulations and human serum using a Nujol-based carbon paste electrode.

Journal: Chemical & pharmaceutical bulletin 20081201

Title: ABCD of the phosphodiesterase family: interaction and differential activity in COPD.

Journal: International journal of chronic obstructive pulmonary disease 20081201

Title: Comparison of acute, chronic and post-treatment effects of carbamazepine and vinpocetine on hearing loss and seizures induced by 4-aminopyridine.

Journal: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20081101

Title: Neuropharmacology.

Journal: Indian journal of pharmacology 20081001

Title: Phosphodiesterase isozymes involved in regulation of formula secretion in isolated mouse stomach in vitro.

Journal: The Journal of pharmacology and experimental therapeutics 20080901

Title: Muscarinic receptor M1 and phosphodiesterase 1 are key determinants in pulmonary vascular dysfunction following perinatal hypoxia in mice.

Journal: American journal of physiology. Lung cellular and molecular physiology 20080701

Title: Bi-layered self-emulsifying pellets prepared by co-extrusion and spheronization: influence of formulation variables and preliminary study on the in vivo absorption.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080601

Title: Optimized preparation of in situ forming microparticles for the parenteral delivery of vinpocetine.

Journal: Chemical & pharmaceutical bulletin 20080601

Title: Reversal of tolerance to nitroglycerin with vinpocetine: a role of calcitonin gene-related peptide.

Journal: International journal of cardiology 20080425

Title: Molecular pharmacology of adipocyte-secreted autotaxin.

Journal: Chemico-biological interactions 20080327

Title: Percutaneous permeation enhancement by terpenes: mechanistic view.

Journal: The AAPS journal 20080301

Title: Synthesis and evaluation of 2'-hydroxyethyl trans-apovincaminate derivatives as antioxidant and cognitive enhancer agents.

Journal: Journal of medicinal chemistry 20080214

Title: Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.

Journal: Journal of medicinal chemistry 20080124

Title: Vinpocetine for acute ischaemic stroke.

Journal: The Cochrane database of systematic reviews 20080123

Title: Functional neuroimaging in multiple sclerosis with radiolabelled glia markers: preliminary comparative PET studies with [11C]vinpocetine and [11C]PK11195 in patients.

Journal: Journal of the neurological sciences 20080115

Title: Changes at the focus of experimental ischemic stroke treated with neuroprotective agents.

Journal: Neuroscience and behavioral physiology 20080101

Title: Self-microemulsifying drug delivery system (SMEDDS) of vinpocetine: formulation development and in vivo assessment.

Journal: Biological & pharmaceutical bulletin 20080101

Title: Mitigation of nociception via transganglionic degenerative atrophy: possible mechanism of vinpocetine-induced blockade of retrograde axoplasmic transport.

Journal: Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 20080101

Title: [Diagnostics and treatment tactics for chronic cerebrovascular disorders with the use of single photon emission computed tomography].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

Title: Multimodal therapy for chronic tinnitus.

Journal: The international tinnitus journal 20080101

Title: [The use of vinpotropile in chronic brain ishemia].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

Title: In vitro antioxidant properties of pentoxifylline and vinpocetine in a rheological model.

Journal: Clinical hemorheology and microcirculation 20080101

Title: [Effect of vasoactive drugs on visual functions and ocular hemodynamics in patients with primary open-angle glaucoma].

Journal: Vestnik oftalmologii 20080101

Title: [Cavinton administration in hypertensive encephalopathy].

Journal: Terapevticheskii arkhiv 20080101

Title: [The results of clinical study of cavinton efficacy inpatients with chronic brain ischemia].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

Title: Development and Validation of RP-HPLC Method for Simultaneous Estimation of Atorvastatin Calcium and Fenofibrate in Tablet Dosage Forms.

Journal: Indian journal of pharmaceutical sciences 20080101

Title: Effects of carbamazepine, phenytoin, valproic acid, oxcarbazepine, lamotrigine, topiramate and vinpocetine on the presynaptic Ca2+ channel-mediated release of [3H]glutamate: comparison with the Na+ channel-mediated release.

Journal: Neuropharmacology 20071201

Title: Vinpocetine ameliorates acute hepatic damage caused by administration of carbon tetrachloride in rats.

