443-72-1,MFCD00075820
Catalog No.:AA00I8BR

443-72-1 | 6-(Methylamino)purine

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250mg
97%
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1g
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$128.00   $90.00
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5g
97%
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$388.00   $271.00
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10g
95%
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$766.00   $536.00
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25g
95%
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$1,369.00 $958.00
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00I8BR
Chemical Name:
6-(Methylamino)purine
CAS Number:
443-72-1
Molecular Formula:
C6H7N5
Molecular Weight:
149.1533
MDL Number:
MFCD00075820
SMILES:
CNc1ncnc2c1[nH]cn2
NSC Number:
11580
Properties
Properties
 
BP:
492.9°C at 760 mmHg  
Form:
Solid  
MP:
≥300°C  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
139  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
0.6  

Upstream Synthesis Route

[1]Patent:EP1724258,2006,A1,.Locationinpatent:Page/Pagecolumn138

[1]Patent:US4423219,1983,A,

[1]Patent:US4900826,1990,A,

[1]Patent:US4423219,1983,A,

[1]EuropeanJournalofMedicinalChemistry,2003,vol.38,#2,p.199-214

Downstream Synthesis Route

[1]ChemicalandPharmaceuticalBulletin,1983,vol.31,p.4270-4276

[1]Patent:US4423219,1983,A

[2]Patent:US4189485,1980,A

[3]EuropeanJournalofMedicinalChemistry,1980,vol.15,p.207-210

[1]EuropeanJournalofMedicinalChemistry,1980,vol.15,p.207-210

[1]Heterocycles,1982,vol.17,p.117-123

[1]JournalofOrganicChemistry,1990,vol.55,p.5761-5766

Literature

Title: Differential effect of three base modifications on DNA thermostability revealed by high resolution melting.

Journal: Analytical chemistry 20120904

Title: RNA methylation by the MIS complex regulates a cell fate decision in yeast.

Journal: PLoS genetics 20120601

Title: Exocyclic carbons adjacent to the N6 of adenine are targets for oxidation by the Escherichia coli adaptive response protein AlkB.

Journal: Journal of the American Chemical Society 20120530

Title: Trmt112 gene expression in mouse embryonic development.

Journal: Acta histochemica et cytochemica 20120426

Title: DNA-Platinum Thin Films for Use in Chemoradiation Therapy Studies.

Journal: Bioinorganic chemistry and applications 20120101

Title: Adenosine Methylation in Arabidopsis mRNA is Associated with the 3' End and Reduced Levels Cause Developmental Defects.

Journal: Frontiers in plant science 20120101

Title: Cellular dynamics of RNA modification.

Journal: Accounts of chemical research 20111220

Title: Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity.

Journal: Environmental health perspectives 20110601

Title: DamIP: using mutant DNA adenine methyltransferase to study DNA-protein interactions in vivo.

Journal: Current protocols in molecular biology 20110401

Title: Enzymatic deamination of the epigenetic base N-6-methyladenine.

Journal: Journal of the American Chemical Society 20110223

Title: IS-linked movement of a restriction-modification system.

Journal: PloS one 20110101

Title: Direct detection and sequencing of damaged DNA bases.

Journal: Genome integrity 20110101

Title: Conflicts targeting epigenetic systems and their resolution by cell death: novel concepts for methyl-specific and other restriction systems.

Journal: DNA research : an international journal for rapid publication of reports on genes and genomes 20101201

Title: Genomic N(6)-methyladenine determination by MEKC with LIF.

Journal: Electrophoresis 20101001

Title: Discrimination of N6-methyl adenine in a specific DNA sequence.

Journal: Chemical communications (Cambridge, England) 20100814

Title: Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds.

Journal: FEBS letters 20100219

Title: Biosynthesis and molecular genetics of polyketides in marine dinoflagellates.

Journal: Marine drugs 20100101

Title: Cloning of NruI and Sbo13I restriction and modification sstems in E. coli and amino acid sequence comparison of M.NruI and M.Sbo13I with other amino-methyltransferases.

