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442-51-3,MFCD00004958
Catalog No.:AA00I8BE

442-51-3 | Harmine

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250mg
≥98%
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$46.00   $32.00
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500mg
≥98%
in stock  
$82.00   $57.00
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1g
≥ 99% (GC)
in stock  
$122.00   $86.00
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5g
≥ 99% (GC)
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$385.00   $269.00
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25g
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  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I8BE
Chemical Name:
Harmine
CAS Number:
442-51-3
Molecular Formula:
C13H12N2O
Molecular Weight:
212.2472
MDL Number:
MFCD00004958
SMILES:
COc1ccc2c(c1)[nH]c1c2ccnc1C
Properties
Properties
 
BP:
421.4°C at 760 mmHg  
Form:
Solid  
MP:
262-264°C(lit.)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
258  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
3.6  

Literature

Title: Harmine is an inflammatory inhibitor through the suppression of NF-κB signaling.

Journal: Biochemical and biophysical research communications 20170729

Title: In vitro monoamine oxidase inhibition potential of alpha-methyltryptamine analog new psychoactive substances for assessing possible toxic risks.

Journal: Toxicology letters 20170415

Title: Monoamine oxidase inhibitory activity in tobacco particulate matter: Are harman and norharman the only physiologically relevant inhibitors?

Journal: Neurotoxicology 20170301

Title: Inhibition of DYRK1A Stimulates Human β-Cell Proliferation.

Journal: Diabetes 20160601

Title: Harmine Induces Adipocyte Thermogenesis through RAC1-MEK-ERK-CHD4 Axis.

Journal: Scientific reports 20160101

Title: A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.

Journal: Nature medicine 20150401

Title: Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.

Journal: Journal of medicinal chemistry 20150326

Title: Inhibition of monoamine oxidase (MAO) by β-carbolines and their interactions in live neuronal (PC12) and liver (HuH-7 and MH1C1) cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20140401

Title: Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.

Journal: Bioorganic & medicinal chemistry letters 20130615

Title: Developments in harmine pharmacology--implications for ayahuasca use and drug-dependence treatment.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20121203

Title: Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.

Journal: Journal of medicinal chemistry 20121108

Title: Metabolic pathways of the psychotropic-carboline alkaloids, harmaline and harmine, by liquid chromatography/mass spectrometry and NMR spectroscopy.

Journal: Food chemistry 20120915

Title: In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism.

Journal: Neuroscience letters 20120906

Title: Structural insights into cholinesterases inhibition by harmane β-carbolinium derivatives: a kinetics-molecular modeling approach.

Journal: Phytochemistry 20120901

Title: Simultaneous determination of alkaloids and flavonoids from aerial parts of Passiflora species and dietary supplements using UPLC-UV-MS and HPTLC.

Journal: Natural product communications 20120901

Title: Binding interaction and rotational-relaxation dynamics of a cancer cell photosensitizer with various micellar assemblies.

Journal: The journal of physical chemistry. B 20120816

Title: Involvement of the cholinergic system of CA1 on harmane-induced amnesia in the step-down passive avoidance test.

Journal: Journal of psychopharmacology (Oxford, England) 20120801

Title: Detection of bioactive exometabolites produced by the filamentous marine cyanobacterium Geitlerinema sp.

Journal: Marine biotechnology (New York, N.Y.) 20120801

Title: InCl3-catalysed synthesis of 2-aryl quinazolin-4(3H)-ones and 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones and their evaluation as potential anticancer agents.

Journal: Bioorganic & medicinal chemistry letters 20120801

Title: Novel trisubstituted harmine derivatives with original in vitro anticancer activity.

Journal: Journal of medicinal chemistry 20120726

Title: Blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor: repeat observation in cases and controls in New York.

Journal: Journal of toxicology and environmental health. Part A 20120615

Title: Library-based discovery of DYRK1A/CLK1 inhibitors from natural product extracts.

Journal: Planta medica 20120601

Title: Solvent effect on copper-catalyzed azide-alkyne cycloaddition (CuAAC): synthesis of novel triazolyl substituted quinolines as potential anticancer agents.

Journal: Bioorganic & medicinal chemistry letters 20120515

Title: Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice.

Journal: Journal of neuroscience research 20120501

Title: Prospective acetylcholinesterase inhibitory activity of indole and its analogs.

Journal: Bioorganic & medicinal chemistry letters 20120415

Title: Synthesis and herbicidal activity evaluation of novel β-carboline derivatives.

Journal: Molecules (Basel, Switzerland) 20120402

Title: Differential interactions of a biological photosensitizer with liposome membranes having varying surface charges.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20120401

Title: Catalysis by molecular iodine: a rapid synthesis of 1,8-dioxo-octahydroxanthenes and their evaluation as potential anticancer agents.

Journal: Bioorganic & medicinal chemistry letters 20120315

Title: Photosensitization of DNA by β-carbolines: kinetic analysis and photoproduct characterization.

Journal: Organic & biomolecular chemistry 20120307

Title: Dyrk1a activates antioxidant NQO1 expression through an ERK1/2-Nrf2 dependent mechanism.

Journal: Molecular genetics and metabolism 20120301

Title: Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [(11)C]-harmine positron emission tomography study.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120301

Title: Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20120301

Title: The harmala alkaloid harmine is a modulator of circadian Bmal1 transcription.

Journal: Bioscience reports 20120201

Title: Effects of apomorphine and β-carbolines on firing rate of neurons in the ventral pallidum in the rats.

Journal: Behavioural brain research 20120201

Title: Ultrasound mediated catalyst free synthesis of 6H-1-benzopyrano[4,3-b]quinolin-6-ones leading to novel quinoline derivatives: their evaluation as potential anti-cancer agents.

Journal: Bioorganic & medicinal chemistry 20120115

Title: The impact of dihydrogen phosphate anions on the excited-state proton transfer of harmane. Effect of β-cyclodextrin on these photoreactions.

Journal: The journal of physical chemistry. A 20120112

Title: Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol.

Journal: Toxicology letters 20120105

Title: Administration of harmine and imipramine alters creatine kinase and mitochondrial respiratory chain activities in the rat brain.

Journal: Depression research and treatment 20120101

Title: Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120101

Title: A searchable cross-platform gene expression database reveals connections between drug treatments and disease.

Journal: BMC genomics 20120101

Title: Metabolism and disposition of N,N-dimethyltryptamine and harmala alkaloids after oral administration of ayahuasca.

Journal: Drug testing and analysis 20120101

Title: Single-cell analysis of population context advances RNAi screening at multiple levels.

Journal: Molecular systems biology 20120101

Title: Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents.

Journal: Frontiers in microbiology 20120101

Title: JKA97, a novel benzylidene analog of harmine, exerts anti-cancer effects by inducing G1 arrest, apoptosis, and p53-independent up-regulation of p21.

Journal: PloS one 20120101

Title: Camel milk modulates the expression of aryl hydrocarbon receptor-regulated genes, Cyp1a1, Nqo1, and Gsta1, in murine hepatoma Hepa 1c1c7 cells.

