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4346-94-5,MFCD00060206
Catalog No.:AA003UQ0

4346-94-5 | Thiosemicarbazide HCl

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  • Technical Information
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Technical Information
Catalog Number:
AA003UQ0
Chemical Name:
Thiosemicarbazide HCl
CAS Number:
4346-94-5
Molecular Formula:
CH6ClN3S
Molecular Weight:
127.5964
MDL Number:
MFCD00060206
SMILES:
C(=S)(N)NN.Cl
NSC Number:
191943
Properties
Properties
 
BP:
208.6°C at 760 mmHg  
Form:
Solid  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
42.2  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
6  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
4  

Literature

Title: Photochemical isomerizations of thiosemicarbazide, a matrix isolation study.

Journal: The journal of physical chemistry. A 20121011

Title: Antifungal effect of 4-arylthiosemicarbazides against Candida species. Search for molecular basis of antifungal activity of thiosemicarbazide derivatives.

Journal: Journal of molecular modeling 20120901

Title: Synthesis and antitumor activity of novel quinazoline derivatives containing thiosemicarbazide moiety.

Journal: European journal of medicinal chemistry 20120801

Title: A highly selective colorimetric sensor for Hg²⁺ based on nitrophenyl-aminothiourea.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120701

Title: Spectral, thermal and biological studies of Mn(II) and Cu(II) complexes with two thiosemicarbazide derivatives.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120615

Title: Problems with molecular mechanics implementations on the example of 4-benzoyl-1-(4-methyl-imidazol-5-yl)-carbonylthiosemicarbazide.

Journal: Journal of molecular modeling 20120301

Title: Synthesis and antityrosinase mechanism of benzaldehyde thiosemicarbazones: novel tyrosinase inhibitors.

Journal: Journal of agricultural and food chemistry 20120215

Title: Neutral gold complexes with tridentate SNS thiosemicarbazide ligands.

Journal: Inorganic chemistry 20120206

Title: 3-mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-β-lactamase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20120101

Title: 2:1 multiplexing function in a simple molecular system.

Journal: Sensors (Basel, Switzerland) 20120101

Title: Growth and characterization of thiosemicarbazide hydrochloride: a semiorganic NLO material.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111101

Title: Synthesis and structure-activity relationship studies of 4-arylthiosemicarbazides as topoisomerase IV inhibitors with Gram-positive antibacterial activity. Search for molecular basis of antibacterial activity of thiosemicarbazides.

Journal: European journal of medicinal chemistry 20111101

Title: Antimicrobial activity and SAR study of some novel thiosemicarbazide derivatives bearing piperidine moiety.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20111101

Title: Absorption spectral analysis of 4f-4f transitions for the complexation of Pr(III) and Nd(III) with thiosemicarbazide in absence and presence of Zn(II) in aqueous and organic solvents.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111015

Title: Elaborated 1H NMR study for the ligitional behavior of two thiosemicarbazide derivatives towards some heavy metals (Sn(II), Sb(III), Pb(II) and Bi(III)), thermal, antibacterial and antifungal studies.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111015

Title: Synthesis, molecular modeling, thermal and spectral studies of metal complexes of hydrazone derived from 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione and thiosemicarbazide.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110901

Title: Synthesis, crystal structures, and biological evaluation of manganese(II) and nickel(II) complexes of 4-cyclohexyl-1-(1-(pyrazin-2-yl)ethylidene)thiosemicarbazide.

Journal: European journal of medicinal chemistry 20110901

Title: Synthesis, molecular modeling and biological evaluation of chalcone thiosemicarbazide derivatives as novel anticancer agents.

Journal: European journal of medicinal chemistry 20110901

Title: The use of umbelliferone in the synthesis of new heterocyclic compounds.

Journal: Molecules (Basel, Switzerland) 20110810

Title: Catalytic enantioselective addition of sodium bisulfite to chalcones.

