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434-03-7,MFCD00003656
Catalog No.:AA003PW1

434-03-7 | Ethisterone

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
≥95%
in stock  
$46.00   $32.00
- +
5g
≥95%
in stock  
$133.00   $93.00
- +
10g
≥95%
in stock  
$199.00   $139.00
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25g
≥95%
in stock  
$272.00   $190.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003PW1
Chemical Name:
Ethisterone
CAS Number:
434-03-7
Molecular Formula:
C21H28O2
Molecular Weight:
312.4458
MDL Number:
MFCD00003656
SMILES:
C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=CC(=O)CC[C@]12C
Properties
Properties
 
BP:
446.4°C at 760 mmHg  
Form:
Solid  
MP:
>270ºC (dec.)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
638  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
3.5  

Literature

Title: Several synthetic progestins disrupt the glial cell specific-brain aromatase expression in developing zebra fish.

Journal: Toxicology and applied pharmacology 20160815

Title: Androgen receptor antagonism by divalent ethisterone conjugates in castrate-resistant prostate cancer cells.

Journal: ACS chemical biology 20121019

Title: Multivalent peptidomimetic conjugates: a versatile platform for modulating androgen receptor activity.

Journal: Journal of the American Chemical Society 20120425

Title: Novel C,N-chelate platinum(II) antitumor complexes bearing a lipophilic ethisterone pendant.

Journal: Journal of inorganic biochemistry 20110401

Title: Current and emerging treatments for uterine myoma - an update.

Journal: International journal of women's health 20110101

Title: Luminescent Au(I)/Cu(I) alkynyl clusters with an ethynyl steroid and related aliphatic ligands: an octanuclear Au4Cu4 cluster and luminescence polymorphism in Au3Cu2 clusters.

Journal: Journal of the American Chemical Society 20100908

Title: Synthesis and solid state characterization of molecular rotors with steroidal stators: ethisterone and norethisterone.

Journal: Organic & biomolecular chemistry 20100628

Title: Treatment of Hereditary Angioedema: items that need to be addressed in practice parameter.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20100101

Title: Cytotoxicity, cellular localisation and biomolecular interaction of non-covalent metallo-intercalators with appended sex hormone steroid vectors.

Journal: Dalton transactions (Cambridge, England : 2003) 20091228

Title: (20S,2''S)-20-[4'-(3''-Hydroxy-2''-methyl-prop-yl)-3'-methylisoxazol-5-yl]-5β-preg-nan-3β,16β-diol.

Journal: Acta crystallographica. Section E, Structure reports online 20091201

Title: Vitellogenin induction by a mixture of steroidal estrogens in freshwater fishes and relevant risk assessment.

Journal: Environmental toxicology 20091001

Title: Danazol for uterine fibroids.

Journal: The Cochrane database of systematic reviews 20090708

Title: Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles.

Journal: PloS one 20090101

Title: Evaluation of extended and continuous use oral contraceptives.

Journal: Therapeutics and clinical risk management 20081001

Title: Structure-activity relationships of synthetic progestins in a yeast-based in vitro androgen bioassay.

Journal: The Journal of steroid biochemistry and molecular biology 20080501

Title: HT update: spotlight on estradiol/norethindrone acetate combination therapy.

Journal: Clinical interventions in aging 20080301

Title: Testicular dysgenesis syndrome and the estrogen hypothesis: a quantitative meta-analysis.

Journal: Environmental health perspectives 20080201

Title: Genetic and chemical modifiers of a CUG toxicity model in Drosophila.

Journal: PloS one 20080101

Title: [The applications of chiroptical spectroscopy for the determination and the detection of steroids and for the examination of their cyclodextrin-mediated enantioselective solubility].

Journal: Acta pharmaceutica Hungarica 20080101

Title: Membranous nephropathy in a patient with hereditary angioedema: a case report.

Journal: Journal of medical case reports 20080101

Title: Secondary sex ratio among women exposed to diethylstilbestrol in utero.