Journal: Journal of biomedicine & biotechnology 20120101

Title: Behavioral competence as a positive youth development construct: a conceptual review.

Journal: TheScientificWorldJournal 20120101

Title: Leishmanicidal activity of nine novel flavonoids from Delphinium staphisagria.

Journal: TheScientificWorldJournal 20120101

Title: A novel RNAi lethality rescue screen to identify regulators of adipogenesis.

Journal: PloS one 20120101

Title: Preclinical and clinical evidence of antioxidant effects of antidepressant agents: implications for the pathophysiology of major depressive disorder.

Journal: Oxidative medicine and cellular longevity 20120101

Title: Intracerebral injection of low amounts of norharman induces moderate Parkinsonism-like behavioral symptoms in rat.

Journal: Neurotoxicology and teratology 20120101

Title: Formation of heterocyclic amines during cooking of duck meat.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20120101

Title: Personality, psychopathology, life attitudes and neuropsychological performance among ritual users of Ayahuasca: a longitudinal study.

Journal: PloS one 20120101

Title: Harmine induces apoptosis in HepG2 cells via mitochondrial signaling pathway.

Journal: Hepatobiliary & pancreatic diseases international : HBPD INT 20111201

Title: Inhibition of human cytochrome P450 enzymes 3A4 and 2D6 by β-carboline alkaloids, harmine derivatives.

Journal: Phytotherapy research : PTR 20111101

Title: Monoamine oxidase A inhibitor occupancy during treatment of major depressive episodes with moclobemide or St. John's wort: an [11C]-harmine PET study.

Journal: Journal of psychiatry & neuroscience : JPN 20111101

Title: [Study on chemical constituents of Peganum multisectum].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20111101

Title: Exploring the strength, mode, dynamics, and kinetics of binding interaction of a cationic biological photosensitizer with DNA: implication on dissociation of the drug-DNA complex via detergent sequestration.

Journal: The journal of physical chemistry. B 20111020

Title: Simiranes A and B: erythroxylanes diterpenes and other compounds from Simira eliezeriana (Rubiaceae).

Journal: Natural product research 20111001

Title: Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation.

Journal: PLoS genetics 20111001

Title: Synthesis, structures, cellular uptake and apoptosis-inducing properties of highly cytotoxic ruthenium-Norharman complexes.

Journal: Dalton transactions (Cambridge, England : 2003) 20110914

Title: Modulation of prototropic activity and rotational relaxation dynamics of a cationic biological photosensitizer within the motionally constrained bio-environment of a protein.

Journal: The journal of physical chemistry. B 20110901

Title: Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.

Journal: Journal of medicinal chemistry 20110811

Title: Screening of medicinal plants from Iranian traditional medicine for acetylcholinesterase inhibition.

Journal: Phytotherapy research : PTR 20110801

Title: The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells.

Journal: Bone 20110801

Title: Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110801

Title: Monoamine oxidase A binding in the prefrontal and anterior cingulate cortices during acute withdrawal from heavy cigarette smoking.

Journal: Archives of general psychiatry 20110801

Title: In vitro and in vivo activities of Peganum harmala extract against Leishmania major.

Journal: Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 20110801

Title: Performance evaluation on a wide set of matrix-assisted laser desorption ionization matrices for the detection of oligosaccharides in a high-throughput mass spectrometric screening of carbohydrate depolymerizing enzymes.

Journal: Rapid communications in mass spectrometry : RCM 20110730

Title: Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors.

Journal: Journal of medicinal chemistry 20110714

Title: Dietary inhibitors of monoamine oxidase A.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20110701

Title: β-Carboline (norharman).

Journal: Acta crystallographica. Section C, Crystal structure communications 20110701

Title: Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

Journal: Journal of medicinal chemistry 20110623

Title: Harmine promotes osteoblast differentiation through bone morphogenetic protein signaling.

Journal: Biochemical and biophysical research communications 20110603

Title: Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression.

Journal: Neuropharmacology 20110601

Title: Synthesis and cytotoxic activity of new β-carboline derivatives.

Journal: Mini reviews in medicinal chemistry 20110601

Title: The inhibition activity of selected beta-carboline alkaloids on enzymes of acetylcholinesterase and butyrylcholinesterase.

Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20110601

Title: A new compound, jolynamine, from marine brown alga Jolyna laminarioides.

Journal: Natural product research 20110501

Title: Selective drug trace detection with low-field NMR.

Journal: The Analyst 20110421

Title: Effects of harmane and other β-carbolines on apomorphine-induced licking behavior in rat.

Journal: Pharmacology, biochemistry, and behavior 20110401

Title: Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A).

Journal: Archives of biochemistry and biophysics 20110315

Title: Partial hepatectomy aggravates cyclosporin A-induced neurotoxicity by lowering the function of the blood-brain barrier in mice.

Journal: Life sciences 20110314

Title: Blood harmane, blood lead, and severity of hand tremor: evidence of additive effects.

Journal: Neurotoxicology 20110301

Title: MAO-inhibitors in Parkinson's Disease.

Journal: Experimental neurobiology 20110301

Title: Screening of non-polar heterocyclic amines in urine by microextraction in packed sorbent-fluorimetric detection and confirmation by capillary liquid chromatography.

Journal: Talanta 20110215

Title: Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system.

Journal: PLoS neglected tropical diseases 20110201

Title: Harmine, a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo.

Journal: European journal of pharmacology 20110115

Title: Activation, regulation, and inhibition of DYRK1A.

Journal: The FEBS journal 20110101

Title: Synthesis and evaluation of β-carboline derivatives as potential monoamine oxidase inhibitors.

Journal: Bioorganic & medicinal chemistry 20110101

Title: Inhibitory effects of herbal alkaloids on the tumor necrosis factor-α and nitric oxide production in lipopolysaccharide-stimulated RAW264 macrophages.

Journal: Chemical & pharmaceutical bulletin 20110101

Title: Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma.

Journal: Chinese medicine 20110101

Title: β-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sites.

Journal: PloS one 20110101

Title: Blood harmane concentrations in 497 individuals relative to coffee, cigarettes, and food consumption on the morning of testing.

Journal: Journal of toxicology 20110101

Title: An integrated bioinformatics approach identifies elevated cyclin E2 expression and E2F activity as distinct features of tamoxifen resistant breast tumors.

Journal: PloS one 20110101

Title: The β-carboline alkaloid harmol induces cell death via autophagy but not apoptosis in human non-small cell lung cancer A549 cells.

Journal: Biological & pharmaceutical bulletin 20110101

Title: Comparative Effects of α-, β-, and γ-Carbolines on Platelet Aggregation and Lipid Membranes.

Journal: Journal of toxicology 20110101

Title: Studies on anti-metastatic and anti-invasive effects of harmine using highly metastatic murine B16F-10 melanoma cells.

Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20110101

Title: Beyond THC: The New Generation of Cannabinoid Designer Drugs.

Journal: Frontiers in behavioral neuroscience 20110101

Title: Role of natural herbs in the treatment of hypertension.