Journal: Angewandte Chemie (International ed. in English) 20110718

Title: Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives.

Journal: European journal of medicinal chemistry 20110701

Title: Design, synthesis and pharmacological evaluation of novel azole derivatives of aryl acetic acid as anti-inflammatory and analgesic agents.

Journal: Journal of enzyme inhibition and medicinal chemistry 20110201

Title: Organocatalytic asymmetric direct vinylogous aldol reactions of γ-crotonolactone with aromatic aldehydes.

Journal: Chemical communications (Cambridge, England) 20110121

Title: A novel series of IKKβ inhibitors part II: description of a potent and pharmacologically active series of analogs.

Journal: Bioorganic & medicinal chemistry letters 20110101

Title: A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit.

Journal: Bioorganic & medicinal chemistry letters 20110101

Title: Synthesis and antimicrobial activity of thiosemicarbazides, s-triazoles and their Mannich bases bearing 3-chlorophenyl moiety.

Journal: European journal of medicinal chemistry 20110101

Title: Menthone aryl acid hydrazones: a new class of anticonvulsants.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20110101

Title: Cytotoxicity of new 5-phenyl-4,5-dihydro-1,3,4-thiadiazole analogues.

Journal: Chemical & pharmaceutical bulletin 20110101

Title: Green synthesis and biological evaluation of some novel azoles as antimicrobial agents.

Journal: Bioorganic & medicinal chemistry letters 20101215

Title: Synthesis, X-ray crystal structures, thermal and electrochemical properties of thiosemicarbazidatodioxouranium(VI) complexes.

Journal: Dalton transactions (Cambridge, England : 2003) 20101114

Title: Synthesis and evaluation of anti-Toxoplasma gondii and antimicrobial activities of thiosemicarbazides, 4-thiazolidinones and 1,3,4-thiadiazoles.

Journal: European journal of medicinal chemistry 20100901

Title: Revisit to the reaction of o-phenylene diamine with thiosemicarbazide to give benzimidazole-2-thione rather than benzotriazine-2-thione and its glycosylation.

Journal: Nucleosides, nucleotides & nucleic acids 20100901

Title: A Hg2+-selective chemodosimeter based on desulfurization of coumarin thiosemicarbazide in aqueous media.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20100701

Title: A fluorimetric semi-microplate format assay of protein carbonyls in blood plasma.

Journal: Analytical biochemistry 20100515

Title: Synthesis, structure, electrochemistry and spectral characterization of (D-glucopyranose)-4-phenylthiosemicarbazide metal complexes and their antitumor activity against Ehrlich ascites carcinoma in Swiss albino mice.

Journal: European journal of medicinal chemistry 20100101

Title: Menthone semicarbazides and thiosemicarbazides as anticonvulsant agents.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20100101

Title: Adsorption and quantum chemical studies on the inhibition potentials of some thiosemicarbazides for the corrosion of mild steel in acidic medium.

Journal: International journal of molecular sciences 20100101

Title: Fluorescent detection of methylmercury by desulfurization reaction of rhodamine hydrazide derivatives.

Journal: Organic & biomolecular chemistry 20091121

Title: Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20091101

Title: Synthesis and anticonvulsant activity of N-(2-hydroxyethyl) cinnamamide derivatives.

Journal: European journal of medicinal chemistry 20090901

Title: Copper(II) and uranyl(II) complexes with acylthiosemicarbazide: synthesis, characterization, antibacterial activity and effects on the growth of promyelocytic leukemia cells HL-60.

Journal: European journal of medicinal chemistry 20090801

Title: Regioselective synthesis of novel 3-alkoxy (phenyl) thiophosphorylamido-2-(per-O-acetylglycosyl-1'-imino)thiazolidine-4-one derivatives from O-alkyl N4-glycosyl(thiosemicarbazido)phosphonothioates.

Journal: Carbohydrate research 20090706

Title: Effects of a thiosemicarbazide camphene derivative on Trichophyton mentagrophytes.