Journal: Environmental health perspectives 20070901

Title: A full conformational characterization of 13-ethylprogestogens through theoretical calculations and nuclear magnetic resonance spectroscopy.

Journal: The Journal of steroid biochemistry and molecular biology 20070201

Title: TOMOCOMD-CARDD descriptors-based virtual screening of tyrosinase inhibitors: evaluation of different classification model combinations using bond-based linear indices.

Journal: Bioorganic & medicinal chemistry 20070201

Title: [Advances in the study of steroidogenic acute regulatory protein].

Journal: Zhonghua nan ke xue = National journal of andrology 20060801

Title: Mortality in women given diethylstilbestrol during pregnancy.

Journal: British journal of cancer 20060703

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: The Evra (ethinyl estradiol/norelgestromin) contraceptive patch: estrogen exposure concerns.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20060117

Title: Gas chromatography/mass spectrometry characterization of urinary metabolites of danazol after oral administration in human.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102

Title: How should we advise patients about the contraceptive patch, given the FDA warning?

Journal: Cleveland Clinic journal of medicine 20060101

Title: New warning on birth control patch.

Journal: FDA consumer 20060101

Title: Hormonal contraception: recent advances.

Journal: The journal of family health care 20060101

Title: Microbial transformation of 17alpha-ethynyl- and 17alpha-ethylsteroids, and tyrosinase inhibitory activity of transformed products.

Journal: Steroids 20051101

Title: [Safety evaluation of a transdermal contraceptive system with an oral contraceptive].

Journal: Ginekologia polska 20051101

Title: Extended use of transdermal norelgestromin/ethinyl estradiol: a randomized trial.

Journal: Obstetrics and gynecology 20050601

Title: Suppression of estrogen-withdrawal headache with extended transdermal contraception.

Journal: Fertility and sterility 20050601

Title: Effect of oral versus transdermal steroidal contraceptives on androgenic markers.

Journal: American journal of obstetrics and gynecology 20050601

Title: Adolescents' experience with the combined estrogen and progestin transdermal contraceptive method Ortho Evra.

Journal: Journal of pediatric and adolescent gynecology 20050401

Title: Preference for and satisfaction of Canadian women with the transdermal contraceptive patch versus previous contraceptive method: an open-label, multicentre study.

Journal: Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 20050401

Title: Steroids' transformations in Penicillium notatum culture.

Journal: Steroids 20050301

Title: Nondaily hormonal contraception: establishing a fit between product characteristics and patient preferences.

Journal: The Journal of family practice 20041101

Title: [Hormonal contraceptive patch].

Journal: Ugeskrift for laeger 20041004

Title: Induction of androgen receptor activity by norgestimate and norelgestromin in MDA-MB 231 breast cancer cells.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20040701

Title: Effects of nitric oxide on aldosterone synthesis and nitric oxide synthase activity in glomerulosa cells from bovine adrenal gland.

Journal: Endocrine 20040601

Title: An evaluation of the use of the transdermal contraceptive patch in adolescents.

Journal: The Journal of adolescent health : official publication of the Society for Adolescent Medicine 20040501

Title: New Product Review (September 2003). Norelgestromin/ethinyl oestradiol transdermal contraceptive system (Evra).

Journal: The journal of family planning and reproductive health care 20040101

Title: Matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 expression is not regulated by norgestimate or norelgestromin.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20040101

Title: Long-term evaluation of the use of the transdermal contraceptive patch in adolescents.

Journal: TheScientificWorldJournal 20040101

Title: [Transdermal contraception--a new beginning].

Journal: Akusherstvo i ginekologiia 20040101

Title: New contraception options.

Journal: Diabetes self-management 20040101

Title: New hormonal contraceptives: a comprehensive review of the literature.

Journal: Pharmacotherapy 20031201

Title: Evra--a patch on oral contraception?

Journal: Drug and therapeutics bulletin 20031201

Title: [Medication of the month. Evra: first contraceptive transdermal patch].

Journal: Revue medicale de Liege 20031101

Title: [A transdermal form of combined hormonal contraceptives (EVRA)].