Journal: Pharmacognosy reviews 20110101

Title: Evaluation of anti-depressant and anxiolytic activity of Rasayana Ghana Tablet (A compound Ayurvedic formulation) in albino mice.

Journal: Ayu 20110101

Title: Long term exposure to norharman exacerbates 6-hydroxydopamine-induced parkinsonism: possible involvement of L-type Ca2+ channels.

Journal: Behavioural brain research 20101220

Title: Harmine inhibits tumour specific neo-vessel formation by regulating VEGF, MMP, TIMP and pro-inflammatory mediators both in vivo and in vitro.

Journal: European journal of pharmacology 20101215

Title: Mitochondrial dysfunction and biotransformation of β-carboline alkaloids, harmine and harmaline, on isolated rat hepatocytes.

Journal: Chemico-biological interactions 20101205

Title: Relationship between blood harmane and harmine concentrations in familial essential tremor, sporadic essential tremor and controls.

Journal: Neurotoxicology 20101201

Title: Interaction of β-carboline alkaloids with RNA.

Journal: DNA and cell biology 20101201

Title: Harman induces CYP1A1 enzyme through an aryl hydrocarbon receptor mechanism.

Journal: Toxicology and applied pharmacology 20101115

Title: Cytotoxic and insecticidal activities of derivatives of harmine, a natural insecticidal component isolated from Peganum harmala.

Journal: Molecules (Basel, Switzerland) 20101102

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Capillary liquid chromatography with diode array and mass spectrometry detection for heterocyclic aromatic amine determination in ready-to-eat food treated with electron-beam irradiation.

Journal: Journal of chromatography. A 20101022

Title: Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.

Journal: Nature communications 20101005

Title: Antibacterial and antifungal activities of (beta)-carboline alkaloids of Peganum harmala (L) seeds and their combination effects.

Journal: Fitoterapia 20101001

Title: Chronic administration of harmine elicits antidepressant-like effects and increases BDNF levels in rat hippocampus.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20101001

Title: Epigallocatechin gallate-induced modulation of FoxO signaling in mammalian cells and C. elegans: FoxO stimulation is masked via PI3K/Akt activation by hydrogen peroxide formed in cell culture.

Journal: Archives of biochemistry and biophysics 20100901

Title: The small molecule phenamil is a modulator of adipocyte differentiation and PPARgamma expression.

Journal: Journal of lipid research 20100901

Title: [Investigation on representation methods of dissolubility property of total alkaloid extract from Peganum harmala].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100901

Title: Beta-carboline alkaloids bind DNA.

Journal: Journal of photochemistry and photobiology. B, Biology 20100802

Title: [Screening of harmine tolerance/degrading bacteria from camel rumen].

Journal: Wei sheng wu xue bao = Acta microbiologica Sinica 20100801

Title: Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds.

Journal: Journal of medicinal chemistry 20100708

Title: Photosensitized cleavage of plasmidic DNA by norharmane, a naturally occurring beta-carboline.

Journal: Organic & biomolecular chemistry 20100607

Title: Involvement of dopamine D1/D2 receptors on harmane-induced amnesia in the step-down passive avoidance test.

Journal: European journal of pharmacology 20100525

Title: A repurposing strategy identifies novel synergistic inhibitors of Plasmodium falciparum heat shock protein 90.

Journal: Journal of medicinal chemistry 20100513

Title: Peganum harmala L. is a candidate herbal plant for preventing dioxin mediated effects.

Journal: Planta medica 20100501

Title: Elevated brain monoamine oxidase A binding in the early postpartum period.

Journal: Archives of general psychiatry 20100501

Title: A class of 3S-2-aminoacyltetrahydro-beta-carboline-3-carboxylic acids: their facile synthesis, inhibition for platelet activation, and high in vivo anti-thrombotic potency.

Journal: Journal of medicinal chemistry 20100422

Title: Composition, standardization and chemical profiling of Banisteriopsis caapi, a plant for the treatment of neurodegenerative disorders relevant to Parkinson's disease.

Journal: Journal of ethnopharmacology 20100421

Title: Bis(7-meth-oxy-1-methyl-4,9-dihydro-3H-β-carbolinium) tetra-chloridozincate.

Journal: Acta crystallographica. Section E, Structure reports online 20100401

Title: Effects of beta-carboline harmine on behavioral and physiological parameters observed in the chronic mild stress model: further evidence of antidepressant properties.

Journal: Brain research bulletin 20100316

Title: Electrophysiological characterization of harmane-induced activation of mesolimbic dopamine neurons.

Journal: European journal of pharmacology 20100310

Title: Electrospray MS-based characterization of beta-carbolines--mutagenic constituents of thermally processed meat.

Journal: Molecular nutrition & food research 20100301

Title: beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO).

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100301

Title: Banisteriopsis caapi, a unique combination of MAO inhibitory and antioxidative constituents for the activities relevant to neurodegenerative disorders and Parkinson's disease.

Journal: Journal of ethnopharmacology 20100203

Title: The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells.

Journal: Phytotherapy research : PTR 20100101

Title: HPLC fingerprints combined with principal component analysis, hierarchical cluster analysis and linear discriminant analysis for the classification and differentiation of Peganum sp. indigenous to China.

Journal: Phytochemical analysis : PCA 20100101

Title: Beta-carboline alkaloids and essential tremor: exploring the environmental determinants of one of the most prevalent neurological diseases.

Journal: TheScientificWorldJournal 20100101

Title: A stem cell-based tool for small molecule screening in adipogenesis.

Journal: PloS one 20100101

Title: Harmine and imipramine promote antioxidant activities in prefrontal cortex and hippocampus.

Journal: Oxidative medicine and cellular longevity 20100101

Title: Anti-tumor Activity of N [(E)-1-(2-hydroxyphenyl) Methylidene], N-[(E)-2-Phenylethylidene], N [(E,2E)-3-Phenyl-2-propenylidene], and N [(E)ethylidene] Isonicotinohydrazide on K562 and Jurkat Cell Lines.

Journal: Journal of young pharmacists : JYP 20100101

Title: Chemical warfare agents.

Journal: Journal of pharmacy & bioallied sciences 20100101

Title: Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77.

Journal: Diabetes 20091201

Title: Hollow fibre-supported liquid membrane extraction and LC-MS/MS detection for the analysis of heterocyclic amines in urine samples.

Journal: Molecular nutrition & food research 20091201

Title: Brain monoamine oxidase A binding in major depressive disorder: relationship to selective serotonin reuptake inhibitor treatment, recovery, and recurrence.

Journal: Archives of general psychiatry 20091201

Title: Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20091113

Title: p38alpha- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress.

Journal: Cellular signalling 20091101

Title: Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation.

Journal: The FEBS journal 20091101

Title: Antiproliferative activity of arborescidine alkaloids and derivatives.

Journal: European journal of medicinal chemistry 20090901

Title: Molecular determinants of beta-carboline inhibition of the glycine receptor.

Journal: Journal of neurochemistry 20090901

Title: Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay.

