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4317-14-0,MFCD00865378
Catalog No.:AA00DJD0

4317-14-0 | amitriptyline N-oxide

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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DJD0
Chemical Name:
amitriptyline N-oxide
CAS Number:
4317-14-0
Molecular Formula:
C20H23NO
Molecular Weight:
293.4027
MDL Number:
MFCD00865378
SMILES:
CN(=O)(CCC=C1c2ccccc2CCc2c1cccc2)C
Properties
Computed Properties
 
Complexity:
375  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
4.5  

Literature

Title: What is the contribution of human FMO3 in the N-oxygenation of selected therapeutic drugs and drugs of abuse?

Journal: Toxicology letters 20160906

Title: Antidepressants for depression in stage 3-5 chronic kidney disease: a systematic review of pharmacokinetics, efficacy and safety with recommendations by European Renal Best Practice (ERBP).

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20121001

Title: Tricyclic antidepressants and headaches: systematic review and meta-analysis.

Journal: BMJ (Clinical research ed.) 20100101

Title: The metabolic fate of amitriptyline, nortriptyline and amitriptylinoxide in man.

Journal: Drug metabolism reviews 20041001

Title: [Polygraphic sleep recordings in patients with endogenous depression before and after treatment with amitriptyline-N-oxide (author's transl)].

Journal: Arzneimittel-Forschung 19760101

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