Journal: Molecules (Basel, Switzerland) 20090513

Title: Facile synthesis of bis(4,5-dihydro-1H-pyrazole-1-carboxamides) and their thio-analogues of potential PGE(2) inhibitory properties.

Journal: European journal of medicinal chemistry 20090501

Title: Syntheses and evaluation of glucosyl aryl thiosemicarbazide and glucosyl thiosemicarbazone derivatives as antioxidant and anti-dyslipidemic agents.

Journal: Bioorganic & medicinal chemistry letters 20090115

Title: Oxotechnetium(V) complexes with a novel class of tridentate thiosemicarbazide ligands.

Journal: Inorganic chemistry 20090105

Title: Study of the enhancement of a new chemiluminescence reaction and its application to determination of beta-lactam antibiotics.

Journal: Luminescence : the journal of biological and chemical luminescence 20090101

Title: Reactivity of thiosemicarbazides with redox active metal ions: controlled formation of coordination complexes versus heterocyclic compounds.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20090101

Title: Synthesis, lipophilicity and antimicrobial activity of new derivatives of thiosemicarbazides and 1,2,4-triazoline-5-thione.

Journal: Acta poloniae pharmaceutica 20090101

Title: Utilization of picolinaldehyde-4-phenyl-3-thiosemicarbazone in sodium dodecylsulfate micelles for the spectrophotometric determination of iron, vanadium, and cobalt following partial least-squares regression analysis.

Journal: Journal of AOAC International 20090101

Title: Synthesis of some novel CoII and CoIII complexes by tribochemical reactions using KI with some derivatives of thiosemicarbazide complexes derived from Girard's T and P.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081215

Title: Synthesis and structural investigation of mono- and polynuclear copper complexes of 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081101

Title: Alumina physically loaded by thiosemicarbazide for selective preconcentration of mercury(II) ion from natural water samples.

Journal: Journal of hazardous materials 20080815

Title: Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors.

Journal: Journal of medicinal chemistry 20080814

Title: In-vitro antibacterial, antifungal activity of some transition metal complexes of thiosemicarbazone Schiff base (HL) derived from N4-(7'-chloroquinolin-4'-ylamino) thiosemicarbazide.

Journal: Journal of enzyme inhibition and medicinal chemistry 20080801

Title: Synthesis and biological evaluation of novel 4-substituted 1-{[4-(10,15,20-triphenylporphyrin-5-yl)phenyl]methylidene}thiosemicarbazides as new class of potential antiprotozoal agents.

Journal: Chemistry & biodiversity 20080501

Title: 1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors.

Journal: Bioorganic & medicinal chemistry 20080201

Title: Bis[1-(2-hydroxyethyl)-4,10-diazapyrazolo[4,3-b]fluoren-5(1H)-one thiosemicarbazonato]zinc(II) dimethylformamide trisolvate monohydrate.

Journal: Acta crystallographica. Section C, Crystal structure communications 20080101

Title: Oscillating chemiluminescence with thiosemicarbazide in a batch reactor.

Journal: Luminescence : the journal of biological and chemical luminescence 20080101

Title: Synthesis, immunological activity and computational study of 5-amino-3-methyl-4-isoxazolecarboxylic acid semicarbazides and thiosemicarbazides.

Journal: Acta poloniae pharmaceutica 20080101

Title: Synthesis and antituberculosis action of some new pyruvic acid derivatives.

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20080101

Title: 4-(N,N-diethylamino) benzaldehyde thiosemicarbazone in the spectrophotometric determination of palladium.

Journal: Annali di chimica 20071001

Title: 1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: synthesis, analgesic-anti-inflammatory and antimicrobial activities.

Journal: Bioorganic & medicinal chemistry 20070901

Title: [Pharmacological effects of volatile oil of Valeriana amurensis on CNS].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070801

Title: Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster.

