[1]CurrentPatentAssignee:CHINESEACADEMYOFSCIENCES-CN109053546,2018,ALocationinpatent:Paragraph0043-0046
[1]CurrentPatentAssignee:CHENGDUCHENLONGZHANGTECH-CN115108964,2022,ALocationinpatent:Paragraph0052-0057
Title: Essential oils of culinary herbs and spices display agonist and antagonist activities at human aryl hydrocarbon receptor AhR.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180101
Title: Protective HSP70 Induction by Z-Ligustilide against Oxygen-Glucose Deprivation Injury via Activation of the MAPK Pathway but Not of HSF1.
Journal: Biological & pharmaceutical bulletin 20150101
Title: Klotho upregulation contributes to the neuroprotection of ligustilide in an Alzheimer's disease mouse model.
Journal: Neurobiology of aging 20140101
Title: Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation.
Journal: Chemical research in toxicology 20130318
Title: Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion.
Journal: Journal of ethnopharmacology 20121121
Title: Z-ligustilide potentiates the cytotoxicity of dopamine in rat dopaminergic PC12 cells.
Journal: Neurotoxicity research 20121101
Title: Chemical and biological assessment of Angelica herbal decoction: comparison of different preparations during historical applications.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120815
Title: Identification and quantification of the major volatile constituents in antidepressant active fraction of xiaoyaosan by gas chromatography-mass spectrometry.
Journal: Journal of ethnopharmacology 20120507
Title: Bioactivity-guided fractionation of the volatile oil of Angelica sinensis radix designed to preserve the synergistic effects of the mixture followed by identification of the active principles.
Journal: Journal of chromatography. A 20120504
Title: [Influence of different solutions on extracting of active components in Danggui Chishao drug pair].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120401
Title: Potential roles of PI3K/Akt and Nrf2-Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation.
Journal: Neuropharmacology 20120301
Title: Anti-inflammatory effects of (Z)-ligustilide through suppression of mitogen-activated protein kinases and nuclear factor-κB activation pathways.
Journal: Archives of pharmacal research 20120301
Title: [Protective effects of Z-ligustilide against cytotoxicity induced by Abeta25-35 in neuron cells].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20120101
Title: Quantitative HPLC method for determining two of the major active phthalides from Ligusticum porteri roots.
Journal: Journal of AOAC International 20120101
Title: Ligustilide: a novel TRPA1 modulator.
Journal: Pflugers Archiv : European journal of physiology 20111201
Title: Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice.
Journal: Fitoterapia 20111001
Title: Neuroprotective effect of ligustilide against ischaemia-reperfusion injury via up-regulation of erythropoietin and down-regulation of RTP801.
Journal: British journal of pharmacology 20110901
Title: Ligustilide prevents LPS-induced iNOS expression in RAW 264.7 macrophages by preventing ROS production and down-regulating the MAPK, NF-κB and AP-1 signaling pathways.
Journal: International immunopharmacology 20110901
Title: Adulticidal activity of phthalides identified in Cnidium officinale rhizome to B- and Q-biotypes of Bemisia tabaci.
Journal: Journal of agricultural and food chemistry 20110810
Title: Identification of novel pregnane X receptor activators from traditional Chinese medicines.
Journal: Journal of ethnopharmacology 20110614
Title: Treatment with Z-ligustilide, a component of Angelica sinensis, reduces brain injury after a subarachnoid hemorrhage in rats.
Journal: The Journal of pharmacology and experimental therapeutics 20110601
Title: Effects of ligustilide on lipopolysaccharide-induced endotoxic shock in rabbits.
Journal: Planta medica 20110501
Title: Isolation and identification of anti-inflammatory constituents from Ligusticum chuanxiong and their underlying mechanisms of action on microglia.
Journal: Neuropharmacology 20110501
Title: Determination of ligustilide in the brains of freely moving rats using microdialysis coupled with ultra performance liquid chromatography/mass spectrometry.
Journal: Fitoterapia 20110401
Title: (Z)-3-butylidenephthalide from Ligusticum porteri , an α-glucosidase inhibitor.