Journal: BMC research notes 20100101

Title: Riboswitches as hormone receptors: hypothetical cytokinin-binding riboswitches in Arabidopsis thaliana.

Journal: Biology direct 20100101

Title: Insensitivity of chloroplast gene expression to DNA methylation.

Journal: Molecular genetics and genomics : MGG 20090701

Title: Effect of 1-methyladenine on thermodynamic stabilities of double-helical DNA structures.

Journal: FEBS letters 20090506

Title: Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more.

Journal: FEMS microbiology reviews 20090501

Title: M1.MboII and M2.MboII type IIS methyltransferases: different specificities, the same target.

Journal: Microbiology (Reading, England) 20090401

Title: H1 histone modulates DNA hydrolysis with WEN1 and WEN2 endonucleases from wheat coleoptiles.

Journal: Biochemistry. Biokhimiia 20090201

Title: Expansion of a chromosomal repeat in Escherichia coli: roles of replication, repair, and recombination functions.

Journal: BMC molecular biology 20090101

Title: Separation of purine and pyrimidine bases by ion chromatography with direct conductivity detection.

Journal: Journal of chromatography. A 20080606

Title: Clocks and switches: bacterial gene regulation by DNA adenine methylation.

Journal: Current opinion in microbiology 20080401

Title: Cell death upon epigenetic genome methylation: a novel function of methyl-specific deoxyribonucleases.

Journal: Genome biology 20080101

Title: Anion-pi interactions in bisadenine derivatives: a combined crystallographic and theoretical study.

Journal: Inorganic chemistry 20071210

Title: A view of an elemental naturalist at the DNA world (base composition, sequences, methylation).

Journal: Biochemistry. Biokhimiia 20071201

Title: Growth of the protozoan parasite Entamoeba histolytica in 5-azacytidine has limited effects on parasite gene expression.

Journal: BMC genomics 20070101

Title: Mapping sequences by parts.

Journal: Algorithms for molecular biology : AMB 20070101

Title: [DNA methylation and epigenetics].

Journal: Genetika 20060901

Title: Calcium-stimulated guanosine--inosine nucleosidase from yellow lupin (Lupinus luteus).

Journal: Phytochemistry 20060701

Title: Undetectable levels of N6-methyl adenine in mouse DNA: Cloning and analysis of PRED28, a gene coding for a putative mammalian DNA adenine methyltransferase.

Journal: FEBS letters 20060529

Title: N6-methyladenine: the other methylated base of DNA.

Journal: BioEssays : news and reviews in molecular, cellular and developmental biology 20060301

Title: N6-methyl-adenine: an epigenetic signal for DNA-protein interactions.

Journal: Nature reviews. Microbiology 20060301

Title: DNA methylation in plants.

Journal: Current topics in microbiology and immunology 20060101

Title: DNA methylation impacts the cleavage activity of Chlorella virus topoisomerase II.

Journal: Biochemistry 20051122

Title: Effect of methylated adenine in plasmid DNA on transgene expression in mice.

Journal: Biological & pharmaceutical bulletin 20051001

Title: Location of the bases modified by M.BcoKIA and M.BcoKIB methylases in the sequence 5 -CTCTTC-3 /5 -GAAGAG-3.

Journal: Biochemistry. Biokhimiia 20051001

Title: Deinococcus radiodurans strain R1 contains N6-methyladenine in its genome.

Journal: Biochemical and biophysical research communications 20050923

Title: MnlI--The member of H-N-H subtype of Type IIS restriction endonucleases.

Journal: Biochimica et biophysica acta 20050810

Title: Enzymatic DNA methylation is an epigenetic control for genetic functions of the cell.

Journal: Biochemistry. Biokhimiia 20050501

Title: DNA-[adenine] methylation in lower eukaryotes.

Journal: Biochemistry. Biokhimiia 20050501

Title: The language of methylation in genomics of eukaryotes.

Journal: Biochemistry. Biokhimiia 20050501

Title: Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues.

Journal: Molecular pharmacology 20050301

Title: Cytokine induction by a bacterial DNA-specific modified base.

Journal: Biochemical and biophysical research communications 20050128

Title: The N6-methyl group of adenine further increases the BI stability of DNA compared to C5-methyl groups.