Journal: Acta biologica Hungarica 20071201

Title: Phosphodiesterase isozymes involved in regulation of HCO3- secretion in isolated mouse duodenum in vitro.

Journal: Biochemical pharmacology 20071115

Title: Application of a novel approach to prepare biodegradable polylactic-co-glycolic acid microspheres: surface liquid spraying.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20071101

Title: Characterization of inhibitors of phosphodiesterase 1C on a human cellular system.

Journal: The FEBS journal 20070901

Title: Cyclodextrin multicomponent complexation and controlled release delivery strategies to optimize the oral bioavailability of vinpocetine.

Journal: Journal of pharmaceutical sciences 20070801

Title: In vitro and in vivo studies on the complexes of vinpocetine with hydroxypropyl-beta-cyclodextrin.

Journal: Archives of pharmacal research 20070801

Title: [Investigation of the effect of vinpocetine on cerebral blood flow and cognitive functions].

Journal: Ideggyogyaszati szemle 20070730

Title: [The role of vinpocetine in the treatment of cerebrovascular diseases based in human studies].

Journal: Orvosi hetilap 20070722

Title: Functional responses of isolated human seminal vesicle tissue to selective phosphodiesterase inhibitors.

Journal: Urology 20070701

Title: Broad spectrum neuroprotection profile of phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation.

Journal: Neuroscience letters 20070517

Title: Exogenous nitric oxide stimulated collagen type I expression and TGF-beta1 production in keloid fibroblasts by a cGMP-dependent manner.

Journal: Nitric oxide : biology and chemistry 20070301

Title: Effects of carbamazepine, phenytoin, lamotrigine, oxcarbazepine, topiramate and vinpocetine on Na+ channel-mediated release of [3H]glutamate in hippocampal nerve endings.

Journal: Neuropharmacology 20070201

Title: Acute and chronic effects of carbamazepine, phenytoin, valproate and vinpocetine on BAEP parameters and threshold in the guinea pig.

Journal: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20070201

Title: [About cavinton therapy of the patients with brain vascular diseases].

Journal: Voenno-meditsinskii zhurnal 20070201

Title: Inhibitory effects of different antioxidants on hyaluronan depolymerization.

Journal: Carbohydrate research 20070115

Title: Effects of phosphodiesterase (PDE) inhibitors on human ether-a-go-go related gene (hERG) channel activity.

Journal: Journal of applied toxicology : JAT 20070101

Title: In vivo selective binding of (R)-[11C]rolipram to phosphodiesterase-4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissues.

Journal: Nuclear medicine and biology 20070101

Title: Effect of vinpocetine on retrograde axoplasmic transport.

Journal: Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 20070101

Title: Hemorheological efficiency of drugs, targeting on intracellular phosphodiesterase activity: in vitro study.

Journal: Clinical hemorheology and microcirculation 20070101

Title: [Effect of vasoactive agents on visual functions and ocular blood flow in patients with early manifestations of age-related macular degeneration].

Journal: Vestnik oftalmologii 20070101

Title: [Pharmacophysiotherapy in combined treatment of neurosensory hypoacusis in the presence of circulatory disorders in the vertebral arteries].

Journal: Vestnik otorinolaringologii 20070101

Title: [The state of cerebral blood flow in hypertensive crises and possibilities of its correction].

Journal: Kardiologiia 20070101

Title: [The use of the combined drug vinpotropil at early stages of cerebrovascular insufficiency].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20070101

Title: [The use of cavinton in patients with lacunar stroke developed against the background of diabetes mellitus and arterial hypertension].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20070101

Title: [Vinpotropile in the treatment of cerebral vascular diseases].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20070101

Title: [Implication of vinpotropile in the treatment of patients with cerebral stroke].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20070101

Title: Modulation of visceral nociception, inflammation and gastric mucosal injury by cinnarizine.

Journal: Drug target insights 20070101

Title: [Retrospective analysis of the effect of vinpocetine infusion in ophthalmologic disorders].

Journal: Orvosi hetilap 20061210

Title: Additive effects of antiepileptic drugs and pentylenetetrazole on hearing.