Journal: Archives of pharmacal research 20090901

Title: Photochemistry of norharmane in aqueous solution.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20090801

Title: Novel insights into adipogenesis from omics data.

Journal: Current medicinal chemistry 20090801

Title: Bioanalytical and clinical evaluation of 103 suspected cases of intoxications with psychoactive plant materials.

Journal: Clinical toxicology (Philadelphia, Pa.) 20090701

Title: DYRK1A is a novel negative regulator of cardiomyocyte hypertrophy.

Journal: The Journal of biological chemistry 20090619

Title: One- and two-photon excitation of beta-carbolines in aqueous solution: pH-dependent spectroscopy, photochemistry, and photophysics.

Journal: The journal of physical chemistry. A 20090618

Title: Harmol induces apoptosis by caspase-8 activation independently of Fas/Fas ligand interaction in human lung carcinoma H596 cells.

Journal: Anti-cancer drugs 20090601

Title: [Simple and rapid screening for psychotropic natural products using Direct Analysis in Real Time (DART)-TOFMS].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090601

Title: The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20090501

Title: A multi-component LC-MS/MS method for detection of ten plant-derived psychoactive substances in urine.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090415

Title: Analysis of toxic alkaloids in body samples.

Journal: Forensic science international 20090310

Title: 3-Hydr-oxy-1,2,3,9-tetra-hydro-pyrrolo[2,1-b]quinazolin-4-ium chloride dihydrate: (+)-vasicinol hydro-chloride dihydrate from Peganum harmala L.

Journal: Acta crystallographica. Section E, Structure reports online 20090301

Title: Synthesis and in vitro cytotoxic evaluation of novel 3,4,5-trimethoxyphenyl substituted beta-carboline derivatives.

Journal: European journal of medicinal chemistry 20090201

Title: The effect of temperature on the stability of compounds used as UV-MALDI-MS matrix: 2,5-dihydroxybenzoic acid, 2,4,6-trihydroxyacetophenone, alpha-cyano-4-hydroxycinnamic acid, 3,5-dimethoxy-4-hydroxycinnamic acid, nor-harmane and harmane.

Journal: Journal of mass spectrometry : JMS 20090201

Title: Antiplatelet activity of beta-carboline alkaloids from Perganum harmala: a possible mechanism through inhibiting PLCgamma2 phosphorylation.

Journal: Vascular pharmacology 20090101

Title: Gas chromatographic analysis of dimethyltryptamine and beta-carboline alkaloids in ayahuasca, an Amazonian psychoactive plant beverage.

Journal: Phytochemical analysis : PCA 20090101

Title: Floral nectar composition of Peganum harmala L.

Journal: Natural product research 20090101

Title: Influence of the dual ABCB1 and ABCG2 inhibitor tariquidar on the disposition of oral imatinib in mice.

Journal: Journal of experimental & clinical cancer research : CR 20090101

Title: DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase.

Journal: PloS one 20090101

Title: Synthesis and cytotoxic activities of 1-benzylidine substituted beta-carboline derivatives.

Journal: Bioorganic & medicinal chemistry letters 20081215

Title: The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4.

Journal: Neuroscience 20081202

Title: DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine.

Journal: The FEBS journal 20081201

Title: Modification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitors.

Journal: Psychopharmacology 20081101

Title: Negative-mode MALDI mass spectrometry for the analysis of pigments using tetrathiafulvalene as a matrix.

Journal: Journal of mass spectrometry : JMS 20081101

Title: Antifungal activity of the termite alkaloid norharmane against the mycelial growth of Metarhizium anisopliae and Aspergillus nomius.

Journal: Journal of invertebrate pathology 20081101

Title: Apparent differences in mechanisms of harmol sulfate biliary excretion in mice and rats.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20081101

Title: Effect of Peganum harmala or its beta-carboline alkaloids on certain antibiotic resistant strains of bacteria and protozoa from poultry.

Journal: Phytotherapy research : PTR 20081101

Title: Oxidative metabolism of the bioactive and naturally occurring beta-carboline alkaloids, norharman and harman, by human cytochrome P450 enzymes.

Journal: Chemical research in toxicology 20081101

Title: Alkaloids induce programmed cell death in bloodstream forms of trypanosomes (Trypanosoma b. brucei).

Journal: Molecules (Basel, Switzerland) 20081003

Title: Identification of N,N-dimethyltryptamine and beta-carbolines in psychotropic ayahuasca beverage.

Journal: Biomedical chromatography : BMC 20081001

Title: Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities.

Journal: Journal of natural medicines 20081001

Title: Environmental epidemiology of essential tremor.

Journal: Neuroepidemiology 20081001

Title: Separation and purification of harmine and harmaline from Peganum harmala using pH-zone-refining counter-current chromatography.

Journal: Journal of separation science 20081001

Title: Cancer and blood concentrations of the comutagen harmane in essential tremor.

Journal: Movement disorders : official journal of the Movement Disorder Society 20080915

Title: Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation.

Journal: Molecular endocrinology (Baltimore, Md.) 20080901

Title: Syrian rue tea: a recipe for disaster.

Journal: Clinical toxicology (Philadelphia, Pa.) 20080901

Title: A case of beta-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract.

Journal: Forensic science international 20080806

Title: A simple, rapid and mild one pot synthesis of benzene ring acylated and demethylated analogues of harmine under solvent-free conditions.

Journal: Molecules (Basel, Switzerland) 20080806

Title: Cytotoxicity of the beta-carboline alkaloids harmine and harmaline in human cell assays in vitro.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080801

Title: The globalization of ayahuasca: harm reduction or benefit maximization?

Journal: The International journal on drug policy 20080801

Title: The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors.

Journal: Bioorganic & medicinal chemistry 20080715

Title: Simultaneous determination of thirteen plant alkaloids in a human specimen by SPE and HPLC.

Journal: Journal of separation science 20080701

Title: Quantification of heterocyclic aromatic amines in fried meat by HPTLC/UV-FLD and HPLC/UV-FLD: a comparison of two methods.

Journal: Journal of agricultural and food chemistry 20080625

Title: Effects of harman and norharman on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells.

Journal: European journal of pharmacology 20080610

Title: Indolealkylamines: biotransformations and potential drug-drug interactions.

Journal: The AAPS journal 20080601

Title: Influence of the presence of methyl cyclodextrins in high-performance liquid chromatography mobile phases on the separation of beta-carboline alkaloids.

Journal: Journal of chromatography. A 20080530

Title: Loss of thalamic serotonin transporters in early drug-naïve Parkinson's disease patients is associated with tremor: an [(123)I]beta-CIT SPECT study.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20080501

Title: Dietary epidemiology of essential tremor: meat consumption and meat cooking practices.

Journal: Neuroepidemiology 20080501

Title: Higher blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations correlate with lower olfactory scores in essential tremor.

Journal: Neurotoxicology 20080501

Title: Ayahuasca versus violence--a case report.

Journal: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20080501

Title: Determination of the cyclic depsipeptide FK228 in human and mouse plasma by liquid chromatography with mass-spectrometric detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080401

Title: Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor.