Journal: The journal of physical chemistry. B 20050113

Title: GATC-specific restriction and modification systems in treponemes.

Journal: Letters in applied microbiology 20040101

Title: Characterization of the LlaCI methyltransferase from Lactococcus lactis subsp. cremoris W15 provides new insights into the biology of type II restriction-modification systems.

Journal: Microbiology (Reading, England) 20031101

Title: Influence of local duplex stability and N6-methyladenine on uracil recognition by mismatch-specific uracil-DNA glycosylase (Mug).

Journal: Chemical research in toxicology 20021201

Title: Synthesis and biological evaluation of novel thioapio dideoxynucleosides.

Journal: Bioorganic & medicinal chemistry 20020501

Title: Sequence permutations in the molecular evolution of DNA methyltransferases.

Journal: BMC evolutionary biology 20020101

Title: Characterization of AloI, a restriction-modification system of a new type.

Journal: Journal of molecular biology 20011123

Title: Identification of a PD-(D/E)XK-like domain with a novel configuration of the endonuclease active site in the methyl-directed restriction enzyme Mrr and its homologs.

Journal: Gene 20010418

Title: mRNA:guanine-N7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships.

Journal: BMC bioinformatics 20010101

Title: Adenine-induced selective apoptosis toward HIV chronically infected cells in vitro.

Journal: Biochemical and biophysical research communications 20000714

Title: Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii.

Journal: Biochemical pharmacology 19951109

Title: Effect of various protein kinase inhibitors on the induction of milk protein gene expression by prolactin.

Journal: Molecular and cellular endocrinology 19930301

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SDS
Tags:443-72-1 Molecular Formula|443-72-1 MDL|443-72-1 SMILES|443-72-1 6-(Methylamino)purine
Catalog No.: AA00I8BR
443-72-1,MFCD00075820
443-72-1 | 6-(Methylamino)purine
Pack Size: 100mg
Purity: 97%
in stock
$35.00 $25.00
Pack Size: 250mg
Purity: 97%
in stock
$52.00 $37.00
Pack Size: 1g
Purity: 97%
in stock
$128.00 $90.00
Pack Size: 5g
Purity: 97%
in stock
$388.00 $271.00
Pack Size: 10g
Purity: 95%
in stock
$766.00 $536.00
Pack Size: 25g
Purity: 95%
in stock
$1,369.00 $958.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00I8BR
Chemical Name: 6-(Methylamino)purine
CAS Number: 443-72-1
Molecular Formula: C6H7N5
Molecular Weight: 149.1533
MDL Number: MFCD00075820
SMILES: CNc1ncnc2c1[nH]cn2
NSC Number: 11580
Properties
BP: 492.9°C at 760 mmHg  
Form: Solid  
MP: ≥300°C  
Storage: Keep in dry area;Room Temperature;  
Complexity: 139  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 11  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 0.6  
Upstream Synthesis Route
87-42-3    74-89-5    443-72-1 

[1]Patent:EP1724258,2006,A1,.Locationinpatent:Page/Pagecolumn138

122-51-0    443-72-1 

[1]Patent:US4423219,1983,A,

7440-02-0    66224-66-6    443-72-1 

[1]Patent:US4900826,1990,A,

83366-44-3    443-72-1 

[1]Patent:US4423219,1983,A,

74-89-5    443-72-1 

[1]EuropeanJournalofMedicinalChemistry,2003,vol.38,#2,p.199-214

Downstream Synthesis Route
5142-22-3    443-72-1 

[1]ChemicalandPharmaceuticalBulletin,1983,vol.31,p.4270-4276

55117-15-2    443-72-1    70091-21-3 

[1]Patent:US4423219,1983,A

[2]Patent:US4189485,1980,A

[3]EuropeanJournalofMedicinalChemistry,1980,vol.15,p.207-210

55117-15-2    443-72-1    76099-78-0 

[1]EuropeanJournalofMedicinalChemistry,1980,vol.15,p.207-210

1867-73-8    443-72-1 

[1]Heterocycles,1982,vol.17,p.117-123

100-44-7    443-72-1    81060-73-3    129918-40-7 

[1]JournalofOrganicChemistry,1990,vol.55,p.5761-5766

Literature fold

Title: Differential effect of three base modifications on DNA thermostability revealed by high resolution melting.

