Name: Name:SB-681323
Brand: AABLOCKS
SKU: AA00DJW7
Rating: 90 (10 reviews)

Catalog No.: AA00DJW7

444606-18-2 | SB-681323

Pack Size： 5mg

Purity： 95%

1 week

$102.00 $72.00

Pack Size： 10mg

Purity： 95%

1 week

$131.00 $92.00

Pack Size： 25mg

Purity： 95%

1 week

$197.00 $138.00

Pack Size： 50mg

Purity： 95%

1 week

$284.00 $199.00

Pack Size： 100mg

Purity： 95%

1 week

$479.00 $336.00

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Technical Information

Catalog Number: AA00DJW7

Chemical Name: SB-681323

CAS Number: 444606-18-2

Molecular Formula: C23H19F3N4O3

Molecular Weight: 456.4172

MDL Number: MFCD16659063

SMILES: OCC(Nc1nc(c2ccc(cc2C)F)c2c(n1)n(c(=O)cc2)c1c(F)cccc1F)CO

Properties

Complexity: 702

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 33

Hydrogen Bond Acceptor Count: 9

Hydrogen Bond Donor Count: 3

Isotope Atom Count: 0

Rotatable Bond Count: 6

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3

Downstream Synthesis Route

444605-93-0

534-03-2

444606-18-2

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-US2004/116697,2004,A1Locationinpatent:Page37-38

[2]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2007/59500,2007,A2Locationinpatent:Page/Pagecolumn87-88

444606-18-2

104-15-4

937169-00-1

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2007/59500,2007,A2Locationinpatent:Page/Pagecolumn87-88

[2]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2007/59500,2007,A2Locationinpatent:Page/Pagecolumn99-100

[3]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2007/59500,2007,A2Locationinpatent:Page/Pagecolumn97-98

[4]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2007/59500,2007,A2Locationinpatent:Page/Pagecolumn101-102

[5]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2007/59500,2007,A2Locationinpatent:Page/Pagecolumn98-99

CASUnavailable

444606-18-2

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2007/59500,2007,A2Locationinpatent:Page/Pagecolumn99-100

[2]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2007/59500,2007,A2Locationinpatent:Page/Pagecolumn100

Literature fold

Title: Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease.

Journal: Journal of medicinal chemistry20111124

Title: A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients.

Journal: Journal of clinical pharmacology20100101

Title: p38 pathway kinases as anti-inflammatory drug targets.

Journal: Journal of dental research20070901

Title: Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signaling suppresses inflammatory bowel disease.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20041001

Title: Singh D, et al. A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. J Clin Pharmacol. 2010 Jan;50(1):94-100.

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