Journal: Journal of natural products 20110325
Title: [Study on feasibility of cutting process of fresh Angelica sinensis Radix].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101201
Title: [Simultaneous determination of five effective components in Rhizoma Chuanxiong by RP-HPLC].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101001
Title: Z-ligustilide attenuates lipopolysaccharide-induced proinflammatory response via inhibiting NF-kappaB pathway in primary rat microglia.
Journal: Acta pharmacologica Sinica 20100701
Title: Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-kappaB trans-activation activity and LPS-induced inflammation.
Journal: Journal of ethnopharmacology 20100527
Title: Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis.
Journal: Planta medica 20100301
Title: [Pharmacological activities of Z-ligustilide and metabolites in rats].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20090901
Title: Z-ligustilide extracted from Radix Angelica Sinensis decreased platelet aggregation induced by ADP ex vivo and arterio-venous shunt thrombosis in vivo in rats.
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090701
Title: Protective effect of Z-ligustilide against amyloid beta-induced neurotoxicity is associated with decreased pro-inflammatory markers in rat brains.
Journal: Pharmacology, biochemistry, and behavior 20090601
Title: Determination of ligustilide in rat brain after nasal administration of essential oil from Rhizoma Chuanxiong.
Journal: Fitoterapia 20090401
Title: [Enzyme kinetics of ligustilide metabolism in rat liver microsomes].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090401
Title: [In situ absorption of self-microemulsifying soft capsule of volatile oil from rhizome of ligusticum chuanxiong in rats' intestine].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090401
Title: Bioactivity-guided fractionation and GC/MS fingerprinting of Angelica sinensis and Angelica archangelica root components for antifungal and mosquito deterrent activity.
Journal: Journal of agricultural and food chemistry 20090128
Title: Optimization and comparison of five methods for extraction of coniferyl ferulate from Angelica sinensis.
Journal: Molecules (Basel, Switzerland) 20090123
Title: Simultaneous determination of phenolic acids and phthalide compounds by liquid chromatography for quality assessment of Rhizoma cnidii.
Journal: Journal of AOAC International 20090101
Title: Identification and comparison of metabolites after oral administration of essential oil of Ligusticum chuanxiong or its major constituent ligustilide in rats.
Journal: Planta medica 20081101
Title: Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1.
Journal: Chemical research in toxicology 20081001
Title: Dynamic nature of the ligustilide complex.
Journal: Journal of natural products 20080901
Title: [Development of gas chromatographic-mass spectrometry-pattern recognition method for the quality control of Chinese Angelica].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080801
Title: Characterization of chemical components in extracts from Si-wu decoction with proliferation-promoting effects on rat mesenchymal stem cells.
Journal: Bioorganic & medicinal chemistry 20080501
Title: Combinatorial anti-Trichophyton effects of Ligusticum chuanxiong essential oil components with antibiotics.
Journal: Archives of pharmacal research 20080401
Title: Pharmacokinetics and metabolism of ligustilide, a major bioactive component in Rhizoma Chuanxiong, in the rat.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080201
Title: Protection against hydrogen peroxide-induced injury by Z-ligustilide in PC12 cells.
Journal: Experimental brain research 20080101
Title: Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats.
Journal: Pharmacology, biochemistry, and behavior 20080101
Title: Application of analytical and preparative high-speed counter-current chromatography for the separation of Z-ligustilide from a crude extract of Angelica sinensis.
Journal: Phytochemical analysis : PCA 20080101
Title: A new procedure for the preparative separation and isolation of Z-ligustilide from the roots of Angelica sinensis.
Journal: Journal of separation science 20070801
Title: Inhibitors of stress-activated protein/mitogen-activated protein kinase pathways.
Journal: Current opinion in pharmacology 20070601
Title: Fast determination of Z-ligustilide in plasma by gas chromatography/mass spectrometry following headspace single-drop microextraction.
Journal: Journal of separation science 20070601
Title: Ligustilide attenuates pain behavior induced by acetic acid or formalin.
Journal: Journal of ethnopharmacology 20070530
Title: Relaxation effects of ligustilide and senkyunolide A, two main constituents of Ligusticum chuanxiong, in rat isolated aorta.
Journal: Journal of ethnopharmacology 20070522
Title: Neuroprotective effect of Z-ligustilide against permanent focal ischemic damage in rats.