Journal: Analytical chemistry20120904

Title: RNA methylation by the MIS complex regulates a cell fate decision in yeast.

Journal: PLoS genetics20120601

Title: Exocyclic carbons adjacent to the N6 of adenine are targets for oxidation by the Escherichia coli adaptive response protein AlkB.

Journal: Journal of the American Chemical Society20120530

Title: Trmt112 gene expression in mouse embryonic development.

Journal: Acta histochemica et cytochemica20120426

Title: DNA-Platinum Thin Films for Use in Chemoradiation Therapy Studies.

Journal: Bioinorganic chemistry and applications20120101

Title: Adenosine Methylation in Arabidopsis mRNA is Associated with the 3' End and Reduced Levels Cause Developmental Defects.

Journal: Frontiers in plant science20120101

Title: Cellular dynamics of RNA modification.

Journal: Accounts of chemical research20111220

Title: Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity.

Journal: Environmental health perspectives20110601

Title: DamIP: using mutant DNA adenine methyltransferase to study DNA-protein interactions in vivo.

Journal: Current protocols in molecular biology20110401

Title: Enzymatic deamination of the epigenetic base N-6-methyladenine.

Journal: Journal of the American Chemical Society20110223

Title: IS-linked movement of a restriction-modification system.

Journal: PloS one20110101

Title: Direct detection and sequencing of damaged DNA bases.

Journal: Genome integrity20110101

Title: Conflicts targeting epigenetic systems and their resolution by cell death: novel concepts for methyl-specific and other restriction systems.

Journal: DNA research : an international journal for rapid publication of reports on genes and genomes20101201

Title: Genomic N(6)-methyladenine determination by MEKC with LIF.

Journal: Electrophoresis20101001

Title: Discrimination of N6-methyl adenine in a specific DNA sequence.

Journal: Chemical communications (Cambridge, England)20100814

Title: Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds.

Journal: FEBS letters20100219

Title: Biosynthesis and molecular genetics of polyketides in marine dinoflagellates.

Journal: Marine drugs20100101

Title: Cloning of NruI and Sbo13I restriction and modification sstems in E. coli and amino acid sequence comparison of M.NruI and M.Sbo13I with other amino-methyltransferases.

Journal: BMC research notes20100101

Title: Riboswitches as hormone receptors: hypothetical cytokinin-binding riboswitches in Arabidopsis thaliana.

Journal: Biology direct20100101

Title: Insensitivity of chloroplast gene expression to DNA methylation.

Journal: Molecular genetics and genomics : MGG20090701

Title: Effect of 1-methyladenine on thermodynamic stabilities of double-helical DNA structures.

Journal: FEBS letters20090506

Title: Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more.

Journal: FEMS microbiology reviews20090501

Title: M1.MboII and M2.MboII type IIS methyltransferases: different specificities, the same target.

Journal: Microbiology (Reading, England)20090401

Title: H1 histone modulates DNA hydrolysis with WEN1 and WEN2 endonucleases from wheat coleoptiles.

Journal: Biochemistry. Biokhimiia20090201

Title: Expansion of a chromosomal repeat in Escherichia coli: roles of replication, repair, and recombination functions.

Journal: BMC molecular biology20090101

Title: Separation of purine and pyrimidine bases by ion chromatography with direct conductivity detection.

Journal: Journal of chromatography. A20080606

Title: Clocks and switches: bacterial gene regulation by DNA adenine methylation.

Journal: Current opinion in microbiology20080401

Title: Cell death upon epigenetic genome methylation: a novel function of methyl-specific deoxyribonucleases.

Journal: Genome biology20080101

Title: Anion-pi interactions in bisadenine derivatives: a combined crystallographic and theoretical study.

Journal: Inorganic chemistry20071210

Title: A view of an elemental naturalist at the DNA world (base composition, sequences, methylation).