Journal: Neurotoxicology 20080301

Title: Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity.

Journal: PLoS medicine 20080301

Title: The endogenous alkaloid harmane: acidifying and activity-reducing effects on hippocampal neurons in vitro.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20080215

Title: Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.

Journal: Journal of medicinal chemistry 20080124

Title: A newly developed assay for the quantitative determination of antimicrobial (anticyanobacterial) activity of both hydrophilic and lipophilic test compounds without any restriction.

Journal: Microbiological research 20080101

Title: Screening of microalgae for species excreting norharmane, a manifold biologically active indole alkaloid.

Journal: Microbiological research 20080101

Title: High-performance thin-layer chromatography densitometric method for the quantification of harmine, harmaline, vasicine, and vasicinone in Peganum harmala.

Journal: Journal of AOAC International 20080101

Title: Antitumor activity of 6-(cyclohexylamino)-1, 3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) complexes on K562 and Jurkat cell lines.

Journal: Bioinorganic chemistry and applications 20080101

Title: Effect of norharmane in vitro on juvenile hormone epoxide hydrolase activity in the lower termite, Reticulitermes speratus.

Journal: Journal of insect science (Online) 20080101

Title: The selectivity of protein kinase inhibitors: a further update.

Journal: The Biochemical journal 20071215

Title: Direct experimental evidence for a heterogeneous reaction of ozone with bromide at the air-aqueous interface.

Journal: The journal of physical chemistry. A 20071004

Title: Role of acetaldehyde in tobacco smoke addiction.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20071001

Title: Coupled hydrogen-bonding interactions between beta-carboline derivatives and acetic acid.

Journal: Magnetic resonance in chemistry : MRC 20071001

Title: Biodistribution and radiation dosimetry of 11C-harmine in baboons.

Journal: Nuclear medicine communications 20070901

Title: Sustained inhibition of brotizolam induced anterograde amnesia by norharmane and retrograde amnesia by L-glutamic acid in mice.

Journal: Behavioural brain research 20070822

Title: Blood harmane is correlated with cerebellar metabolism in essential tremor: a pilot study.

Journal: Neurology 20070807

Title: Effects of ayahuasca on psychometric measures of anxiety, panic-like and hopelessness in Santo Daime members.

Journal: Journal of ethnopharmacology 20070725

Title: Differential effects of dopamine melanin on norharman-induced toxicity in PC12 cells.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20070701

Title: Antioxidant properties of beta-carboline alkaloids are related to their antimutagenic and antigenotoxic activities.

Journal: Mutagenesis 20070701

Title: A study on the antitumoral and differentiation effects of peganum harmala derivatives in combination with ATRA on leukaemic cells.

Journal: Archives of pharmacal research 20070701

Title: Quantification of the neurotoxic beta-carboline harmane in barbecued/grilled meat samples and correlation with level of doneness.

Journal: Journal of toxicology and environmental health. Part A 20070601

Title: Targeting fat to prevent diabetes.

Journal: Cell metabolism 20070501

Title: The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression.

Journal: Cell metabolism 20070501

Title: Surfactant chain-length-dependent modulation of the prototropic transformation of a biological photosensitizer: norharmane in anionic micelles.

Journal: Langmuir : the ACS journal of surfaces and colloids 20070424

Title: Solid-phase fluorescence and ionization efficiency in negative-ion matrix-assisted laser desorption/ionization of neutral oligosaccharides: interaction between beta-carboline matrix and ammonium salt.

Journal: Journal of the American Society for Mass Spectrometry 20070401

Title: Factors influencing the norharman and harman contents in espresso coffee.

Journal: Journal of agricultural and food chemistry 20070307

Title: Determination of beta-carboline alkaloids in foods and beverages by high-performance liquid chromatography with electrochemical detection at a glassy carbon electrode modified with carbon nanotubes.

Journal: Analytica chimica acta 20070307

Title: Detection of aminophenylnorharman, a possible endogenous mutagenic and carcinogenic compound, in human urine samples.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070101

Title: Structural characterization of native high-methoxylated pectin using nuclear magnetic resonance spectroscopy and ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Comparative use of 2,5-dihydroxybenzoic acid and nor-harmane as UV-MALDI matrices.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: A quantitative synthesis of the medicinal ethnobotany of the Malinké of Mali and the Asháninka of Peru, with a new theoretical framework.

Journal: Journal of ethnobiology and ethnomedicine 20070101

Title: Analysis of hallucinogenic constituents in Amanita mushrooms circulated in Japan.

Journal: Forensic science international 20061220

Title: The important role of Bcrp (Abcg2) in the biliary excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in mice.

Journal: Molecular pharmacology 20061201

Title: Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice.

Journal: The Journal of pharmacology and experimental therapeutics 20061201

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6.

Journal: Toxicology and applied pharmacology 20061101

Title: Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression.

Journal: Archives of general psychiatry 20061101

Title: Effects of beta-carboline alkaloids on the object recognition task in mice.

Journal: Life sciences 20061026

Title: Efficacy of planar chromatography coupled to (tandem) mass spectrometry for employment in trace analysis.

Journal: Journal of chromatography. A 20060922

Title: Neurochemical mechanisms of the dorsal pallidum in the antiaversive effects of anxiolytics in various models of anxiety.

Journal: Neuroscience and behavioral physiology 20060901

Title: Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin.

Journal: Journal of neurochemistry 20060901

Title: Partial least squares-based multivariate spectral calibration method for simultaneous determination of beta-carboline derivatives in Peganum harmala seed extracts.

Journal: Analytica chimica acta 20060811

Title: Vasorelaxant effects of harmine and harmaline extracted from Peganum harmala L. seeds in isolated rat aorta.

Journal: Pharmacological research 20060801

Title: Antidepressant-like effect of harmane and other beta-carbolines in the mouse forced swim test.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20060701

Title: Protective effects of Peganum harmala L. extract, harmine and harmaline against human low-density lipoprotein oxidation.

Journal: The Journal of pharmacy and pharmacology 20060701

Title: Phytochemical and pharmacological study of roots and leaves of Guiera senegalensis J.F. Gmel (Combretaceae).

Journal: Journal of ethnopharmacology 20060630

Title: Effect of monoamine oxidase inhibition on amphetamine-evoked changes in dopamine receptor availability in the living pig: a dual tracer PET study with [11C]harmine and [11C]raclopride.

Journal: Synapse (New York, N.Y.) 20060601

Title: Identification of norharman as the cytotoxic compound produced by the sponge (Hymeniacidon perleve)-associated marine bacterium Pseudoalteromonas piscicida and its apoptotic effect on cancer cells.

Journal: Biotechnology and applied biochemistry 20060601

Title: [Harmine induces apoptosis in human SGC-7901 cells].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060601

Title: Norharman-induced motoric impairment in mice: neurodegeneration and glial activation in substantia nigra.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20060301

Title: Positron emission tomography quantification of [11C]-harmine binding to monoamine oxidase-A in the human brain.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20060301

Title: In vitro and ex vivo distribution of [3H]harmane, an endogenous beta-carboline, in rat brain.