Journal: Neuroscience letters 20061009

Title: Tumoral calcinosis: Clinical and biochemical aspects of a patient treated with vinpocetine.

Journal: European journal of internal medicine 20061001

Title: [Plant metabolites as nootropics and cognitives].

Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20060901

Title: Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20060810

Title: Single and combined effects of carbamazepine and vinpocetine on depolarization-induced changes in Na+, Ca2+ and glutamate release in hippocampal isolated nerve endings.

Journal: Neurochemistry international 20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Inhibition of phosphodiesterase 1 augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs with acute pulmonary hypertension.

Journal: American journal of physiology. Lung cellular and molecular physiology 20060401

Title: New HPLC-MS method for quantitative determination of apovincaminic acid in human plasma.

Journal: Journal of separation science 20060201

Title: Determination of apovincaminic acid in human plasma by high-performance liquid chromatography using solid-phase extraction and ultraviolet detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060118

Title: Restoration of neuronal plasticity by a phosphodiesterase type 1 inhibitor in a model of fetal alcohol exposure.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060118

Title: [The safe use of cavinton forte in discirculatory encephalopathy].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

Title: Herbal medicine in the treatment of Alzheimer's disease.

Journal: American journal of Alzheimer's disease and other dementias 20060101

Title: [Disturbances of brain metabolism in blood circulation disorders and their correction with cavinton].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

Title: [Effect of cavinton on the hemorheological parameters of chronic cerebrovascular patients].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

Title: [Cavinton forte treatment of cerebral vascular insufficiency in patients with coronary heart disease and arterial hypertension].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

Title: Vinpocetine and piracetam exert antinociceptive effect in visceral pain model in mice.

Journal: Pharmacological reports : PR 20060101

Title: [Experimental study of the efficacy of apovincaminic acid derivative on the model of reperfusive cerebral damage].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20060101

Title: Catharanthus roseus flower extract has wound-healing activity in Sprague Dawley rats.

Journal: BMC complementary and alternative medicine 20060101

Title: [Changes in the focus of experimental ischemic stroke under the influence of neuroprotective drugs].

Journal: Morfologiia (Saint Petersburg, Russia) 20060101

Title: [An effect of vinpocetine (cavinton) on endothelium function in patients with chronic cerebral ischemia].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

Title: Increase in tumor oxygenation and potentiation of radiation effects using pentoxifylline, vinpocetine and ticlopidine hydrochloride.

Journal: Journal of radiation research 20051201

Title: Eburnamine derivatives and the brain.

Journal: Medicinal research reviews 20051101

Title: Acute and chronic effects of vinpocetine on cerebral hemodynamics and neuropsychological performance in multi-infarct patients.

Journal: Journal of clinical pharmacology 20050901

Title: Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in the guinea pig gall bladder.

Journal: The Journal of veterinary medical science 20050701

Title: Vinpocetine blockade of sodium channels inhibits the rise in sodium and calcium induced by 4-aminopyridine in synaptosomes.

Journal: Neurochemistry international 20050601

Title: Spectrophotometric and liquid chromatographic determination of fenofibrate and vinpocetine and their hydrolysis products.

Journal: Farmaco (Societa chimica italiana : 1989) 20050501

Title: Neuroprotective activity of proproten in rats with experimental local photothrombosis of the prefrontal cortex.

Journal: Bulletin of experimental biology and medicine 20050401

Title: In vitro controlled release of vinpocetine-cyclodextrin-tartaric acid multicomponent complexes from HPMC swellable tablets.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20050321

Title: [11C]vinpocetine: a prospective peripheral benzodiazepine receptor ligand for primate PET studies.

Journal: Journal of the neurological sciences 20050315

Title: Effects of vinpocetine on the redistribution of cerebral blood flow and glucose metabolism in chronic ischemic stroke patients: a PET study.

Journal: Journal of the neurological sciences 20050315

Title: [Drug therapy of female urinary incontinence].

Journal: Der Urologe. Ausg. A 20050301

Title: Expression and functional activity of phosphodiesterase type 5 in human and rabbit vas deferens.

Journal: Molecular human reproduction 20050201

Title: cAMP phosphodiesterase inhibitors potentiate effects of prostacyclin analogs in hypoxic pulmonary vascular remodeling.

