Home Indole and Oxindoles 439288-66-1
439288-66-1,MFCD12912327
Catalog No.:AA00DA7W

439288-66-1 | 2-(4-(4,9-Diethoxy-1-oxo-1H-benzo[f]isoindol-2(3H)-yl)phenyl)-N-(phenylsulfonyl)acetamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$16.00   $11.00
- +
5mg
98+%
in stock  
$35.00   $25.00
- +
10mg
98+%
in stock  
$51.00   $36.00
- +
25mg
98+%
in stock  
$86.00   $61.00
- +
250mg
95%
in stock  
$601.00   $421.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DA7W
Chemical Name:
2-(4-(4,9-Diethoxy-1-oxo-1H-benzo[f]isoindol-2(3H)-yl)phenyl)-N-(phenylsulfonyl)acetamide
CAS Number:
439288-66-1
Molecular Formula:
C30H28N2O6S
Molecular Weight:
544.6181
MDL Number:
MFCD12912327
SMILES:
CCOc1c2C(=O)N(Cc2c(c2c1cccc2)OCC)c1ccc(cc1)CC(=O)NS(=O)(=O)c1ccccc1
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
953  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  
XLogP3:
4.8  

Literature

Title: EP4 receptor stimulation down-regulates human eosinophil function.

Journal: Cellular and molecular life sciences : CMLS 20111101

Title: The role of the prostaglandin EP4 receptor in the regulation of human outflow facility.

Journal: Investigative ophthalmology & visual science 20110601

Title: Differential reactivity of human mammary artery and saphenous vein to prostaglandin E(2) : implication for cardiovascular grafts.

Journal: British journal of pharmacology 20110601

Title: Effect of PGE2 on DA tone by EP4 modulating Kv channels with different oxygen tension between preterm and term.

Journal: International journal of cardiology 20110217

Title: Differential regulation of the aggressive phenotype of inflammatory breast cancer cells by prostanoid receptors EP3 and EP4.

Journal: Cancer 20100601

Title: Prostaglandin E2 mediates cough via the EP3 receptor: implications for future disease therapy.

Journal: American journal of respiratory and critical care medicine 20091115

Title: EP4 and EP2 receptor subtypes involved in colonic secretion in rat.

Journal: Basic & clinical pharmacology & toxicology 20080901

Title: Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon.

Journal: British journal of pharmacology 20080501

Title: Molecular and pharmacological blockade of the EP4 receptor selectively inhibits both proliferation and invasion of human inflammatory breast cancer cells.

Journal: Journal of experimental therapeutics & oncology 20080101

Title: Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta.

Journal: British journal of pharmacology 20071101

Title: Selective PPARdelta agonist treatment increases skeletal muscle lipid metabolism without altering mitochondrial energy coupling: an in vivo magnetic resonance spectroscopy study.

Journal: American journal of physiology. Endocrinology and metabolism 20071101

Title: GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist.

Journal: British journal of pharmacology 20060601

Title: Piglet saphenous vein contains multiple relaxatory prostanoid receptors: evidence for EP4, EP2, DP and IP receptor subtypes.

Journal: British journal of pharmacology 20050201

Title: Wilson RJ, et al. GW627368X ((N-{2--(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[fisoindol-2-yl)phenylacetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist. Br J Pharmacol. 2006 Jun;148(3):326-39.

Title: Robertson FM, et al. Molecular and pharmacological blockade of the EP4 receptor selectively inhibits both proliferation and invasion of human inflammatory breast cancer cells. J Exp Ther Oncol. 2008;7(4):299-312.

Title: Parida S, et al. Molecular inhibition of prostaglandin E2 with GW627368X: Therapeutic potential and preclinical safety assessment in mouse sarcoma model. Cancer Biol Ther. 2015;16(6):922-32.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 439288-66-1
Tags:439288-66-1 Molecular Formula|439288-66-1 MDL|439288-66-1 SMILES|439288-66-1 2-(4-(4,9-Diethoxy-1-oxo-1H-benzo[f]isoindol-2(3H)-yl)phenyl)-N-(phenylsulfonyl)acetamide