Journal: Neuropharmacology 20060301

Title: Preparation, structure and spasmolytic activities of some derivatives of harmine series of alkaloids.

Journal: Natural product research 20060301

Title: Autoradiographical distribution of imidazoline binding sites in monoamine oxidase A deficient mice.

Journal: Journal of neurochemistry 20060301

Title: Effect of chlorine as substituent on the photochemistry and acid-base properties of beta-carboline alkaloids.

Journal: Journal of photochemistry and photobiology. B, Biology 20060201

Title: Human monoamine oxidase enzyme inhibition by coffee and beta-carbolines norharman and harman isolated from coffee.

Journal: Life sciences 20060118

Title: Antialgal, antibacterial and antifungal activity of two metabolites produced and excreted by cyanobacteria during growth.

Journal: Microbiological research 20060101

Title: Centrally acting imidazolines stimulate vascular alpha 1A-adrenergic receptors in Rat-Tail Artery.

Journal: Cellular and molecular neurobiology 20060101

Title: DNA binding properties of 9-substituted harmine derivatives.

Journal: Biochemical and biophysical research communications 20051223

Title: Harmane inhibits serotonergic dorsal raphe neurons in the rat.

Journal: Psychopharmacology 20051101

Title: Investigation of the separation of heterocyclic aromatic amines by reversed phase ion-pair liquid chromatography coupled with tandem mass spectrometry: the role of ion pair reagents on LC-MS/MS sensitivity.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051025

Title: Simultaneous determination of nineteen hallucinogenic tryptamines/beta-calbolines and phenethylamines using gas chromatography-mass spectrometry and liquid chromatography-electrospray ionisation-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051015

Title: Design, synthesis and in vitro and in vivo antitumor activities of novel beta-carboline derivatives.

Journal: European journal of medicinal chemistry 20051001

Title: Isolation and characterization of norharmane from Reticulitermes termites (Isoptera: Rhinotermitidae).

Journal: Journal of economic entomology 20051001

Title: Depressant effect of mitochondrial respiratory complex inhibitors on proteasome inhibitor-induced mitochondrial dysfunction and cell death in PC12 cells.

Journal: Neurochemical research 20050901

Title: High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain.

Journal: European journal of pharmacology 20050822

Title: Blood harmane concentrations and dietary protein consumption in essential tremor.

Journal: Neurology 20050809

Title: Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent.

Journal: Phytochemistry 20050701

Title: Photochemistry of the alkaloids eudistomin N (6-bromo-nor-harmane) and eudistomin O (8-bromo-nor-harmane) and other bromo-beta-carbolines.

Journal: Journal of photochemistry and photobiology. B, Biology 20050701

Title: Antibacterial activity of 1-methyl-7-methoxy-beta-carboline and its phenacyl and coumarine analogues.

Journal: Pakistan journal of pharmaceutical sciences 20050701

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Phytochemical analyses of Banisteriopsis caapi and Psychotria viridis.

Journal: Journal of psychoactive drugs 20050601

Title: Various alkaloid profiles in decoctions of Banisteriopsis caapi.

Journal: Journal of psychoactive drugs 20050601

Title: Fast and slow metabolizers of Hoasca.

Journal: Journal of psychoactive drugs 20050601

Title: Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis.

Journal: International journal of cancer 20050501

Title: [DNA and chemical analyses of commercial fly agaric-related products].

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20050401

Title: Comparison of the Protective Effect of Indole beta-carbolines and R-(-)-deprenyl Against Nitrogen Species-Induced Cell Death in Experimental Culture Model of Parkinson's Disease.

Journal: Journal of clinical neurology (Seoul, Korea) 20050401

Title: Encapsulation of norharmane in cyclodextrin: formation of 1:1 and 1:2 inclusion complexes.

Journal: Journal of photochemistry and photobiology. B, Biology 20050301

Title: Lack of combination hepatocarcinogenicity of harman, norharman and amitrole when given with NaNO2 in the rat.

Journal: The Journal of toxicological sciences 20050201

Title: Photophysics in motionally constrained bioenvironment: interaction of norharmane with bovine serum albumin.

Journal: Photochemistry and photobiology 20050101

Title: Modulation of voltage-gated channel currents by harmaline and harmane.

Journal: British journal of pharmacology 20050101

Title: Matrix-assisted ultraviolet laser desorption/ionization time-of-flight mass spectrometry of beta-(1 --> 3), beta-(1 --> 4)-xylans from Nothogenia fastigiata using nor-harmane as matrix.

Journal: Rapid communications in mass spectrometry : RCM 20050101

Title: Fluorescence quenching of beta-carboline alkaloids in micellar media. A study to select the adequate surfactant to use in analytical techniques.

Journal: Luminescence : the journal of biological and chemical luminescence 20050101

Title: Beta-carboline and quinoline alkaloids in root cultures and intact plants of Peganum harmala.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20050101

Title: Comprehensive photochemistry and photophysics of land- and marine-based beta-carbolines employing time-resolved emission and flash transient spectroscopy.

Journal: Photochemistry and photobiology 20050101

Title: Antimicrobial activity and main chemical composition of two smoke condensates from Peganum harmala seeds.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20050101

Title: A fatal intoxication following the ingestion of 5-methoxy-N,N-dimethyltryptamine in an ayahuasca preparation.

Journal: Journal of analytical toxicology 20050101

Title: Harmane and harmalan are bioactive components of classical clonidine-displacing substance.

Journal: Biochemistry 20041228

Title: Relative exposure to beta-carbolines norharman and harman from foods and tobacco smoke.

Journal: Food additives and contaminants 20041101

Title: The putative imidazoline receptor agonist, harmane, promotes intracellular calcium mobilisation in pancreatic beta-cells.

Journal: European journal of pharmacology 20041006

Title: Carcinogenicity of aminophenylnorharman, a possible novel endogenous mutagen, formed from norharman and aniline, in F344 rats.

Journal: Carcinogenesis 20041001

Title: Norharman and alcohol-dependency in male Wistar rats.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20041001

Title: Tacrolimus-induced neurotoxicity and nephrotoxicity is ameliorated by administration in the dark phase in rats.

Journal: Cellular and molecular neurobiology 20041001

Title: Protective effect of 1-methylated beta-carbolines against 3-morpholinosydnonimine-induced mitochondrial damage and cell viability loss in PC12 cells.

Journal: Neurochemical research 20041001

Title: Synthesis, acute toxicities, and antitumor effects of novel 9-substituted beta-carboline derivatives.

Journal: Bioorganic & medicinal chemistry 20040901

Title: Identification of cytochrome P-450s involved in the formation of APNH from norharman with aniline.

Journal: Mutation research 20040808

Title: Antibiotic-mediated release of tumour necrosis factor alpha and norharman in patients with hospital-acquired pneumonia and septic encephalopathy.

Journal: Intensive care medicine 20040801

Title: Modulation of cytochrome P450 1A1 by food-derived heterocyclic aromatic amines.