Journal: American journal of physiology. Lung cellular and molecular physiology 20050101

Title: Multicomponent complex formation between vinpocetine, cyclodextrins, tartaric acid and water-soluble polymers monitored by NMR and solubility studies.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050101

Title: Pharmacokinetics and comparative bioavailability of two vinpocetine tablet formulations in healthy volunteers by using the metabolite apovincaminic acid as pharmacokinetic parameter.

Journal: Arzneimittel-Forschung 20050101

Title: Vinpocetine prevents 4-aminopyridine-induced changes in the EEG, the auditory brainstem responses and hearing.

Journal: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20041201

Title: Review of phosphodiesterases in the urogenital system: new directions for therapeutic intervention.

Journal: The journal of sexual medicine 20041101

Title: Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in guinea pig taenia coli.

Journal: The Journal of veterinary medical science 20040901

Title: [Optimization of microemulsion containing vinpocetine and its physicochemical properties].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040901

Title: Phosphodiesterase inhibition by a gastroprotective agent irsogladine: preferential blockade of cAMP hydrolysis.

Journal: Life sciences 20040827

Title: Cyclic nucleotide-dependent phosphodiesterases (PDEI) inhibition by muscarinic antagonists in bovine tracheal smooth muscle.

Journal: Biochemical pharmacology 20040815

Title: The effect of citric acid added to hydroxypropyl methylcellulose (HPMC) matrix tablets on the release profile of vinpocetine.

Journal: Drug development and industrial pharmacy 20040701

Title: Preparation, evaluation, and NMR characterization of vinpocetine microemulsion for transdermal delivery.

Journal: Drug development and industrial pharmacy 20040701

Title: Vinpocetine inhibits the epileptic cortical activity and auditory alterations induced by pentylenetetrazole in the guinea pig in vivo.

Journal: Epilepsy research 20040601

Title: Preparation and evaluation of microemulsion of vinpocetine for transdermal delivery.

Journal: Die Pharmazie 20040401

Title: Identification, characterization and subcellular localization of TcPDE1, a novel cAMP-specific phosphodiesterase from Trypanosoma cruzi.

Journal: The Biochemical journal 20040215

Title: Neuroprotection in ischemic/hypoxic disorders: from the preclinical to the clinical testing.

Journal: Advances in experimental medicine and biology 20040101

Title: [Use of cavinton in neuropaediatrics].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20040101

Title: [Human positron emission tomography with oral 11C-vinpocetine].

Journal: Orvosi hetilap 20031116

Title: Physicochemical investigation of the effects of water-soluble polymers on vinpocetine complexation with beta-cyclodextrin and its sulfobutyl ether derivative in solution and solid state.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20031101

Title: Vinpocetine is a potent blocker of rat NaV1.8 tetrodotoxin-resistant sodium channels.

Journal: The Journal of pharmacology and experimental therapeutics 20030801

Title: Investigation and physicochemical characterization of vinpocetine-sulfobutyl ether beta-cyclodextrin binary and ternary complexes.

Journal: Chemical & pharmaceutical bulletin 20030801

Title: Asymptomatic ischemic cerebrovascular disorders and neuroprotection with vinpocetine.

Journal: Ideggyogyaszati szemle 20030520

Title: [Effect of vinpocetin on the hemorheologic parameters in patients with chronic cerebrovascular disease].

Journal: Orvosi hetilap 20030518

Title: Lipophilicity of vinpocetine and related compounds characterized by reversed-phase thin-layer chromatography.

Journal: Journal of chromatography. A 20030509

Title: The lowdown on Ginkgo biloba.

Journal: Scientific American 20030401

Title: Large-conductance Ca2+- activated K+ channels:physiological role and pharmacology.

Journal: Current medicinal chemistry 20030401

Title: [Myogenic effects of cyclic guanosine monophosphate in smooth muscle cells. Role of protein kinase C].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20030401

Title: Localization of cyclic nucleotide phosphodiesterase 2 in the brain-derived Triton-insoluble low-density fraction (raft).

Journal: Neuroscience research 20030201

Title: A vinca alkaloid enhances morphological dynamics of dendritic spines of neocortical layer 2/3 pyramidal cells.

