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442666-98-0,MFCD03308216
Catalog No.:AA00DB20

442666-98-0 | Anguizole

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$211.00   $148.00
- +
10mg
≥98%
in stock  
$307.00   $215.00
- +
50mg
≥98%
in stock  
$897.00   $628.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DB20
Chemical Name:
Anguizole
CAS Number:
442666-98-0
Molecular Formula:
C17H11ClF2N4O2S
Molecular Weight:
408.8096
MDL Number:
MFCD03308216
SMILES:
O=C(c1cc2n(n1)c(cc(n2)c1ccco1)C(Cl)(F)F)NCc1cccs1
Properties
Computed Properties
 
Complexity:
561  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
3.1  

Literature

Title: Discovery of a novel class of potent HCV NS4B inhibitors: SAR studies on piperazinone derivatives.

Journal: Journal of medicinal chemistry 20140313

Title: A hepatitis C virus NS4B inhibitor suppresses viral genome replication by disrupting NS4B's dimerization/multimerization as well as its interaction with NS5A.

Journal: Virus genes 20131201

Title: A small molecule inhibits HCV replication and alters NS4B's subcellular distribution.

Journal: Antiviral research 20100701

Title: Bryson, Paul D. et al. A small molecule inhibits HCV replication and alters NS4B's subcellular distribution Antiviral Research (2010), 87(1), 1-8.

Title: Cho, Nam-Joon et al. Identification of a class of HCV inhibitors directed against the nonstructural protein NS4B. Science Translational Medicine (2010), 2(15), No pp. given.

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SDS
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