Journal: Toxicology 20040701

Title: Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake.

Journal: Journal of neurochemistry 20040501

Title: Photophysics of norharmane in micellar environments: a fluorometric study.

Journal: Biophysical chemistry 20040501

Title: Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine.

Journal: Biochemical and biophysical research communications 20040423

Title: Pi-delocalized beta-carbolinium cations as potential antimalarials.

Journal: Bioorganic & medicinal chemistry letters 20040405

Title: Effects of ayahuasca on binocular rivalry with dichoptic stimulus alternation.

Journal: Psychopharmacology 20040401

Title: Transport of harman alkaloids across Caco-2 cell monolayers.

Journal: Chemical & pharmaceutical bulletin 20040401

Title: Harmine: evaluation of its antileishmanial properties in various vesicular delivery systems.

Journal: Journal of drug targeting 20040401

Title: Exposure to beta-carbolines norharman and harman.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040325

Title: Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.

Journal: Bioorganic & medicinal chemistry letters 20040223

Title: Trypanocidal constituents in plants 3. Leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense.

Journal: Biological & pharmaceutical bulletin 20040101

Title: In vitro activity of the beta-carboline alkaloids harmane, harmine, and harmaline toward parasites of the species Leishmania infantum.

Journal: Experimental parasitology 20040101

Title: Ultrastructural changes induced in HeLa cells after phototoxic treatment with harmine.

Journal: Journal of applied toxicology : JAT 20040101

Title: Binding of beta-carbolines at 5-HT(2) serotonin receptors.

Journal: Bioorganic & medicinal chemistry letters 20031215

Title: Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans.

Journal: European journal of pharmacology 20031215

Title: Potent genotoxicity of aminophenylnorharman, formed from non-mutagenic norharman and aniline, in the liver of gpt delta transgenic mouse.

Journal: Carcinogenesis 20031201

Title: Craving for cigarettes among low and high dependent smokers: impact of norharman.

Journal: Addiction biology 20031201

Title: Endogenous beta-carbolines as clonidine-displacing substances.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Characterization of [(3)H]harmane binding to rat whole brain membranes.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Effect of harmane on mononeuropathic pain in rats.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Inhibitory effect of harmane on morphine-dependent Guinea pig ileum.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Effect of harmane on the convulsive threshold in epilepsy models in mice.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Harmane induces anxiolysis and antidepressant-like effects in rats.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Endogenous imidazoline receptor ligands relax rat aorta by an endothelium-dependent mechanism.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Atypical [(3)H]clonidine binding sites in human caudate and platelets on cryostat-cut sections.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Possibility of the involvement of 9H-pyrido[3,4-b]indole (norharman) in carcinogenesis via inhibition of cytochrome P450-related activities and intercalation to DNA.

Journal: Mutation research 20031110

Title: Effects of harman and harmine on naloxone-precipitated withdrawal syndrome in morphine-dependent rats.

Journal: Life sciences 20030919

Title: Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors.

Journal: Journal of medicinal chemistry 20030828

Title: Detection and characterization of cyclodextrin complexes with beta-carboline derivatives by spectroscopic techniques.

Journal: Journal of pharmaceutical and biomedical analysis 20030808

Title: Demonstration of high monoaminoxidase-A levels in neuroendocrine gastroenteropancreatic tumors in vitro and in vivo-tumor visualization using positron emission tomography with 11C-harmine.

Journal: Nuclear medicine and biology 20030801

Title: Human pharmacology of ayahuasca: subjective and cardiovascular effects, monoamine metabolite excretion, and pharmacokinetics.

Journal: The Journal of pharmacology and experimental therapeutics 20030701

Title: Microbial metabolites of harman alkaloids.

Journal: Chemical & pharmaceutical bulletin 20030601

Title: Agmatine and imidazoline systems--fourth international symposium: 9-11 April 2003, San Diego, CA, USA.

Journal: IDrugs : the investigational drugs journal 20030601

Title: Activities of extract and constituents of Banisteriopsis caapi relevant to parkinsonism.

Journal: Pharmacology, biochemistry, and behavior 20030601

Title: Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine.

Journal: The Journal of pharmacology and experimental therapeutics 20030401

Title: 11C-harmine as a potential PET tracer for ductal pancreas cancer: in vitro studies.

Journal: European radiology 20030401

Title: Sulfate conjugating and transport functions of MDCK distal tubular cells.

Journal: Kidney international 20030301

Title: HPLC method for the analysis of harmol, harmalol, harmine and harmaline in the seeds of Peganum harmala L.

Journal: Journal of pharmaceutical and biomedical analysis 20030226

Title: Isolation and identification of two [(3)H]norharman- ([(3)H]beta-carboline)-binding proteins from rat liver.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030125

Title: Identification of harman as the antibiotic compound produced by a tunicate-associated bacterium.

Journal: Marine biotechnology (New York, N.Y.) 20030101

Title: Effects of the Amazonian psychoactive beverage Ayahuasca on binocular rivalry: interhemispheric switching or interhemispheric fusion?

Journal: Journal of psychoactive drugs 20030101

Title: Synthesis of some phenacyl derivatives of 1-methyl-7-methoxy-beta-carboline and their behavioural study.

Journal: Pakistan journal of pharmaceutical sciences 20030101

Title: Elevation of blood beta-carboline alkaloids in essential tremor.

Journal: Neurology 20021224

Title: Inhibitors alter the spectrum and redox properties of monoamine oxidase A.

Journal: Biochimica et biophysica acta 20021216

Title: Sphingolipids from Conyza canadensis.

Journal: Phytochemistry 20021201

Title: Determination of N,N-dimethyltryptamine and beta-carboline alkaloids in human plasma following oral administration of Ayahuasca.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021105

Title: Exudation of fluorescent beta-carbolines from Oxalis tuberosa L roots.

Journal: Phytochemistry 20021101

Title: Identification of brain proteins that interact with 2-methylnorharman. An analog of the parkinsonian-inducing toxin, MPP+.

Journal: Neuroscience research 20021101

Title: Collision-induced dissociation actualized the H+-promoted reaction as observed in vitro; harman formation from beta-carboline-type monoterpenoid glucoindole alkaloids.

Journal: Chemical & pharmaceutical bulletin 20021101

Title: Structure of DNA adduct formed with aminophenylnorharman, being responsible for the comutagenic action of norharman with aniline.

Journal: Chemical research in toxicology 20021001

Title: In vitro and in vivo formation of aminophenylnorharman from norharman and aniline.

Journal: Mutation research 20020930

Title: Trypanocidal constituents in plants 1. Evaluation of some Mexican plants for their trypanocidal activity and active constituents in Guaco, roots of Aristolochia taliscana.

Journal: Biological & pharmaceutical bulletin 20020901

Title: Dynamic study of excited state hydrogen-bonded complexes of harmane in cyclohexane-toluene mixtures.

Journal: Photochemistry and photobiology 20020901

Title: Collective poisoning with hallucinogenous herbal tea.