Journal: Brain research bulletin 20030115

Title: Implication of calmodulin-dependent phosphodiesterase type 1 during bovine sperm capacitation.

Journal: Journal of andrology 20030101

Title: Vinpocetine for cognitive impairment and dementia.

Journal: The Cochrane database of systematic reviews 20030101

Title: Cyclic AMP-mediated regulation of striatal glutamate release: interactions of presynaptic ligand- and voltage-gated ion channels and G-protein-coupled receptors.

Journal: Neurochemistry international 20030101

Title: [Cavinton prevention of neurosensory hypoacousis in patients with different forms of tuberculosis].

Journal: Vestnik otorinolaringologii 20030101

Title: [Studying cGMP-dependent mechanisms of vinpocetine effect on smooth muscle cells].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20030101

Title: [Blood flow insufficiency in vertebrobasilar system].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20030101

Title: 'Brain-specific' nutrients: a memory cure?

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20030101

Title: [Effect of vinpocetine on cerebral circulation in rats after exposure to radiation].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20030101

Title: [Memory and potassium channels].

Journal: Uspekhi fiziologicheskikh nauk 20030101

Title: [Use of instenon in complex treatment of patients with optic nerve atrophy caused by craniocerebral trauma].

Journal: Vestnik oftalmologii 20030101

Title: [Neuroprotection strategies: effect of vinpocetine in vitro oxidative stress models].

Journal: Acta medica portuguesa 20030101

Title: PET studies on the brain uptake and regional distribution of [11C]vinpocetine in human subjects.

Journal: Acta neurologica Scandinavica 20021201

Title: [Cerebral uptake and regional distribution of [11C]-vinpocetin after intravenous administration to healthy men: a PET study].

Journal: Orvosi hetilap 20021124

Title: Clinical and non-clinical investigations using positron emission tomography, near infrared spectroscopy and transcranial Doppler methods on the neuroprotective drug vinpocetine: a summary of evidences.

Journal: Journal of the neurological sciences 20021115

Title: Cerebral uptake of [ethyl-11C]vinpocetine and 1-[11C]ethanol in cynomolgous monkeys: a comparative preclinical PET study.

Journal: Nuclear medicine and biology 20021001

Title: Selective suppression of the slow-inactivating potassium currents by nootropics in molluscan neurons.

Journal: The international journal of neuropsychopharmacology 20020901

Title: Drug distribution in man: a positron emission tomography study after oral administration of the labelled neuroprotective drug vinpocetine.

Journal: European journal of nuclear medicine and molecular imaging 20020801

Title: The effect of phosphodiesterase inhibition on gallbladder motility in vitro.

Journal: The Journal of surgical research 20020615

Title: Vinpocetine increases cerebral blood flow and oxygenation in stroke patients: a near infrared spectroscopy and transcranial Doppler study.

Journal: European journal of ultrasound : official journal of the European Federation of Societies for Ultrasound in Medicine and Biology 20020601

Title: Relationship between bicarbonate and cyclic nucleotide in the promoting effects on head-to-head agglutination in boar spermatozoa.

Journal: Asian journal of andrology 20020601

Title: Vinpocetine. Monograph.

Journal: Alternative medicine review : a journal of clinical therapeutic 20020601

Title: Functional plasticity of cyclic AMP hydrolysis in rat adenohypophysial corticotroph cells.

Journal: Cellular signalling 20020501

Title: Piracetam and vinpocetine exert cytoprotective activity and prevent apoptosis of astrocytes in vitro in hypoxia and reoxygenation.

Journal: Neurotoxicology 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Phosphodiesterase inhibitors cause relaxation of the internal anal sphincter in vitro.

Journal: Diseases of the colon and rectum 20020401

Title: [Scavenger effect of various cerebrovascular drugs].

Journal: Orvosi hetilap 20020106

Title: Assessing the emetic potential of PDE4 inhibitors in rats.

Journal: British journal of pharmacology 20020101

Title: Cyclic nucleotide phosphodiesterases in rabbit detrusor smooth muscle.

Journal: Urology 20020101

Title: In vitro antioxidant properties of pentoxifylline, piracetam, and vinpocetine.