Journal: Ceska gynekologie 20031001

Title: Ortho Evra/Evra versus oral contraceptives: follicular development and ovulation in normal cycles and after an intentional dosing error.

Journal: Fertility and sterility 20030701

Title: New drugs 2003, part II.

Journal: Nursing 20030701

Title: Transdermal delivery of sex steroids for hormone replacement therapy and contraception. A review of principles and practice.

Journal: The Journal of reproductive medicine 20030701

Title: Ortho Evra, a new contraceptive patch.

Journal: Pharmacotherapy 20030401

Title: CD spectrometric methods for the simultaneous determination of ethisterone and its delta5-isomer.

Journal: Analytical and bioanalytical chemistry 20030301

Title: Transdermal contraceptive patch delivering norelgestromin and ethinyl estradiol. Effects on the lipid profile.

Journal: The Journal of reproductive medicine 20030301

Title: Serum distribution of the major metabolites of norgestimate in relation to its pharmacological properties.

Journal: Contraception 20030201

Title: Norelgestromin as selective estrogen enzyme modulator in human breast cancer cell lines. Effect on sulfatase activity in comparison to medroxyprogesterone acetate.

Journal: The Journal of steroid biochemistry and molecular biology 20030201

Title: Progress in contraception: new technology.

Journal: International journal of fertility and women's medicine 20030101

Title: Women prefer Ortho Evra patch.

Journal: AWHONN lifelines 20030101

Title: Transdermal ethinylestradiol/norelgestromin: a review of its use in hormonal contraception.

Journal: Treatments in endocrinology 20030101

Title: The introduction of a transdermal hormonal contraceptive (Ortho Evra/Evra).

Journal: Fertility and sterility 20020201

Title: Pharmacokinetic overview of Ortho Evra/Evra.

Journal: Fertility and sterility 20020201

Title: Contraceptive efficacy and cycle control with the Ortho Evra/Evra transdermal system: the analysis of pooled data.

Journal: Fertility and sterility 20020201

Title: A comparative and pooled analysis of the safety and tolerability of the contraceptive patch (Ortho Evra/Evra).

Journal: Fertility and sterility 20020201

Title: Assessment of compliance with a weekly contraceptive patch (Ortho Evra/Evra) among North American women.

Journal: Fertility and sterility 20020201

Title: Integrated summary of Ortho Evra/Evra contraceptive patch adhesion in varied climates and conditions.

Journal: Fertility and sterility 20020201

Title: Pharmacokinetics of a contraceptive patch (Evra/Ortho Evra) containing norelgestromin and ethinyloestradiol at four application sites.

Journal: British journal of clinical pharmacology 20020201

Title: The transdermal contraceptive patch: a new approach to hormonal contraception.

Journal: International journal of fertility and women's medicine 20020101

Title: Transdermal contraception.

Journal: Seminars in reproductive medicine 20011201

Title: Pharmacokinetics of norelgestromin and ethinyl estradiol delivered by a contraceptive patch (Ortho Evra/Evra) under conditions of heat, humidity, and exercise.

Journal: Journal of clinical pharmacology 20011201

Title: Pharmacokinetics of norelgestromin and ethinyl estradiol from two consecutive contraceptive patches.

Journal: Journal of clinical pharmacology 20011101

Title: The effect of structural QSAR parameters on skin penetration.

Journal: International journal of pharmaceutics 20010417

Title: GC-MS characterization of urinary metabolites and changes of ethisterone and testosterone profile after oral administration of danazol in equine.

Journal: Journal of veterinary pharmacology and therapeutics 20010401

Title: Cardiovascular birth defects and antenatal exposure to female sex hormones.

Journal: The New England journal of medicine 19770113

Title: Endometrial carcinoma after cyclical oestrogen-progestogen therapy for Turner's syndrome.

Journal: British journal of obstetrics and gynaecology 19750501

Title: Endometrial carcinoma after stilbestrol therapy in gonadal dysgenesis.

Journal: The New England journal of medicine 19720928

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