Journal: Forensic science international 20020814

Title: Identification and occurrence of the bioactive beta-carbolines norharman and harman in coffee brews.

Journal: Food additives and contaminants 20020801

Title: Tetrahydro-beta-carboline alkaloids that occur in foods and biological systems act as radical scavengers and antioxidants in the ABTS assay.

Journal: Free radical research 20020801

Title: Thermodynamic study of small hydrophobic ions at the water-lipid interface.

Journal: Journal of colloid and interface science 20020701

Title: Affinitive separation and on-line identification of antitumor components from Peganum nigellastrum by coupling a chromatographic column of target analogue imprinted polymer with mass spectrometry.

Journal: Analytical chemistry 20020515

Title: Natural variations of precursors in pig meat affect the yield of heterocyclic amines--effects of RN genotype, feeding regime, and sex.

Journal: Journal of agricultural and food chemistry 20020508

Title: The levels of norharman are high enough after smoking to affect monoamineoxidase B in platelets.

Journal: European journal of pharmacology 20020419

Title: Beta-carbolines as specific inhibitors of cyclin-dependent kinases.

Journal: Bioorganic & medicinal chemistry letters 20020408

Title: Induction of sister chromatid exchanges and chromosome aberrations in cultured mammalian cells treated with aminophenylnorharman formed by norharman with aniline.

Journal: Mutation research 20020325

Title: Genotoxic and recombinogenic activities of the two beta-carboline alkaloids harman and harmine in Saccharomyces cerevisiae.

Journal: Mutation research 20020320

Title: Maternal and developmental toxicity in mice by aminophenylnorharman, formed from norharman and aniline.

Journal: Human & experimental toxicology 20020301

Title: The impact of smoking and drinking on plasma levels of norharman.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020201

Title: Synergistic in vitro antimalarial activity of plant extracts used as traditional herbal remedies in Mali.

Journal: Parasitology research 20020201

Title: An in vitro evaluation of human DNA topoisomerase I inhibition by Peganum harmala L. seeds extract and its beta-carboline alkaloids.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20020101

Title: Interaction of folk medicinal plant extracts with human alpha2-adrenoceptor subtypes.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101

Title: An in vitro study on the kinetics, subcellular distribution and phototoxicity of harmine in human tumor cells.

Journal: Bollettino chimico farmaceutico 20020101

Title: [Serum norharman and harman analysis using high pressure liquid chromatography/mass spectrometry and value of beta-carbolines as blood alcohol markers].

Journal: Archiv fur Kriminologie 20020101

Title: Toxicokinetics of tremorogenic natural products, harmane and harmine, in male Sprague-Dawley rats.

Journal: Journal of toxicology and environmental health. Part A 20011221

Title: Degradation of tetrahydro-beta-carbolines in the presence of nitrite: HPLC-MS analysis of the reaction products.

Journal: Journal of agricultural and food chemistry 20011201

Title: Effects of harmine on dopamine output and metabolism in rat striatum: role of monoamine oxidase-A inhibition.

Journal: Psychopharmacology 20011201

Title: Genotoxic effects of the alkaloids harman and harmine assessed by comet assay and chromosome aberration test in mammalian cells in vitro.

Journal: Pharmacology & toxicology 20011201

Title: Spasmolytic effects of three harmala alkaloids on guinea-pig isolated trachea.

Journal: Pharmacology & toxicology 20011101

Title: Pharmacokinetics of the beta-carboline norharman in man.

Journal: Life sciences 20010921

Title: Testicular toxicity in F344 rats by aminophenylnorharman, formed from norharman and aniline.

Journal: Toxicology and applied pharmacology 20010901

Title: [Neurochemical characteristics of the ventromedial hypothalamus and anti-aversive effects of anxiolytic agents in various anxiety models].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20010901

Title: Stimulatory effect of harmane and other beta-carbolines on locus coeruleus neurons in anaesthetized rats.

Journal: Neuroscience letters 20010810

Title: Oxidative DNA damage by an N-hydroxy metabolite of the mutagenic compound formed from norharman and aniline.

Journal: Mutation research 20010725

Title: Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives.

Journal: Journal of natural products 20010701

Title: Structures of mutagens produced by the co-mutagen norharman with o- and m-toluidine isomers.

Journal: Mutation research 20010627

Title: The acute effects of norharman on cocaine self-administration and sensorimotor function in male Wistar rats.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20010601

Title: Tryptophan: a precursor for the endogenous synthesis of norharman in man.

Journal: Neuroscience letters 20010511

Title: Protective effect of harmaline and harmalol against dopamine- and 6-hydroxydopamine-induced oxidative damage of brain mitochondria and synaptosomes, and viability loss of PC12 cells.

Journal: The European journal of neuroscience 20010501

Title: Identification of co-mutagenic chlorinated harmans in final effluent from a sewage treatment plant.

Journal: Mutation research 20010405

Title: Hydrogen bonding NH/pi interactions between betacarboline and methyl benzene derivatives.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20010401

Title: Comparative study on the vasorelaxant effects of three harmala alkaloids in vitro.

Journal: Japanese journal of pharmacology 20010301

Title: Norharman, an indoleamine-derived beta-carboline, but not Trp-P-2, a gamma-carboline, induces apoptotic cell death in human neuroblastoma SH-SY5Y cells.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20010101

Title: Evaluation of pyridoindoles, pyridylindoles and pyridylpyridoindoles as matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20010101

Title: Pharmepéna-Psychonautics: Human intranasal, sublingual and oral pharmacology of 5-methoxy-N,N-dimethyl-tryptamine.

Journal: Journal of psychoactive drugs 20010101

Title: Steroid hormone activity of flavonoids and related compounds.

Journal: Breast cancer research and treatment 20000701

Title: Synthesis of some 11C-labelled MAO-A inhibitors and their in vivo uptake kinetics in rhesus monkey brain.

Journal: Nuclear medicine and biology 19970701

Title: Effects of beta- and gamma-carboline derivatives of DNA topoisomerase activities.

Journal: Mutation research 19960201

Title: Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies.

Journal: Journal of medicinal chemistry 19930430

Title: Studies on the mechanism of chlordecone-induced tremor in rats.

Journal: Neurotoxicology 19850101

Title: Inhibition of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by beta-carboline and indole derivatives.

Journal: Archives of biochemistry and biophysics 19840801

Title: Inhibition of benzodiazepine and GABA receptor binding by amino-gamma-carbolines and other amino acid pyrolysate mutagens.

Journal: European journal of pharmacology 19840210

Title: Anticonvulsant effects of caerulein, cholecystokinin octapeptide (CCK-8) and diazepam against seizures produced in mice by harman, thiosemicarbazide and isoniazid.

Journal: Neuroscience letters 19810702

Title: Anti-tremor action of C10Dichol, a peripheral acetylcholine synthesis inhibitor.

Journal: British journal of pharmacology 19800101

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Tags:442-51-3 Molecular Formula|442-51-3 MDL|442-51-3 SMILES|442-51-3 Harmine