Journal: Clinical neuropharmacology 20020101

Title: Modulation of TNF and GM-CSF release from dispersed human nasal polyp cells and human whole blood by inhibitors of different PDE isoenzymes and glucocorticoids.

Journal: Pulmonary pharmacology & therapeutics 20020101

Title: Autoradiographic evaluation of [11C]vinpocetine binding in the human postmortem brain.

Journal: Acta biologica Hungarica 20020101

Title: Effect of inhibitors of cyclic nucleotide phosphodiesterases on electrical and contractile activity of smooth muscle cells.

Journal: Bulletin of experimental biology and medicine 20020101

Title: [Investigation of vasoactive agents with indole skeletons at Richter Ltd].

Journal: Acta pharmaceutica Hungarica 20020101

Title: [Neuroprotective effects of vinpocetine in vivo and in vitro. Apovincaminic acid derivatives as potential therapeutic tools in ischemic stroke].

Journal: Acta pharmaceutica Hungarica 20020101

Title: Characterization and functional relevance of cyclic nucleotide phosphodiesterase isoenzymes of the human prostate.

Journal: The Journal of urology 20011201

Title: Identification and functional study of phosphodiesterases in rat urinary bladder.

Journal: Urological research 20011201

Title: Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance.

Journal: Circulation 20011106

Title: Phosphodiesterase 1 inhibition in the treatment of lower urinary tract dysfunction: from bench to bedside.

Journal: World journal of urology 20011101

Title: The nootropic drug vinpocetine inhibits veratridine-induced [Ca2+]i increase in rat hippocampal CA1 pyramidal cells.

Journal: Neurochemical research 20010901

Title: Characterization of vinpocetine effects on DA and DOPAC release in striatal isolated nerve endings.

Journal: Brain research 20010803

Title: Ibudilast attenuates astrocyte apoptosis via cyclic GMP signalling pathway in an in vitro reperfusion model.

Journal: British journal of pharmacology 20010701

Title: Characterization of r-[11C]rolipram for PET imaging of phosphodieterase-4: in vivo binding, metabolism, and dosimetry studies in rats.

Journal: Nuclear medicine and biology 20010501

Title: Vinpocetine-induced stimulation of calcium-activated potassium currents in rat pituitary GH3 cells.

Journal: Biochemical pharmacology 20010401

Title: [The effect of a single-dose intravenous vinpocetine on brain metabolism in patients with ischemic stroke].

Journal: Orvosi hetilap 20010304

Title: [The use of vinpocetine in chronic disorders caused by cerebral hypoperfusion].

Journal: Orvosi hetilap 20010225

Title: The nootropic drug vinpocetine modulates different types of potassium currents in molluscan neurons.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20010201

Title: The effects of phosphodiesterase inhibition on cyclic GMP and cyclic AMP accumulation in the hippocampus of the rat.

Journal: Brain research 20010112

Title: Dependence of soluble guanylyl cyclase activity on calcium signaling in pituitary cells.

Journal: The Journal of biological chemistry 20010105

Title: Vinpocetine treatment in acute ischaemic stroke: a pilot single-blind randomized clinical trial.

Journal: European journal of neurology 20010101

Title: [Cavinton in epilepsy treatment and prevention].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20010101

Title: [Complex effects of cavinton on climacteric symptoms].

Journal: Akusherstvo i ginekologiia 20010101

Title: In vitro-in vivo correlation of the pharmacokinetics of vinpocetine.

Journal: Polish journal of pharmacology 20010101

Title: Identification of human PDE7B, a cAMP-specific phosphodiesterase.

Journal: Biochemical and biophysical research communications 20000519

Title: Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases.

Journal: The Journal of biological chemistry 19960112

Title: Cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human detrusor smooth muscle. II. Effect of various PDE inhibitors on smooth muscle tone and cyclic nucleotide levels in vitro.

Journal: Urological research 19960101

Title: Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle.

Journal: Biochemical pharmacology 19840201

Title: The synthesis of ethyl apovincaminate.

Journal: Arzneimittel-Forschung 19760101

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Tags:42971-09-5 Molecular Formula|42971-09-5 MDL|42971-09-5 SMILES|42971-09-5 Vinpocetine |Heterocyclic_Building_Blocks