Journal: Biochemistry. Biokhimiia20071201

Title: Growth of the protozoan parasite Entamoeba histolytica in 5-azacytidine has limited effects on parasite gene expression.

Journal: BMC genomics20070101

Title: Mapping sequences by parts.

Journal: Algorithms for molecular biology : AMB20070101

Title: [DNA methylation and epigenetics].

Journal: Genetika20060901

Title: Calcium-stimulated guanosine--inosine nucleosidase from yellow lupin (Lupinus luteus).

Journal: Phytochemistry20060701

Title: Undetectable levels of N6-methyl adenine in mouse DNA: Cloning and analysis of PRED28, a gene coding for a putative mammalian DNA adenine methyltransferase.

Journal: FEBS letters20060529

Title: N6-methyladenine: the other methylated base of DNA.

Journal: BioEssays : news and reviews in molecular, cellular and developmental biology20060301

Title: N6-methyl-adenine: an epigenetic signal for DNA-protein interactions.

Journal: Nature reviews. Microbiology20060301

Title: DNA methylation in plants.

Journal: Current topics in microbiology and immunology20060101

Title: DNA methylation impacts the cleavage activity of Chlorella virus topoisomerase II.

Journal: Biochemistry20051122

Title: Effect of methylated adenine in plasmid DNA on transgene expression in mice.

Journal: Biological & pharmaceutical bulletin20051001

Title: Location of the bases modified by M.BcoKIA and M.BcoKIB methylases in the sequence 5 -CTCTTC-3 /5 -GAAGAG-3.

Journal: Biochemistry. Biokhimiia20051001

Title: Deinococcus radiodurans strain R1 contains N6-methyladenine in its genome.

Journal: Biochemical and biophysical research communications20050923

Title: MnlI--The member of H-N-H subtype of Type IIS restriction endonucleases.

Journal: Biochimica et biophysica acta20050810

Title: Enzymatic DNA methylation is an epigenetic control for genetic functions of the cell.

Journal: Biochemistry. Biokhimiia20050501

Title: DNA-[adenine] methylation in lower eukaryotes.

Journal: Biochemistry. Biokhimiia20050501

Title: The language of methylation in genomics of eukaryotes.

Journal: Biochemistry. Biokhimiia20050501

Title: Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues.

Journal: Molecular pharmacology20050301

Title: Cytokine induction by a bacterial DNA-specific modified base.

Journal: Biochemical and biophysical research communications20050128

Title: The N6-methyl group of adenine further increases the BI stability of DNA compared to C5-methyl groups.

Journal: The journal of physical chemistry. B20050113

Title: GATC-specific restriction and modification systems in treponemes.

Journal: Letters in applied microbiology20040101

Title: Characterization of the LlaCI methyltransferase from Lactococcus lactis subsp. cremoris W15 provides new insights into the biology of type II restriction-modification systems.

Journal: Microbiology (Reading, England)20031101

Title: Influence of local duplex stability and N6-methyladenine on uracil recognition by mismatch-specific uracil-DNA glycosylase (Mug).

Journal: Chemical research in toxicology20021201

Title: Synthesis and biological evaluation of novel thioapio dideoxynucleosides.

Journal: Bioorganic & medicinal chemistry20020501

Title: Sequence permutations in the molecular evolution of DNA methyltransferases.

Journal: BMC evolutionary biology20020101

Title: Characterization of AloI, a restriction-modification system of a new type.

Journal: Journal of molecular biology20011123

Title: Identification of a PD-(D/E)XK-like domain with a novel configuration of the endonuclease active site in the methyl-directed restriction enzyme Mrr and its homologs.

Journal: Gene20010418

Title: mRNA:guanine-N7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships.

Journal: BMC bioinformatics20010101

Title: Adenine-induced selective apoptosis toward HIV chronically infected cells in vitro.

Journal: Biochemical and biophysical research communications20000714

Title: Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii.

Journal: Biochemical pharmacology19951109

Title: Effect of various protein kinase inhibitors on the induction of milk protein gene expression by prolactin.

Journal: Molecular and cellular endocrinology19930301

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