Journal: Journal of the American Chemical Society 20070523

Title: Complexation versus thiadiazole formation for reactions of thiosemicarbazides with copper(II).

Journal: Dalton transactions (Cambridge, England : 2003) 20070328

Title: Spectroscopic studies of some thiosemicarbazide compounds derived from Girard's T and P.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070201

Title: GABA in regulation of communicative activity and sexual motivation of male mice with different psychoemotional status.

Journal: Bulletin of experimental biology and medicine 20070201

Title: Synthesis of novel 2-phenylsulfonylhydrazono-3-(2',3',4',6'-tetra-O-acetyl-beta-d-glucopyranosyl)thiazolidine-4-ones from thiosemicarbazide precursors.

Journal: Carbohydrate research 20061211

Title: Ligands for molecular imaging: the synthesis of bis(thiosemicarbazone) ligands.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20060816

Title: Transition metal complexes with thiosemicarbazide-based ligands. LIII. [4-(2-Diphenylphosphino-alpha-ethoxybenzyl-kappaP)-S-methyl-1-(4-oxidopent-3-en-4-ylidene-kappaO)thiosemicarbazido-kappa(2)N(1),N(4)]nickel(II).

Journal: Acta crystallographica. Section C, Crystal structure communications 20060701

Title: Analgesic and anticonvulsant effects of extracts from the leaves of Kalanchoe crenata (Andrews) Haworth (Crassulaceae).

Journal: Journal of ethnopharmacology 20060615

Title: Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi.

Journal: Bioorganic & medicinal chemistry 20060601

Title: Spectroscopic, cyclic voltammetric and biological studies of transition metal complexes with mixed nitrogen-sulphur (NS) donor macrocyclic ligand derived from thiosemicarbazide.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051101

Title: Synthesis and antiamoebic activity of 3,7-dimethyl-pyrazolo[3,4-e][1,2,4] triazin-4-yl thiosemicarbazide derivatives.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050601

Title: Effect of bis(acetato)tetrakis(imidazole) copper(II) in delaying the onset and reducing the mortality rate of strychnine- and thiosemicarbazide- induced convulsions.

Journal: Biological trace element research 20041001

Title: Synthesis and potential antimycotic activity of 4-substituted-3-(thiophene-2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones.

Journal: Acta pharmaceutica (Zagreb, Croatia) 20040901

Title: Incorporation of thiosemicarbazide in Amberlite IRC-50 for separation of astatine from alpha-irradiated bismuth oxide.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20040601

Title: Interactions between 1-benzoyl-4-p-chlorophenyl thiosemicarbazide and serum albumin: investigation by fluorescence spectroscopy.

Journal: Bioorganic & medicinal chemistry 20040102

Title: EPR, magnetic and spectral studies of copper(II) and nickel(II) complexes of schiff base macrocyclic ligand derived from thiosemicarbazide and glyoxal.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040101

Title: Biochemical and toxicological evaluation of agent-cofactor reactivity as a mechanism of action for osteolathyrism.

Journal: Toxicology 20020815

Title: Design of non-peptide CCK2 and NK1 peptidomimetics using 1-(2-nitrophenyl)thiosemicarbazide as a novel common scaffold.

Journal: Bioorganic & medicinal chemistry letters 20010312

Title: Expression of anti-neuroexcitation peptide (ANEP) of scorpion Buthus martensii Karsch in Escherichia coli.

Journal: Preparative biochemistry & biotechnology 20010201

Title: A 3D QSAR study of monoamino oxidase-B inhibitors using the chemical function based pharmacophore generation approach.

Journal: Journal of enzyme inhibition 20010101

Title: [Central inhibition action of Valeriana jatamansii Jones].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 19940101

Title: Anticonvulsant effects of caerulein, cholecystokinin octapeptide (CCK-8) and diazepam against seizures produced in mice by harman, thiosemicarbazide and isoniazid.

Journal: Neuroscience letters 19810702

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