Journal: Biological & pharmaceutical bulletin 20070201
Title: Ligustilide reduces phenylephrine induced-aortic tension in vitro but has no effect on systolic pressure in spontaneously hypertensive rats.
Journal: The American journal of Chinese medicine 20070101
Title: Ligustilide inhibits spontaneous and agonists- or K+ depolarization-induced contraction of rat uterus.
Journal: Journal of ethnopharmacology 20061103
Title: [High performance liquid chromatography-mass spectrometry analysis of radix Angelica sciensis].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20061101
Title: Determination of ligustilide in rat blood and tissues by capillary gas chromatography/mass spectrometry.
Journal: Biomedical chromatography : BMC 20061001
Title: Ligustilide induces vasodilatation via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release.
Journal: Vascular pharmacology 20060901
Title: [Studies on chemical constituents from Ligusticum glaucescens Franch].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060901
Title: Ligustilide inhibits vascular smooth muscle cells proliferation.
Journal: European journal of pharmacology 20060807
Title: Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice.
Journal: Brain research 20060802
Title: Factors affecting stability of z-ligustilide in the volatile oil of radix angelicae sinensis and ligusticum chuanxiong and its stability prediction.
Journal: Drug development and industrial pharmacy 20060701
Title: [Determination of ligustilide for quality assessment of Ligusticum chuanxiong].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060701
Title: Live cell extraction and HPLC-MS analysis for predicting bioactive components of traditional Chinese medicines.
Journal: Journal of pharmaceutical and biomedical analysis 20060503
Title: Analysis of volatile oil in Rhizoma ligustici chuanxiong-Radix paeoniae rubra by gas chromatography-mass spectrometry and chemometric resolution.
Journal: Acta pharmacologica Sinica 20060401
Title: Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.
Journal: Journal of natural products 20060401
Title: Optimization of pressurized liquid extraction for Z-ligustilide, Z-butylidenephthalide and ferulic acid in Angelica sinensis.
Journal: Journal of pharmaceutical and biomedical analysis 20060318
Title: Inhibitory effects of ligustilide and butylidenephthalide on bFGF-stimulated proliferation of rat smooth muscle cells.
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060201
Title: Screening, analysis and in vitro vasodilatation of effective components from Ligusticum Chuanxiong.
Journal: Life sciences 20051126
Title: LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui.
Journal: Analytical and bioanalytical chemistry 20050901
Title: [Determination of lactone components in chuanxiong by reversed-phase high performance liquid chromatography].
Journal: Se pu = Chinese journal of chromatography 20050901
Title: [The new progress of the study about volatile oil of the angelica].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050901
Title: Larvicidal and adulticidal activity of alkylphthalide derivatives from rhizome of Cnidium officinale against Drosophila melanogaster.
Journal: Journal of agricultural and food chemistry 20050713
Title: Development of pressurized hot water extraction followed by headspace solid-phase microextraction and gas chromatography-mass spectrometry for determination of ligustilides in Ligusticum chuanxiong and Angelica sinensis.
Journal: Journal of separation science 20050701
Title: [Study on preparation of refined Xiong-gui sustained release pills].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050501
Title: [Determination of ligustilide in volatile oil from rhizome of ligusticum chuanxiong by RP-HPLC].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040201
Title: [Isolation and identification of the ligustilide compounds from the root of Angelica sinensis].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030501
Title: [Constituent analysis of essential oils from radix of Angelica acutiloba].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020701
Title: [Studies on chemical constituents of the rhizomae of Ligusticum chuanxiong].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020701
Title: [Studies on the stability of ligustilide with solvent effect].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20011001
Title: Eun Sik Choi, et al. Ligustilide attenuates vascular inflammation and activates Nrf2/HO-1 induction and, NO synthesis in HUVECs. Phytomedicine. 2018 Jan 1;38:12-23.
Title: Wu Q, et al. Protective effect of ligustilide against glutamate-induced apoptosis in PC12 cells. Yao Xue Xue Bao. 2015 Feb;50(2):162-8.
Title: Jing Ma, et al. Ligustilide promotes apoptosis of cancer-associated fibroblasts via the TLR4 pathways. Food Chem Toxicol. 2020 Jan;135:110991.
